Affiliation: Osaka University of Pharmaceutical Sciences
Fujimori K, Fukuhara A, Inui T, Allhorn M. Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. J Neurochem. 2012;120:279-91 pubmed publisher
..Thus, L-PGDS might potentially serve as an agent for prevention of human neurodegenerative diseases caused by oxidative stress and apoptosis. ..
Nagai S, Matsumoto C, Shibano M, Fujimori K. Suppression of Fatty Acid and Triglyceride Synthesis by the Flavonoid Orientin through Decrease of C/EBP? Expression and Inhibition of PI3K/Akt-FOXO1 Signaling in Adipocytes. Nutrients. 2018;10: pubmed publisher
..These results indicate that a plant flavonoid orientin suppressed the expression of the Ppar? gene through repression of C/ebp? expression and inhibition of the phosphoinositide 3-kinase /Akt-FOXO1 signaling in adipocytes. ..
Fujimori K, Ueno T, Amano F. Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells. Prostaglandins Other Lipid Mediat. 2010;93:52-9 pubmed publisher
..Therefore, PGF(2alpha) suppressed the progression of early phase adipogenesis after determination of the cell fate that causes MSC to differentiate into adipocytes. ..
Gambo Y, Matsumura M, Fujimori K. Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor ? via direct and indirect mechanisms. Mol Cell Endocrinol. 2016;431:1-11 pubmed publisher
Fujimori K, Amano F. Forkhead transcription factor Foxa1 is a novel target gene of C/EBP? and suppresses the early phase of adipogenesis. Gene. 2011;473:150-6 pubmed publisher
..These results suggest that Foxa1 plays a suppressive role in the early phase of adipogenesis, acting under the control of C/EBP?, and might be involved in the regulation of the rate of progression of the early phase of adipogenesis. ..
Watanabe R, Kurose T, Morishige Y, Fujimori K. Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y Cells. Neurochem Res. 2018;43:488-499 pubmed publisher
..This is the first report that the PI3K-Akt signaling is involved in the fisetin-protected ROS-mediated neuronal cell death. ..
Fujimori K, Ueno T, Nagata N, Kashiwagi K, Aritake K, Amano F, et al
. Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase. J Biol Chem. 2010;285:8880-6 pubmed publisher
..These results indicate that AKR1B3 acts as the PGFS in adipocytes and that AKR1B3-produced PGF(2alpha) suppressed adipocyte differentiation by acting through FP receptors. ..
Fujimori K, Maruyama T, Kamauchi S, Urade Y. Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated ?¹²-PGJ? acting through PPAR?-dependent and independent pathways. Gene. 2012;505:46-52 pubmed publisher
Kimura H, Fujimori K. Activation of early phase of adipogenesis through Krüppel-like factor KLF9-mediated, enhanced expression of CCAAT/enhancer-binding protein ? in 3T3-L1 cells. Gene. 2014;534:169-76 pubmed publisher
..These results indicate that KLF9 activated the early phase of adipogenesis by enhancing the expression of the C/EBP? gene in 3T3-L1 cells. ..