Jeffery R Wickens

Summary

Affiliation: Okinawa Institute of Science and Technology
Country: Japan

Publications

  1. pmc Origins of altered reinforcement effects in ADHD
    Espen Borgå Johansen
    Centre for Advanced Study CAS at the Norwegian Academy for Science and Letters, Oslo, Norway
    Behav Brain Funct 5:7. 2009
  2. doi request reprint Synaptic plasticity in the basal ganglia
    Jeffery R Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, Initial Research Project, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
    Behav Brain Res 199:119-28. 2009
  3. ncbi request reprint Dopaminergic mechanisms in actions and habits
    Jeffery R Wickens
    Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
    J Neurosci 27:8181-3. 2007
  4. pmc Animal models to guide clinical drug development in ADHD: lost in translation?
    Jeffery R Wickens
    Okinawa Institute of Science and Technology, Okinawa, Japan
    Br J Pharmacol 164:1107-28. 2011
  5. ncbi request reprint Striatal contributions to reward and decision making: making sense of regional variations in a reiterated processing matrix
    Jeffery R Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa, Japan
    Ann N Y Acad Sci 1104:192-212. 2007
  6. doi request reprint Neural control of dopamine neurotransmission: implications for reinforcement learning
    Mayank Aggarwal
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919 1, Tancha, Onna Son, Kunigami, Okinawa 904 0412, Japan
    Eur J Neurosci 35:1115-23. 2012
  7. doi request reprint A Ca(2+) threshold for induction of spike-timing-dependent depression in the mouse striatum
    Tomomi Shindou
    Okinawa Institute of Science and Technology, Okinawa 904 0412, Japan
    J Neurosci 31:13015-22. 2011
  8. doi request reprint Neurobiology of ADHD
    Gail Tripp
    Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa 904 2234, Japan
    Neuropharmacology 57:579-89. 2009
  9. doi request reprint A role for phasic dopamine neuron firing in habit learning
    Mayank Aggarwal
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919 1, Tancha, Onna Son, Kunigami, Okinawa 904 0412, Japan
    Neuron 72:892-4. 2011
  10. ncbi request reprint Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network
    Wei Xing Pan
    Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9001, New Zealand
    J Neurosci 25:6235-42. 2005

Collaborators

Detail Information

Publications18

  1. pmc Origins of altered reinforcement effects in ADHD
    Espen Borgå Johansen
    Centre for Advanced Study CAS at the Norwegian Academy for Science and Letters, Oslo, Norway
    Behav Brain Funct 5:7. 2009
    ..Theoretical and experimental analyses of these moderating factors will help to determine just how reinforcement processes are altered in ADHD. Such analyses can only help to improve treatment strategies for ADHD...
  2. doi request reprint Synaptic plasticity in the basal ganglia
    Jeffery R Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, Initial Research Project, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
    Behav Brain Res 199:119-28. 2009
    ..Of particular interest is the question of how to link the molecular and cellular mechanisms of synaptic plasticity to learning operations at the systems level, which are expressed behaviourally as reinforcement-related learning...
  3. ncbi request reprint Dopaminergic mechanisms in actions and habits
    Jeffery R Wickens
    Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
    J Neurosci 27:8181-3. 2007
    ..The locus of these actions within the cortical and corticostriatal circuitry is a focus on ongoing research...
  4. pmc Animal models to guide clinical drug development in ADHD: lost in translation?
    Jeffery R Wickens
    Okinawa Institute of Science and Technology, Okinawa, Japan
    Br J Pharmacol 164:1107-28. 2011
    ..Therefore, operant behaviour paradigms that measure the effects of drugs in situations of delayed reinforcement, whether in normal rats or selected models, show promise for the future...
  5. ncbi request reprint Striatal contributions to reward and decision making: making sense of regional variations in a reiterated processing matrix
    Jeffery R Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa, Japan
    Ann N Y Acad Sci 1104:192-212. 2007
    ..These differences may be important for understanding regional variations in the contribution to reinforcement of habits, versus incentive processes that are sensitive to the value of expected rewards...
  6. doi request reprint Neural control of dopamine neurotransmission: implications for reinforcement learning
    Mayank Aggarwal
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919 1, Tancha, Onna Son, Kunigami, Okinawa 904 0412, Japan
    Eur J Neurosci 35:1115-23. 2012
    ....
  7. doi request reprint A Ca(2+) threshold for induction of spike-timing-dependent depression in the mouse striatum
    Tomomi Shindou
    Okinawa Institute of Science and Technology, Okinawa 904 0412, Japan
    J Neurosci 31:13015-22. 2011
    ..These findings confirm a spine [Ca(2+)](i) threshold for induction of t-LTD in the corticostriatal pathway, mediated by the supralinear increase in [Ca(2+)](i) associated with pre-post induction protocols...
  8. doi request reprint Neurobiology of ADHD
    Gail Tripp
    Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa 904 2234, Japan
    Neuropharmacology 57:579-89. 2009
    ..We discuss how a failure of this transfer may give rise to many symptoms of ADHD, and propose that methylphenidate might act to compensate for the proposed dopamine transfer deficit...
  9. doi request reprint A role for phasic dopamine neuron firing in habit learning
    Mayank Aggarwal
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 1919 1, Tancha, Onna Son, Kunigami, Okinawa 904 0412, Japan
    Neuron 72:892-4. 2011
    ..These findings indicate that brain regions sensitive to phasic dopamine signals may underlie habit learning...
  10. ncbi request reprint Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network
    Wei Xing Pan
    Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9001, New Zealand
    J Neurosci 25:6235-42. 2005
    ..Such properties enable rapid but stable initiation of learning when the number of stimulus-reward pairings is limited, conferring significant adaptive advantages in real-world environments...
  11. ncbi request reprint Computational models of the basal ganglia: from robots to membranes
    Kevin Gurney
    Adaptive Behaviour Research Group, Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
    Trends Neurosci 27:453-9. 2004
    ..We identify distinct modelling strategies that can deliver important and complementary insights into the nature of problems the basal ganglia have evolved to solve, and describe methods that are used to solve them...
  12. ncbi request reprint Dopamine-dependent plasticity of corticostriatal synapses
    John N J Reynolds
    The Neuroscience Research Centre, University of Otago, Dunedin, New Zealand
    Neural Netw 15:507-21. 2002
    ..It is argued that this function, and the experimental data from which it arises, are compatible with existing models which associate the reward-related firing of dopamine neurons with changes in corticostriatal synaptic efficacy...
  13. doi request reprint Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference model
    Wei Xing Pan
    Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    J Neurosci 28:9619-31. 2008
    ..These findings are consistent with the hypothesis that extinction processes at both cellular and behavioral levels involve a dynamic interaction between new (inhibitory) learning, forgetting, and unlearning...
  14. doi request reprint Actions of adenosine A 2A receptors on synaptic connections of spiny projection neurons in the neostriatal inhibitory network
    Tomomi Shindou
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    J Neurophysiol 99:1884-9. 2008
    ..This neuromodulatory action on lateral inhibition in the striatum may underlie, in part, the therapeutic efficacy of adenosine-based treatments for Parkinson's disease...
  15. ncbi request reprint Simulation of GABA function in the basal ganglia: computational models of GABAergic mechanisms in basal ganglia function
    Jeffery R Wickens
    Basal Ganglia Research Group, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Prog Brain Res 160:313-29. 2007
    ..The paper concludes with suggestions for further theoretical and experimental studies...
  16. ncbi request reprint The corticostriatal input to giant aspiny interneurons in the rat: a candidate pathway for synchronising the response to reward-related cues
    John N J Reynolds
    Department of Anatomy and Structural Biology and the Neuroscience Research Centre, School of Medical Sciences, University of Otago, P O Box 913, Lindo Feguson Bldg, Dunedin, New Zealand
    Brain Res 1011:115-28. 2004
    ..These inputs may be involved in the synchronised convergence of reward-related cues from spatially distinct cortical areas onto giant aspiny interneurons...
  17. ncbi request reprint Neural mechanisms of reward-related motor learning
    Jeffery R Wickens
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Curr Opin Neurobiol 13:685-90. 2003
    ..This learning mechanism may play a special role in the translation of reward signals into context-dependent response probability or directional bias in movement responses...
  18. ncbi request reprint Inhibitory interactions between spiny projection neurons in the rat striatum
    Mark J Tunstall
    Department of Anatomy and Structural Biology and the Neuroscience Research Centre, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Neurophysiol 88:1263-9. 2002
    ....