Hidetoshi Eguchi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint A phase I trial of combination therapy using gemcitabine and S-1 concurrent with full-dose radiation for resectable pancreatic cancer
    Hidetoshi Eguchi
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita 565 0871, Osaka, Japan
    Cancer Chemother Pharmacol 73:309-15. 2014
  2. doi request reprint Arterial stimulation and venous sampling for glucagonomas of the pancreas
    Hidetoshi Eguchi
    Department of Surgery, Osaka University, Osaka, Japan
    Hepatogastroenterology 59:276-9. 2012
  3. doi request reprint A thick pancreas is a risk factor for pancreatic fistula after a distal pancreatectomy: selection of the closure technique according to the thickness
    Hidetoshi Eguchi
    Department of Surgery, Graduate School of Medicine, Osaka University, Japan
    Dig Surg 28:50-6. 2011
  4. ncbi request reprint [A long-term survival case of hepatocellular carcinoma with lymph node metastasis on the posterior surface of the pancreas head and portal vein tumor thrombus successfully treated with hepatopancreatoduodenectomy and adjuvant interferon-alpha and 5-fluoro
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2389-91. 2009
  5. ncbi request reprint [A case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus]
    Hisanori Hatano
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2374-6. 2009
  6. ncbi request reprint [A case of complete response to S-1 therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection]
    Akira Tomokuni
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2383-5. 2009
  7. doi request reprint Serum REG4 level is a predictive biomarker for the response to preoperative chemoradiotherapy in patients with pancreatic cancer
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Pancreas 38:791-8. 2009
  8. doi request reprint Myelotoxicity of preoperative chemoradiotherapy is a significant determinant of poor prognosis in patients with T4 esophageal cancer
    Norikatsu Miyoshi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 99:302-6. 2009
  9. ncbi request reprint [A long-term survival case of pancreatic cancer with hepatic metastasis after pancreaticoduodenectomy successfully treated by s-1 and gemcitabine combination chemotherapy]
    Hiromitsu Hoshino
    Department of Surgery, Graduate School of Medicine, Osaka University, and Osaka National Hospital, National Hospital Organization
    Gan To Kagaku Ryoho 36:2419-21. 2009
  10. ncbi request reprint Hepatic resection followed by IFN-alpha and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Japan
    Hepatogastroenterology 54:172-9. 2007

Detail Information

Publications94

  1. ncbi request reprint A phase I trial of combination therapy using gemcitabine and S-1 concurrent with full-dose radiation for resectable pancreatic cancer
    Hidetoshi Eguchi
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita 565 0871, Osaka, Japan
    Cancer Chemother Pharmacol 73:309-15. 2014
    ....
  2. doi request reprint Arterial stimulation and venous sampling for glucagonomas of the pancreas
    Hidetoshi Eguchi
    Department of Surgery, Osaka University, Osaka, Japan
    Hepatogastroenterology 59:276-9. 2012
    ..The aim of this study was to clarify the clinical significance of ASVS for glucagonomas...
  3. doi request reprint A thick pancreas is a risk factor for pancreatic fistula after a distal pancreatectomy: selection of the closure technique according to the thickness
    Hidetoshi Eguchi
    Department of Surgery, Graduate School of Medicine, Osaka University, Japan
    Dig Surg 28:50-6. 2011
    ..Hand-sewn closures or stapler closures of the pancreatic remnant after a distal pancreatectomy have commonly been employed; however, the choice of technique in each patient depending on their clinical characteristics has not been discussed...
  4. ncbi request reprint [A long-term survival case of hepatocellular carcinoma with lymph node metastasis on the posterior surface of the pancreas head and portal vein tumor thrombus successfully treated with hepatopancreatoduodenectomy and adjuvant interferon-alpha and 5-fluoro
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2389-91. 2009
    ....
  5. ncbi request reprint [A case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus]
    Hisanori Hatano
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2374-6. 2009
    ..Thereafter, sustained partial remission was achieved. In case of combined hepatocellular and cholangiocarcinoma, we need to create a treatment strategy against characteristics of both components...
  6. ncbi request reprint [A case of complete response to S-1 therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection]
    Akira Tomokuni
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2383-5. 2009
    ..This case illustrates that S-1 may be an effective treatment for HCC with extrahepatic metastasis...
  7. doi request reprint Serum REG4 level is a predictive biomarker for the response to preoperative chemoradiotherapy in patients with pancreatic cancer
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Pancreas 38:791-8. 2009
    ..The aim of this study was to prospectively evaluate the predictive value of REG4, a new member of the regenerating (REG) islet-derived family of proteins...
  8. doi request reprint Myelotoxicity of preoperative chemoradiotherapy is a significant determinant of poor prognosis in patients with T4 esophageal cancer
    Norikatsu Miyoshi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 99:302-6. 2009
    ..This study retrospectively analyzed the prognostic factors in patients with curatively resected cancer after chemoradiotherapy...
  9. ncbi request reprint [A long-term survival case of pancreatic cancer with hepatic metastasis after pancreaticoduodenectomy successfully treated by s-1 and gemcitabine combination chemotherapy]
    Hiromitsu Hoshino
    Department of Surgery, Graduate School of Medicine, Osaka University, and Osaka National Hospital, National Hospital Organization
    Gan To Kagaku Ryoho 36:2419-21. 2009
    ..S-1 and gemcitabine combination therapy is not only effective but also well tolerated and safe. This combination therapy should be considered one of selective choices for advanced or metastatic pancreatic cancer...
  10. ncbi request reprint Hepatic resection followed by IFN-alpha and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Japan
    Hepatogastroenterology 54:172-9. 2007
    ..In this study, this therapy was applied for resectable advanced HCC (Vp3) as a postoperative adjuvant...
  11. ncbi request reprint [A case of complete response to interferon-α and S-1 combination therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection]
    Yoshiteru Katsura
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 38:2487-9. 2011
    ..Diagnostic imaging and tumor markers showed a marked improvement after 4 courses of S-1/IFN therapy, and he is still alive with good condition without recurrence and progression of tumors...
  12. ncbi request reprint Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis
    Yusuke Takahashi
    Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan
    Oncol Rep 30:1488-96. 2013
    ..The present study strongly supports the clinical significance of HMGA1 expression as a predictive indicator of lymph node metastasis in CRC cases, even in submucosal invasive cases which could be cured by local resection...
  13. ncbi request reprint [Long-term survival of a patient with hepatocellular carcinoma with portal vein tumor thrombus treated with interferon-α and 5-fluorouracil combination therapy]
    Yujiro Tsuda
    Dept of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 40:1804-6. 2013
    ..Therefore, even if patients have HCC with PVTT in the main branch and severe liver cirrhosis, long-term survival is possible by administration of a combination of FAIT and TACE. ..
  14. doi request reprint Fibrin sealant with PGA felt for prevention of bile leakage after liver resection
    Shogo Kobayashi
    Department of Surgery, Osaka University, Osaka, Japan
    Hepatogastroenterology 59:2564-8. 2012
    ..We performed preliminary evaluation of fibrin sealing combined with PGA felt (PGA-FS) as hemostat and to prevent biliary leakage, in comparison with the conventional fibrin-coated collagen fleece (FC-CF), retrospectively...
  15. doi request reprint Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection
    Daisaku Yamada
    Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Ann Surg Oncol 19:S355-64. 2012
    ..One function of this demethylase is to amplify hypoxia-inducible gene expression. We hypothesized that the demethylase would be a significant marker of hepatocellular carcinoma...
  16. doi request reprint Perineural invasion and lymph node involvement as indicators of surgical outcome and pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy for resectable pancreatic cancer
    Hidenori Takahashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg 255:95-102. 2012
    ..To analyze the histopathological indicators significantly associated with surgical outcome and the pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy (CRT) and subsequent pancreatectomy...
  17. pmc Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cells
    Hiroshi Wada
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita 565 0871 Osaka, Japan
    BMC Cancer 9:361. 2009
    ....
  18. doi request reprint Once-daily prolonged-release tacrolimus in de novo liver transplantation: a single center cohort study
    Shigeru Marubashi
    Department of Surgery, Osaka University, Osaka, Japan
    Hepatogastroenterology 59:1184-8. 2012
    ..The feasibility of oral administration of once-daily prolonged-release tacrolimus (TAC-PR) in de novo liver transplantation is not clear and therefore was investigated further...
  19. ncbi request reprint [Pancreatic cancer showing complete pathological response to preoperative chemoradiotherapy-a case report]
    Keiko Tanizaki
    Dept of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 40:1872-4. 2013
    ..Histopathological examination revealed no cancer cells in the pancreas or the dissected lymph nodes. The pathological effect was judged as grade IV. The patient has had no recurrence for 8 months since pancreatectomy. ..
  20. ncbi request reprint A simple and safe anastomosis in pancreaticogastrostomy using mattress sutures
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Am J Surg 196:130-4. 2008
    ..Postoperative amylase levels in the drainage fluid decreased significantly and none of the 17 patients developed pancreatic fistula formation. The technique is simple and shortens the time required for anastomosis...
  21. ncbi request reprint [A long-term survival case of hepatocellular carcinoma with portal vein and inferior vena cava tumor thrombi]
    Yasuji Hashimoto
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 37:2693-5. 2010
    ..This case suggests that some patients with advanced HCC with tumor thrombus can get a long-term survival when intrahepatic lesions are controlled by various therapies including IFN-α/5-FU combination therapy...
  22. doi request reprint Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells
    Masahiro Murakami
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Ann Surg Oncol 18:589-96. 2011
    ..In this study, we showed the VEGF-related effects of IFN/5-FU therapy using VEGF-receptor (VEGFR) selective inhibitor, PTK787/ZK222584 (PTK/ZK), in HCC cells...
  23. ncbi request reprint Role of intraoperative cytology combined with histology in detecting continuous and skip type intraductal cancer existence for intraductal papillary mucinous carcinoma of the pancreas
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Cancer 107:2567-75. 2006
    ..Recent reports suggest a higher frequency of cancer recurrence in the remnant pancreas after surgical resection of IPMN. It is therefore important to precisely detect intraductal cancer extension and skip lesions when resecting IPMN...
  24. doi request reprint Treatment of borderline cases for curative resection of biliary tract cancer
    Shogo Kobayashi
    Department of Surgery, Osaka University, Suita, Osaka, Japan
    J Surg Oncol 104:499-503. 2011
    ..To dissect the high rate of non-curative resection associated with biliary tract cancer, we compared the outcome of non-curative resection with that of inoperable cancer in patients referred for surgery...
  25. ncbi request reprint Utility of 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography in differential diagnosis of benign and malignant intraductal papillary-mucinous neoplasm of the pancreas
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Oncol Rep 24:613-20. 2010
    ..5 offered the best diagnosis of malignant IPMN. These results suggest that FDG-PET is useful for differentiation of malignant IPMN of the pancreas, and that it should be performed in combination with other conventional imaging modalities...
  26. doi request reprint Serum CA19-9 alterations during preoperative gemcitabine-based chemoradiation therapy for resectable invasive ductal carcinoma of the pancreas as an indicator for therapeutic selection and survival
    Hidenori Takahashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City, Japan
    Ann Surg 251:461-9. 2010
    ..To evaluate serum CA19-9 alterations during preoperative gemcitabine-based chemoradiation therapy (CRT) for resectable pancreatic cancer (PC) in the earlier identification of patients who are likely to benefit from subsequent resection...
  27. ncbi request reprint [A case of a patient with hepatocellular carcinoma who achieved long-term survival after repeated transcatheter arterial chemoembolization and sorafenib therapy]
    Ryota Mukai
    Dept of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 40:1813-5. 2013
    ..Therefore, he underwent additional TACE for the intrahepatic lesions. The patient is still alive with recurrences 4 years and 8 months after the initial recurrence. ..
  28. doi request reprint Equivalent outcomes after anatomical and non-anatomical resection of small hepatocellular carcinoma in patients with preserved liver function
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Dig Dis Sci 57:1942-8. 2012
    ..Although anatomical resection (AR) is considered better than non-anatomical resection (NAR) for the treatment for hepatocellular carcinoma (HCC), there is only limited evidence in support of this argument...
  29. doi request reprint Long-term outcome of combined interferon-α and 5-fluorouracil treatment for advanced hepatocellular carcinoma with major portal vein thrombosis
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Japan
    Oncology 80:63-9. 2011
    ....
  30. ncbi request reprint [A long-term survival case of hepatocellular carcinoma with bone metastasis and inferior vena cava tumor thrombus successfully treated with multidisciplinary therapy]
    Daisaku Yamada
    Dept of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 37:2670-2. 2010
    ..This case suggests that some patients with highly progressive HCC involving inferior vena cava tumor thrombus (Vv3) and bone metastasis can gain a long-term survival by multidisciplinary therapy including TACE and Interferon-α and S-1...
  31. ncbi request reprint [A case of locally advanced pancreatic cancer with superior membrane artery invasion successfully resected after gemcitabine-based chemoradiotherapy]
    Yoshiaki Ohmura
    Department of Surgery, Graduate School of Medicine, Osaka University, and Osaka National Hospital, National Hospital Organization
    Gan To Kagaku Ryoho 36:2428-9. 2009
    ..Adjuvant chemotherapy with 6 courses of GEM was also performed. The patient has no recurrence, suggesting the efficacy of GEM-based CRT for locally advanced borderline unresectable pancreatic cancer...
  32. doi request reprint Synergistic antitumor effect of interferon-ß with gemcitabine in interferon-α-non-responsive pancreatic cancer cells
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Int J Oncol 38:1237-43. 2011
    ..In conclusion, our results indicated that the growth-inhibitory effect of IFN-ß with gemcitabine was synergistic not only in pancreatic cancer cells with strong expression of IFNAR2, but also in those with weak expression of IFNAR2...
  33. ncbi request reprint Laparoscopy-assisted hybrid left-side donor hepatectomy
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    World J Surg 37:2202-10. 2013
    ..However, its safety and efficacy still remain to be established. We aimed to evaluate the feasibility, safety and efficacy of laparoscopy-assisted hybrid donor hepatectomy (LADH) to obtain left side grafts...
  34. doi request reprint Plasma miR-21 is a novel diagnostic biomarker for biliary tract cancer
    Tomoya Kishimoto
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Cancer Sci 104:1626-31. 2013
    ..2%, 82.6%, and 72.6%, respectively. These sets of values were improved by combining miR-21 and CA19-9 measurements. Plasma miR-21 is a novel diagnostic biomarker for BTC, and may be useful in distinguishing between BTC and BBD patients...
  35. ncbi request reprint [A case of successful treatment by interferon-α and 5-fluorouracil combination therapy (FAIT) and transcatheter arterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus]
    Tomoya Kishimoto
    Dept of Surgery, Osaka University, Graduate School of Medicine
    Gan To Kagaku Ryoho 38:2484-6. 2011
    ..This case suggested that some patient of HCC with PVTT could get a long-term survival if an initial treatment was succeeded and could apply further treatment such as TACE...
  36. doi request reprint PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection
    Takehiro Noda
    The Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Liver Int 32:110-8. 2012
    ..Hypoxia also stimulates expression of procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) genes via the HIF-1 pathway...
  37. ncbi request reprint Liver perfusion chemotherapy for selected patients at a high-risk of liver metastasis after resection of duodenal and ampullary cancers
    Takehiro Noda
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg 246:799-805. 2007
    ..To evaluate the prognostic benefit of postoperative liver perfusion chemotherapy (LPC) in patients who undergo curative resection of duodenal and ampullary cancers...
  38. ncbi request reprint [A case of advanced hepatocellular carcinoma with inferior vena cava tumor thrombus and multiple intrahepatic metastases treated successfully by transcatheter arterial chemoembolization and radical hepatectomy]
    Chihiro YAMANAKA
    Dept of Gastroenterological Surgery, Osaka University, Graduated School of Medicine, Japan
    Gan To Kagaku Ryoho 39:1819-21. 2012
    ..This case suggested that long-term survival is possible by surgery and repeated TACE in case of good liver function by a sustained virologic response (SVR) via treatment with IFN-α for hepatitis C virus...
  39. doi request reprint Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer
    Daisaku Yamada
    Department of Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2 2 E2, Suita, Osaka 565 0871, Japan
    Eur J Cancer 49:1725-40. 2013
    ....
  40. ncbi request reprint Association of the primary tumor location with the site of tumor recurrence after curative resection of thoracic esophageal carcinoma
    Yuichiro Doki
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    World J Surg 29:700-7. 2005
    ..Regional radiotherapy might be expected to have an adjuvant effect on Ut/Mt tumors and systemic chemotherapy on Lt tumors...
  41. ncbi request reprint Intraductal papillary-mucinous carcinoma of the pancreas with tumor thrombus in the portal vein: a report of two cases
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 54:1585-8. 2007
    ..In addition, a higher possibility for subsequent liver metastasis should be anticipated after the tumor forms a thrombus in the portal vein...
  42. pmc Risk of recurrence in a long-term follow-up after surgery in 417 patients with hepatitis B- or hepatitis C-related hepatocellular carcinoma
    Yo Sasaki
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg 244:771-80. 2006
    ..The aim of this study is to clarify the difference of risk of recurrence after hepatic resection between patients with hepatitis B- and hepatitis C-related hepatocellular carcinoma (HCC)...
  43. doi request reprint Clinical significance of alpha-fetoprotein mRNA in peripheral blood in liver resection for hepatocellular carcinoma
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Ann Surg Oncol 18:2200-9. 2011
    ..However, its interpretation and clinical significance remains to be determined. This study was designed to evaluate the clinical significance of detecting AFP mRNA positive cells in peripheral blood...
  44. ncbi request reprint Feasibility and efficacy of combination therapy with preoperative and postoperative chemoradiation, extended pancreatectomy, and postoperative liver perfusion chemotherapy for locally advanced cancers of the pancreatic head
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg Oncol 12:629-36. 2005
    ..We performed a combination of chemoradiation and liver perfusion chemotherapy and extended pancreatectomy...
  45. ncbi request reprint Successful adult ABO incompatible living donor liver transplantation: experience with double infusion through the hepatic artery and portal vein
    Shogo Kobayashi
    Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Hepatogastroenterology 58:503-7. 2011
    ..Herein, we describe our experience with five ABO-incompatible LDLT patients who received double-infusion therapy via both the HA and PV...
  46. ncbi request reprint Hepatic artery reconstruction in living donor liver transplantation: risk factor analysis of complication and a role of MDCT scan for detecting anastomotic stricture
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    World J Surg 37:2671-7. 2013
    ....
  47. doi request reprint MicroRNA-29a induces resistance to gemcitabine through the Wnt/β-catenin signaling pathway in pancreatic cancer cells
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Int J Oncol 43:1066-72. 2013
    ....
  48. doi request reprint Predicting the necessity of autologous blood collection and storage before surgery for hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Surg Oncol 108:486-91. 2013
    ..It remains unclear what kinds of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) actually need autologous blood storage/transfusion...
  49. doi request reprint Intragraft transcriptome level of CXCL9 as biomarker of acute cellular rejection after liver transplantation
    Tadafumi Asaoka
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Surg Res 178:1003-14. 2012
    ..The aim of the present study was to identify molecular biomarkers for ACR in liver allograft...
  50. ncbi request reprint [A case of hepatocellular carcinoma treated by transcatheter arterial chemoembolization and hepatectomy after subtotal stomach preserving pancreaticoduodenectomy for duodenal cancer]
    Sakae Maeda
    Dept of Gastroenterological Surgery, Osaka University, Osaka, Japan
    Gan To Kagaku Ryoho 39:1988-90. 2012
    ..Liver resection was carried out with the aim of achieving A-P point. In this case then, several radical treatments have been completed without any biliary complication...
  51. doi request reprint Clinicopathological features of long-term survivors for advanced biliary tract cancer and impact of the number of lymph nodes involved
    Shogo Kobayashi
    Department of Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2 2 E2, Suita, Osaka 565 0871, Japan
    Int J Surg 11:145-51. 2013
    ..To investigate the characteristics of long-term survivors after surgery for advanced biliary tract cancer (BTC), especially those with local invasion and/or lymph node involvement...
  52. ncbi request reprint Hepatectomy based on the tumor hemodynamics for hepatocellular carcinoma: a comparison among the hybrid and pure laparoscopic procedures and open surgery
    Shogo Kobayashi
    Department of Surgery, Osaka University, Yamadaoka 2 2 E2, Suita, Osaka 565 0871, Japan
    Surg Endosc 27:610-7. 2013
    ....
  53. ncbi request reprint [A case of long-term survival for advanced gallbladder cancer]
    Daisuke Takiuchi
    Department of Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 36:2395-7. 2009
    ..We additionally performed adjuvant chemotherapy with 6 courses of 800 mg/m2 of gemcitabine (GEM) on days 1, 8 and 15 for every 35 days. No recurrent signs were observed for 33 months after curative operation...
  54. ncbi request reprint A safe protocol of intermittent hilar vascular clamping for hepatic resection in cirrhosis
    Hiroaki Nagano
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita 565 0871 Osaka, Japan
    Hepatogastroenterology 56:1439-44. 2009
    ..Postoperative liver function was assessed at days 1, 3 and 5...
  55. doi request reprint Mural nodule in branch duct-type intraductal papillary mucinous neoplasms of the pancreas is a marker of malignant transformation and indication for surgery
    Hirofumi Akita
    Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan
    Am J Surg 202:214-9. 2011
    ..This study aimed to elucidate the preoperative clinical factors that identify high-risk malignant transformation in branch duct-type IPMN...
  56. ncbi request reprint Patients with pancreatic intraductal papillary mucinous neoplasms are at high risk of colorectal cancer development
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 139:749-54. 2006
    ....
  57. pmc Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita, 565 0871 Osaka, Japan
    World J Gastroenterol 16:5603-10. 2010
    ..To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function, postoperative complications and cancer prognosis...
  58. doi request reprint Effects of preceding interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery and Hepatology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Surg Oncol 102:308-14. 2010
    ..Despite such effectiveness, HCC develops even in HCV patients successfully treated with IFN therapy...
  59. doi request reprint Usefulness of the CLIP scoring system for prediction of postoperative prognosis of patients with large hepatocellular carcinoma
    Takehiro Noda
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Hepatobiliary Pancreat Surg 16:538-45. 2009
    ..The aim of this study was to identify the staging system with the best prognostic value for such patients...
  60. doi request reprint Prognosis of hepatocellular carcinoma with biliary tumor thrombi after liver surgery
    Takehiro Noda
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Surgery 149:371-7. 2011
    ..We analyzed retrospectively the clinicopathologic features of 22 patients with HCC with BTT to identify the prognostic factors associated with operative outcome...
  61. doi request reprint Real-time intraoperative assessment of residual liver functional reserve using pulse dye densitometry
    Hirofumi Akita
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka Suita, Osaka, 565 0871, Japan
    World J Surg 32:2668-74. 2008
    ..The aim of this study was to assess the utility of ICG-R15 measured by pulse dye densitometry to predict residual liver function prior to hepatectomy...
  62. ncbi request reprint Combination of IFN-alpha and 5-fluorouracil induces apoptosis through IFN-alpha/beta receptor in human hepatocellular carcinoma cells
    Motoi Kondo
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka E2, Suita, Osaka 565 0871, Japan
    Clin Cancer Res 11:1277-86. 2005
    ..In the present study, we examined whether apoptosis through IFN-alpha/beta receptor (IFN-alpha/betaR) was associated with the effects of combination therapy...
  63. ncbi request reprint Surgery for hepatocellular carcinoma with tumor thrombus extending into the right atrium: report of a successful resection without the use of cardiopulmonary bypass
    Mamoru Uemura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 51:1259-62. 2004
    ..Surgery without the use of cardiopulmonary bypass is safe and can be minimally invasive when it is performed with a reliable diagnosis and technique...
  64. doi request reprint Xenon-inhalation computed tomography for noninvasive quantitative measurement of tissue blood flow in pancreatic tumor
    Masaru Kubota
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Dig Dis Sci 57:801-5. 2012
    ....
  65. ncbi request reprint Long-term follow-up of glucose tolerance function after pancreaticoduodenectomy: comparison between pancreaticogastrostomy and pancreaticojejunostomy
    Osamu Ishikawa
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 136:617-23. 2004
    ....
  66. doi request reprint IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Int J Cancer 130:319-27. 2012
    ..Our results indicated that IGFBP7 expression correlated significantly with the malignant potential in HCC cells, suggesting that the expression could be a useful prognostic marker for HCC...
  67. doi request reprint In situ telomerase activity in pancreatic juice may discriminate pancreatic cancer from other pancreatic diseases
    Hiroyuki Uehara
    Departments of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Pancreas 36:236-40. 2008
    ..In the present study using an in situ TRAP assay, we investigated the specificity of telomerase activity in pancreatic juice for pancreatic cancer...
  68. doi request reprint Experience with the use of fibrin sealant plus polyglycolic acid felt at the cut surface of the liver in laparoscopic hepatectomy
    Shogo Kobayashi
    Department of Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2 2 E2, Suita, Osaka 565 0871, Japan
    Surg Endosc 25:3590-6. 2011
    ..This study aimed to investigate the feasibility and efficacy of using fibrin sealant with PGA felt in laparoscopic hepatectomy...
  69. doi request reprint Multidetector computed tomography for preoperative prediction of postsurgical prognosis of patients with extrahepatic biliary cancer
    Shogo Kobayashi
    Department of Surgery, Osaka University, Yamadaoka 2 2 E2, Suita, Osaka, Japan
    J Surg Oncol 101:376-83. 2010
    ..We evaluated various prognostic factors and non-curative surgical factors using multidetector computed tomography (MDCT)...
  70. ncbi request reprint Advantage of pancreaticogastrostomy in detecting recurrent intraductal papillary mucinous carcinoma in the remnant pancreas: a case of successful re-resection after pancreaticoduodenectomy
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Japan
    J Surg Oncol 93:511-5. 2006
    ..Based on this experience, we decided to recommend PG for all patients deemed to be at high risk for the recurrence of cancer in the pancreatic remnants following PD for IPMC of the pancreatic head...
  71. doi request reprint Real-time and the in vivo detection of minute cancer invasion to the portal-superior mesenteric vein using contact endoscopy during a pancreatic cancer resection
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    Am J Surg 198:e66-71. 2009
    ..Thus, contact endoscopy is considered a promising modality for making a real-time diagnosis on the precise location of minute cancer, without requiring any tissue sampling...
  72. doi request reprint Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer
    Shogo Kobayashi
    Department of Surgery, Osaka University, Suita, Osaka, Japan
    J Surg Oncol 103:223-9. 2011
    ..FDG-PET has been used for the diagnosis of cancer and metastatic lesions. Herein, we retrospectively evaluated the utility of FDG-PET for detection of lymph node metastasis in biliary tract cancer...
  73. ncbi request reprint [A case of curative resected hilar bile duct cancer with hepatic artery and portal vein reconstructions]
    Yoshiteru Katsura
    Dept of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
    Gan To Kagaku Ryoho 37:2720-2. 2010
    ..g. inferior mesenteric vein. The patient is alive without any evidence of recurrence for 8 months after the surgery...
  74. doi request reprint Donor hepatectomy for living donor liver transplantation: learning steps and surgical outcome
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, 565 0871, Osaka, Japan
    Dig Dis Sci 56:2482-90. 2011
    ..There is little information on the impact of team experience and learning on the surgical outcome. The aim of this study was to clarify the impact of team experience in a single center on the outcome of live donor hepatectomy...
  75. pmc Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Osaka, Japan
    World J Gastroenterol 17:3709-15. 2011
    ..To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC)...
  76. ncbi request reprint A successful resection and long-term survival of a patient with intrahepatic recurrences of combined hepatocellular-cholangiocarcinoma: report of a case
    Hidetoshi Eguchi
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Japan
    Surg Today 32:742-6. 2002
    ..To improve the poor prognosis of combined HCC-CC, clinicopathological features of this disease and the therapy selection for recurrent tumors should be discussed...
  77. doi request reprint Increased immunogenicity of tumor-associated antigen, mucin 1, engineered to express alpha-gal epitopes: a novel approach to immunotherapy in pancreatic cancer
    Takashi Deguchi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Cancer Res 70:5259-69. 2010
    ..The results suggested that vaccination using cells engineered to express alpha-gal epitopes is a novel strategy for treatment of pancreatic cancer...
  78. doi request reprint Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Hepatol 56:167-75. 2012
    ..The aim of this study was to evaluate the significance of plasma microRNA-21 level as a biochemical marker for hepatocellular carcinoma...
  79. ncbi request reprint Fibrosis in non-cancerous tissue is the unique prognostic factor for primary hepatocellular carcinoma without hepatitis B or C viral infection
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    World J Surg 30:1729-35. 2006
    ....
  80. doi request reprint A single-incision laparoscopic hepatectomy for hepatocellular carcinoma: initial experience in a Japanese patient
    Shogo Kobayashi
    Department of Surgery, Osaka University, Yamadaoka 2 2, Suita City, Osaka, Japan
    Minim Invasive Ther Allied Technol 19:367-71. 2010
    ..Various aspects of the procedure were not different from TLS. SILH is a safe procedure with several advantages. The procedure is promising as minimally invasive liver surgery...
  81. pmc Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava
    Yoshito Tomimaru
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita, 565 0871, Osaka, Japan
    World J Gastroenterol 15:4204-8. 2009
    ..To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC...
  82. doi request reprint Evaluation of a new immunoassay for therapeutic drug monitoring of tacrolimus in adult liver transplant recipients
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    J Clin Pharmacol 50:705-9. 2010
    ..The effects of maintaining low levels of FK should be evaluated in liver transplant recipients...
  83. ncbi request reprint Early ligation of the inferior pancreaticoduodenal artery to reduce blood loss during pancreaticoduodenectomy
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 51:4-5. 2004
    ..This approach was feasible in reducing blood loss presumably related to blood congestion...
  84. ncbi request reprint Presence of minute cancer cell dissemination in peritoneal lavage fluid detected by reverse transcription PCR is an independent prognostic factor in patients with resectable pancreatic cancer
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 146:888-95. 2009
    ....
  85. doi request reprint Salvage cystic duct anastomosis using a magnetic compression technique for incomplete bile duct reconstruction in living donor liver transplantation
    Shigeru Marubashi
    Department of Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Liver Transpl 16:33-7. 2010
    ..A combination of the MCA technique and cystic duct anastomosis is life-saving in certain situations and should be considered as the treatment of choice...
  86. ncbi request reprint Adult capillary hemangioma of the liver: report of a case
    Takehiro Noda
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Surg Today 35:796-9. 2005
    ..Thus, we must be aware of the possibility of capillary hemangioma when finding an atypical liver tumor inconsistent with HCC or cavernous hemangioma...
  87. pmc Liver metastasis originating from colorectal cancer with macroscopic portal vein tumor thrombosis: a case report and review of the literature
    Yoshito Tomimaru
    Department of Surgery, Yao Municipal Hospital, Osaka, Japan
    J Med Case Reports 4:382. 2010
    ..Macroscopic tumor thrombi occupying the main portal branch are rarely seen in patients with liver metastasis...
  88. ncbi request reprint The significance of surgical resection for pulmonary metastasis from hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Am J Surg 192:46-51. 2006
    ..Until now there have been few reports about surgical resection for pulmonary metastasis from HCC. The aim of the present study was to evaluate the significance of surgical resection for pulmonary metastasis from HCC...
  89. ncbi request reprint Surgical significance of superficial cancer spread in early gallbladder cancer
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Jpn J Clin Oncol 35:134-8. 2005
    ....
  90. ncbi request reprint Isolated metastasis to the gallbladder from hepatocellular carcinoma
    Masahiro Murakami
    Department of Surgery Graduate School of Medicine, Osaka University, 2 2 Yamadaoka E 2, Suita, 565 0871, Osaka, Japan
    Hepatol Res 40:793-8. 2010
    ..Conclusion: Our eight cases of GB metastasis from HCC were closely related to PVTT. Surgical resection and multimodal treatment would be necessary for long-term survival in cases with isolated GB metastasis...
  91. ncbi request reprint Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against Hepatocellular Carcinoma
    Tameyoshi Yamamoto
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka, University, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Clin Cancer Res 10:7884-95. 2004
    ....
  92. doi request reprint Role of the liver in determining alloimmune response in vitro following donor-specific spleen cell injection
    Masaki Okuyama
    Department of Surgery, Graduate School of Medicine Osaka University, Osaka 565 0871, Japan
    Transpl Immunol 22:150-6. 2010
    ..Our findings suggest that liver and other organs may behave differently to alloantigen, suggesting the importance of an early Th1 reaction in the liver and spleen...
  93. doi request reprint A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation
    Kunihito Gotoh
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi, Higashinari ku, Osaka, Japan
    J Surg Oncol 100:75-9. 2009
    ..The clear delineation between tumor and normal tissue is ideal for real-time surgical navigation imaging. We present a novel indocyanine green (ICG) fluorescence imaging technique to visualize hepatocellular carcinoma (HCC)...
  94. ncbi request reprint Liver abscess formation after microwave coagulation therapy applied for hepatic metastases from surgically excised bile duct cancer: report of a case
    Osakuni Morimoto
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Suita, Japan
    Surg Today 32:454-7. 2002
    ..Treatment resulted in a rapid resolution of symptoms. Our case indicated that care should be exercised in using MCT for the treatment of liver tumors in patients who have undergone reconstructive surgery of the biliary tract...