Okinawa Institute of Science and Technology

Summary

Organization: Okinawa Institute of Science and Technology
Country: Japan

Top Publications

  1. ncbi A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives
    Shogo Endo
    Unit for Molecular Neurobiology of Learning and Memory, Initial Research Project, Okinawa Institute of Science and Technology, Uruma, Japan
    Biochem Biophys Res Commun 341:261-5. 2006
  2. doi Synaptic plasticity in the basal ganglia
    Jeffery R Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, Initial Research Project, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
    Behav Brain Res 199:119-28. 2009
  3. doi Patterns and pauses in Purkinje cell simple spike trains: experiments, modeling and theory
    E De Schutter
    Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Japan Theoretical Neurobiology, University of Antwerp, Belgium
    Neuroscience 162:816-26. 2009
  4. pmc Vesicular glutamate filling and AMPA receptor occupancy at the calyx of Held synapse of immature rats
    Takayuki Yamashita
    Okinawa Institute of Science and Technology Promotion Corporation, Okinawa 904 2234, Japan
    J Physiol 587:2327-39. 2009
  5. doi An advanced filter-feeder hypothesis for urochordate evolution
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Zoolog Sci 26:97-111. 2009
  6. pmc Domain shuffling and the evolution of vertebrates
    Takeshi Kawashima
    Okinawa Institute of Science and Technology, Uruma, Okinawa, Japan
    Genome Res 19:1393-403. 2009
  7. doi Neurobiology of ADHD
    Gail Tripp
    Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa 904 2234, Japan
    Neuropharmacology 57:579-89. 2009
  8. doi Validation of decision-making models and analysis of decision variables in the rat basal ganglia
    Makoto Ito
    Neural Computation Unit, Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan or
    J Neurosci 29:9861-74. 2009
  9. pmc A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina
    Rodrigo Publio
    Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
    PLoS ONE 4:e6970. 2009
  10. doi A high recovery microsampling device based on a microdialysis probe for peptide sampling
    Michael C Roy
    Okinawa Institute of Science and Technology OIST, Suzaki 12 2, Uruma, Okinawa 904 2234, Japan
    Anal Biochem 399:305-7. 2010

Detail Information

Publications33

  1. ncbi A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives
    Shogo Endo
    Unit for Molecular Neurobiology of Learning and Memory, Initial Research Project, Okinawa Institute of Science and Technology, Uruma, Japan
    Biochem Biophys Res Commun 341:261-5. 2006
    ..These results suggest that the Gln residue of subdomain V is important in determining the susceptibility of ERK1/2 to 1NA-PP1 without significant changes in their enzymatic characteristics...
  2. doi Synaptic plasticity in the basal ganglia
    Jeffery R Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, Initial Research Project, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
    Behav Brain Res 199:119-28. 2009
    ..Of particular interest is the question of how to link the molecular and cellular mechanisms of synaptic plasticity to learning operations at the systems level, which are expressed behaviourally as reinforcement-related learning...
  3. doi Patterns and pauses in Purkinje cell simple spike trains: experiments, modeling and theory
    E De Schutter
    Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Japan Theoretical Neurobiology, University of Antwerp, Belgium
    Neuroscience 162:816-26. 2009
    ..Conversely, the regular spike patterns may be a rate code, which presets the amplitude of future rebound bursts...
  4. pmc Vesicular glutamate filling and AMPA receptor occupancy at the calyx of Held synapse of immature rats
    Takayuki Yamashita
    Okinawa Institute of Science and Technology Promotion Corporation, Okinawa 904 2234, Japan
    J Physiol 587:2327-39. 2009
    ..We conclude that rapid AMPAR desensitization, caused by glutamate released from multiple vesicles during synaptic transmission, underlies postsynaptic AMPAR saturation at this immature calyceal synapse before the onset of hearing...
  5. doi An advanced filter-feeder hypothesis for urochordate evolution
    Nori Satoh
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Zoolog Sci 26:97-111. 2009
    ..Thus, urochordates are close relatives to vertebrates...
  6. pmc Domain shuffling and the evolution of vertebrates
    Takeshi Kawashima
    Okinawa Institute of Science and Technology, Uruma, Okinawa, Japan
    Genome Res 19:1393-403. 2009
    ..Our analyses shed new light on the role of domain shuffling, especially in the evolution of vertebrates and chordates...
  7. doi Neurobiology of ADHD
    Gail Tripp
    Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa 904 2234, Japan
    Neuropharmacology 57:579-89. 2009
    ..We discuss how a failure of this transfer may give rise to many symptoms of ADHD, and propose that methylphenidate might act to compensate for the proposed dopamine transfer deficit...
  8. doi Validation of decision-making models and analysis of decision variables in the rat basal ganglia
    Makoto Ito
    Neural Computation Unit, Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan or
    J Neurosci 29:9861-74. 2009
    ..Information represented in the NAc and VP might contribute to a choice mechanism that is situated elsewhere...
  9. pmc A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina
    Rodrigo Publio
    Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
    PLoS ONE 4:e6970. 2009
    ....
  10. doi A high recovery microsampling device based on a microdialysis probe for peptide sampling
    Michael C Roy
    Okinawa Institute of Science and Technology OIST, Suzaki 12 2, Uruma, Okinawa 904 2234, Japan
    Anal Biochem 399:305-7. 2010
    ..A probe made of a low molecular weight cutoff membrane is suitable for filtering off proteins. The new probe can be a useful tool for high recovery of peptides from living tissues...
  11. pmc Hippocampal cells encode places by forming small anatomical clusters
    N H Nakamura
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 166:994-1007. 2010
    ..We propose that spatial encoding recruits specific cell ensembles in the hippocampus and that with repeated exposure to the same place the ensembles become better organized to more accurately represent the "spatial map."..
  12. doi Dealing with the devil in the detail - some thoughts about the next model of the basal ganglia
    GORDON ARBUTHNOTT
    Brain Mechanisms for Behaviour Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
    Parkinsonism Relat Disord 15:S139-42. 2009
    ..Then maybe a new functional model will emerge that is less tied to anatomical and physiological simplification, but perhaps will still allow us to engineer therapeutic strategies to help patients with movement disorders...
  13. doi Comparative dating of attine ant and lepiotaceous cultivar phylogenies reveals coevolutionary synchrony and discord
    Alexander S Mikheyev
    Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA
    Am Nat 175:E126-33. 2010
    ....
  14. pmc Developmental shift to a mechanism of synaptic vesicle endocytosis requiring nanodomain Ca2+
    Takayuki Yamashita
    Cellular and Molecular Synaptic Function Unit, Initial Research Project, Okinawa Institute of Science and Technology Promotion Corporation, Okinawa, Japan
    Nat Neurosci 13:838-44. 2010
    ....
  15. pmc Rapid microsatellite isolation from a butterfly by de novo transcriptome sequencing: performance and a comparison with AFLP-derived distances
    Alexander S Mikheyev
    Okinawa Institute of Science and Technology, Onna, Japan
    PLoS ONE 5:e11212. 2010
    ..We attempted to circumvent this problem by bioinformatic mining of microsatellite sequences from a de novo-sequenced transcriptome of a butterfly (Euphydryas editha)...
  16. pmc Sox genes in the coral Acropora millepora: divergent expression patterns reflect differences in developmental mechanisms within the Anthozoa
    Chuya Shinzato
    ARC Centre of Excellence for Coral Reef Studies and Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
    BMC Evol Biol 8:311. 2008
    ..To better understand both the evolution of the Sox family and the roles of these genes in cnidarians, we are studying the Sox gene complement of the coral, Acropora millepora (Class Anthozoa)...
  17. doi Finding intrinsic rewards by embodied evolution and constrained reinforcement learning
    Eiji Uchibe
    Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
    Neural Netw 21:1447-55. 2008
    ..We show in hardware experiments that the robots can find appropriate 'intrinsic' rewards for the vision of battery packs and other robots to promote approach behaviors...
  18. pmc Forward shift from reverse replay
    Adam Ponzi
    Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma shi, Okinawa, Japan
    Cogn Neurodyn 3:39-46. 2009
    ..Simulations show that the CA1 firing fields show positive movement in center of mass toward reward locations over many trials with negative shift in first few trials, and development of positive skew...
  19. ncbi [How does fission yeast cut8 regulate the nuclear localization of proteasome?]
    Kijiro Takeda
    Tanpakushitsu Kakusan Koso 51:1241-4. 2006
  20. ncbi Central gustatory projections and side-specificity of operant antennal muscle conditioning in the honeybee
    S Shuichi Haupt
    Neurobiologie, Institut für Ökologie, TU Berlin FR1 1, Franklinstr 28 9, 10587, Berlin, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:523-35. 2007
    ..With contralateral antennal sucrose stimulation, conditioning was unsuccessful. Thus, muscle activity induced by gustatory stimulation was important for learning success and conditioning was side-specific...
  21. ncbi Thinking outside the pyramidal cell: unexplored contributions of interneurons and neuropeptide Y to estrogen-induced synapse formation in the hippocampus
    Nozomu H Nakamura
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Rev Neurosci 18:1-13. 2007
    ....
  22. ncbi Striatal contributions to reward and decision making: making sense of regional variations in a reiterated processing matrix
    Jeffery R Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa, Japan
    Ann N Y Acad Sci 1104:192-212. 2007
    ..These differences may be important for understanding regional variations in the contribution to reinforcement of habits, versus incentive processes that are sensitive to the value of expected rewards...
  23. pmc Mapping function onto neuronal morphology
    Klaus M Stiefel
    Theoretical and Experimental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22, Suzaki, Uruma, Okinawa, Japan
    J Neurophysiol 98:513-26. 2007
    ..The automated mapping between neuronal function and structure introduced here could allow a large catalog of computational functions to be built indexed by morphological structure...
  24. ncbi Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombe
    Mizuki Shimanuki
    Initial Research Project IRP, Okinawa Institute of Science and Technology Promotion Corporation OIST, Uruma 904 2234, Okinawa, Japan
    Genes Cells 12:677-92. 2007
    ....
  25. ncbi Dopaminergic mechanisms in actions and habits
    Jeffery R Wickens
    Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
    J Neurosci 27:8181-3. 2007
    ..The locus of these actions within the cortical and corticostriatal circuitry is a focus on ongoing research...
  26. ncbi Research review: dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHD
    Gail Tripp
    Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, Uruma, Okinawa, Japan
    J Child Psychol Psychiatry 49:691-704. 2008
    ..The extent to which DTD explains symptoms of ADHD and effects of pharmacological interventions is discussed. We conclude by considering the neural changes underlying the etiology of DTD...
  27. pmc Why are computational neuroscience and systems biology so separate?
    Erik De Schutter
    Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Japan
    PLoS Comput Biol 4:e1000078. 2008
    ..Finally, I speculate about how the relationship between the two fields may evolve in the near future...
  28. doi GABAA receptors in deep cerebellar nuclei play important roles in mouse eyeblink conditioning
    Toshiro Sakamoto
    Unit for Molecular Neurobiology of Learning and Memory, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
    Brain Res 1230:125-37. 2008
    ....
  29. pmc Intrinsic gain modulation and adaptive neural coding
    Sungho Hong
    Physiology and Biophysics Department, University of Washington, Seattle, Washington, USA
    PLoS Comput Biol 4:e1000119. 2008
    ..Our results describe how both variance-dependent gain modulation and adaptive neural computation result from intrinsic nonlinearity...
  30. doi Gene expression profiling of neuropeptides in mouse cerebellum, hippocampus, and retina
    Kiyotaka Akiyama
    Molecular Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
    Nutrition 24:918-23. 2008
    ..We examined gene expression profiling in single neuron types and small regions of the nervous system...
  31. doi Non-parametric algorithmic generation of neuronal morphologies
    Benjamin Torben-Nielsen
    TENU, Okinawa Institute of Science and Technology, Okinawa, Japan
    Neuroinformatics 6:257-77. 2008
    ..The opportunities and limitations of data-driven algorithmic reconstruction of neurons are discussed...
  32. ncbi JDRC 8: Cell biology and development
    Mary Ann Price
    Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma shi, Okinawa, 904 2234, Japan
    Fly (Austin) 1:294-6. 2007
    ..This review will cover diverse topics roughly divided into four areas: cell biology and signaling, the cytoskeleton, transcription and cell fate determination and metabolism...
  33. pmc MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
    Tomáš Pluskal
    G0 Cell Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan
    BMC Bioinformatics 11:395. 2010
    ..An ongoing challenge of these molecular profiling approaches, however, is the development of better data processing methods. Here we introduce a new generation of a popular open-source data processing toolbox, MZmine 2...