Osamu Hayaishi

Summary

Affiliation: Osaka Bioscience Institute
Country: Japan

Publications

  1. ncbi request reprint Prostaglandin D2 and sleep--a molecular genetic approach
    O Hayaishi
    Osaka Bioscience Institute, Japan
    J Sleep Res 8:60-4. 1999
  2. ncbi request reprint Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka, Japan
    Drug News Perspect 17:105-9. 2004
  3. ncbi request reprint Memoirs of a biochemist
    Osamu Hayaishi
    Osaka Bioscience Institute, Osaka, Japan
    IUBMB Life 58:242-5. 2006
  4. ncbi request reprint Musajo Memorial Award Lecture: "Metabolism to function--an odyssey with tryptophan"
    Osamu Hayaishi
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Adv Exp Med Biol 527:1-11. 2003
  5. doi request reprint From oxygenase to sleep
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Biol Chem 283:19165-75. 2008
  6. ncbi request reprint An odyssey with oxygen
    Osamu Hayaishi
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Biochem Biophys Res Commun 338:2-6. 2005
  7. ncbi request reprint Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Japan
    Neuroscientist 8:12-5. 2002
  8. ncbi request reprint Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Appl Physiol (1985) 92:863-8. 2002
  9. ncbi request reprint Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep
    O Hayaishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 5650874, Japan
    Arch Ital Biol 142:533-9. 2004
  10. pmc Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2
    O Hayaishi
    Osaka Bioscience Institute, Suita, Japan
    Philos Trans R Soc Lond B Biol Sci 355:275-80. 2000

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Prostaglandin D2 and sleep--a molecular genetic approach
    O Hayaishi
    Osaka Bioscience Institute, Japan
    J Sleep Res 8:60-4. 1999
    ..These observations suggest that PGD2 may induce sleep via leptomeningeal PGD2 receptors with subsequent activation of the ventrolateral preoptic area neurons...
  2. ncbi request reprint Role of orexin and prostaglandin E(2) in activating histaminergic neurotransmission
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka, Japan
    Drug News Perspect 17:105-9. 2004
    ..The results reported herein may provide new insights into the molecular mechanisms of sleep-wake regulation and may lead to the development of new anti-sleep drugs as well as new hypnotic agents...
  3. ncbi request reprint Memoirs of a biochemist
    Osamu Hayaishi
    Osaka Bioscience Institute, Osaka, Japan
    IUBMB Life 58:242-5. 2006
  4. ncbi request reprint Musajo Memorial Award Lecture: "Metabolism to function--an odyssey with tryptophan"
    Osamu Hayaishi
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Adv Exp Med Biol 527:1-11. 2003
  5. doi request reprint From oxygenase to sleep
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Biol Chem 283:19165-75. 2008
  6. ncbi request reprint An odyssey with oxygen
    Osamu Hayaishi
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Biochem Biophys Res Commun 338:2-6. 2005
  7. ncbi request reprint Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Japan
    Neuroscientist 8:12-5. 2002
    ....
  8. ncbi request reprint Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Appl Physiol (1985) 92:863-8. 2002
    ..Available evidence indicated that the PGD(2) system is involved in the homeostatic regulation of non-rapid eye movement sleep and that the arousal effect of orexin A is mediated by the histamine H(1) receptor system...
  9. ncbi request reprint Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep
    O Hayaishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 5650874, Japan
    Arch Ital Biol 142:533-9. 2004
    ....
  10. pmc Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2
    O Hayaishi
    Osaka Bioscience Institute, Suita, Japan
    Philos Trans R Soc Lond B Biol Sci 355:275-80. 2000
    ..Adenosine may be involved in the signal transduction associated with PGD2...
  11. pmc Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
    Yo Oishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 105:19992-7. 2008
    ..These results indicate that endogenous adenosine in the TMN suppresses the histaminergic system via A(1)R to promote NREM sleep...
  12. pmc Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:17949-54. 2006
    ..These results clearly show that the lipocalin-type PGDS/PGD2/DP1R system plays pivotal roles in the regulation of physiological sleep...
  13. ncbi request reprint The role of adenosine in the regulation of sleep
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Top Med Chem 11:1047-57. 2011
    ..The potential therapeutic applications of agonists and antagonists of these receptors in sleep disorders are briefly discussed...
  14. ncbi request reprint Sleep regulation in adenosine A2A receptor-deficient mice
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Neurology 61:S94-6. 2003
  15. doi request reprint Prostaglandin D(2) is crucial for seizure suppression and postictal sleep
    Mahesh K Kaushik
    International Institute for Integrative Sleep Medicine WPI IIIS, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Exp Neurol 253:82-90. 2014
    ..These findings demonstrate that PGD2 produced by H-PGDS and acting on DP1R is essential for seizure suppression and that the L-PGDS/PGD2/DP1R system regulates sleep that follows seizures. ..
  16. ncbi request reprint Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
    ..Thus, caffeine-induced wakefulness depends on adenosine A2A receptors...
  17. pmc Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92. 2006
    ....
  18. ncbi request reprint Prostaglandins and adenosine in the regulation of sleep and wakefulness
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Opin Pharmacol 7:33-8. 2007
    ....
  19. pmc Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 31:10067-75. 2011
    ..Our observations suggest that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain...
  20. ncbi request reprint Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep
    Tetsuya Okada
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Biochem Biophys Res Commun 312:29-34. 2003
    ..These results demonstrate that the leptomeninges control the extracellular level of adenosine in the subarachnoid space by their high 5(')-nucleotidase and ADA activities and regulate non-rapid eye movement sleep...
  21. ncbi request reprint Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 23:5975-83. 2003
    ..Furthermore, EP4 agonist perfusion into the TMN induced wakefulness. These findings indicate that PGE2 induces wakefulness through activation of the histaminergic system via EP4 receptors...
  22. doi request reprint Prostaglandin D2 and sleep/wake regulation
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4, Furuedai, Suita, Osaka 565 0874, Japan
    Sleep Med Rev 15:411-8. 2011
    ....
  23. ncbi request reprint Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    IUBMB Life 58:254-6. 2006
  24. ncbi request reprint Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme
    Daisuke Irikura
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 6 2 4 Furuedai, Suita, Osaka 565 0874
    J Biochem 133:29-32. 2003
    ..8, and c = 105.3 A. The selenomethionyl crystals obtained with citrate belong to orthorhombic space group C222(1) with lattice constants a = 45.5, b = 66.8, and c = 104.5 A. The native crystals diffracted beyond 2.1 A resolution...
  25. ncbi request reprint [Functional analyses of lipocalin-type and hematopoietic prostaglandin D synthases]
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka, Japan
    Nihon Yakurigaku Zasshi 123:5-13. 2004
    ..H-PGDS-KO mice showed an allergic reaction weaker than that of the wild-type mice...
  26. ncbi request reprint Characterization of the unfolding process of lipocalin-type prostaglandin D synthase
    Takashi Inui
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation and Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 278:2845-52. 2003
    ..Therefore, L-PGDS is a unique protein whose enzyme activity and ligand-binding property are biphasically altered during the unfolding process by denaturants...
  27. ncbi request reprint "Fifty years of oxygen activation"
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Osaka, Japan
    J Biol Inorg Chem 10:1-2. 2005
  28. ncbi request reprint Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages
    Michael Lazarus
    Department of Molecular Behavioral Biology, Japan Science and Technology Corporation, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Arch Biochem Biophys 397:336-41. 2002
    ..Taken together, these results demonstrate that mPGES-1 is an efficient downstream enzyme for the production of PGE2 in the activated macrophages treated by lipopolysaccharide...
  29. ncbi request reprint Osamu Hayaishi: pioneer first of the oxygenases, then the molecular basis of sleep and throughout a great statesman of science
    Arthur Kornberg
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    IUBMB Life 58:253. 2006
  30. ncbi request reprint Congratulatory dedication to Professor Osamu Hayaishi: from Bethesda to Ueno Park (Japan Academy)
    Takashi Sugimura
    President Emeritus, National Cancer Center, Chairman of Section II, The Japan Academy, Tokyo, Japan
    IUBMB Life 58:251-2. 2006
  31. ncbi request reprint The 50th anniversary of the discovery of oxygenases
    Shozo Yamamoto
    Department of Food and Nutrition, Kyoto Women s University Faculty of Home Economics, Kyoto, Japan
    IUBMB Life 58:248-50. 2006
  32. ncbi request reprint An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats
    Zong Yuan Hong
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    J Neurochem 92:1542-9. 2005
    ..These results suggest that the A(2A)R agonist induced sleep by inhibiting the histaminergic system through increasing GABA release in the tuberomammillary nucleus...