Affiliation: Osaka University
Fujiwara Y, Kurokawa T, Takeshita K, Kobayashi M, Okochi Y, Nakagawa A, et al
. The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1. Nat Commun. 2012;3:816 pubmed publisher
Okuda H, Yonezawa Y, Takano Y, Okamura Y, Fujiwara Y. Direct Interaction between the Voltage Sensors Produces Cooperative Sustained Deactivation in Voltage-gated H+ Channel Dimers. J Biol Chem. 2016;291:5935-47 pubmed publisher
..These results provide new insight into the cooperative function of voltage-gated channels, where adjacent voltage sensor helices make direct physical contact and work as a single unit according to the gating process. ..
Fujiwara Y, Kurokawa T, Takeshita K, Nakagawa A, Larsson H, Okamura Y. Gating of the designed trimeric/tetrameric voltage-gated H+ channel. J Physiol. 2013;591:627-40 pubmed publisher
Fujiwara Y, Takeshita K, Nakagawa A, Okamura Y. Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel. J Biol Chem. 2013;288:17968-75 pubmed publisher
..Thus, the biochemical properties of the cytoplasmic coiled-coil domain in the Hv channel depend on the redox condition, which may play a role in redox sensing in the phagosome. ..