Y Fujimoto

Summary

Affiliation: Osaka University of Pharmaceutical Sciences
Country: Japan

Publications

  1. ncbi request reprint N-ethylmaleimide inhibits xanthine oxidase activity with no detectable change in xanthine dehydrogenase activity in rabbit liver
    Y Fujimoto
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Life Sci 68:517-24. 2000
  2. ncbi request reprint Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide
    Y Fujimoto
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Nitric Oxide 5:77-81. 2001
  3. ncbi request reprint Simultaneous measurement of prostaglandin and arachidonoyl CoA formed from arachidonic acid in rabbit kidney medulla microsomes: the roles of Zn2+ and Cu2+ as modulators of formation of the two products
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Prostaglandins Leukot Essent Fatty Acids 61:105-12. 1999
  4. ncbi request reprint Effect of 13-hydroperoxyoctadecadienoic acid on the supply of arachidonic acid for prostaglandin synthesis from arachidonoyl-CoA mediated by the cytosolic or microsomal acyl-CoA hydrolase in rabbit kidney medulla
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    IUBMB Life 48:539-42. 1999
  5. ncbi request reprint Existence of acyl-CoA hydrolase-mediated pathway supplying arachidonic acid for prostaglandin synthesis in microsomes from rabbit kidney medulla
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    Prostaglandins Other Lipid Mediat 57:63-72. 1999
  6. ncbi request reprint The regulation of prostaglandin and arachidonoyl-CoA formation from arachidonic acid in rabbit kidney medulla microsomes by palmitoyl-CoA
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Life Sci 66:1147-53. 2000
  7. ncbi request reprint Inhibition of prostaglandin delta 13 reductase activity in rabbit kidney cortex by glutathione disulfide
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    Prostaglandins 43:435-43. 1992
  8. ncbi request reprint The effects of arachidonic acid and its CoA ester on the catabolism of prostaglandin E2 in rabbit kidney cortex
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    Biochem Int 27:291-9. 1992
  9. ncbi request reprint Effects of Fe(2+), Zn(2+), Cu(2+) and Se(4+) on the synthesis and catabolism of prostaglandins in rabbit gastric antral mucosa
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Kawai, Matsubara, Osaka, Japan
    Prostaglandins Leukot Essent Fatty Acids 54:193-7. 1996
  10. ncbi request reprint Tetrahydrobiopterin inhibits copper-induced oxidation of low density lipoprotein
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences Takatsuki, Japan
    Res Commun Mol Pathol Pharmacol 107:397-406. 2000

Detail Information

Publications11

  1. ncbi request reprint N-ethylmaleimide inhibits xanthine oxidase activity with no detectable change in xanthine dehydrogenase activity in rabbit liver
    Y Fujimoto
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Life Sci 68:517-24. 2000
    ..Also, NEM inhibited the Cu2+- and trypsin-induced XO activities, but did not affect the XD activity at the same concentration range. These results demonstrate that NEM can be a selective inhibitor of XO activity in rabbit liver...
  2. ncbi request reprint Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide
    Y Fujimoto
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Nitric Oxide 5:77-81. 2001
    ....
  3. ncbi request reprint Simultaneous measurement of prostaglandin and arachidonoyl CoA formed from arachidonic acid in rabbit kidney medulla microsomes: the roles of Zn2+ and Cu2+ as modulators of formation of the two products
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Prostaglandins Leukot Essent Fatty Acids 61:105-12. 1999
    ..Furthermore, this study showed that Zn2+ and Cu2+ can modulate PG and AA-CoA formation by affecting COX activity, ACS activity, and/or the AA flow into the two enzymatic pathways...
  4. ncbi request reprint Effect of 13-hydroperoxyoctadecadienoic acid on the supply of arachidonic acid for prostaglandin synthesis from arachidonoyl-CoA mediated by the cytosolic or microsomal acyl-CoA hydrolase in rabbit kidney medulla
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    IUBMB Life 48:539-42. 1999
    ..These results suggest that 13-HPODE may modulate PG levels in rabbit kidney medulla by inhibiting the microsomal ACH activity...
  5. ncbi request reprint Existence of acyl-CoA hydrolase-mediated pathway supplying arachidonic acid for prostaglandin synthesis in microsomes from rabbit kidney medulla
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    Prostaglandins Other Lipid Mediat 57:63-72. 1999
    ..These results suggest that, in kidney medulla, the microsomes as well as the cytosol have the potential route that supplies AA from AA-CoA for PG synthesis and that this pathway is mediated by acyl-CoA hydrolase...
  6. ncbi request reprint The regulation of prostaglandin and arachidonoyl-CoA formation from arachidonic acid in rabbit kidney medulla microsomes by palmitoyl-CoA
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Life Sci 66:1147-53. 2000
    ....
  7. ncbi request reprint Inhibition of prostaglandin delta 13 reductase activity in rabbit kidney cortex by glutathione disulfide
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    Prostaglandins 43:435-43. 1992
    ....
  8. ncbi request reprint The effects of arachidonic acid and its CoA ester on the catabolism of prostaglandin E2 in rabbit kidney cortex
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan
    Biochem Int 27:291-9. 1992
    ..These results suggest that arachidonic acid and arachidonoyl CoA can be important modulating factors in prostaglandin catabolism by the kidney cortex...
  9. ncbi request reprint Effects of Fe(2+), Zn(2+), Cu(2+) and Se(4+) on the synthesis and catabolism of prostaglandins in rabbit gastric antral mucosa
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Kawai, Matsubara, Osaka, Japan
    Prostaglandins Leukot Essent Fatty Acids 54:193-7. 1996
    ..These results suggest that Fe(2+), Zn(2+), Cu(2+) and Se(4+) can be modulators of the gastric antral mucosal PG levels by affecting the PG synthesizing enzymes, PG catabolizing enzyme and/or non-enzymatic reduction of PGG or PGH to PGF...
  10. ncbi request reprint Tetrahydrobiopterin inhibits copper-induced oxidation of low density lipoprotein
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences Takatsuki, Japan
    Res Commun Mol Pathol Pharmacol 107:397-406. 2000
    ..These results suggest that BPH4 could act as an efficacious endogenous inhibitor of atherogenic LDL modification...
  11. ncbi request reprint The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes
    S Sakuma
    Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Prostaglandins Leukot Essent Fatty Acids 64:61-5. 2001
    ..On the other hand, LA-CoA decreased formation of both PG and AA-CoA. These results suggest that fatty acyl CoA esters can be regulators of PG and AA-CoA formation in kidney medulla under physiological conditions...