Akira Ooki

Summary

Country: Japan

Publications

  1. doi request reprint DNA damage-inducible gene, reprimo functions as a tumor suppressor and is suppressed by promoter methylation in gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University School of Medicine, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Mol Cancer Res 11:1362-74. 2013
  2. doi request reprint Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer
    A Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Oncogene 29:3263-75. 2010
  3. pmc Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    BMC Cancer 11:122. 2011
  4. ncbi request reprint Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case
    Takatoshi Nakamura
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara Kanagawa, 252 0374, Japan
    Surg Today 42:1096-9. 2012
  5. doi request reprint Short- and long-term outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Hepatogastroenterology 58:1947-50. 2011
  6. pmc Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis
    Mina Waraya
    Department of Surgery, Kitasato University Hospital, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0375, Japan
    BMC Cancer 12:397. 2012
  7. doi request reprint Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Int J Cancer 127:543-54. 2010
  8. pmc Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan
    Neoplasia 14:559-71. 2012
  9. ncbi request reprint Clinical significance of total gastrectomy for proximal gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:2875-83. 2008
  10. ncbi request reprint Lymph node metastasis density (ND)-factor association with malignant degree and ND40 as "non-curative factor" in gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:435-41. 2008

Collaborators

Detail Information

Publications14

  1. doi request reprint DNA damage-inducible gene, reprimo functions as a tumor suppressor and is suppressed by promoter methylation in gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University School of Medicine, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Mol Cancer Res 11:1362-74. 2013
    ..However, Reprimo methylation abrogates its expression and effects. The clinical assessment of Reprimo promoter methylation may serve not only as a predictive marker for chemotherapy, but also as a marker for tumor aggressiveness...
  2. doi request reprint Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer
    A Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Oncogene 29:3263-75. 2010
    ..Taken together, HOPX-beta promoter methylation is a frequent and cancer-specific event in gastric cancer. Quantitative assessment of HOPX-beta methylation has great clinical potential as a marker of tumor aggressiveness...
  3. pmc Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    BMC Cancer 11:122. 2011
    ..In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer...
  4. ncbi request reprint Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case
    Takatoshi Nakamura
    Department of Surgery, School of Medicine, Kitasato University, 1 15 1 Kitasato, Minami Ku, Sagamihara Kanagawa, 252 0374, Japan
    Surg Today 42:1096-9. 2012
    ..There was no evidence of recurrence 2 years 6 months after surgery. Preoperative adjuvant chemotherapy with imatinib mesylate may permit the use of less invasive treatment procedures, allowing anal preservation...
  5. doi request reprint Short- and long-term outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer
    Takatoshi Nakamura
    Department of Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Hepatogastroenterology 58:1947-50. 2011
    ..We studied the safety and outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer...
  6. pmc Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis
    Mina Waraya
    Department of Surgery, Kitasato University Hospital, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0375, Japan
    BMC Cancer 12:397. 2012
    ..In this current study, we for the first time examined methylation level of HOPX and tested the functional relevance in pancreatic cancer (PC)...
  7. doi request reprint Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara, Kanagawa, Japan
    Int J Cancer 127:543-54. 2010
    ..Moreover, the expression status may be a landmark to select patients with benefit from PRL-3-targeted therapy. Thus, PRL-3 could be a convergent therapeutic target against ESCC with LNM...
  8. pmc Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer
    Hiroshi Katoh
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan
    Neoplasia 14:559-71. 2012
    ..014). In conclusion, HOPX-β promoter methylation is a frequent and cancer-specific event in CRC progression. This epigenetic alteration may have clinical ramifications in the diagnosis and treatment of CRC patients...
  9. ncbi request reprint Clinical significance of total gastrectomy for proximal gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:2875-83. 2008
    ..The principal difference between total gastrectomy (TG) and proximal gastrectomy (PG) is whether lymph node (LN) 4d is dissected by radical lymphadenectomy...
  10. ncbi request reprint Lymph node metastasis density (ND)-factor association with malignant degree and ND40 as "non-curative factor" in gastric cancer
    Keishi Yamashita
    Department of Surgery, Kitasato University Hospital, Kitasato 1 15 1, Sagamihara 228 8555, Kanagawa, Japan
    Anticancer Res 28:435-41. 2008
    ..Interestingly, ND40 relevance was validated in the prospective and independent set of gastric cancer patients (p = 0.002)...
  11. ncbi request reprint Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer
    Akira Ooki
    Department of Surgery, Kitasato University Hospital, Sagamihara 228 8555, Kanagawa, Japan
    Oncol Rep 21:1467-75. 2009
    ..We propose that PRL-3 expression can have a clinical potential as a prognostic biomarker that may facilitate the development of adjuvant chemotherapy for advanced gastric cancer with stage I disease...
  12. doi request reprint Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13
    Hiroshi Kawamata
    Department of Surgery, Kitasato University School of Medicine, Japan
    Genomics 106:71-5. 2015
    ..In conclusion, the current data may lead to the development of personalized medicine for recurrent CRC, although further validation study is still required. ..
  13. ncbi request reprint Lymph node metastasis density and growth pattern as independent prognostic factors in advanced esophageal squamous cell carcinoma
    Akira Ooki
    Department of Surgery, Kitasato University Higashi Hospital, Asamizodai 2 1 1, Sagamihara 228 8520 Kanagawa, Japan
    World J Surg 31:2184-91. 2007
    ..Thus staging could be expanded to make the prognosis a valuable clinical tool, and to improve knowledge of the biological traits of advanced ESCC...
  14. doi request reprint Oncological outcomes of laparoscopic surgery in elderly patients with colon cancer: a comparison of patients 64 years or younger with those 75 years or older
    Takatoshi Nakamura
    Department of Surgery, Kitasato University, Kanagawa, Japan
    Hepatogastroenterology 58:1200-4. 2011
    ..We compared the results of laparoscopic resection of colon cancer between patients 75 years or older and those 64 years or younger, to confirm whether this procedure is warranted in elderly patients...