Ko Fujimori

Summary

Affiliation: Osaka University of Pharmaceutical Sciences
Country: Japan

Publications

  1. pmc Prostaglandins as PPARγ Modulators in Adipogenesis
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    PPAR Res 2012:527607. 2012
  2. doi request reprint Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan Electronic address
    Mol Cell Endocrinol 384:12-22. 2014
  3. doi request reprint Avicularin, a plant flavonoid, suppresses lipid accumulation through repression of C/EBPα-activated GLUT4-mediated glucose uptake in 3T3-L1 cells
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Agric Food Chem 61:5139-47. 2013
  4. doi request reprint Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Gene 505:46-52. 2012
  5. doi request reprint Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Prostaglandins Other Lipid Mediat 93:52-9. 2010
  6. ncbi request reprint Increased production of lipocalin-type prostaglandin D synthase in leptomeningeal cells through contact with astrocytes
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Neurosci Lett 423:133-7. 2007
  7. doi request reprint Forkhead transcription factor Foxa1 is a novel target gene of C/EBPβ and suppresses the early phase of adipogenesis
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka, Japan
    Gene 473:150-6. 2011
  8. doi request reprint Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka, Japan
    J Neurochem 120:279-91. 2012
  9. doi request reprint Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Prostaglandins Other Lipid Mediat 94:96-103. 2011
  10. pmc Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Biol Chem 285:8880-6. 2010

Collaborators

  • Y Urade
  • Makio Shibano
  • Yoshiki Mino
  • Maria Allhorn
  • Yoshiyuki Ishii
  • Takeshi Kobayashi
  • Yutaka Inagaki
  • Yuta Morishige
  • Fumio Amano
  • Atsushi Koike
  • Miki Yuyama
  • Hiroko Kimura
  • Misato Yazaki
  • Namiko Suematsu
  • Toshiyuki Ueno
  • Mafuyu Ono
  • Noriko Minami
  • Kosuke Aritake
  • Shigeru Shimamoto
  • Takeshi Muraki
  • Kiyoshi Higashi
  • Kiyoko Kohama
  • Hideya Mori
  • Isato Minamiguchi
  • Masaaki Tanda
  • Kaori Kashiwagi
  • Miki Hosoda
  • Tatsuji Yasuda
  • Toshiharu Tsurumura
  • Takashi Inui
  • Yuji Kobayashi
  • Tadayasu Ohkubo
  • Takuya Yoshida
  • Keigo Gohda
  • Koichi Ishikawa
  • Fumikazu Okajima
  • Yoshihide Ohe
  • Mami Ishizaka
  • Hideo Kaneko
  • Iwao Nakatsuka
  • Atsuhito Nakao

Detail Information

Publications34

  1. pmc Prostaglandins as PPARγ Modulators in Adipogenesis
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    PPAR Res 2012:527607. 2012
    ..This paper focuses on potential roles of PGs as PPARγ modulators in adipogenesis and regulators of obesity...
  2. doi request reprint Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan Electronic address
    Mol Cell Endocrinol 384:12-22. 2014
    ..These results indicate that CREB-dependent expression of COX-2 for the production of anti-adipogenic PGs is critical for the regulation of the early phase of adipogenesis. ..
  3. doi request reprint Avicularin, a plant flavonoid, suppresses lipid accumulation through repression of C/EBPα-activated GLUT4-mediated glucose uptake in 3T3-L1 cells
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Agric Food Chem 61:5139-47. 2013
    ..These results indicate that avicularin inhibited the accumulation of the intracellular lipids by decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes...
  4. doi request reprint Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Gene 505:46-52. 2012
    ....
  5. doi request reprint Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Prostaglandins Other Lipid Mediat 93:52-9. 2010
    ..Therefore, PGF(2alpha) suppressed the progression of early phase adipogenesis after determination of the cell fate that causes MSC to differentiate into adipocytes...
  6. ncbi request reprint Increased production of lipocalin-type prostaglandin D synthase in leptomeningeal cells through contact with astrocytes
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Neurosci Lett 423:133-7. 2007
    ..These results indicate that leptomeningeal cells enhance their L-PGDS production by a slow activation of L-PGDS gene expression through their contact with astrocytes...
  7. doi request reprint Forkhead transcription factor Foxa1 is a novel target gene of C/EBPβ and suppresses the early phase of adipogenesis
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka, Japan
    Gene 473:150-6. 2011
    ..These results suggest that Foxa1 plays a suppressive role in the early phase of adipogenesis, acting under the control of C/EBPβ, and might be involved in the regulation of the rate of progression of the early phase of adipogenesis...
  8. doi request reprint Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka, Japan
    J Neurochem 120:279-91. 2012
    ..Thus, L-PGDS might potentially serve as an agent for prevention of human neurodegenerative diseases caused by oxidative stress and apoptosis...
  9. doi request reprint Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Prostaglandins Other Lipid Mediat 94:96-103. 2011
    ..These results indicate that niacin promoted adipogenesis by suppressing the production of the anti-adipogenic PGF(2α) through down-regulation of C/EBPβ-activated cyclooxygenase-2 expression in adipocytes...
  10. pmc Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Biol Chem 285:8880-6. 2010
    ..These results indicate that AKR1B3 acts as the PGFS in adipocytes and that AKR1B3-produced PGF(2alpha) suppressed adipocyte differentiation by acting through FP receptors...
  11. doi request reprint Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Gene 426:72-80. 2008
    ..These results indicate that PGD(2) production stimulated by serum starvation is mediated by both COX-2 and L-PGDS through enhancement of USF1 in TE671 cells...
  12. pmc Synergistic suppression of early phase of adipogenesis by microsomal PGE synthase-1 (PTGES1)-produced PGE2 and aldo-keto reductase 1B3-produced PGF2α
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    PLoS ONE 7:e44698. 2012
    ....
  13. doi request reprint Very long-chain-fatty acids enhance adipogenesis through coregulation of Elovl3 and PPARγ in 3T3-L1 cells
    Takeshi Kobayashi
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    Am J Physiol Endocrinol Metab 302:E1461-71. 2012
    ..Elovl3-produced C18:1 and C20:1 VLCFAs acted as agonists of PPARγ in 3T3-L1 cells. Thus, the Elovl3-PPARγ cascade is a novel regulatory circuit for the regulation of adipogenesis through improvement of PPARγ function in adipocytes...
  14. doi request reprint Activation of early phase of adipogenesis through Krüppel-like factor KLF9-mediated, enhanced expression of CCAAT/enhancer-binding protein β in 3T3-L1 cells
    Hiroko Kimura
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Gene 534:169-76. 2014
    ..These results indicate that KLF9 activated the early phase of adipogenesis by enhancing the expression of the C/EBPβ gene in 3T3-L1 cells...
  15. doi request reprint Suppression of adipogenesis by valproic acid through repression of USF1-activated fatty acid synthesis in adipocytes
    Miki Yuyama
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Biochem J 459:489-503. 2014
    ..These results indicate that VPA suppressed adipogenesis through the down-regulation of USF1-activated fatty acid synthesis in adipocytes...
  16. ncbi request reprint Cooperative activation of lipocalin-type prostaglandin D synthase gene expression by activator protein-2beta in proximal promoter and upstream stimulatory factor 1 within intron 4 in human brain-derived TE671 cells
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka, Japan
    Gene 397:143-52. 2007
    ..These results indicate that L-PGDS gene expression in TE671 cells was activated by USF1 through the aE-box within intron 4 and cooperatively by AP-2beta in the promoter in a cell-type-specific manner...
  17. pmc Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level
    Misato Yazaki
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    Mol Biol Cell 23:12-21. 2012
    ..These results indicate that COX-1 and H-PGDS were rapidly ubiquitinated and degraded through the ubiquitin-proteasome system in response to the elevation of the intracellular calcium level...
  18. doi request reprint Simultaneous Addition of Shikonin and Its Derivatives with Lipopolysaccharide Induces Rapid Macrophage Death
    Atsushi Koike
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences
    Biol Pharm Bull 39:969-76. 2016
    ..These results indicate that SHK derivatives induce caspase-dependent apoptotic cell death of LPS-treated macrophages and suggest that SHK acts during an early stage of LPS signaling. ..
  19. doi request reprint Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade
    Toshiyuki Ueno
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Japan
    FEBS J 278:2901-12. 2011
    ..Thus, PGF(2α) forms a positive feedback loop that coordinately suppresses the early phase of adipogenesis through the increased production of anti-adipogenic PGF(2α) and PGE(2) ...
  20. doi request reprint Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells
    Mafuyu Ono
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Agric Food Chem 59:13346-52. 2011
    ..Thus, dietary apigenin may contribute to lower body-fat content and body-weight gain through the activation of AMPK...
  21. doi request reprint Use of Flow Cytometry for Quantitative Analysis of Metabolism of Viable but Non-culturable (VBNC) Salmonella
    Yuta Morishige
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences
    Biol Pharm Bull 38:1255-64. 2015
    ..These results suggest that the VBNC state might be characterized by different metabolic activities that vary and correspond to the kind and strength of the stress, threatening bacterial survival in an adverse environment. ..
  22. ncbi request reprint Induction of viable but non-culturable (VBNC) state in Salmonella cultured in M9 minimal medium containing high glucose
    Yuta Morishige
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences
    Biol Pharm Bull 37:1617-25. 2014
    ..These results suggest that the excessive amount of glucose in the M9 medium might have injured SE cells in the VBNC state by being metabolized to formic acid and other acidic compounds. ..
  23. doi request reprint Nitric oxide is an important regulator of heme oxygenase-1 expression in the lipopolysaccharide and interferon-γ-treated murine macrophage-like cell line J774.1/JA-4
    Atsushi Koike
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences
    Biol Pharm Bull 38:7-16. 2015
    ..These results suggest that, among ROS, NO plays an important role in HO-1 induction in activated macrophages treated with LPS+IFN-γ...
  24. doi request reprint Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka, 569 1094, Japan
    Methods Mol Biol 1164:177-96. 2014
    ..Moreover, we describe that PGD2 and its metabolites are involved in the regulation of adipogenesis through PPARγ-dependent and -independent mechanisms. ..
  25. pmc Differential resuscitative effect of pyruvate and its analogues on VBNC (viable but non-culturable) Salmonella
    Yuta Morishige
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Nasahara, Takatsuki, Osaka 569 1094, Japan
    Microbes Environ 28:180-6. 2013
    ....
  26. doi request reprint Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells
    Namiko Suematsu
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Neurosci Lett 504:223-7. 2011
    ..Thus, quercetin might potentially serve as an agent for prevention of neurodegenerative diseases caused by oxidative stress and apoptosis...
  27. doi request reprint Regulatory role of cardiolipin in the activity of an ATP-dependent protease, Lon, from Escherichia coli
    Noriko Minami
    Laboratory of Biodefense and Regulation, Graduate School of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Biochem 149:519-27. 2011
    ..These results suggest that Lon interacts with CL in biological membranes, which may regulate the functions of Lon as a protein-degrading centre in accordance with environmental changes inside cells...
  28. ncbi request reprint Effects of interleukin-1beta and prostaglandin E2 on prostaglandin D synthase production in cultivated rat leptomeningeal cells
    Takeshi Muraki
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    J Cereb Blood Flow Metab 24:409-18. 2004
    ..These results demonstrate the importance of inflammatory stimuli as a physiologic regulator of the leptomeningeal cell function...
  29. ncbi request reprint Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 280:18452-61. 2005
    ..These results reveal a novel transcriptional regulatory mechanism responsible for the high level expression of the human L-PGDS gene in TE671 cells...
  30. ncbi request reprint Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells
    Ko Fujimori
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation and the Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 278:6018-26. 2003
    ..Moreover, the L-PGDS gene is a unique gene that is activated slowly by the NF-kappa B system...
  31. ncbi request reprint Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
    Kiyoshi Higashi
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Konohana ku, Osaka 554 8558, Japan
    J Biol Chem 278:43470-9. 2003
    ..They also indicate that IFN-gamma/YB-1 inhibits COL1A2 transcription by dual actions: via the IFN-gamma response element and through a cross-talk with the TGF-beta/Smad signaling pathway...
  32. ncbi request reprint Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Gene 375:14-25. 2006
    ....
  33. ncbi request reprint A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 282:18458-66. 2007
    ..Liver X receptor-mediated up-regulation of L-PGDS through activation of SREBP-1c is a novel path-way to enhance adipocyte differentiation...
  34. ncbi request reprint NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity
    Shigeru Shimamoto
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:31373-9. 2007
    ....