Research Topics
| Jeffery R WickensSummaryAffiliation: Okinawa Institute of Science and Technology Country: Japan Publications
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Detail Information
Publications
Origins of altered reinforcement effects in ADHDEspen Borgå Johansen
Centre for Advanced Study CAS at the Norwegian Academy for Science and Letters, Oslo, Norway
Behav Brain Funct 5:7. 2009..Theoretical and experimental analyses of these moderating factors will help to determine just how reinforcement processes are altered in ADHD. Such analyses can only help to improve treatment strategies for ADHD...
Synaptic plasticity in the basal gangliaJeffery R Wickens
Neurobiology Research Unit, Okinawa Institute of Science and Technology, Initial Research Project, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
Behav Brain Res 199:119-28. 2009..Of particular interest is the question of how to link the molecular and cellular mechanisms of synaptic plasticity to learning operations at the systems level, which are expressed behaviourally as reinforcement-related learning...
Dopaminergic mechanisms in actions and habitsJeffery R Wickens
Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
J Neurosci 27:8181-3. 2007..The locus of these actions within the cortical and corticostriatal circuitry is a focus on ongoing research...- Animal models to guide clinical drug development in ADHD: lost in translation?Jeffery R Wickens
Okinawa Institute of Science and Technology, Okinawa, Japan
Br J Pharmacol 164:1107-28. 2011..Therefore, operant behaviour paradigms that measure the effects of drugs in situations of delayed reinforcement, whether in normal rats or selected models, show promise for the future... - Striatal contributions to reward and decision making: making sense of regional variations in a reiterated processing matrixJeffery R Wickens
Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa, Japan
Ann N Y Acad Sci 1104:192-212. 2007..These differences may be important for understanding regional variations in the contribution to reinforcement of habits, versus incentive processes that are sensitive to the value of expected rewards... - Neural control of dopamine neurotransmission: implications for reinforcement learningMayank Aggarwal
Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919 1, Tancha, Onna Son, Kunigami, Okinawa 904 0412, Japan
Eur J Neurosci 35:1115-23. 2012.... - A Ca(2+) threshold for induction of spike-timing-dependent depression in the mouse striatumTomomi Shindou
Okinawa Institute of Science and Technology, Okinawa 904 0412, Japan
J Neurosci 31:13015-22. 2011..These findings confirm a spine [Ca(2+)](i) threshold for induction of t-LTD in the corticostriatal pathway, mediated by the supralinear increase in [Ca(2+)](i) associated with pre-post induction protocols... - Neurobiology of ADHDGail Tripp
Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa 904 2234, Japan
Neuropharmacology 57:579-89. 2009..We discuss how a failure of this transfer may give rise to many symptoms of ADHD, and propose that methylphenidate might act to compensate for the proposed dopamine transfer deficit... - A role for phasic dopamine neuron firing in habit learningMayank Aggarwal
Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919 1, Tancha, Onna Son, Kunigami, Okinawa 904 0412, Japan
Neuron 72:892-4. 2011..These findings indicate that brain regions sensitive to phasic dopamine signals may underlie habit learning... - Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning networkWei-Xing Pan
Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9001, New Zealand
J Neurosci 25:6235-42. 2005..Such properties enable rapid but stable initiation of learning when the number of stimulus-reward pairings is limited, conferring significant adaptive advantages in real-world environments... - Computational models of the basal ganglia: from robots to membranesKevin Gurney
Adaptive Behaviour Research Group, Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Trends Neurosci 27:453-9. 2004..We identify distinct modelling strategies that can deliver important and complementary insights into the nature of problems the basal ganglia have evolved to solve, and describe methods that are used to solve them... - Dopamine-dependent plasticity of corticostriatal synapsesJohn N J Reynolds
The Neuroscience Research Centre, University of Otago, Dunedin, New Zealand
Neural Netw 15:507-21. 2002..It is argued that this function, and the experimental data from which it arises, are compatible with existing models which associate the reward-related firing of dopamine neurons with changes in corticostriatal synaptic efficacy... - Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference modelWei Xing Pan
Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
J Neurosci 28:9619-31. 2008..These findings are consistent with the hypothesis that extinction processes at both cellular and behavioral levels involve a dynamic interaction between new (inhibitory) learning, forgetting, and unlearning... - Actions of adenosine A 2A receptors on synaptic connections of spiny projection neurons in the neostriatal inhibitory networkTomomi Shindou
Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
J Neurophysiol 99:1884-9. 2008..This neuromodulatory action on lateral inhibition in the striatum may underlie, in part, the therapeutic efficacy of adenosine-based treatments for Parkinson's disease... - Simulation of GABA function in the basal ganglia: computational models of GABAergic mechanisms in basal ganglia functionJeffery R Wickens
Basal Ganglia Research Group, School of Medical Sciences, University of Otago, Dunedin, New Zealand
Prog Brain Res 160:313-29. 2007..The paper concludes with suggestions for further theoretical and experimental studies... - The corticostriatal input to giant aspiny interneurons in the rat: a candidate pathway for synchronising the response to reward-related cuesJohn N J Reynolds
Department of Anatomy and Structural Biology and the Neuroscience Research Centre, School of Medical Sciences, University of Otago, P O Box 913, Lindo Feguson Bldg, Dunedin, New Zealand
Brain Res 1011:115-28. 2004..These inputs may be involved in the synchronised convergence of reward-related cues from spatially distinct cortical areas onto giant aspiny interneurons... - Neural mechanisms of reward-related motor learningJeffery R Wickens
Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
Curr Opin Neurobiol 13:685-90. 2003..This learning mechanism may play a special role in the translation of reward signals into context-dependent response probability or directional bias in movement responses... - Inhibitory interactions between spiny projection neurons in the rat striatumMark J Tunstall
Department of Anatomy and Structural Biology and the Neuroscience Research Centre, School of Medical Sciences, University of Otago, Dunedin, New Zealand
J Neurophysiol 88:1263-9. 2002....