S Akira


Affiliation: Osaka University
Country: Japan


  1. Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, et al. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc Natl Acad Sci U S A. 2017;114:2681-2686 pubmed publisher
    ..Thus, TIPARP is a viral RNA-sensing PRR that mediates antiviral responses triggered by BAX- and BAK1-dependent mitochondrial damage. ..
  2. Nagahama Y, Shimoda M, Mao G, Singh S, Kozakai Y, Sun X, et al. Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism. Proc Natl Acad Sci U S A. 2018;115:11036-11041 pubmed publisher
    ..These findings provide evidence that Regnase-1 deficiency has beneficial effects on the prevention and/or blocking of intestinal inflammatory disorders. ..
  3. Akira S. Innate immunity and adjuvants. Philos Trans R Soc Lond B Biol Sci. 2011;366:2748-55 pubmed publisher
    ..I will review the mechanisms of pathogen recognition by TLRs and cytoplasmic receptors, and then discuss the roles of these receptors in the development of adaptive immunity in response to viral infection. ..
  4. Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, et al. 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. J Biol Chem. 2015;290:9377-86 pubmed publisher
    ..Strikingly, administration of a c-Src inhibitor markedly prevented bone loss in AZI2 knock-out mice. Together, these findings indicate that AZI2 regulates bone mass by fine-tuning osteoclast survival. ..
  5. Maruyama K, Akira S. Emerging molecules in the interface between skeletal system and innate immunity. Pharmacol Res. 2015;99:223-8 pubmed publisher
    ..These findings may offer an invaluable opportunity to regulate bone-destructive diseases, such as osteoporosis and rheumatoid arthritis. ..
  6. Ishii K, Akira S. Potential link between the immune system and metabolism of nucleic acids. Curr Opin Immunol. 2008;20:524-9 pubmed publisher
  7. Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, et al. Bone-protective Functions of Netrin 1 Protein. J Biol Chem. 2016;291:23854-23868 pubmed
    ..Strikingly, netrin 1 treatment prevented bone erosion in an autoimmune arthritis model and age-related bone destruction. Therefore, the netrin 1-UNC5b axis is a novel therapeutic target for bone-destructive diseases. ..
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    Akira S. The role of IL-18 in innate immunity. Curr Opin Immunol. 2000;12:59-63 pubmed
    ..The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response. ..
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    Akira S, Hoshino K, Kaisho T. The role of Toll-like receptors and MyD88 in innate immune responses. J Endotoxin Res. 2000;6:383-7 pubmed
    ..We have recently found that the MyD88-independent pathway is involved in LPS-induced maturation of dendritic cells (DCs). ..

More Information


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    Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783-801 pubmed
    ..New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity. ..
  2. Akira S. Regnase-1, a ribonuclease involved in the regulation of immune responses. Cold Spring Harb Symp Quant Biol. 2013;78:51-60 pubmed publisher
    ..Regnase-1 protein is cleaved by Malt1 and inactivated in response to T-cell receptor stimulation. Thus, Regnase-1 is a key molecule in the regulation of immune responses. ..
  3. Maeda K, Akira S. TLR7 Structure: Cut in Z-Loop. Immunity. 2016;45:705-707 pubmed publisher
    ..2016) generate structures of TLR7 bound to multiple ligands and provide insight into the mechanism of TLR7 ligand recognition that highlights the differences in the features of the TLR subfamily. ..
  4. Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, et al. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Proc Natl Acad Sci U S A. 2017;114:E7331-E7340 pubmed publisher
    ..In conclusion, Batf2 has an antitumor effect through the up-regulation of IL-12 p40 in tumor-associated macrophages, which eventually induces CD8+ T-cell activation and accumulation within the tumor. ..