Katsuyuki Aozasa

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Expression of cell adhesion molecules and chemokine receptors: angioinvasiveness in nasal NK/T-cell lymphoma
    Angen Liu
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Oncol Rep 13:613-20. 2005
  2. ncbi request reprint Loss of expression of Epstein-Barr virus nuclear antigen-2 correlates with a poor prognosis in cases of pyothorax-associated lymphoma
    Tetsuya Takakuwa
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Cancer 118:2782-9. 2006
  3. pmc Successful treatment of recurrent small bowel adenocarcinoma by cytoreductive surgery and chemotherapy: a case report and review of the literature
    Tomoki Yamano
    Department of Surgery, Kawachi General Hospital, 1 31 Yokomakura, Higashiosaka, Osaka 578 0954, Japan
    J Med Case Reports 4:213. 2010
  4. doi request reprint Epidemiology and pathogenesis of nasal NK/T-cell lymphoma: a mini-review
    Katsuyuki Aozasa
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    ScientificWorldJournal 11:422-8. 2011
  5. ncbi request reprint Pyothorax-associated lymphoma: a lymphoma developing in chronic inflammation
    Katsuyuki Aozasa
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    Adv Anat Pathol 12:324-31. 2005
  6. pmc Nasal NK/T-cell lymphoma: epidemiology and pathogenesis
    Katsuyuki Aozasa
    Department of Pathology C3, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Hematol 87:110-7. 2008
  7. doi request reprint Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma
    Nur Rahadiani
    Department of Pathology, Osaka University, Graduate School of Medicine, Osaka, Japan
    Ann Surg Oncol 17:1311-23. 2010
  8. pmc Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    Yoshihiro Oka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:13885-90. 2004
  9. ncbi request reprint Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication
    Yoshihiko Hoshida
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Rheumatol 34:322-31. 2007
  10. ncbi request reprint Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
    Suhana Mamat
    Department of Pathology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Oncol Rep 23:1221-7. 2010

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Expression of cell adhesion molecules and chemokine receptors: angioinvasiveness in nasal NK/T-cell lymphoma
    Angen Liu
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Oncol Rep 13:613-20. 2005
    ..Immunohistochemistry showed expression of these molecules in NKTCL cells. These findings suggest that EBV infection might be involved in the pathogenesis of angioinvasion of NKTCL through up-regulation of alpha M by LMP-1...
  2. ncbi request reprint Loss of expression of Epstein-Barr virus nuclear antigen-2 correlates with a poor prognosis in cases of pyothorax-associated lymphoma
    Tetsuya Takakuwa
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Cancer 118:2782-9. 2006
    ..Loss of EBNA-2 expression, irrespective of the latency pattern, is correlated with a poor prognosis, suggesting that down-regulation of the EBNA-2 expression could be selection pressure for the progression of PAL...
  3. pmc Successful treatment of recurrent small bowel adenocarcinoma by cytoreductive surgery and chemotherapy: a case report and review of the literature
    Tomoki Yamano
    Department of Surgery, Kawachi General Hospital, 1 31 Yokomakura, Higashiosaka, Osaka 578 0954, Japan
    J Med Case Reports 4:213. 2010
    ..We present a case of recurrent small bowel adenocarcinoma successfully treated by cytoreductive surgery and palliative chemotherapy...
  4. doi request reprint Epidemiology and pathogenesis of nasal NK/T-cell lymphoma: a mini-review
    Katsuyuki Aozasa
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    ScientificWorldJournal 11:422-8. 2011
    ..Case-control studies showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism...
  5. ncbi request reprint Pyothorax-associated lymphoma: a lymphoma developing in chronic inflammation
    Katsuyuki Aozasa
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    Adv Anat Pathol 12:324-31. 2005
    ..Use of an artificial pneumothorax, EBV infection, and cytokines and reactive oxygen species produced in longstanding pyothorax might be important factors for PAL development...
  6. pmc Nasal NK/T-cell lymphoma: epidemiology and pathogenesis
    Katsuyuki Aozasa
    Department of Pathology C3, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Hematol 87:110-7. 2008
    ..Case-control study showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism...
  7. doi request reprint Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma
    Nur Rahadiani
    Department of Pathology, Osaka University, Graduate School of Medicine, Osaka, Japan
    Ann Surg Oncol 17:1311-23. 2010
    ..The objectives of the present study were to examine the role of podoplanin in esophageal squamous-cell carcinoma (ESCC)...
  8. pmc Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    Yoshihiro Oka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:13885-90. 2004
    ..It was therefore demonstrated that WT1 vaccination could induce WT1-specific cytotoxic T lymphocytes and result in cancer regression without damage to normal tissues...
  9. ncbi request reprint Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication
    Yoshihiko Hoshida
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Rheumatol 34:322-31. 2007
    ..Our objective was to characterize MTX-LPD in comparison to non-MTX-LPD and sporadic LPD in patients with RA...
  10. ncbi request reprint Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
    Suhana Mamat
    Department of Pathology, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Oncol Rep 23:1221-7. 2010
    ..As compared to cancer cells, normal endometrium continuously expressed CDCP1. These suggested that the attitude of CDCP1 in cancers of lung and endometrium was different. Different role of CDCP1 by tissues and cancers is discussed...
  11. ncbi request reprint Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T- and natural killer (NK)/T-cell malignancies
    Shin ichi Nakatsuka
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871
    Cancer Sci 94:87-91. 2003
    ..These findings suggested that suppression of DAP kinase expression by DNA methylation might play a substantial role in the development of not only B-cell, but also T- and NK/T-cell lymphomas...
  12. pmc Tumorigenic role of orphan nuclear receptor NR0B1 in lung adenocarcinoma
    Tomofumi Oda
    Department of Pathology, Graduate School of Medicine, Osaka University, Yamada oka 2 2, Suita, Japan
    Am J Pathol 175:1235-45. 2009
    ..In conclusion, NR0B1 might play a role in the malignant potential of lung adenocarcinoma...
  13. doi request reprint Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications
    Nur Rahadiani
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan
    Cancer Sci 102:903-8. 2011
    ..010 for overall survival [OS]), and high ALDH1 expression was an independent factor for poor prognosis. Aldehyde dehydrogenase 1 is a candidate for CIC marker for uterine endometrioid adenocarcinoma...
  14. ncbi request reprint Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection
    Angen Liu
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Cancer Sci 97:605-10. 2006
    ..These findings show that alterations in the ATR gene result in an abnormal response to DNA double-strand break and single-strand break repair, suggesting a role for ATR gene alterations in NKTCL lymphomagenesis...
  15. ncbi request reprint Methylation of promoter region in p27 gene plays a role in the development of lymphoid malignancies
    Shin ichi Nakatsuka
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Int J Oncol 22:561-8. 2003
    ..These findings suggested that gene methylation plays a role in loss of expression of p27, which gives the cells proliferative advantages...
  16. ncbi request reprint Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 10:651-7. 2004
    ..The present study was designed to investigate the prognostic significance of VCP expression in colorectal adenocarcinoma...
  17. ncbi request reprint p53, K-ras, c-kit and beta-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan
    Tadashi Hongyo
    Department of Radiation Biology and Medical Genetics, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Oncol Rep 13:265-71. 2005
    ..In conclusion, different frequency of p53 mutations with different pattern of exon involvement and difference in age of disease onset is evident between sinonasal NKTCL in Korea and Japan...
  18. ncbi request reprint Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Yamadaoka, Suita City, Japan
    Oncology 66:468-75. 2004
    ..To determine the prognostic value of valosin-containing protein (VCP) expression and the Ki-67 labeling index (LI) in pancreatic endocrine neoplasms (PENs), the present analysis was employed...
  19. doi request reprint Polymorphous lymphoproliferative disorder: a clinicopathological analysis
    Naoto Nakamichi
    Department of Pathology C3, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Virchows Arch 456:269-76. 2010
    ..7 +/- 17.3%. Thus, polymorphous LPD is relatively rare in Japan and is a heterogeneous disease with monoclonal proliferation of B or T cells; additionally, it is occasionally EBV-associated, and behaves as an aggressive lymphoma...
  20. ncbi request reprint Overexpression of the Wilms' tumor gene WT1 in esophageal cancer
    Yusuke Oji
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, 1 7, Yamada oka, Suita, Osaka 565 0871, Japan
    Anticancer Res 24:3103-8. 2004
    ..The Wilms' tumor gene WT1 is overexpressed in various kinds of solid cancers. However, it remains unclear whether WT1 is expressed in esophageal squamous cell carcinoma...
  21. ncbi request reprint Hepatoma-derived growth factor is a novel prognostic factor for hepatocellular carcinoma
    Kenya Yoshida
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Yamada oka 2 2, Suita, 565 0871 Osaka, Japan
    Ann Surg Oncol 13:159-67. 2006
    ..This study investigated the correlation of HDGF expression with differentiation and prognosis of hepatocellular carcinoma (HCC)...
  22. ncbi request reprint Hepatoma-derived growth factor is a novel prognostic factor for patients with pancreatic cancer
    Hirokazu Uyama
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Yamada oka, Suita, Osaka, Japan
    Clin Cancer Res 12:6043-8. 2006
    ..Cases showing positive staining in < 90% and > 90% of tumor cells were regarded as HDGF labeling index (LI) levels 1 and 2, respectively. HDGF LI was determined separately for the nucleus and the cytoplasm...
  23. doi request reprint (18)F-FDG PET analysis of schwannoma: increase of SUVmax in the delayed scan is correlated with elevated VEGF/VPF expression in the tumors
    Kenichiro Hamada
    Department of Orthopedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Skeletal Radiol 38:261-6. 2009
    ....
  24. ncbi request reprint Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Suita
    Ann Surg Oncol 11:165-72. 2004
    ..In the present study, association of VCP expression with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma (PDAC) was examined...
  25. ncbi request reprint Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability
    Maria Francisca Ham
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Cancer Sci 97:226-34. 2006
    ..This might result in inactivation of the DSB repair system, thus inducing an acceleration of genome instability and accumulation of genetic damage...
  26. doi request reprint Decreased immunostaining for macrophage scavenger receptor is associated with poor prognosis of prostate cancer
    Hitoshi Takayama
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    BJU Int 103:470-4. 2009
    ....
  27. doi request reprint 18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of glucose transporter 1 and hexokinase II
    Kenichiro Hamada
    Department of Orthopedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Nucl Med 22:699-705. 2008
    ....
  28. ncbi request reprint Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China
    Yoshihiko Hoshida
    Department of Pathology C3, Osaka University Medical School, Suita
    Cancer Sci 94:297-301. 2003
    ..These differences might be caused by migration of susceptible populations or some environmental confounding factors...
  29. ncbi request reprint Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas
    Takafumi Ueda
    Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka
    Cancer Sci 94:271-6. 2003
    ....
  30. doi request reprint Vascular endothelial growth factor receptor 1 expression in pelvic lymph nodes predicts the risk of cancer progression after radical prostatectomy
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Cancer Sci 100:1047-50. 2009
    ..Although larger validation studies are required, our results suggest that VEGFR1 expression in pelvic lymph nodes predicts the risk of biochemical PSA recurrence after radical prostatectomy...
  31. ncbi request reprint Prognostic significance of activated AKT expression in soft-tissue sarcoma
    Yasuhiko Tomita
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Cancer Res 12:3070-7. 2006
    ..AKT is a serine/threonine kinase which is important in tumorigenesis. Several molecules involved in AKT pathway are dysregulated in various kinds of human cancers...
  32. doi request reprint Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung
    Jun Ichiro Ikeda
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer Sci 100:429-33. 2009
    ..Multivariate analysis revealed that only CDCP1 expression was an independent prognostic factor for both OS and DFS. CDCP1 expression level is a useful marker for prediction of patients with lung adenocarcinoma..
  33. ncbi request reprint Diffuse large B-cell lymphoma in the young in Japan: a study by the Osaka Lymphoma Study Group
    Amane Yamauchi
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Hematol 82:893-7. 2007
    ..DLBCL in the young in Japan is characterized by a much lower frequency of the GCB phenotype compared to that in Western countries...
  34. ncbi request reprint False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression
    Kenichiro Hamada
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Skeletal Radiol 35:306-10. 2006
    ..An immunohistochemical analysis demonstrated weak expression of both Glut-1 and HK-II. These findings suggest that Glut-1 and HK-II expression are not strongly related to FDG uptake in chondroblastoma...
  35. doi request reprint Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group
    Naoki Wada
    Departments of Pathology, Osaka University Graduate School of Medicine, Suita, 2 2 Yamadaoka, Suita, Osaka 565 0871, Osaka, Japan
    Pathol Res Pract 206:439-44. 2010
    ..Univariate analysis revealed that advanced stage was an unfavorable factor for overall survival (P=0.060). SEDLBCL is different from nodal and CNS DLBCL, but an association with EBV is unlikely in every group...
  36. ncbi request reprint Expression level of hepatoma-derived growth factor correlates with tumor recurrence of esophageal carcinoma
    Shinji Yamamoto
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka, Japan, 5650871
    Ann Surg Oncol 14:2141-9. 2007
    ..In the present study, association of HDGF expression with recurrence and prognosis of esophageal carcinoma (EC) was examined...
  37. ncbi request reprint Epstein-Barr virus is integrated between REL and BCL-11A in American Burkitt lymphoma cell line (NAB-2)
    Wen Juan Luo
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Lab Invest 84:1193-9. 2004
    ..Integration event in NAB-2 might alter the regulation of the oncogenes and provide advantage for continuous cell proliferation...
  38. ncbi request reprint Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma
    Shinji Yamamoto
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Osaka 565 0871, Japan
    Ann Surg Oncol 11:697-704. 2004
    ..This study was designed to evaluate the prognostic significance of VCP expression in non-small-cell lung carcinoma (NSCLC)...
  39. ncbi request reprint Reassessment of the 1993 Osaka grading system for localized soft tissue sarcoma in Japan
    Yasuhiko Tomita
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Anticancer Res 26:4665-9. 2006
    ..The present study was conducted to evaluate the utility of the Osaka system under recent therapeutic regimens...
  40. ncbi request reprint Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer
    Yusuke Oji
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Cancer Sci 94:606-11. 2003
    ..These findings indicate an important role of the wild-type WT1 gene in the tumorigenesis of primary thyroid cancer...
  41. ncbi request reprint Prognostic significance of BACH2 expression in diffuse large B-cell lymphoma: a study of the Osaka Lymphoma Study Group
    Emiko Sakane-Ishikawa
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan
    J Clin Oncol 23:8012-7. 2005
    ..BACH2 possesses an inhibitory effect on proliferation of Raji cell lines derived from Burkitt's lymphoma. In this study, the prognostic significance of BACH2 expression was examined in diffuse large B-cell lymphoma (DLBCL)...
  42. ncbi request reprint Correlation between promoter hypermethylation of GSTP1 and response to chemotherapy in diffuse large B cell lymphoma
    Itsuko Nakamichi
    Department of Pathology C3, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann Hematol 86:557-64. 2007
    ..2%; p < 0.05). However, GSTP1 promoter hypermethylation was not an independent prognosticator in multivariate analysis. Methylation status of GSTP1 could be an indicator of drug response and a prognosticator for DLBCL...
  43. ncbi request reprint Prognostic significance of CD100 expression in soft tissue sarcoma
    Eweseng Ch'ng
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer 110:164-72. 2007
    ..The expression of CD100 in soft tissue sarcoma (STS) and its correlation with clinicopathologic factors and prognostic significance were evaluated...
  44. doi request reprint Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer
    Norio Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, Japan
    BJU Int 107:1918-22. 2011
    ..To evaluate tumour-associated macrophage (TAM) infiltration in prostate biopsy specimens as a possible prognostic factor for prostate cancer (PCa) after hormonal therapy...
  45. ncbi request reprint Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer
    Yuichi Tsujimoto
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 10:3007-12. 2004
    ..In the present study, the correlation of VCP with recurrence and prognosis in patients with prostate cancer (PCA) receiving conservative therapy was examined...
  46. ncbi request reprint Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Cancer Res 10:2846-50. 2004
    ..In addition, activated extracellular signal-regulated kinase 1 and 2 (ERK1/2) and the proliferation activity of tumor cells detected by Ki-67 immunohistochemistry were examined...
  47. ncbi request reprint Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 10:5558-65. 2004
    ..In the present study, we examined the association of VCP with the recurrence and prognosis of ESCC...
  48. ncbi request reprint Distinct pattern of gene expression in pyothorax-associated lymphoma (PAL), a lymphoma developing in long-standing inflammation
    Mieko Nishiu
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Cancer Sci 95:828-34. 2004
    ..This study shows that PAL is a distinctive subtype of DLBCL not only in its clinical presentation, but also in its molecular profile...
  49. doi request reprint Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis: a study of the Osaka Lymphoma Study Group
    Naoki Wada
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Histopathology 60:924-32. 2012
    ..Diffuse large B cell lymphoma (DLBCL) occasionally shows an interfollicular pattern of proliferation (DLBCL-IF) preserving lymphoid follicles. In this study, clinicopathological findings in 31 cases of DLBCL-IF were analysed...
  50. ncbi request reprint Overexpression of the Wilms' tumor gene W T1 in primary astrocytic tumors
    Yusuke Oji
    Department of Bioinformatics, Osaka University Graduate School of Medicine, 1 7 Yamada oka, Suita, Osaka 565 0871, Japan
    Cancer Sci 95:822-7. 2004
    ..These results may indicate that the W T1 gene plays an important role in tumorigenesis of primary astrocytic tumors...
  51. ncbi request reprint ATR alterations in Hodgkin's lymphoma
    Angen Liu
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Oncol Rep 19:999-1005. 2008
    ..These findings suggested the role of ATR gene alterations in HL lymphomagenesis...
  52. ncbi request reprint In situ shortening of CAG repeat length within the androgen receptor gene in prostatic cancer and its possible precursors
    Yuichi Tsujimoto
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    Prostate 58:283-90. 2004
    ..Shorter CAG repeat lengths are associated with higher transcriptional activity. The previous studies using peripheral blood leukocytes showed the relationship between shorter CAG repeat length and risk for prostate cancer (PCA)...
  53. doi request reprint Synergistic effect of interleukin-6 and endoplasmic reticulum stress inducers on the high level of ABCG2 expression in plasma cells
    Naoto Nakamichi
    Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Lab Invest 89:327-36. 2009
    ..These suggest that ABCG2 is a surviving factor for plasma cells. To our knowledge, this is the first study reporting the effect of ER stress on ABCG2 expression...
  54. doi request reprint (18)F-FDG PET for the evaluation of thymic epithelial tumors: Correlation with the World Health Organization classification in addition to dual-time-point imaging
    Atsuo Inoue
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Eur J Nucl Med Mol Imaging 36:1219-25. 2009
    ..Our aim was to determine dual-phase (18)F-FDG PET imaging features for various subtypes of thymic epithelial tumors based on the World Health Organization classification...
  55. ncbi request reprint High tolerance to apoptotic stimuli induced by serum depletion and ceramide in side-population cells: high expression of CD55 as a novel character for side-population
    Jing Xian Xu
    Department of Pathology, Graduate School of Medicine, Osaka University, Yamada oka 2 2, Suita 565 0871, Japan
    Exp Cell Res 313:1877-85. 2007
    ..These findings indicated that SP cells as revealed to be CD55(hi) cells were tolerant to apoptosis. The high expression of CD55 may be a useful character for SP cells in evaluating their functions...
  56. doi request reprint Presence of B-cell clones in T-cell lymphoma
    Mona A A Zaki
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Eur J Haematol 86:412-9. 2011
    ..Conclusions:  These findings suggest a role for EBV in the evolution of B-cell clones in T-cell lymphomas...
  57. ncbi request reprint Mutations of p53, c-kit, K-ras, and beta-catenin gene in non-Hodgkin's lymphoma of adrenal gland
    Shin ichi Nakatsuka
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Jpn J Cancer Res 93:267-74. 2002
    ..All but one mutation were transition mutations, indicating that some endogenous mutagens act in lymphomagenesis in the adrenal gland. Our results suggest that p53 and c-kit gene mutations might play a role in adrenal lymphomagenesis...
  58. ncbi request reprint Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma
    Angen Liu
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    Lab Invest 85:436-46. 2005
    ..These findings showed that mutations of ATR gene result in failure for DNA DSB and SSB repair, suggesting the role of ATM and ATR gene mutations in PAL lymphomagenesis...
  59. ncbi request reprint E74-like factor 2 regulates valosin-containing protein expression
    Binglin Zhang
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 356:536-41. 2007
    ..These findings indicate that ELF2/NERF promotes VCP transcription and that ELF2/NERF-VCP pathway might be important for cell survival and proliferation under cytokine stress...
  60. ncbi request reprint DNA sequences of the immunoglobulin heavy chain variable region gene in pyothorax-associated lymphoma
    Hideaki Miwa
    Department of Pathology, Osaka University Graduate School of Medicine, Japan
    Oncology 62:241-50. 2002
    ..Antigen-selected maturation might not take place in PAL, which is distinct from the majority of B cell lymphomas...
  61. doi request reprint Prognostic significance of CD55 expression in breast cancer
    Jun Ichiro Ikeda
    Department of Pathology, Graduate School of Medicine, Osaka University, Yamada oka 2 2, Suita 565 0871, Japan
    Clin Cancer Res 14:4780-6. 2008
    ....
  62. ncbi request reprint Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma
    Maria Francisca Ham
    Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 98:1041-7. 2007
    ..These findings indicated that condensin gene alteration might play a role in genome instability, which accelerates the accumulation of other gene alterations in PAL...
  63. doi request reprint Prognostic significance of phosphorylated FOXO1 expression in soft tissue sarcoma
    Binglin Zhang
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Ann Surg Oncol 16:1925-37. 2009
    ..Expression of FOXO1 in soft tissue sarcoma (STS) and its correlation with clinicopathological factors and prognostic significance were evaluated...
  64. doi request reprint E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth
    Ying Qiu
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Exp Mol Pathol 84:226-9. 2008
    ..These findings indicate that ELF2 transactivates VCP promoter through binding to two motifs, with a predominant contribution of the upstream one...
  65. ncbi request reprint TP53 gene mutation, an unfavorable prognostic factor for malignant lymphomas in autoimmune diseases
    Yoshihiko Hoshida
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Oncology 69:175-83. 2005
    ..To investigate whether mutations of the TP53 tumor suppressor gene are associated with a poor prognosis in lymphoproliferative disorders (LPD) developing in patients with a history of autoimmune disease (AID)...
  66. ncbi request reprint WT1 peptide vaccination combined with BCG-CWS is more efficient for tumor eradication than WT1 peptide vaccination alone
    Hiroko Nakajima
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, 1 7 Yamada oka, Suita City, 565 0871 Osaka, Japan
    Cancer Immunol Immunother 53:617-24. 2004
    ..Therefore, WT1 peptide vaccination combined with BCG-CWS may be applied to cancer immunotherapy in clinical settings...
  67. ncbi request reprint Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients
    Yoshihiko Hoshida
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Lab Invest 82:257-64. 2002
    ..These findings suggested that p53 gene mutations might play a central role in development of peripheral T-cell lymphoma including adult T-cell leukemia/lymphoma in renal transplant patients...
  68. ncbi request reprint Postatrophic hyperplasia of the prostate in Japan: histologic and immunohistochemical features and p53 gene mutation analysis
    Yuichi Tsujimoto
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Prostate 52:279-87. 2002
    ....
  69. ncbi request reprint Lymphoproliferative disorders in autoimmune diseases in Japan: analysis of clinicopathological features and Epstein-Barr virus infection
    Yoshihiko Hoshida
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Int J Cancer 108:443-9. 2004
    ..e., LPD in RA showed the most favorable prognosis. In conclusion, LPD in AID generally shared common features with sporadic LPD except for a much higher EBV-positive rate in T cell LPD...
  70. ncbi request reprint Pyothorax-associated lymphoma
    Katsuyuki Aozasa
    Department of Pathology C3, Osaka University Graduate School of Medicine, Osaka, Japan
    J Clin Exp Hematop 46:5-10. 2006
    ..Aozasa as a distinctive clinicopathologic entity in 1987, and now listed as the disease entity in the WHO classification of Tumours, Pathology & Genetics, Tumours of the Lung, Pleura, Thymus and Heart (2004)...
  71. ncbi request reprint MR imaging of thymic epithelial tumors: correlation with World Health Organization classification
    Atsuo Inoue
    Department of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiat Med 24:171-81. 2006
    ..The aim of this study was to determine magnetic resonance imaging (MRI) features of various subtypes of thymic epithelial tumors based on the World Health Organization classification...
  72. doi request reprint WT1 (Wilms tumor 1) peptide immunotherapy for childhood rhabdomyosarcoma: a case report
    Hideaki Ohta
    Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Pediatr Hematol Oncol 26:74-83. 2009
    ..She is currently still on continued WT1 peptide immunotherapy in a disease-free condition for 22 months. WT1 peptide-based immunotherapy should be a promising option for high-risk rhabdomyosarcoma in childhood...
  73. pmc Tumorigenic potential of mononucleated small cells of Hodgkin lymphoma cell lines
    Jun Ichiro Ikeda
    Department of Pathology, Graduate School of Medicine, Osaka University, Yamada oka 2 2, Suita 565 0871, Japan
    Am J Pathol 177:3081-8. 2010
    ..These findings suggest that smaller cells or Hodgkin cells that show low-ROS concentrations and high FoxO3a expression levels might be candidates for HL CSCs...
  74. ncbi request reprint Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma
    Yusuke Oji
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Cancer Sci 94:712-7. 2003
    ..These results may indicate an important role of the wild-type WT1 gene in tumorigenesis of colorectal adenocarcinoma...
  75. ncbi request reprint Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging
    Kenichiro Hamada
    Department of Nuclear Medicine and Tracer Kintetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Skeletal Radiol 34:52-7. 2005
    ..Although the mechanism responsible for the increased FDG uptake in benign schwannomas remains unknown, we discuss our findings in the context of tumor cellularity and briefly review other studies on the subject...
  76. ncbi request reprint Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS)
    Yukiyoshi Okauchi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita
    Intern Med 48:1025-30. 2009
    ..MEN1 gene analysis verified the presence of a mutation and the glucagonoma was confirmed after operation. In conclusion, ASVS could be useful for the diagnosis of glucagonoma...
  77. ncbi request reprint Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence
    Shinji Yamamoto
    Departments of Surgery and Clinical Oncology, and Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Clin Oncol 21:447-52. 2003
    ..In this study, association of VCP expression with recurrence of hepatocellular carcinoma (HCC) and patient survival was examined...
  78. ncbi request reprint Identification of Epstein-Barr virus integrated sites in lymphoblastoid cell line (IB4)
    Tetsuya Takakuwa
    Department of Pathology C3, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Virus Res 108:133-8. 2005
    ..5 kbp from each other. The integration sites identified were apart from the genes of the host genome, indicating that both host gene and EBV latent genes are not altered by the integration event...
  79. doi request reprint Kaposiform hemangioendothelioma arising in the deltoid muscle without the Kasabach-Merritt phenomenon
    Noriyuki Tamai
    Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Skeletal Radiol 39:1043-6. 2010
    ..Knowledge of the radiological findings of this uncommon tumor might be helpful for diagnosis. We present the MRI features of a case of KHE with neither typical skin lesions nor the Kasabach-Merritt phenomenon...
  80. doi request reprint Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate
    Norio Nonomura
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:1570-3. 2010
    ..Decreased infiltration of MSR-positive cells in negative first biopsy specimens was correlated with positive findings in the repeat biopsy. The MSR count might be a good indicator for avoiding unnecessary repeat biopsies...
  81. ncbi request reprint Simian virus 40 sequences in malignant lymphomas in Japan
    Shin ichi Nakatsuka
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Res 63:7606-8. 2003
    ..SV40 is a new candidate etiologic factor for malignant lymphoma not only in the United States but also in Japan...
  82. doi request reprint Clinicopathologic factors influencing postoperative prognosis in patients with small-sized adenocarcinoma of the lung
    Masayoshi Inoue
    Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    J Thorac Cardiovasc Surg 135:830-6. 2008
    ..The present study aimed to clarify the histopathologic factors influencing nodal involvement and prognosis of such patients...
  83. doi request reprint Pretreatment leukocytosis is an indicator of poor prognosis in patients with cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Gynecol Oncol 122:25-32. 2011
    ..The aim of this study was to investigate the prognostic value of pretreatment leukocytosis in patients with cervical cancer in relation to well-established conventional risk factors...
  84. ncbi request reprint WT1 peptide-based immunotherapy for patients with lung cancer: report of two cases
    Akihiro Tsuboi
    Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Japan
    Microbiol Immunol 48:175-84. 2004
    ..These results provided us with the first clinical evidence demonstrating that WT1 peptide-based immunotherapy should be a promising treatment for patients with lung cancer...
  85. ncbi request reprint Abdominal Tuberculosis: peritoneal involvement shown by F-18 FDG PET
    Hiroaki Shimamoto
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Nucl Med 32:716-8. 2007
    ..Tuberculous peritonitis should be considered as a potential interpretive pitfall in mimicking peritoneal carcinomatosis...
  86. ncbi request reprint Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia
    Satoru Toyosawa
    Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Mod Pathol 17:573-8. 2004
    ..Paranuclear DMP1 staining in the tumor cells was also observed. These findings indicate that DMP1 immunohistochemistry is a useful tool for identifying PMTs...
  87. ncbi request reprint Malignancies in organ transplant recipients
    Yoshihiko Hoshida
    Department of Pathology, Osaka University Medical School, Osaka, Japan
    Pathol Int 54:649-58. 2004
    ..The epidemiology and characteristics of representative malignancies in transplant recipients are described, with a review of pertinent literature...
  88. ncbi request reprint Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
    Norihiro Nishimoto
    Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Blood 106:2627-32. 2005
    ..Most adverse events were mild to moderate in severity. MRA was tolerated well and significantly alleviated chronic inflammatory symptoms and wasting in patients with MCD...
  89. doi request reprint Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme
    Shuichi Izumoto
    Department of Neurosurgery, Nagoya University, Nagoya, Japan
    J Neurosurg 108:963-71. 2008
    ..The object of this study was to investigate the safety and clinical responses of immunotherapy targeting the WT1 (Wilms tumor 1) gene product in patients with recurrent glioblastoma multiforme (GBM)...
  90. doi request reprint The role of fine-needle aspiration cytology and magnetic resonance imaging in the management of parotid mass lesions
    Hidenori Inohara
    Department of Otolaryngology, Osaka University School of Medicine, Suita, Japan
    Acta Otolaryngol 128:1152-8. 2008
    ..MRI can be reserved until FNAC shows the indication for surgical intervention...
  91. ncbi request reprint VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line
    Tatsuya Asai
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Jpn J Cancer Res 93:296-304. 2002
    ..Anti-apoptotic potential in these cells owing to constant NFkappaB activation via efficient cytoplasmic p-IkappaBalpha degrading activity may explain the increased metastatic potential of these cells...
  92. ncbi request reprint Significance of electrostimulation in detecting neurovascular bundle during radical prostatectomy
    Akira Tsujimura
    Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Urol 13:926-31. 2006
    ....
  93. ncbi request reprint Enhanced expression of neuron-specific enolase (NSE) in pyothorax-associated lymphoma (PAL)
    Shin ichi Nakatsuka
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Jpn J Cancer Res 93:411-6. 2002
    ..These findings suggest the posttranscriptional regulation of NSE in PAL. Thus, an elevation of serum NSE level in patients with chronic pyothorax may be an indicator of PAL development...
  94. ncbi request reprint Pyothorax-associated lymphoma: a review of 106 cases
    Shin ichi Nakatsuka
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan
    J Clin Oncol 20:4255-60. 2002
    ..Pyothorax-associated lymphoma (PAL) is a non-Hodgkin's lymphoma developing in the pleural cavity after a long-standing history of pyothorax. Full details of PAL are provided here...
  95. ncbi request reprint Pyothorax-associated lymphoma: an unusual case with both T- and B-cell genotypes
    Itsuko Nakamichi
    Department of Pathology C3, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Virchows Arch 447:888-91. 2005
    ..The patients died of tumors 14 months after admission. Aberrant genotype and immunophenotype of PAL cells is discussed in reviewing the pertinent literature...
  96. ncbi request reprint A phase I/II trial of a WT1 (Wilms' tumor gene) peptide vaccine in patients with solid malignancy: safety assessment based on the phase I data
    Satoshi Morita
    Department of Epidemiology and Health Care Research, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Jpn J Clin Oncol 36:231-6. 2006
    ..We conducted a phase I study to investigate the safety of a weekly WT1 tumor vaccine therapy in patients with solid tumors that had been refractory to all other anti-cancer therapies...
  97. ncbi request reprint Gene mutation analysis of sinonasal lymphomas in Indonesia
    Antonius Nikolas Kurniawan
    Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia Dr Cipto Mangunkusumo Hospital, Jalan Salemba Raya, Jakarta 10430, Indonesia
    Oncol Rep 15:1257-63. 2006
    ..These findings suggest that gene mutations might be the driving-force for B-cell lymphoma, whereas combined EBV infection and gene mutations contribute to NKTCL development in Indonesia...
  98. pmc Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression
    Tetsuya Takakuwa
    Department of Pathology, Osaka University Graduate School of Medicine, Yamada oka, Suita, Osaka, Japan
    Am J Pathol 164:967-74. 2004
    ..BACH2 was not expressed in the Raji cell line. Because BACH2 is a putative tumor suppressor gene, loss of its expression through EBV integration might contribute to lymphomagenesis...
  99. ncbi request reprint Analysis of p53 and Bak gene mutations in lymphoproliferative disorders developing in rheumatoid arthritis
    Jing Xian Xu
    Department of Pathology C3, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Cancer Res Clin Oncol 133:125-33. 2007
    ..To study the molecular changes underscoring the RA-LPD, mutations of p53 and Bak gene were analyzed in RA-LPD with (MTX-LPD) or without methotrexate treatment for RA (non-MTX-LPD)...
  100. ncbi request reprint Epstein-Barr virus (EBV)-encoded RNA promotes growth of EBV-infected T cells through interleukin-9 induction
    Lixin Yang
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita ku, Sapporo 060 0815, Japan
    Cancer Res 64:5332-7. 2004
    ..Analysis of nasal lymphoma biopsies indicated that three of four specimens expressed IL-9. The present findings suggest that EBV directly affects the pathogenesis of EBV-associated T-cell diseases...
  101. pmc Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth
    Ying Qiu
    Department of Pathology, Medical School of Tongji University, Shanghai, China
    Am J Pathol 170:152-9. 2007
    ..These findings indicate that PBX1 plays a crucial role in VCP expression and function and that the PBX-VCP pathway might be important for cell survival under cytokine stress...