Ryota Hashimoto

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:431-8. 2010
  2. pmc Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e29780. 2012
  3. pmc The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e35696. 2012
  4. pmc The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Behav Brain Funct 9:40. 2013
  5. doi request reprint The KCNH2 gene is associated with neurocognition and the risk of schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:114-20. 2013
  6. pmc NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala
    Mina Delawary
    Division of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Brain 3:37. 2010
  7. pmc Laughter and humor as complementary and alternative medicines for dementia patients
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    BMC Complement Altern Med 10:28. 2010
  8. doi request reprint The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suite, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1459-64. 2010
  9. ncbi request reprint Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling
    Ryota Hashimoto
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, 4 1 1 Suita, Osaka 565 0871, Japan
    Hum Mol Genet 15:3024-33. 2006
  10. ncbi request reprint [Risk genes for schizophrenia and neuronal plasticity: molecular target for antipsychotic discovery]
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:103-7. 2010

Detail Information

Publications110 found, 100 shown here

  1. doi request reprint A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:431-8. 2010
    ..This haplotype did not affect IQ and its sub-scores as measured by the Wechsler Adult Intelligence Scale-Revised in both groups. These data suggest that DTNBP1 may have impact on parts of memory functions...
  2. pmc Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e29780. 2012
    ....
  3. pmc The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e35696. 2012
    ..Schizotypal personality disorder has a strong familial relationship with schizophrenia. Several susceptibility genes for schizophrenia have been related to schizotypal traits...
  4. pmc The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Behav Brain Funct 9:40. 2013
    ..To date, the role of these SNPs on gray matter (GM) volumes remains unclear...
  5. doi request reprint The KCNH2 gene is associated with neurocognition and the risk of schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:114-20. 2013
    ..The aims of this study were to investigate whether the KCNH2 polymorphism is associated with schizophrenia-related neurocognitive deficits and to confirm the association between the variant and schizophrenia...
  6. pmc NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala
    Mina Delawary
    Division of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Brain 3:37. 2010
    ..There is growing evidence implicating the glutamate system in the pathophysiology and treatment of anxiety disorders, though the molecular mechanism by which the glutamate system regulates anxiety-like behavior remains unclear...
  7. pmc Laughter and humor as complementary and alternative medicines for dementia patients
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    BMC Complement Altern Med 10:28. 2010
    ..The number of dementia patients has increased worldwide, with an estimated 13.7 million dementia patients in the Asia Pacific region alone. This number is expected to increase to 64.6 million by the year 2050...
  8. doi request reprint The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suite, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1459-64. 2010
    ..018). In contrast, there was no genotype effect for any index in the healthy control subjects (P > 0.05). Our data suggest that rs1344706 may be related to memory dysfunction in schizophrenia. © 2010 Wiley-Liss, Inc...
  9. ncbi request reprint Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling
    Ryota Hashimoto
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, 4 1 1 Suita, Osaka 565 0871, Japan
    Hum Mol Genet 15:3024-33. 2006
    ..A possible biological mechanism of MDD might be implicated by these convergent data that Cys704 DISC1 is associated with the lower biological activity on ERK signaling, reduced brain gray matter volume and an increased risk for MDD...
  10. ncbi request reprint [Risk genes for schizophrenia and neuronal plasticity: molecular target for antipsychotic discovery]
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:103-7. 2010
    ..To investigate dysbindin function in the brain could shed light on the etiology of schizophrenia and lead us to new hypotheses, novel diagnostic tools, and more effective therapies for the disorder...
  11. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia
    R Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    Mol Psychiatry 12:1026-32. 2007
    ..These convergent data suggest that alterations in PACAP signaling might contribute to the pathogenesis of schizophrenia...
  12. doi request reprint Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Osaka, Japan
    World J Biol Psychiatry 10:65-9. 2009
    ..These data support the notion that myelination abnormalities in basal ganglia-thalamic system are related to the pathophysiology of schizophrenia...
  13. ncbi request reprint A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Lett 428:17-20. 2007
    ..These results suggest that the Val/Met polymorphism of the COMT gene may play a role in HA in Japanese population...
  14. ncbi request reprint Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 61:360-7. 2008
    ..There was no genotype effect on retrieval related brain activity. These data indicated a genetic mechanism for normal variation in human memory and suggest effects of BDNF signaling on hippocampal function in humans...
  15. doi request reprint Association analysis between schizophrenia and the AP-3 complex genes
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Neurosci Res 65:113-5. 2009
    ..80) was no longer positive after correction for multiple testing (corrected P=0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population...
  16. doi request reprint Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Neurosci Lett 468:300-2. 2010
    ..The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD...
  17. doi request reprint Effect of the brain-derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease
    R Hashimoto
    Department of Clinical Disorder Research, The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Genes Brain Behav 8:43-52. 2009
    ....
  18. doi request reprint No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan
    Schizophr Res 129:80-4. 2011
    ..28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia...
  19. pmc Variants of the RELA gene are associated with schizophrenia and their startle responses
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Dev, United Graduate School of Child Dev Osaka Univ Kanazawa Univ and Hamamatsu Univ School of Med Osaka, Japan
    Neuropsychopharmacology 36:1921-31. 2011
    ..These findings suggest that variants of the RELA gene are associated with risk for schizophrenia and PPI deficits in a Japanese population...
  20. doi request reprint Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects
    Ryota Hashimoto
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Psychiatry Clin Neurosci 63:550-6. 2009
    ..This report investigated the relationship between cognitive function and the dysbindin gene...
  21. pmc Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder
    Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2, Yamadaoka, Suita, 565 0871, Osaka, Japan
    Mol Autism 2:9. 2011
    ..abstract:..
  22. pmc Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia
    Keizo Takao
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Mol Brain 1:11. 2008
    ..To address this issue, we have carried out a comprehensive behavioral analysis of the sdy mouse in this study...
  23. doi request reprint Association study of KIBRA gene with memory performance in a Japanese population
    Yuka Yasuda
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:852-7. 2010
    ..KIBRA is highly expressed in the brain and kidneys, and is reported to be involved in synaptic plasticity. Therefore, we first tried to replicate the association between the SNP and memory performance in a Japanese subjects...
  24. ncbi request reprint TGFBR2 gene expression and genetic association with schizophrenia
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho Tokushima 770 8503, Japan
    J Psychiatr Res 42:425-32. 2008
    ..Our results suggest that the TGFBR2 gene itself does not link to schizophrenia but that the TGFBR2 mRNA levels in the peripheral leukocytes may be a potential state marker for schizophrenia...
  25. ncbi request reprint Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060 8638, Japan
    Neurosci Lett 391:7-10. 2005
    ..Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments...
  26. doi request reprint Genome-wide association study of schizophrenia in a Japanese population
    Masashi Ikeda
    Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    Biol Psychiatry 69:472-8. 2011
    ..Moreover, a substantial polygenic component to the disorder consisting of a large number of such alleles has been reported by the International Schizophrenia Consortium...
  27. doi request reprint The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
    ..003). We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations...
  28. doi request reprint Influence of the NRGN gene on intellectual ability in schizophrenia
    Kazutaka Ohi
    1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan 2 Core Research for Evolutionary Science and Technology CREST of Japan Science and Technology Agency JST, Saitama, Japan 3 National Hospital Organization, Yamato Mental Medical Center, Nara, Japan
    J Hum Genet 58:700-5. 2013
    ..Our findings suggest that the genetic risk variant in the neurogranin gene may be related to reduced intellectual ability. ..
  29. pmc Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening
    Branko Aleksic
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 39:720-8. 2013
    ..02). These findings demonstrate that VAV3 can be seen as novel candidate gene for schizophrenia in which both rare and common variants may be related to increased genetic risk for schizophrenia in Japanese population...
  30. doi request reprint The AKT1 gene is associated with attention and brain morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:100-13. 2013
    ..A meta-analysis of the associations between genetic variants in the AKT1 gene and schizophrenia found that a single nucleotide polymorphism (SNP5; rs2494732) was associated with schizophrenia in Asian populations...
  31. doi request reprint A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 513:204-8. 2012
    ..0054). These findings suggest possible associations between the SNP in the CHI3L1 gene, the risk for schizophrenia, and higher serum YKL-40 levels and personality traits in a Japanese population...
  32. doi request reprint Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:405-13. 2012
    ....
  33. doi request reprint Decreased α event-related synchronization in the left posterior temporal cortex in schizophrenia: a magnetoencephalography-beamformer study
    Koji Ikezawa
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Neurosci Res 71:235-43. 2011
    ..This upper alpha ERS deficit may indicate left temporal dysfunction and visual-information processing impairment in schizophrenia, and upon further confirmation it might represent a neurophysiological state marker of the disorder...
  34. doi request reprint Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography
    Leonides Canuet
    Department of Psychiatry and Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Epilepsy Behav 17:109-19. 2010
    ....
  35. doi request reprint No association between the Bcl2-interacting killer (BIK) gene and schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Lett 463:60-3. 2009
    ..105, rs2235316: corrected p=0.108). We conclude that BIK might not play a major role in the susceptibility of schizophrenia in Japanese population...
  36. doi request reprint Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
    Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 495:216-20. 2011
    ..30). These results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects...
  37. ncbi request reprint A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:204-8. 2008
    ..We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings...
  38. doi request reprint Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 109:80-5. 2009
    ..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population...
  39. ncbi request reprint A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hum Genet 55:469-72. 2010
    ..39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects...
  40. ncbi request reprint The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia
    Takashi Ohnishi
    Department of Radiology, National Center Hospital of Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira City, Tokyo, Japan
    Brain 129:399-410. 2006
    ..Our findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia...
  41. doi request reprint Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects
    Hidetoshi Takahashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Psychophysiology 47:831-7. 2010
    ..The total SPQ score, cognitive/perceptual score, and interpersonal score correlated negatively with PPI at SnR of +16 and +20 dB. We conclude that PPI is associated with the trait of schizotypy in healthy Asian subjects...
  42. doi request reprint Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers
    Nuripa Jenishbekovna Aidaralieva
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Hum Genet 53:296-302. 2008
    ..We propose that the DNM2 gene is a novel susceptibility gene for LOAD...
  43. ncbi request reprint A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Neuropsychopharmacol 9:83-8. 2006
    ..The association between the -116C/G polymorphism and clinical efficacy of mood stabilizers should be further investigated in a prospective study with a larger sample...
  44. doi request reprint Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks: a near-infrared spectroscopy
    Michiyo Azechi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 117:52-60. 2010
    ..Our findings suggest that NIRS measurement could be applied to differentiate patients with schizophrenia from healthy subjects...
  45. doi request reprint A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome
    Sanae Fukuda
    Department of Biomarker and Molecular Biophysics, Osaka City University Graduate School of Medicine, Osaka, Japan
    Life Sci 86:722-5. 2010
    ..We focused on the overlapping symptoms between CFS and MDD and performed an association study of the functional single-nucleotide polymorphism (SNP) in the DISC1 gene with CFS...
  46. doi request reprint Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization
    Kyoko Kubota
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 379:191-5. 2009
    ..These findings suggest that dysbindin plays a key role in coordinating JNK signaling and actin cytoskeleton required for neural development...
  47. doi request reprint No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population
    Kunihiro Kawashima
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1327-31. 2008
    ..However, these associations could not be confirmed in the second-set analysis. These results suggest that the SNARE complex-related genes do not play a major role in susceptibility to schizophrenia in the Japanese population...
  48. ncbi request reprint The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder
    Ryota Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Biol Psychiatry 57:1097-102. 2005
    ..The BCR gene encodes a Rho GTPase activating protein, which is known to play important roles in neurite growth and axonal guidance...
  49. doi request reprint Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia
    Hidetoshi Takahashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 62:187-94. 2008
    ..This did not correlate with any clinical variable in each group. Our results indicate that PPI and habituation of ASR are impaired in Asian patients with schizophrenia...
  50. doi request reprint Prepulse inhibition of the startle response with chronic schizophrenia: a replication study
    Masatsugu Moriwaki
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 65:259-62. 2009
    ..The gender and smoking state were not correlated with ASR, HAB or any PPI in multiple regression analysis. In conclusion, we were able to replicate the finding of HAB impairment and PPI deficit in chronic Japanese schizophrenic patients...
  51. doi request reprint Personality traits and schizophrenia: evidence from a case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychiatry Res 198:7-11. 2012
    ..23 for PS, and those of the character traits were -0.96 for SD, -0.47 for CO and 0.61 for ST. These findings suggest that patients with schizophrenia have a unique temperament and character profile compared with the general population...
  52. doi request reprint The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1309-15. 2011
    ..013). These data suggest that the SIGMAR1 polymorphism is associated with an increased risk of schizophrenia and differential activation of the PFC...
  53. doi request reprint IQ decline and memory impairment in Japanese patients with chronic schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Psychiatry Res 158:251-5. 2008
    ..Our results suggest that schizophrenia patients experience marked IQ decline due to the development of illness and their wide-ranging memory impairments are even more severe than the IQ decline...
  54. doi request reprint Association study between the pericentrin (PCNT) gene and schizophrenia
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
    Neuromolecular Med 12:243-7. 2010
    ..In the haplotypic analysis, we could not find any significant association in our subjects, either. This gene may not play a major role independently in the etiology of SZ in the Japanese population...
  55. doi request reprint The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis
    Ayako Nunokawa
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 116:61-7. 2010
    ..Our updated meta-analysis also failed to confirm the existence of a protective haplotype. To draw a definitive conclusion, further studies using larger samples and sufficient markers should be carried out in various ethnic populations...
  56. doi request reprint Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study
    Hideki Amagane
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 118:106-12. 2010
    ..Our results suggest that MYH9 does not confer increased susceptibility to schizophrenia in the Japanese population, although we could not exclude possible contributions of other genes on 22q to the pathogenesis of schizophrenia...
  57. ncbi request reprint Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho, Tokushima 770 8503, Japan
    Neurosci Lett 415:28-33. 2007
    ..48), either. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients...
  58. ncbi request reprint Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging
    Takeyuki Mori
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira City, Tokyo, 187 8551, Japan
    Psychiatry Res 154:133-45. 2007
    ..Our data confirmed decreased FA in schizophrenics, compared to controls in the widespread WM areas. Such decreased FA values in schizophrenia might be attributable, at least in part, to progressive changes after the onset of the illness...
  59. ncbi request reprint The Gem interacting protein (GMIP) gene is associated with major depressive disorder
    Kazuyuki Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Neurogenetics 6:127-33. 2005
    ..Further study needs to be undertaken to validate the association between the GMIP gene and MDD...
  60. ncbi request reprint No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Biol Psychiatry 56:376-8. 2004
    ....
  61. doi request reprint The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia
    Satomi Umeda-Yano
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan
    Schizophr Res 146:273-8. 2013
    ..These results provide basis for a more progressive investigation of ZNF804A contributions to the susceptibility or pathophysiology of schizophrenia...
  62. doi request reprint Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression
    Kyoko Kubota
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan
    J Neurochem 110:496-508. 2009
    ..Our findings indicate that TRAP1 mediates TNF-alpha/TNF receptor 1 signaling to modulate N-cadherin expression and to regulate cell adhesion and synaptic morphology, which may contribute to the pathogenesis of major depression...
  63. pmc Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility
    Itaru Kushima
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 38:552-60. 2012
    ..5) in kalrn or ephb1...
  64. doi request reprint Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    J Hum Genet 56:478-83. 2011
    ..Our findings suggest that the gene expression profile of immortalized lymphocyte from schizophrenic patients is different from that in postmortem brain tissue at least with respect to the dysbindin-1 and NRG-1 genes...
  65. doi request reprint Impairment of motor dexterity in schizophrenia assessed by a novel finger movement test
    Akira Midorikawa
    Department of Psychology, Chuo University, Tokyo, Japan
    Psychiatry Res 159:281-9. 2008
    ..The present results suggest that impairment in motor dexterity is a major characteristic of schizophrenia, which might be independent of cognitive functions...
  66. ncbi request reprint Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks: a two-channel near-infrared spectroscopy study
    Koji Ikezawa
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita, Osaka, 565 0871 Japan
    Schizophr Res 108:93-103. 2009
    ....
  67. doi request reprint The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel
    Kohji Mori
    Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 10:117-23. 2010
    ..Thus, one might evaluate compounds by analyzing the generation ratio of the βAPP intracellular domain (AICD) species (ε-cleavage-derived), instead of that of Aβ42...
  68. ncbi request reprint Antipsychotic medication and cognitive function in schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Schizophr Res 86:138-46. 2006
    ..Alternatively, poorer cognitive function may be due in part to polypharmacy or excessive dosing. Further investigations are required to draw any conclusions...
  69. doi request reprint Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population
    Branko Aleksic
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Schizophr Res 118:113-7. 2010
    ..However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia...
  70. doi request reprint Apolipoprotein E and central nervous system disorders: reviews of clinical findings
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychiatry Clin Neurosci 64:592-607. 2010
    ..The pathogenic role of ApoE-4 is still to be clarified; however, diverse evidence suggests that ApoE may play pleiotropic functions in dementia and central nervous system disorders...
  71. doi request reprint Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI)
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Psychiatry Res 160:175-83. 2008
    ....
  72. ncbi request reprint [How far have biomarkers in psychiatry advanced?]
    Ryota Hashimoto
    Department of Psychiatry, Osaka University Graduate School of Medicine
    Seishin Shinkeigaku Zasshi 115:1203-10. 2013
    ....
  73. ncbi request reprint Plasma levels of mature brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan
    Neurosci Lett 556:37-41. 2013
    ..Our results do not support the view that peripheral BDNF levels are associated with schizophrenia. MMP-9 may play a role in the pathophysiology of schizophrenia and serve as a biomarker for schizophrenia. ..
  74. pmc Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain
    Hiroaki Okuda
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    PLoS ONE 5:e8773. 2010
    ..Using the yeast-two-hybrid screening system, we examined the candidate proteins interacting with Dysbindin and revealed one of these candidates to be the transcription factor NF-YB...
  75. doi request reprint KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort
    Noriyuki Hayashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Japan
    Dement Geriatr Cogn Disord 30:302-8. 2010
    ..Importantly, the association between KIBRA and episodic memory in AD has never been addressed. In this study, we investigated whether the KIBRA rs17070145 SNP influences AD episodic memory and the disease in a Japanese cohort...
  76. doi request reprint No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia
    Maiko Kitazawa
    Juntendo University Schizophrenia Projects, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:456-64. 2012
    ..Taken together these results indicate that the genes HIST1H2BJ, PRSS16, and PGBD1 were not associated with Japanese patients with schizophrenia...
  77. doi request reprint Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects
    Hidetoshi Takahashi
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 1878553, Japan
    Neurosci Res 72:187-93. 2012
    ..Our results suggest that impaired sensorimotor gating, evaluated as lower PPI of ASR, of healthy subjects is correlated with self transcendence, the character which is closely related with schizophrenia and schizotypy...
  78. pmc Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 7:e36836. 2012
    ....
  79. pmc Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse
    Naomi Nihonmatsu-Kikuchi
    Mood Disorders Research Team, Tokyo Institute of Psychiatry, Tokyo, Japan
    PLoS ONE 6:e15886. 2011
    ..3%, p = 0.01). These findings suggest that dysbindin plays a role during differentiation process in the adult hippocampal neurogenesis and that its deficit may negatively affect neurogenesis-related functions such as cognition and mood...
  80. pmc Correlated alterations in serotonergic and dopaminergic modulations at the hippocampal mossy fiber synapse in mice lacking dysbindin
    Katsunori Kobayashi
    Department of Pharmacology, Nippon Medical School, Tokyo, Japan
    PLoS ONE 6:e18113. 2011
    ..The altered monoaminergic modulation at the mossy fiber synapse could be a candidate pathophysiological basis for impairment of hippocampus-dependent brain functions in schizophrenia...
  81. doi request reprint Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone
    Hitoshi Hashimoto
    Osaka University, Suita, Japan
    J Neurochem 110:595-602. 2009
    ..The present results suggest that alterations in PACAP signaling might contribute to the pathogenesis of certain depressive conditions amenable to atypical antipsychotic drugs...
  82. doi request reprint Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
    Schizophr Res 101:1-8. 2008
    ..Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases...
  83. pmc Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage
    Hiroaki Kazui
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord Extra 1:20-30. 2011
    ..These results should help clinicians to distinguish ES combined with AD-aMCI from ES alone...
  84. ncbi request reprint High dopamine turnover in the brains of Sandy mice
    Tomotaka Murotani
    Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1 7 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 421:47-51. 2007
    ..These data demonstrate that DA turnover in the specific regions of the brain of the Sdy mouse was increased, and the Sdy mouse is a possible useful candidate animal for studying the pathogenic mechanism of schizophrenia...
  85. ncbi request reprint A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 129:44-6. 2004
    ..Our results suggest that the S205L polymorphism of the p75NTR gene is involved in the pathogenesis of depressive disorder and suicidal behavior...
  86. ncbi request reprint Discrepancy of performance among working memory-related tasks in autism spectrum disorders was caused by task characteristics, apart from working memory, which could interfere with task execution
    Takayuki Nakahachi
    Department of Clinical Neuroscience, Osaka University Graduate School of Medicine, Osaka Second Police Hospital, Suita, Osaka, Japan
    Psychiatry Clin Neurosci 60:312-8. 2006
    ..Therefore, to evaluate working memory in ASD, tasks that could stimulate psychopathology specific to ASD should be avoided...
  87. pmc PACAP is implicated in the stress axes
    Hitoshi Hashimoto
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Pharm Des 17:985-9. 2011
    ..This article aims to overview the molecular mechanisms and psychiatric implications of PACAP-dependent stress responses...
  88. ncbi request reprint Identification and characterization of coding single-nucleotide polymorphisms within human protocadherin-alpha and -beta gene clusters
    Rie Miki
    KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka 1 3, Suita 565 0871, Japan
    Gene 349:1-14. 2005
    ..These gene conversions were caused by the unequal crossing-over of homologous sequence regions. Thus, nonsynonymous variations in the Pcdh-alpha and -beta genes are possible contributors to the variations in human brain function...
  89. doi request reprint Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein
    Takao Hikita
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466 8550, Japan
    J Neurochem 110:1567-74. 2009
    ..In primary cultured rat hippocampal neurons, a part of dysbindin was co-localized with Munc18-1 at pre-synaptic terminals. Our result suggests a role for dysbindin in synaptic vesicle exocytosis via interaction with Munc18-1...
  90. ncbi request reprint Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Neurosci Lett 369:1-3. 2004
    ..Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder...
  91. ncbi request reprint Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice
    Kazuhiro Tanaka
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5091-7. 2006
    ....
  92. ncbi request reprint Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin
    Natsuko Kumamoto
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 345:904-9. 2006
    ..These data suggest that dysbindin might regulate the dopamine release of the dopaminergic system via modulation of the expression of SNAP25...
  93. ncbi request reprint Postsynaptic density: a key convergent site for schizophrenia susceptibility factors and possible target for drug development
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Drugs Today (Barc) 43:645-54. 2007
    ..PSD may be a promising target for novel classes of drugs to treat schizophrenia...
  94. ncbi request reprint The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease
    Ryo Kimura
    Department of Psychiatry, Osaka University Graduate School of Medicine, 2 2 D3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Mol Genet 16:15-23. 2007
    ..Our result indicates that DYRK1A could be a key molecule bridging between beta-amyloid production and tau phosphorylation in AD...
  95. ncbi request reprint Neuronal roles of the integrin-associated protein (IAP/CD47) in developing cortical neurons
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry of Japan, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 279:43245-53. 2004
    ..These observations suggest that the IAP plays important roles in dendritic outgrowth and synaptic transmission in developing cortical neurons through the activation of MAPK...
  96. ncbi request reprint Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 13:2699-708. 2004
    ..Genetic variants associated with impairments of these functions of dysbindin could play an important role in the pathogenesis of schizophrenia...
  97. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  98. ncbi request reprint A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men
    Ryota Hashimoto
    Schizophr Res 73:383-5. 2005
  99. doi request reprint Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia
    Satoko Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 373:298-302. 2008
    ..These findings indicate that sdy mice display a number of behavioral abnormalities associated with schizophrenia and suggest that these abnormalities may be mediated by reductions in forebrain dopamine transmission...
  100. ncbi request reprint A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats
    Kyung Won Hong
    The United Graduate School of Agricultural Science, Gifu University, Gifu 501 1193, Japan
    Neurosci Lett 412:195-200. 2007
    ..001), indicating the importance of substitutions in other regions. Our findings on the chimpanzee SNP will be a useful genetic marker in understanding the individual difference in the serotonin-related behavior...
  101. doi request reprint No association between the NDE1 gene and schizophrenia in the Japanese population
    Shusuke Numata
    Schizophr Res 99:367-9. 2008