Toshiaki Hanafusa

Summary

Affiliation: Osaka Medical College
Country: Japan

Publications

  1. pmc Fulminant type 1 diabetes as a model of nature to explore the role of C-peptide
    Yuko Murase-Mishiba
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Japan
    Exp Diabetes Res 2008:819123. 2008
  2. pmc The thyroid function of Graves' disease patients is aggravated by depressive personality during antithyroid drug treatment
    Atsushi Fukao
    Ibaraki City Public Health Medical Center, 3 13 5 Kasuga, Ibaraki, Osaka, Japan
    Biopsychosoc Med 5:9. 2011
  3. ncbi request reprint Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners
    Toshiaki Hanafusa
    First Department of Internal Medicine in the Osaka Medical College, Osaka, Japan
    Nat Clin Pract Endocrinol Metab 3:36-45; quiz 2p following 69. 2007
  4. doi request reprint Insulitis in human type 1 diabetes
    Toshiaki Hanafusa
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    Ann N Y Acad Sci 1150:297-9. 2008
  5. doi request reprint Primary cutaneous diffuse large B-cell lymphoma, leg type, with features simulating POEMS syndrome
    Shoko Nakayama
    Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Eur J Haematol 84:79-83. 2010
  6. doi request reprint Minimal-change nephrotic syndrome preceding Hodgkin lymphoma by 5 years with expression of tumor necrosis factor alpha in Hodgkin-Reed-Sternberg cells
    Shoko Nakayama
    Department of Internal Medicine I, Osaka Medical College, Takatsuki City, Osaka 569 0801, Japan
    Hum Pathol 41:1196-9. 2010
  7. pmc An approach for diagnosing plasma cell myeloma by three-color flow cytometry based on kappa/lambda ratios of CD38-gated CD138(+) cells
    Shoko Nakayama
    First Department of Internal Medicine I, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka, 569 0801, Japan
    Diagn Pathol 7:131. 2012
  8. doi request reprint Combination with corticosteroids and cyclosporin-A improves pulmonary function test results and chest HRCT findings in dermatomyositis patients with acute/subacute interstitial pneumonia
    Takuya Kotani
    First Department of Internal Medicine, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka, Japan
    Clin Rheumatol 30:1021-8. 2011
  9. ncbi request reprint Efficacy and safety of liposomal amphotericin B for deep mycosis in patients with connective tissue disease
    Takuya Kotani
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, 569 8686, Japan
    J Infect Chemother 19:691-7. 2013
  10. ncbi request reprint Trisomy 21 as the sole acquired karyotypic abnormality in biphenotypic acute leukemia
    Satoko Oka
    Department of Internal Medicine I, Osaka Medical College, Osaka, Japan
    Int J Hematol 85:270-2. 2007

Detail Information

Publications140 found, 100 shown here

  1. pmc Fulminant type 1 diabetes as a model of nature to explore the role of C-peptide
    Yuko Murase-Mishiba
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Japan
    Exp Diabetes Res 2008:819123. 2008
    ....
  2. pmc The thyroid function of Graves' disease patients is aggravated by depressive personality during antithyroid drug treatment
    Atsushi Fukao
    Ibaraki City Public Health Medical Center, 3 13 5 Kasuga, Ibaraki, Osaka, Japan
    Biopsychosoc Med 5:9. 2011
    ..abstract:..
  3. ncbi request reprint Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners
    Toshiaki Hanafusa
    First Department of Internal Medicine in the Osaka Medical College, Osaka, Japan
    Nat Clin Pract Endocrinol Metab 3:36-45; quiz 2p following 69. 2007
    ..Otherwise, the death of the patient is likely to occur within 24 h. All medical practitioners must remember that this extremely rapidly progressing type of diabetes does exist, and they must pay special attention not to overlook it...
  4. doi request reprint Insulitis in human type 1 diabetes
    Toshiaki Hanafusa
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    Ann N Y Acad Sci 1150:297-9. 2008
    ....
  5. doi request reprint Primary cutaneous diffuse large B-cell lymphoma, leg type, with features simulating POEMS syndrome
    Shoko Nakayama
    Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Eur J Haematol 84:79-83. 2010
    ....
  6. doi request reprint Minimal-change nephrotic syndrome preceding Hodgkin lymphoma by 5 years with expression of tumor necrosis factor alpha in Hodgkin-Reed-Sternberg cells
    Shoko Nakayama
    Department of Internal Medicine I, Osaka Medical College, Takatsuki City, Osaka 569 0801, Japan
    Hum Pathol 41:1196-9. 2010
    ..The production of TNF-alpha by Hodgkin-Reed-Sternberg cells might play a key role as a potential mediator of minimal-change NS...
  7. pmc An approach for diagnosing plasma cell myeloma by three-color flow cytometry based on kappa/lambda ratios of CD38-gated CD138(+) cells
    Shoko Nakayama
    First Department of Internal Medicine I, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka, 569 0801, Japan
    Diagn Pathol 7:131. 2012
    ..For differentiating reactive plasmacytosis from clonal plasma cell (PC) neoplasms such as PCM, it is important to accurately determine the expression of cytoplasmic immunoglobulin light chains...
  8. doi request reprint Combination with corticosteroids and cyclosporin-A improves pulmonary function test results and chest HRCT findings in dermatomyositis patients with acute/subacute interstitial pneumonia
    Takuya Kotani
    First Department of Internal Medicine, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka, Japan
    Clin Rheumatol 30:1021-8. 2011
    ..014). Early intervention with prednisolone and CSA combination therapy and tight control of the daily CSA dose by monitoring the C2 level improved PFT and chest HRCT findings in DM-A/SIP...
  9. ncbi request reprint Efficacy and safety of liposomal amphotericin B for deep mycosis in patients with connective tissue disease
    Takuya Kotani
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, 569 8686, Japan
    J Infect Chemother 19:691-7. 2013
    ..No patient died of IFI. Regarding potential adverse reactions, there were no significant changes in serum creatinine and potassium levels. L-AMB is effective and well-tolerated for treatment of IFI in patients with CTDs. ..
  10. ncbi request reprint Trisomy 21 as the sole acquired karyotypic abnormality in biphenotypic acute leukemia
    Satoko Oka
    Department of Internal Medicine I, Osaka Medical College, Osaka, Japan
    Int J Hematol 85:270-2. 2007
  11. ncbi request reprint Switching to aggressive statin improves vascular endothelial function in patients with stable coronary artery disease
    Masaaki Hoshiga
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka, Japan
    J Atheroscler Thromb 17:705-11. 2010
    ..Aggressive statins effectively reduce lipid levels, but whether their other effects are more powerful than those of regular statins is unknown...
  12. ncbi request reprint Early intervention with corticosteroids and cyclosporin A and 2-hour postdose blood concentration monitoring improves the prognosis of acute/subacute interstitial pneumonia in dermatomyositis
    Takuya Kotani
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    J Rheumatol 35:254-9. 2008
    ....
  13. ncbi request reprint TNF-α expression in tumor cells as a novel prognostic marker for diffuse large B-cell lymphoma, not otherwise specified
    Shoko Nakayama
    Department of Internal Medicine I Division of Mathematics Division of Surgical Pathology, Osaka Medical College, Osaka, Japan
    Am J Surg Pathol 38:228-34. 2014
    ..The therapeutic strategy of DLBCL, NOS patients should be based on correct prognosis; therefore, patients with poor prognoses could be more accurately detected by evaluating both TNF-α expression levels and the IPI...
  14. doi request reprint Immunohistological analysis in diagnosis of plasma cell myeloma based on cytoplasmic kappa/lambda ratio of CD38-positive plasma cells
    Shoko Nakayama
    Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    Hematology 17:317-20. 2012
    ..7%, and a specificity of 94.7%. The detection of the cytoplasmic kappa/lambda ratio of CD38-positive plasma cells may be a useful tool in the diagnosis of PCM and the correct diagnosis of PCM may be achieved more simply...
  15. ncbi request reprint Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism
    Mitsuru Ito
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Am J Med 117:696-9. 2004
  16. doi request reprint Rabbit plaque models closely resembling lesions in human coronary artery disease
    Taichi Okabe
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Int J Cardiol 147:271-7. 2011
    ..A suitable animal model is required to investigate plaque biology. Here, we examined 6 rabbit models of plaque generated by balloon injury and sequential combinations of normal and high-cholesterol diets...
  17. doi request reprint Antifungal prophylaxis with micafungin in neutropenic patients with hematological malignancies
    Yuji Hirata
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 0801, Japan
    Leuk Lymphoma 51:853-9. 2010
    ..99, respectively. Micafungin, 150 mg daily, is an effective and safe drug for antifungal prophylaxis, and monitoring of BG antigenemia is a useful tool for diagnosis of IFI in neutropenic patients with hematological malignancies...
  18. ncbi request reprint [Megaloblastic anemia associated with salazosulfapyridine treatment for rheumatoid arthritis]
    Shoko Nakayama
    Depatment of Internal Medicine I, Osaka Medical College, Japan
    Rinsho Ketsueki 49:1609-13. 2008
    ..Currently, SASP is widely used and one of the key drugs in the treatment of RA. This case suggests that SASP therapy in RA might result in megaloblastic anemia...
  19. doi request reprint Therapeutic drug monitoring of cyclosporine microemulsion in interstitial pneumonia with dermatomyositis
    Koji Nagai
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, 569 8686, Japan
    Mod Rheumatol 21:32-6. 2011
    ..It is also suggested that preprandial, once daily administration of CSA is beneficial in DM patients with progressive IP...
  20. ncbi request reprint Expression of TH1/TH2-related chemokine receptors on peripheral T cells and correlation with clinical disease activity in patients with multiple sclerosis
    Hideto Nakajima
    Division of Neurology, First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Eur Neurol 52:162-8. 2004
    ..The increased percentage of CD4+CXCR3+ cells in the blood was associated with relapses in MS. This study suggested that the CD4+CXCR3+/CD4+CCR4+ ratio could be a sensitive maker of immune dysfunction in MS...
  21. doi request reprint Flow cytometric immunophenotyping of peripheral T cell neoplasms using CD3 gating
    Satoshi Hara
    Department of Internal Medicine I, Osaka Medical College, Osaka, Japan
    Acta Haematol 121:11-8. 2009
    ..Abnormal CD3 T cell populations were distinguishable from the normal T cell population, using this CD3 gating strategy...
  22. ncbi request reprint [A patient with interstitial pneumonia associated with dermatomyositis who relapsed after reducing cyclosporin-A treatment]
    Takuya Kotani
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka
    Nihon Rinsho Meneki Gakkai Kaishi 30:139-43. 2007
    ..Furthermore, it is suggested that the trough concentration level of Cy-A is not always a useful parameter...
  23. ncbi request reprint Unique intestinal CT imaging with bleeding from a duodenal diverticulum following myelodysplastic syndrome
    Kichinosuke Kobayashi
    Department of Internal Medicine I, Osaka Medical College, Takatsuki
    Intern Med 47:1039-41. 2008
    ..Therefore, the correct diagnosis of intestinal hemorrhage is important, as severe enterocolitis may cause a patient with MDS to bleed from the diverticulum...
  24. ncbi request reprint Flow cytometric immunophenotyping of adult T-cell leukemia/lymphoma using CD3 gating
    Taiji Yokote
    First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Am J Clin Pathol 124:199-204. 2005
    ..Herein we report a novel strategy for flow cytometric immunophenotyping of ATLL facilitated by CD3(low) gating...
  25. doi request reprint Good response to infliximab in a patient with deep vein thrombosis associated with Behçet disease
    Shuzo Yoshida
    First Department of Internal Medicine, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka 569 8686, Japan
    Mod Rheumatol 22:791-5. 2012
    ..Although further studies are needed to confirm the efficacy and safety of its use, anti-TNF-α antibody may be worth considering as treatment for refractory venous thrombosis in patients with Behçet disease...
  26. ncbi request reprint Microscopic polyangiitis complicated with cerebral infarction and hemorrhage: a case report and review of literature
    Kentaro Isoda
    First Department of Internal Medicine, Osaka Medical College
    Nihon Rinsho Meneki Gakkai Kaishi 33:111-5. 2010
    ..Cerebral infarction and hemorrhage are rare complications in MPA and are associated with poor prognosis. Published literature on these complications is reviewed...
  27. pmc Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury
    Masaaki Ii
    The First Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    Atherosclerosis 206:77-85. 2009
    ..DHEAS may play a pathophysiological role for vascular remodeling in cardiovascular disease...
  28. pmc Postural abnormality as a risk marker for leg deep venous thrombosis in Parkinson's disease
    Kazushi Yamane
    Division of Neurology, The First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    PLoS ONE 8:e66984. 2013
    ....
  29. ncbi request reprint Effective treatment of a case of refractory mycosis fungoides with imatinib
    Satoko Oka
    First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Br J Haematol 133:353. 2006
  30. doi request reprint Acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto's thyroiditis
    Shoko Nakayama
    Department of Internal Medicine I, Osaka Medical College, Takatsuki City, Osaka, 569 0801, Japan
    Endocrine 36:147-50. 2009
    ..The leukemic blast cells were positive for VLA-4 and negative for LFA-1 by immunohistochemistry. The presence of VLA-4 in blast cells might play a key role in the migration of blast cells to the thyroid glands...
  31. ncbi request reprint Serum levels of matrix metalloproteinase (MMP) 9, a risk factor for acute coronary syndrome, are reduced independently of serum MMP-3 by anti-TNF-α antibody (infliximab) therapy in patients with rheumatoid arthritis
    Takuya Kotani
    Department of Internal Medicine I, Osaka Medical College, Osaka 569 8686, Japan
    J Pharmacol Sci 120:50-3. 2012
    ..0425). The serum MMP-9 level was high in the RA patients with active disease, and it was reduced by infliximab independently of the reduction in disease activity. Thus, infliximab may reduce the risk of cardiovascular events directly...
  32. ncbi request reprint Cell shrinkage evoked by Ca2+-free solution in rat alveolar type II cells: Ca2+ regulation of Na+-H+ exchange
    Hitoshi Murao
    Central Clinical Laboratory, Osaka Medical College, Takatsuki, 569 8686, Japan
    Exp Physiol 90:203-13. 2005
    ..Ionomycin increased [Ca2+]i in fura-2-loaded AT-II cells. In conclusion, the Na+-H+ exchange activities of AT-II cells, which maintain the volume and pHi, are regulated by [Ca2+]i...
  33. ncbi request reprint HCO(-3)-dependent pHi recovery and overacidification induced by NH+4 pulse in rat lung alveolar type II cells: HCO(-3)-dependent NH3 excretion from lungs?
    Sachiko Tokuda
    Central Research Laboratory Nakahari Project, Osaka Medical College, 2 7 Daigakucho, Takatsuki 569 8686, Japan
    Pflugers Arch 455:223-39. 2007
    ....
  34. ncbi request reprint Successful treatment of multi-agent chemotherapy with rituximab for IgM plasma cell leukemia
    Satoko Oka
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 0801, Japan
    Leuk Res 30:1581-3. 2006
    ..The clinical symptoms disappeared, leading to the tumor load reduction. To the best of our knowledge, this is the first report of successful treatment of multi-agent chemotherapy with rituximab for IgM PCL...
  35. ncbi request reprint Hyperthyroidism associated with Philadelphia-chromosome-positive acute lymphoblastic leukemia
    Satoko Oka
    First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Clin Oncol 24:3500-2. 2006
  36. ncbi request reprint Isolated adrenocorticotropic hormone deficiency with transient thyroiditis inducing an adrenal crisis
    Tetsuya Hiraiwa
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Med Princ Pract 16:230-3. 2007
    ..It was the aim of this study to describe a patient with isolated adrenocorticotropic hormone deficiency presenting with a variety of involuntary movements who developed an adrenal crisis due to transient thyroiditis...
  37. ncbi request reprint [Acute pancreatitis during the treatment of relapsed acute promyelocytic leukemia with As2O3]
    Takeshi Yamano
    First Department of Internal Medicine, Osaka Medical College
    Rinsho Ketsueki 47:23-5. 2006
    ..Intravenous gabexate mesilate was administered, and the pancreatitis improved. Acute pancreatitis should be considered as a possible complication during treatment with As2O3...
  38. ncbi request reprint Asymptomatic acute ischemic stroke after primary percutaneous coronary intervention in patients with acute coronary syndrome might be caused mainly by manipulating catheters or devices in the ascending aorta, regardless of the approach to the coronary art
    Motonobu Murai
    1st Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    Circ J 72:51-5. 2008
    ..Asymptomatic acute ischemic stroke (aAIS) following primary percutaneous coronary intervention (p-PCI) in patients with acute coronary syndrome (ACS) has not been studied in detail...
  39. ncbi request reprint Glycated albumin to glycated hemoglobin ratio is a sensitive indicator of blood glucose variability in patients with fulminant type 1 diabetes
    Hiroaki Matsumoto
    The First Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 51:1315-21. 2012
    ....
  40. doi request reprint Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis
    Yoko Tabushi
    Department of Clinical Pathology, Osaka Medical College, Osaka, Japan
    Ann Clin Biochem 45:413-7. 2008
    ..Identification of the presence of citrullinated proteins in rheumatoid synovial fluids is important for the elucidation of the aetiology of RA as well as in the differential diagnosis of rheumatic-related diseases...
  41. ncbi request reprint Patients with malignancy requiring urgent therapy: CASE 2. Bilateral renal swelling induced by adult T-cell leukemia/lymphoma
    Taiji Yokote
    First Department of Internal Medicine, and Division of Surgical Pathology, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Clin Oncol 23:6793-4. 2005
  42. ncbi request reprint Pulmonary parenchymal infiltrates in a patient with CD20-positive multiple myeloma
    Taiji Yokote
    First Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    Eur J Haematol 74:61-5. 2005
    ..Immunohistochemistry revealed positive staining in MM cells with surface CD20, surface CD38, and cytoplasmic IgG. This report represents the first reported case of pulmonary parenchymal infiltrates in a patient with CD20-positive MM...
  43. pmc A rare case of primary clear cell sarcoma of the pubic bone resembling small round cell tumor: an unusual morphological variant
    Shoko Nakayama
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 0801, Japan
    BMC Cancer 12:538. 2012
    ..Only a few cases of primary CCS arising in the ulna, metatarsals, ribs, radius, sacrum, and humerus have been reported, and primary CCS arising in the pubic bone has not been reported till date...
  44. ncbi request reprint Plaque-stabilizing effect of angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker in a rabbit plaque model
    Junko Hotchi
    Department of Internal Medicine I, Osaka Medical College, Osaka, Japan
    J Atheroscler Thromb 20:257-66. 2013
    ..The objective of this study was to compare the efficacy and mechanisms of plaque stabilization by ACEI or ARB and to determine the effects of combination therapy...
  45. doi request reprint Onset and spreading patterns of lower motor neuron involvements predict survival in sporadic amyotrophic lateral sclerosis
    Chieko Fujimura-Kiyono
    Division of Neurology, First Department of Internal Medicine, Osaka Medical College, Takatsukishi, Osaka, Japan
    J Neurol Neurosurg Psychiatry 82:1244-9. 2011
    ....
  46. ncbi request reprint The Proton Pump Inhibitor Lansoprazole, but not Rabeprazole, the Increased Blood Concentrations of Calcineurin Inhibitors in Japanese Patients with Connective Tissue Diseases
    Kentaro Isoda
    Department of Internal Medicine I, Osaka Medical College, Japan
    Intern Med 53:1413-8. 2014
    ..Conclusion Combining agents that are mainly metabolized by CYP3A4 such as LPZ elevates the blood concentrations of TAC and CSA, which could leading to adverse events. ..
  47. pmc Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis
    Hideto Nakajima
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
    BMC Neurol 10:45. 2010
    ..Central scotoma is recognized as a characteristic visual field defect pattern of optic neuritis (ON), however, the differing pathogenic mechanisms of NMO and MS may result in different patterns of visual field defects for ON...
  48. ncbi request reprint [Effective measurement of coronary flow velocity reserve (CFVR) with transthoracic Doppler echocardiography (TTDE) for plasma cell leukemia with hyperviscosity syndrome]
    Satoko Oka
    First Department of Internal Medicine, Osaka Medical College
    Rinsho Ketsueki 47:16-22. 2006
    ..Noninvasive assessment of CFVR by TTDE is significantly useful for the patients who have renal failure and need chemotherapy...
  49. doi request reprint Syndrome of inappropriate antidiuretic hormone secretion associated with acute myeloid leukemia with multilineage dysplasia
    Shoko Nakayama
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka 569 0801, Japan
    Endocrine 35:290-2. 2009
    ..According to us, this is the first case report of SIADH in an AML patient with multilineage dysplasia, showing blast cells immunostained for ADH, which clearly demonstrated that the tumor cells produced ADH...
  50. ncbi request reprint Fulminant type 1 diabetes mellitus: a new class of type 1 diabetes
    Saeko Shibasaki
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
    Adv Exp Med Biol 771:20-3. 2012
    ..Intensive insulin therapy is a standard therapy. We should pay special attention to early development of microvascular complications in fulminant Type 1 diabetes...
  51. doi request reprint Increased serum matrix metalloproteinase-9 in neuromyelitis optica: implication of disruption of blood-brain barrier
    Takafumi Hosokawa
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 568 8686, Japan
    J Neuroimmunol 236:81-6. 2011
    ..Our results indicate that MMP-9, promoted by elevated IL-8 activation, plays a crucial role in the pathogenesis of NMO through the BBB disruption...
  52. ncbi request reprint [Successful treatment of early intervention with tacrolimus for a patient with lupus nephritis III+V]
    Shuzo Yoshida
    First Department of Internal Medicine, Osaka Medical College Takatsuki, Osaka
    Nihon Rinsho Meneki Gakkai Kaishi 31:460-4. 2008
    ..We report a patient with refractory proteinuria due to class III/V lupus nephritis who achieved a Tac-induced complete remission...
  53. doi request reprint VIPoma with expression of both VIP and VPAC1 receptors in a patient with WDHA syndrome
    Shoko Nakayama
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 0801, Japan
    Endocrine 35:143-6. 2009
    ..This is the first case report of a VIPoma that immunostains for VIP and VPAC1 receptors and indicates that abundant VIP produced by VIPoma might inhibit its growth and reduce VIP secretion via the VPAC1 receptor in vivo...
  54. ncbi request reprint Endophthalmitis due to Trichosporon beigelii in acute leukemia
    Satoshi Hara
    Department of Internal Medicine I, Osaka Medical College, Osaka, Japan
    Int J Hematol 85:415-7. 2007
    ..Endophthalmitis due to trichosporonosis is difficult to treat. The administration of AMPH-B is likely to be more effective in treating endophthalmitis due to trichosporonosis when the disease is at an early stage...
  55. ncbi request reprint [A refractory case of MPO-ANCA-associated vasculitis presented with gastrointestinal ulcer, rapidly progressive glomerular nephritis and pulmonary multiple nodules]
    Daisuke Wakura
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 33:31-6. 2010
    ..We report a refractory case of ANCA-related angiitis presented with gastrointestinal ulcer, rapidly progressive nephritis and multiple lung nodules...
  56. ncbi request reprint Bronchial infiltration with diffuse large B-cell lymphoma
    Satoshi Hara
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka, Japan
    Leuk Res 30:1319-22. 2006
    ..Here, we provide the first report of this condition confirmed by a histopathological study and the presence of an immunoglobulin heavy chain (IgH) gene rearrangement detected by a polymerase chain reaction (PCR)...
  57. doi request reprint Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice
    Tomohiro Fujisaka
    Departments of Cardiology, Osaka Medical College, Osaka, Japan
    Atherosclerosis 226:82-7. 2013
    ..We herein examined the effect of the administration of angiotensin II (Ang II) on the development of aortic valve thickening in apolipoprotein-E (ApoE)-deficient mice...
  58. doi request reprint Possible de novo CTG repeat expansion in the DMPK gene of a patient with cardiomyopathy
    Daisuke Furutama
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku cho, Takatsuki 569 8686, Japan
    J Clin Neurosci 17:408-9. 2010
    ..Here we report possible de novo CTG repeat expansion in the DMPK gene in a patient with cardiomyopathy, who was not diagnosed as having myotonic dystrophy type 1 (DM1) by conventional genetic tests...
  59. ncbi request reprint [A case of systemic lupus erythematosus associated with hypertrophic cardiomyopathy]
    Takuya Kotani
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka
    Nihon Rinsho Meneki Gakkai Kaishi 28:413-7. 2005
    ..There appears to have been a chance association between SLE and HCM, considering the clinical courses in reported cases and the pathological findings in our case...
  60. ncbi request reprint Vascular Behçet's disease with coronary artery aneurysm
    Kumiko Arishiro
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka
    Intern Med 45:903-7. 2006
    ..We speculated that Behçet's disease might be involved in coronary lesion, especially in CAA formation. We decided to increase the dose of prednisolone and to add warfarin. The size of the CAA was not altered after 6 months...
  61. ncbi request reprint [Intestinal bleeding during the treatment of chronic myeloid leukemia with imatinib mesylate]
    Taiji Yokote
    First Department of Internal Medicine, Osaka Medical College
    Rinsho Ketsueki 46:1060-4. 2005
    ..The patient declined any treatment except for transfusion and died suddenly after ten days. The present case suggests that we should carefully consider the possibility of intestinal bleeding when prescribing imatinib mesylate...
  62. ncbi request reprint Decreased CD14+CCR2+ monocytes in active multiple sclerosis
    Hideto Nakajima
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 8686, Japan
    Neurosci Lett 363:187-9. 2004
    ..In the pathogenesis of MS, the CD14+CCR2+ blood monocytes may play an important role in the shift from active MS to a state in which the disease is in remission...
  63. pmc Pre-treatment ferritin level and alveolar-arterial oxygen gradient can predict mortality rate due to acute/subacufte interstitial pneumonia in dermatomyositis treated by cyclosporine a/glucocorticosteroid combination therapy: a case control study
    Kentaro Isoda
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
    PLoS ONE 9:e89610. 2014
    ..We retrospectively studied outcomes, prognostic factors, and their relations with survival rate in patients with DM-A/SIP treated with early cyclosporine A (CSA)/GC combination therapy and 2-hour postdose blood concentration monitoring...
  64. ncbi request reprint Location of out-of-hospital cardiac arrests in Takatsuki City: where should automated external defibrillator be placed
    Hideyuki Muraoka
    Department of Emergency Medicine, Osaka Mishima Emergency and Critical Care Center, Takatsuki, Japan
    Circ J 70:827-31. 2006
    ..Public access defibrillation has been introduced to improve the outcome of patients experiencing out-of-hospital cardiac arrest (OHCA). The aim of this study was to examine the best location for automated external defibrillators (AED)...
  65. doi request reprint Microscopic polyangiitis complicated by oculomotor nerve palsy
    Yuri Hiramatsu
    Department of Internal Medicine I, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka, Japan
    Jpn J Ophthalmol 57:221-4. 2013
    ..Microscopic polyangiitis (MPA) is a necrotizing vasculitis of the small vessels. Among the nerve lesions of MPA, the incidence of multiple mononeuritis is high, but cranial nerve palsy is rarely reported...
  66. ncbi request reprint Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis
    Kiichi Unoda
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka, 569 0801, Japan
    J Neuroimmunol 256:7-12. 2013
    ..Thus EPA shows promise as a potential new therapeutic agent against multiple sclerosis...
  67. ncbi request reprint Successful treatment of thrombotic thrombocytopenic purpura with repeated plasma exchange in a patient with microscopic polyangitis
    Koji Nagai
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, 569 8686, Japan
    Mod Rheumatol 18:643-6. 2008
    ..The findings in this case suggested that ANCA-associated vasculitis may be involved in the development and the pathogenesis of TTP, and that repeated PE may need to be performed in addition to immunosuppressive therapy...
  68. pmc Development of Fibrosis in Nonalcoholic Steatosis through Combination of a Synthetic Diet Rich in Disaccharide and Low-Dose Lipopolysaccharides in the Livers of Zucker (fa/fa) Rats
    Shinya Fukunishi
    Department of Legal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    J Clin Biochem Nutr 45:322-8. 2009
    ..Synthetic diet-fed Zucker (fa/fa) rats treated with LPS could be useful for understanding the development of hepatic fibrosis in the two-hit theory...
  69. ncbi request reprint [Septic shock induced by Serratia marcescens complicating adult T-cell leukemia (ATL)]
    Satoko Oka
    First Department of Internal Medicine, Osaka Medical College
    Kansenshogaku Zasshi 80:257-61. 2006
    ..Bacterial infection may be a life-threatening complication in the immunocompromised hosts and elderly patients, particularly when granulocytopenia has been induced by chemotherapy, and thus such these patients require careful management...
  70. ncbi request reprint [Psoriasis-like eruption induced by adalimumab in a patient with rheumatoid arthritis : a case report and review of literature]
    Haruna Kuno
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka
    Nihon Rinsho Meneki Gakkai Kaishi 35:520-5. 2012
    ..After 4 months, the eruptions improved. Psoriasis-like eruptions due to anti-TNF drugs are rarely observed, but adverse effects require caution. This case is reported along with a review of the literature...
  71. doi request reprint Glycaemic instability correlates with a hyperglucagonaemic response in patients with type 1 diabetes without residual beta-cell function
    Megumi Bessho
    Department of Internal Medicine I, Osaka Medical College, Osaka, Japan
    Diabetes Res Clin Pract 102:e38-40. 2013
    ..AUCIRG positively correlated with the SD and mean amplitude of glycaemic excursions, thus glucagon might contribute to glycaemic instability, independent of endogenous insulin. ..
  72. pmc Interferon-β1b Increases Th2 Response in Neuromyelitis Optica
    Hideto Nakajima
    Division of Neurology, Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Int J Mol Sci 13:12213-23. 2012
    ..In the present study, Th2 predominance is involved in the pathogenesis of NMO...
  73. doi request reprint Immunohistological diagnosis of plasma cell myeloma based on cytoplasmic kappa/lambda ratio of CD138-positive plasma cells
    Shoko Nakayama-Ichiyama
    Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    Leuk Lymphoma 53:2205-9. 2012
    ..35 and 5.5, a sensitivity of 100% and a specificity of 98.0%. Detection of the cytoplasmic kappa/lambda ratio of CD138-positive plasma cells could be a useful tool for simple, efficient and accurate diagnosis of PCM...
  74. doi request reprint Fulminant type 1 diabetes--an important subtype in East Asia
    Akihisa Imagawa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Osaka, Japan
    Diabetes Metab Res Rev 27:959-64. 2011
    ..These findings suggest that viral infection in the susceptible individual might trigger anti-viral immune response and that pancreatic beta cells are rapidly destroyed through the accelerated immune reaction...
  75. doi request reprint A case of fulminant type 1 diabetes mellitus after influenza B infection
    Hiroyuki Sano
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku cho, Takatsuki City, Osaka 569 8686, Japan
    Diabetes Res Clin Pract 79:e8-9. 2008
    ..The fact that fulminant type 1 diabetes developed after the infection of such a common virus suggest that factors within host will play more important roles than virus itself in the etiology of fulminant type 1 diabetes...
  76. ncbi request reprint [A fulminant case of systemic sclerosis/dermatomyositis complicating thrombotic microangiopathy and diffuse alveolar hemorrhage]
    Takeshi Shoda
    First Department of Internal Medicine, Osaka Medical College
    Nihon Kokyuki Gakkai Zasshi 47:227-31. 2009
    ..He died of progressive respiratory failure. TMA and diffuse alveolar hemorrhage are rare but important complications of dermatomyositis and systemic sclerosis and need special care...
  77. ncbi request reprint Hypopituitarism in a patient with transsphenoidal cephalocele: longitudinal changes in endocrinological abnormalities
    Keiji Tanimoto
    Department of Internal Medicine I, Osaka Medical College, Takatsuki, Japan
    Endocr J 58:193-8. 2011
    ..This dysfunction requires the selection of a treatment that will not aggravate the condition further...
  78. doi request reprint Low CTLA-4 expression in CD4+ helper T-cells in patients with fulminant type 1 diabetes
    Fumitaka Haseda
    Department of Internal Medicine I, Osaka Medical College, Japan
    Immunol Lett 139:80-6. 2011
    ..Intracellular expression of CTLA-4 in CD4(+) helper T-cells was not correlated with two CTLA-4 polymorphisms. In conclusion, the expression of CTLA-4 in CD4(+) helper T-cells was low in patients with fulminant type 1 diabetes...
  79. ncbi request reprint Nasal-type NK/T cell lymphoma of the orbit with distant metastases
    Hiroko Kuwabara
    Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan
    Hum Pathol 34:290-2. 2003
    ..TCR and Ig genes of a cardiac lesion were in germ line configuration. This case demonstrated that nasal-type NK/T cell lymphomas with a poor prognosis can occur in the orbit...
  80. ncbi request reprint Resolution of cranial MRI and SPECT abnormalities in a patient with Wilson's disease following oral zinc monotherapy
    Shimon Ishida
    The First Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 51:1759-63. 2012
    ..After the patient's regimen was changed to zinc therapy, her neurological condition gradually improved, and she showed almost complete recovery within two years. Serial MRI and SPECT studies showed a marked improvement in the lesions...
  81. ncbi request reprint Long-term feeding of a synthetic diet rich in disaccharides induces hepatic fibrosis in nonalcoholic fatty liver disease in Zucker rats
    Shinya Fukunishi
    Department of Legal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Int J Mol Med 25:187-93. 2010
    ..However, they also suggest that long-term feeding of this synthetic diet to Zucker (fa/fa) rats is useful for studying the hepatic fibrogenesis during the pathogenesis of NAFLD...
  82. doi request reprint Exendin-4, a glucagon-like peptide-1 receptor agonist, suppresses pancreatic β-cell destruction induced by encephalomyocarditis virus
    Hiroyuki Sano
    Department of Internal Medicine I, Osaka Medical College, 2 7 Daigaku cho, Takatsuki City, Osaka 569 8686, Japan
    Biochem Biophys Res Commun 404:756-61. 2011
    ..These results suggested that exendin-4 limits β-cell destruction by protecting β cells and reducing the inflammatory response of macrophages...
  83. ncbi request reprint [Hemophagocytic syndrome as primary manifestation in a patient with systemic lupus erythematosus after parturition]
    Shuzo Yoshida
    First Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka
    Nihon Rinsho Meneki Gakkai Kaishi 32:66-70. 2009
    ..The additional therapy of tacrolimus (3 mg/day) improved clinical and laboratory findings. This is a rare SLE case associated with HPS as primary manifestation after parturition...
  84. ncbi request reprint Expression of toll-like receptors in the pancreas of recent-onset fulminant type 1 diabetes
    Saeko Shibasaki
    First Department of Internal Medicine, Osaka Medical College, Japan
    Endocr J 57:211-9. 2010
    ..In conclusion, our results suggest that macrophage-dominated insulitis rather than T cell autoimmunity contributes to beta cell destruction in fulminant type 1 diabetes...
  85. doi request reprint Changes in optic nerve head blood flow, visual function, and retinal histology in hypercholesterolemic rabbits
    Maho Shibata
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 93:818-24. 2011
    ..Downregulation of eNOS activity might be one of the causes for impairment of the autoregulation. Enhanced activity of iNOS might be involved in the impaired visual function and histology...
  86. doi request reprint Uniformity in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes
    Akihisa Imagawa
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Japan
    Diabetes Res Clin Pract 82:233-7. 2008
    ..Our present study revealed common feature in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes except pregnant women...
  87. doi request reprint Anhedonia in Japanese patients with Parkinson's disease
    Shinya Fujiwara
    Division of Neurology, The First Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    Geriatr Gerontol Int 11:275-81. 2011
    ..This study examined hedonic tone in patients with PD using the Snaith-Hamilton Pleasure Scale (SHAPS) and investigated the associations with depressive mood by the Self-Rating Questionnaire for Depression (SRQ-D)...
  88. ncbi request reprint Successful catheter interventional therapy for acute coronary syndrome secondary to kawasaki disease in young adults
    Nobuyuki Negoro
    First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Circ J 67:362-5. 2003
    ..Conventional catheter intervention was effective treatment. The sequelae of KD should be recognized as independent coronary risk factors...
  89. ncbi request reprint Vascular endothelial growth factor and interleukin 6 expression by Hodgkin/Reed-Sternberg cells
    Taiji Yokote
    Department of First Internal Medicine Division of Surgical Pathology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Br J Haematol 125:1. 2004
  90. ncbi request reprint Multiple sclerosis after allergen-specific immunotherapy and influenza vaccination
    Hideto Nakajima
    Division of Neurology, First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Eur Neurol 50:248-9. 2003
  91. doi request reprint Cardio-ankle vascular index as a predictor of cognitive impairment in community-dwelling elderly people: four-year follow-up
    Naomune Yamamoto
    Department of Medicine, Tokyo Women s Medical University, Medical Center East, Arakawa, Tokyo, Japan
    Dement Geriatr Cogn Disord 28:153-8. 2009
    ..The aim of the study was to evaluate the cardio-ankle vascular index (CAVI) as a predictor of longitudinal changes in cognitive function in older individuals...
  92. doi request reprint Lifestyle intervention reversed cognitive function in aged people with diabetes mellitus: two-year follow up
    Naomune Yamamoto
    Department of Medicine, Tokyo Women s Medical University, Medical Center East, Nishiogu, 2 1 10, Arakawa, Tokyo 116 8567, Japan
    Diabetes Res Clin Pract 85:343-6. 2009
    ..Lifestyle intervention has a beneficial effect on cognitive decline in elderly people with type 2 diabetes mellitus...
  93. pmc Successful treatment of long-term severe progressive interstitial pneumonia with low-dose corticosteroid and azathioprine in a patient with diffuse systemic sclerosis
    Takuya Kotani
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Case Report Rheumatol 2012:143927. 2012
    ..The beneficial effect has continued for 3 years with no side effects being observed during the course...
  94. ncbi request reprint Clinical significance of calcification in ascending aorta as a marker for the requirement of coronary revascularization
    Yoshihiro Takeda
    Department of First Internal Medicine, Osaka Medical College, Takatsuki, Japan
    J Atheroscler Thromb 16:346-54. 2009
    ....
  95. ncbi request reprint Hypertensive brainstem encephalopathy without parieto-occipital lesion--two case reports
    Yoshimitsu Doi
    Division of Neurology, The First Department of Internal Medicine, Osaka Medical College, Japan
    Neurol Med Chir (Tokyo) 46:75-9. 2006
    ....
  96. doi request reprint Exacerbation of thyroid associated ophthalmopathy after arterial embolization therapy in a patient with Graves' disease
    Tetsuya Hiraiwa
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    Endocrine 35:302-5. 2009
    ..Our experience argues for the use of caution when arterial embolization is considered for GD patients with even the mildest TAO (NOSPECS classification, class I)...
  97. ncbi request reprint Focal hepatic steatosis surrounding a metastatic insulinoma
    Atsushi Takeshita
    Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan
    Pathol Int 58:59-63. 2008
    ..Focal hepatic steatosis caused by the local effects of insulin can present as a focal rim surrounding a metastatic insulinoma...
  98. ncbi request reprint The relationship of psychological factors to the prognosis of hyperthyroidism in antithyroid drug-treated patients with Graves' disease
    Atsushi Fukao
    First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Clin Endocrinol (Oxf) 58:550-5. 2003
    ..This study has examined not only emotional stresses but also patients' personality traits using specific tests...
  99. ncbi request reprint Re-entry circuit in ventricular tachycardia due to focal fatty-fibrosis in a patient with myotonic dystrophy
    Hideyuki Muraoka
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 0801
    Intern Med 44:129-35. 2005
    ..Radiofrequency catheter ablation at the biopsy site could eliminate VT, so it was strongly suggested that the re-entry circuit was formed by focal fatty-fibrosis. Careful observation should be continued for a long period...
  100. ncbi request reprint A renoprotective effect of low dose losartan in patients with type 2 diabetes
    Hideaki Sawaki
    First Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Diabetes Res Clin Pract 79:86-90. 2008
    ..The observed decrease in UACR in the losartan-treated group might be attributed to a direct renoprotective action in addition to a subtle decrease in systolic blood pressure at home...
  101. ncbi request reprint [Fulminant type 1 diabetes]
    Akihisa Imagawa
    First Department of Internal Medicine, Osaka Medical College
    Nihon Rinsho . 2006