Kentaro Akiyama

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint An analysis of the persistent presence of opportunistic pathogens on patient-derived dental impressions and gypsum casts
    Hiroshi Egusa
    Department of Fixed Frost hodontics, Osaka University Graduate School of Dentistry, Osaka, Japan
    Int J Prosthodont 21:62-8. 2008
  2. doi request reprint Application of cyclic strain for accelerated skeletal myogenic differentiation of mouse bone marrow-derived mesenchymal stromal cells with cell alignment
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Suita City, Japan
    Tissue Eng Part A 19:770-82. 2013
  3. doi request reprint Stem cells in dentistry--Part II: Clinical applications
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Prosthodont Res 56:229-48. 2012
  4. doi request reprint Stem cells in dentistry--part I: stem cell sources
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Prosthodont Res 56:151-65. 2012
  5. pmc Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Infect Immun 73:622-6. 2005
  6. doi request reprint The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Bone 49:264-74. 2011
  7. pmc Gingival fibroblasts as a promising source of induced pluripotent stem cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    PLoS ONE 5:e12743. 2010
  8. doi request reprint Enhanced bone regeneration via multimodal actions of synthetic peptide SVVYGLR on osteoprogenitors and osteoclasts
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Division of Oromaxillofacial Regeneration, Osaka University Graduate School of Dentistry, Suita City, Osaka 565 0871, Japan
    Biomaterials 30:4676-86. 2009
  9. ncbi request reprint Clinical evaluation of the efficacy of removing microorganisms to disinfect patient-derived dental impressions
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Osaka, Japan
    Int J Prosthodont 21:531-8. 2008
  10. ncbi request reprint In vitro mechanisms of interleukin-8-mediated responses of human gingival epithelial cells to Candida albicans infection
    Hiroshi Egusa
    Department of Prosthetic Dentistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Med Microbiol 296:301-11. 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint An analysis of the persistent presence of opportunistic pathogens on patient-derived dental impressions and gypsum casts
    Hiroshi Egusa
    Department of Fixed Frost hodontics, Osaka University Graduate School of Dentistry, Osaka, Japan
    Int J Prosthodont 21:62-8. 2008
    ....
  2. doi request reprint Application of cyclic strain for accelerated skeletal myogenic differentiation of mouse bone marrow-derived mesenchymal stromal cells with cell alignment
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Suita City, Japan
    Tissue Eng Part A 19:770-82. 2013
    ....
  3. doi request reprint Stem cells in dentistry--Part II: Clinical applications
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Prosthodont Res 56:229-48. 2012
    ..Finally, the marketing of stem cell technology in dental stem cell banks with a view toward future regenerative therapies is introduced...
  4. doi request reprint Stem cells in dentistry--part I: stem cell sources
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Prosthodont Res 56:151-65. 2012
    ..Additionally, appropriate sources of stem cells for regenerative dentistry are discussed with regard to differentiation capacity, accessibility and possible immunomodulatory properties...
  5. pmc Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Infect Immun 73:622-6. 2005
    ..albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans...
  6. doi request reprint The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Bone 49:264-74. 2011
    ..The small molecule harmine is therefore expected to provide an experimental tool for investigating signaling cascades in osteoclastogenesis, especially those centered on DYRK1A-mediated NFATc1 and Id2 regulation...
  7. pmc Gingival fibroblasts as a promising source of induced pluripotent stem cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    PLoS ONE 5:e12743. 2010
    ..Oral gingiva, which is often resected during general dental treatments and treated as biomedical waste, is an easily obtainable tissue, and cells can be isolated from patients with minimal discomfort...
  8. doi request reprint Enhanced bone regeneration via multimodal actions of synthetic peptide SVVYGLR on osteoprogenitors and osteoclasts
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Division of Oromaxillofacial Regeneration, Osaka University Graduate School of Dentistry, Suita City, Osaka 565 0871, Japan
    Biomaterials 30:4676-86. 2009
    ..These data suggest that SVVYGLR is an effective bioactive peptide for bone tissue regeneration that promotes attachment and proliferation of osteogenic cells while also suppressing osteoclastogenesis...
  9. ncbi request reprint Clinical evaluation of the efficacy of removing microorganisms to disinfect patient-derived dental impressions
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Osaka, Japan
    Int J Prosthodont 21:531-8. 2008
    ..The objective of this study was to clinically evaluate the disinfection efficacy of commercially available agents in removing oral pathogens from patient-derived impressions...
  10. ncbi request reprint In vitro mechanisms of interleukin-8-mediated responses of human gingival epithelial cells to Candida albicans infection
    Hiroshi Egusa
    Department of Prosthetic Dentistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Int J Med Microbiol 296:301-11. 2006
    ..The molecular mechanisms governing the IL-8 response of HGECs to C. albicans infection likely involve multiple converging signal transduction pathways, including those mediated by IL-1alpha and ICAM-1 activation...
  11. ncbi request reprint Downregulation of extracellular matrix-related gene clusters during osteogenic differentiation of human bone marrow- and adipose tissue-derived stromal cells
    Hiroshi Egusa
    Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA
    Tissue Eng 13:2589-600. 2007
    ..This change may serve to normalize gene expression in mixed populations of stem cells derived from different tissues...
  12. ncbi request reprint Oral candidosis in HIV-infected patients
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Suita City, Osaka 565 0871, Japan
    Curr HIV Res 6:485-99. 2008
    ....
  13. doi request reprint Alginate hydrogel as a promising scaffold for dental-derived stem cells: an in vitro study
    Alireza Moshaverinia
    Center for Craniofacial and Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, 90089, USA
    J Mater Sci Mater Med 23:3041-51. 2012
    ..These findings demonstrate for the first time that immobilization of PDLSCs and GMSCs in the alginate microspheres provides a promising strategy for bone tissue engineering...
  14. pmc Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis
    Kentaro Akiyama
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Cell Stem Cell 10:544-55. 2012
    ..These data therefore demonstrate a previously unrecognized mechanism underlying BMMSC-based immunotherapy involving coupling via FAS/FASL to induce T cell apoptosis...
  15. pmc Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α
    Yi Liu
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, California, USA
    Nat Med 17:1594-601. 2011
    ..These data collectively show a previously unrecognized role of recipient T cells in BMMSC-based tissue engineering...
  16. pmc IFN-γ and TNF-α synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFκB signaling
    Lei Wang
    University of Southern California, Los Angeles, CA, USA
    Stem Cells 31:1383-95. 2013
    ..In summary, this study reveals that inflammation factors, such as IFN-γ and TNF-α, synergistically induce MSC deficiency via NFκB/SMAD7 signaling and tumorigenesis via NFκB-mediated oncogene activation...
  17. pmc A subset of IL-17(+) mesenchymal stem cells possesses anti-Candida albicans effect
    RuiLi Yang
    Department of Orthodontics, Peking University, School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Beijing 100081, China
    Cell Res 23:107-21. 2013
    ..albicans-infected mice. In summary, this study shows that MSCs contain an IL-17(+) subset capable of inhibiting C. albicans growth, but attenuating MSC-based immunosuppression via NFκB-mediated downregulation of TGF-β...
  18. pmc Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw
    Yinghua Zhao
    Center for Craniofacial Molecular Biology, Herman School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Calcif Tissue Int 91:400-8. 2012
    ..Taken together, our findings demonstrate that (99)Tc-MDP therapy may be a promising approach in the treatment of osteoporosis with less risk of causing BRONJ...
  19. doi request reprint Lineage differentiation of mesenchymal stem cells from dental pulp, apical papilla, and periodontal ligament
    Kentaro Akiyama
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 887:111-21. 2012
    ..In order to encourage orofacial MSC investigation, we provide detailed protocols for assessing lineage -differentiation of orofacial MSCs...
  20. pmc Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering
    Alireza Moshaverinia
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, USA
    Biomaterials 34:6572-9. 2013
    ..This strategy of engineering the microenvironment with captured BMP signals is a promising modality for repair and regeneration of craniofacial, axial and appendicular bone defects. ..
  21. pmc Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice
    Takashi Kikuiri
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA
    J Bone Miner Res 25:1668-79. 2010
    ..These findings provide evidence of an immunity-based mechanism of BRONJ-like disease and support the rationale for in vivo immunomodulatory therapy using Tregs or MSCs to treat BRONJ...
  22. pmc Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice
    Takayoshi Yamaza
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Blood 113:2595-604. 2009
    ....
  23. pmc Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors
    Sara Parsa
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Development 137:3743-52. 2010
    ..Taken together, our results demonstrate that FGFR2b signaling regulates both the establishment of the incisor stem cell niches in the embryo and the regenerative capacity of incisors in the adult...