Research Topics
| Hiroyuki OkuraSummaryCountry: Japan Publications
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Detail Information
Publications
Impact of deep vessel wall injury and vessel stretching on subsequent arterial remodeling after balloon angioplasty: a serial intravascular ultrasound studyHiroyuki Okura
Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, Calif 94305-5637, USA
Am Heart J 144:323-8. 2002..The differences in the remodeling process may have implications regarding adjunctive therapies to prevent restenosis after balloon angioplasty...- Noninvasive diagnosis of ischemic and nonischemic cardiomyopathy using coronary flow velocity measurements of the left anterior descending coronary artery by transthoracic Doppler echocardiographyHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
J Am Soc Echocardiogr 19:552-8. 2006.... - Characterization of late incomplete stent apposition: a comparison among bare-metal stents, intracoronary radiation and sirolimus-eluting stentsAkiyoshi Miyazawa
Center for Cardiovascular Technology, Stanford University Medical Center, 300 Pasteur Drive, Room H3554, Stanford, CA, 94305, USA
J Invasive Cardiol 19:515-8. 2007..However, no study has systematically compared the morphology of LISA seen with various treatment modalities... - Aortic atherosclerotic plaque and long-term prognosis in patients with atrial fibrillation-a transesophageal echocardiography studyHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Circ J 77:68-72. 2012..0 mm in thickness are predictors of cardiovascular events after stroke. The aim of this study was to investigate impact of AoP ≥ 4.0 mm or LASEC on cardiovascular events in patients with atrial fibrillation (AF)... 
Age- and gender-specific changes in the left ventricular relaxation: a Doppler echocardiographic study in healthy individualsHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Circ Cardiovasc Imaging 2:41-6. 2009..The aim of this study was to investigate age- and gender-specific changes in tissue Doppler-derived left ventricular diastolic index, E'...- Impact of statin therapy on systemic inflammation, left ventricular systolic and diastolic function and prognosis in low risk ischemic heart disease patients without history of congestive heart failureHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai
Intern Med 46:1337-43. 2007..The aim of this study was to investigate the impact of statin on systemic inflammation, left ventricular systolic and diastolic function and prognosis in low risk ischemic heart disease (IHD) patients... - The relationship between coronary plaque characteristics and small embolic particles during coronary stent implantationTakahiro Kawamoto
Division of Cardiology, Kawasaki Medical School Hospital, Matsushima, Kurashiki, Japan
J Am Coll Cardiol 50:1635-40. 2007..We investigated the relationship between coronary plaque components and small embolic particles during stenting and examined the influence on the coronary microcirculation... - Atherosclerotic plaque with ultrasonic attenuation affects coronary reflow and infarct size in patients with acute coronary syndrome: an intravascular ultrasound studyHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Circ J 71:648-53. 2007..No reflow following percutaneous coronary intervention (PCI) is a major concern in patients with acute coronary syndrome (ACS) and it may be influenced by the preexisting plaque type... 
Impact of arterial remodelling and plaque rupture on target and non-target lesion revascularisation after stent implantation in patients with acute coronary syndrome: an intravascular ultrasound studyHiroyuki Okura
The Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Heart 93:1219-25. 2007..To investigate the impact of arterial remodelling on long-term clinical outcome after stent implantation in patients with acute coronary syndrome (ACS)...- Elevated E/E' predicts prognosis in congestive heart failure patients with preserved systolic functionHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Circ J 73:86-91. 2009..The purpose of this study was to investigate whether E/E' predicts prognosis in HFPSF... - Effect of culprit-lesion remodeling versus plaque rupture on three-year outcome in patients with acute coronary syndromeHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Am J Cardiol 103:791-5. 2009..04). In conclusion, culprit-lesion remodeling rather than the presence or absence of culprit-lesion plaque rupture was a strong predictor of long-term (3-year) clinical outcome in patients with acute coronary syndrome... - Tissue Doppler-derived index of left ventricular filling pressure, E/E', predicts survival of patients with non-valvular atrial fibrillationH Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Heart 92:1248-52. 2006..To investigate whether the ratio of early transmitral flow velocity (E) to early diastolic mitral annular velocity (E') predict prognosis in patients with non-valvular atrial fibrillation... - Incidence and predictors of plaque rupture in the peripheral arteriesHiroyuki Okura
Bell Land General Hospital, Sakai, Japan
Circ Cardiovasc Interv 3:63-70. 2010..Plaque rupture may be present in the peripheral arteries of the patients at high risk for cardiovascular events and is possibly associated with vascular vulnerability... - Successful stent implantation guided by intravascular ultrasound and a Doppler guidewire without contrast injection in a patient with allergy to iodinated contrast mediaHiroyuki Okura
Kawasaki Medical School, Kurashiki, Japan
J Invasive Cardiol 23:297-9. 2011..Thus, PCI without contrast injection under IVUS and a Doppler guidewire-guidance may be feasible in selected patients with allergy to iodinated contrast... - Functional mitral regurgitation predicts prognosis independent of left ventricular systolic and diastolic indices in patients with ischemic heart diseaseHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
J Am Soc Echocardiogr 21:355-60. 2008.... - Coronary microvascular endothelial function deteriorates late (12 months) after sirolimus-eluting stent implantationYoshinori Miyamoto
Department of Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
J Cardiol 56:229-35. 2010..The purpose of this study was to evaluate coronary microvascular endothelial function late (6 and 12 months) after sirolimus-eluting stent (SES) implantation using transthoracic Doppler echocardiography... - C-reactive protein predicts non-target lesion revascularization and cardiac events following percutaneous coronary intervention in patients with angina pectorisKoichiro Imai
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan
J Cardiol 53:388-95. 2009..C-reactive protein (CRP) plays a pivotal role in the pathogenesis of atherosclerosis progression. We hypothesized that CRP might be related to progression of non-target lesion and prognosis in patients with angina pectoris... - Systemic inflammation and left atrial thrombus in patients with non-rheumatic atrial fibrillationTomoko Maehama
Department of Cardiology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701 0192, Japan
J Cardiol 56:118-24. 2010..To test this hypothesis, we evaluated the relationship between CRP and LA thrombus in patients with non-rheumatic AF... - Usefulness of CHADS2 score to predict C-reactive protein, left atrial blood stasis, and prognosis in patients with nonrheumatic atrial fibrillationTomoko Maehama
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan
Am J Cardiol 106:535-8. 2010..In conclusion, in patients with nonrheumatic AF, CHADS2 score is related to systemic inflammation, left atrial thrombus formation, and prognosis... - Mechanism of increasing systolic coronary flow velocity in patients with aortic regurgitationTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
J Heart Valve Dis 17:89-93. 2008..Thus, an evaluation was made of the flow velocity pattern of the epicardial coronary artery in these patients... - Plaque characteristics of thin-cap fibroatheroma evaluated by OCT and IVUSYoshinori Miyamoto
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
JACC Cardiovasc Imaging 4:638-46. 2011..The purpose of this study was to assess plaque characteristics of optical coherence tomography (OCT)-derived thin-cap fibroatheroma (TCFA) by integrated backscatter intravascular ultrasound (IB-IVUS)... - Clinical implication of energy loss coefficient in patients with severe aortic stenosis diagnosed by Doppler echocardiographyTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ J 72:1265-9. 2008..Therefore, the purpose of this study was to evaluate the clinical impact of ELCo in patients with severe aortic stenosis (AS)... - C-Reactive protein predicts severity, progression, and prognosis of asymptomatic aortic valve stenosisKoichiro Imai
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan
Am Heart J 156:713-8. 2008..C-Reactive protein (CRP) has been shown to play a pivotal role in the pathogenesis of atherosclerosis progression. The aim of this study was to assess whether CRP predicts severity, progression, and prognosis of aortic valve stenosis (AS)... - Comprehensive evaluation of left ventricular strain using speckle tracking echocardiography in normal adults: comparison of three-dimensional and two-dimensional approachesKen Saito
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan
J Am Soc Echocardiogr 22:1025-30. 2009..We sought to investigate the feasibility of the newly developed three-dimensional speckle tracking (3DT) method to assess longitudinal, circumferential, and radial strain values, and then compared the data with those measured by 2DT... - Quantitative measurement of mitral valve coaptation in functional mitral regurgitation: In vivo experimental study by real-time three-dimensional echocardiographyRyotaro Yamada
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
J Cardiol 53:94-101. 2009..This study aimed to quantify the degree of MV coaptation in experimental models of functional MR caused by acute left ventricular (LV) pressure overload, using real-time three-dimensional (3D) echocardiography... - Frequency and spatial distribution of thin-cap fibroatheroma assessed by 3-vessel intravascular ultrasound and optical coherence tomography: an ex vivo validation and an initial in vivo feasibility studyTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kawasaki Medical School, Kurashiki 701 0192, Japan
Circ J 73:1086-91. 2009.... - Assessment of the coronary calcification by optical coherence tomographyTeruyoshi Kume
Kawasaki Medical School, Department of Cardiology, Kurashiki, Japan
EuroIntervention 6:768-72. 2011..Optical coherence tomography (OCT) can delineate calcified plaque without artefacts. The aim of this study was to evaluate the ability of OCT to quantify calcified plaque in ex vivo human coronary arteries... - Influence of chronic tethering of the mitral valve on mitral leaflet size and coaptation in functional mitral regurgitationKen Saito
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
JACC Cardiovasc Imaging 5:337-45. 2012.... - Three-dimensional quantitation of mitral valve coaptation by a novel software system with transthoracic real-time three-dimensional echocardiographyMiwako Tsukiji
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
J Am Soc Echocardiogr 21:43-6. 2008..1% vs. 18% +/- 8.0%, P = .004). The custom quantitation software system with 3D echocardiography allowed us to assess the degree of mitral valve coaptation... - Target lesion thin-cap fibroatheroma defined by virtual histology intravascular ultrasound affects microvascular injury during percutaneous coronary intervention in patients with angina pectorisRyotaro Yamada
Division of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ J 74:1658-62. 2010..The purpose of this study was to investigate the relationship between thin-cap fibroatheroma (TCFA) defined by VH-IVUS and a change in the IMR during PCI in patients with angina pectoris (AP)... - Assessment of the histological characteristics of coronary arterial plaque with severe calcificationTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ J 71:643-7. 2007..Therefore, the purpose of this study was to investigate plaque characteristics behind severe calcification by histological examination... - Relationship between coronary remodeling and plaque characterization in patients without clinical evidence of coronary artery diseaseTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
Atherosclerosis 197:799-805. 2008.... - A prospective, multicenter, randomized trial to assess efficacy of pioglitazone on in-stent neointimal suppression in type 2 diabetes: POPPS (Prevention of In-Stent Neointimal Proliferation by Pioglitazone Study)Tsutomu Takagi
Division of Cardiology, Takagi Cardiology Clinic, Kyoto, Japan
JACC Cardiovasc Interv 2:524-31. 2009..The aim of this study was to clarify whether pioglitazone suppresses in-stent neointimal proliferation and reduces restenosis and target lesion revascularization (TLR) after percutaneous coronary intervention (PCI)... - Development of cardiac dysfunction induced by repetitive transient myocardial ischemia is inhibited by edaravone in conscious ratsEiji Toyota
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Clin Exp Pharmacol Physiol 36:e20-5. 2009..We speculate that edaravone is a potential therapeutic agent that may interfere with the progression of cardiac dysfunction in high-risk patients with RI... - Prevalence and correlates of physiological valvular regurgitation in healthy subjectsHiroyuki Okura
Division of Cardiology, Bell Land General Hospital, Sakai, Japan
Circ J 75:2699-704. 2011..The aim of this study was to investigate the prevalence and correlates of valvular regurgitation in healthy individuals... - Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunctionTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ J 72:106-8. 2008..The purpose of this study was to investigate evidence of local release of catecholamines from the hearts of patients with tako-tsubo-like LV dysfunction... - Relationship between arterial and fibrous cap remodeling: a serial three-vessel intravascular ultrasound and optical coherence tomography studyRyotaro Yamada
Division of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ Cardiovasc Interv 3:484-90. 2010.... - Images in cardiovascular medicine. Fibrin clot visualized by optical coherence tomographyTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan
Circulation 118:426-7. 2008 - A comparison between 40 MHz intravascular ultrasound iMap imaging system and integrated backscatter intravascular ultrasoundRyotaro Yamada
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
J Cardiol 61:149-54. 2013..iMap is a newly developed intravascular ultrasound (IVUS) tissue characterization system based on pattern recognition of the radio frequency (RF) signals... - Natural history of stent edge dissection, tissue protrusion and incomplete stent apposition detectable only on optical coherence tomography after stent implantation – preliminary observation – Teruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ J 76:698-703. 2012.... - Evaluation of coronary endothelial function by catheter-type NO sensor in high-fat-diet-induced obese dogsTeruyoshi Kume
Division of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ J 73:562-7. 2009..Direct measurement of plasma nitric oxide (NO) concentration is possible with a newly developed catheter-type sensor... - Rapid progression of mild to moderate aortic stenosis in patients older than 80 yearsTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
J Am Soc Echocardiogr 20:1243-6. 2007..The purpose of this study was to evaluate the rate of progression of mild and moderate aortic stenosis in patients aged 80 years and older... - Novel rat model of ischemic cardiomyopathy induced by repetitive myocardial ischemia/reperfusion injury while consciousEiji Toyota
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
Circ J 71:788-95. 2007..A rodent model of ischemic cardiomyopathy (ICM) induced by repetitive brief ischemia/reperfusion (I/R) injury while conscious has not been previously established... - Impact of energy loss coefficient on left ventricular mass regression in patients undergoing aortic valve replacement: preliminary observationTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan
J Am Soc Echocardiogr 22:454-7. 2009..The purpose of this study was to evaluate the impact of Doppler-derived energy loss coefficient (ELCo) on the regression of left ventricular (LV) hypertrophy after aortic valve replacement (AVR) in patients with severe aortic stenosis... - Comparison of quantitative measurements between two different intravascular ultrasound systems: in vitro and in vivo studiesRyotaro Yamada
Division of Cardiology, Kawasaki Medical School, Kurashiki, Japan
J Cardiol 61:201-5. 2013..The aim of study was to compare two different IVUS catheters and consoles to verify their accuracy and compatibility... - Geometric changes of tricuspid valve tenting in tricuspid regurgitation secondary to pulmonary hypertension quantified by novel system with transthoracic real-time 3-dimensional echocardiographyRenan Sukmawan
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
J Am Soc Echocardiogr 20:470-6. 2007..This study suggested usefulness of the novel system with 3DE in evaluation of tricuspid valve geometry... - A case of platypnea orthodeoxia syndrome: a persistent history taking was the key to the diagnosisTakashi Ohfuji
Department of Respiratory Medicine, Kawasaki Medical School, Japan
Intern Med 51:1701-4. 2012..This case highlights the necessity of awareness of this syndrome and the occult atrial septal defect... - Measurement of the thickness of the fibrous cap by optical coherence tomographyTeruyoshi Kume
Department of Cardiology, Kawasaki Medical School, Kurashiki 701 0192, Japan
Am Heart J 152:755.e1-4. 2006..The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to measure the thickness of the fibrous cap within lipid-rich plaque... - Mechanisms of acute lumen gain following cutting balloon angioplasty in calcified and noncalcified lesions: an intravascular ultrasound studyHiroyuki Okura
Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, California 94305, USA
Catheter Cardiovasc Interv 57:429-36. 2002..On the other hand, for calcified lesions, the CB achieves larger lumen gain, especially in lesions with evidence of dissections... - Histological characteristics of plaque with ultrasonic attenuation: a comparison between intravascular ultrasound and histologyRyotaro Yamada
Department of Cardiology, Kawasaki Medical School, Okayama
J Cardiol 50:223-8. 2007..However, histological evaluation of plaque with ultrasonic attenuation has not been performed. This study evaluated the histological characteristics of plaque with ultrasonic attenuation assessed by IVUS... - Late incomplete apposition with excessive remodeling of the stented coronary artery following intravascular brachytherapyHiroyuki Okura
Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, California 94305, USA
Am J Cardiol 92:587-90. 2003..The long-term clinical impact of this finding is unclear... - Impact of different definitions on the interpretation of coronary remodeling determined by intravascular ultrasoundKiyoshi Hibi
Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305, USA
Catheter Cardiovasc Interv 65:233-9. 2005..The marked variability in categorization of remodeling underscores the importance of developing a standard methodology... - Targeting the adventitia with intracoronary beta-radiation: comparison of two dose prescriptions and the role of centering coronary arteriesGrzegorz L Kałuza
Methodist DeBakey Heart Center and Baylor College of Medicine, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 52:184-91. 2002..To compare by intravascular ultrasound (IVUS) the efficacy of delivering the prescribed dose to the adventitia between two commonly used dose prescriptions for intracoronary radiotherapy...