Takao Yasuhara

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis
    T Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA USA
    Neuroscience 149:182-91. 2007
  2. ncbi request reprint Neurorescue effects of VEGF on a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Brain Res 1053:10-8. 2005
  3. ncbi request reprint Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:51-6. 2007
  4. ncbi request reprint Intracerebral transplantation of genetically engineered cells for Parkinson's disease: toward clinical application
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Transplant 16:125-32. 2007
  5. doi request reprint Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts
    T Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    J Cell Mol Med 14:914-21. 2010
  6. pmc Regenerative medicine for epilepsy: from basic research to clinical application
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Int J Mol Sci 14:23390-401. 2013
  7. pmc Neuroprotective effects of liraglutide for stroke model of rats
    Kenichiro Sato
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama 700 8558, Japan
    Int J Mol Sci 14:21513-24. 2013
  8. ncbi request reprint Proximal vertebral body fracture after 4-level fusion using l1 as the upper instrumented vertebra for lumbar degenerative disease: report of 2 cases with literature review
    Takao Yasuhara
    Department of Spinal Surgery, Shinkomonji Hospital, Kitakyushu, Fukuoka 800 0057, Japan
    Acta Med Okayama 67:197-202. 2013
  9. doi request reprint Posterior reversible encephalopathy syndrome
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Kita ku, Okayama 700 8558, Japan
    J Clin Neurosci 18:406-9. 2011
  10. ncbi request reprint Chiari malformation with thick occipital bone
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 65:59-61. 2011

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis
    T Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA USA
    Neuroscience 149:182-91. 2007
    ..The use of the HS model in conjunction with CNS disease models should further elucidate the role of exercise in neurogenesis and neurotrophic factors in neurologic disorders...
  2. ncbi request reprint Neurorescue effects of VEGF on a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Brain Res 1053:10-8. 2005
    ..Our results suggest that VEGF is a highly potent neurorescue molecule for Parkinson's disease therapy...
  3. ncbi request reprint Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:51-6. 2007
    ..In this review, we present an outline of our studies and other key studies related to GDNF, the current state of the research, problems to be overcome, and predictions regarding the use of GDNF therapy for PD in the future...
  4. ncbi request reprint Intracerebral transplantation of genetically engineered cells for Parkinson's disease: toward clinical application
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Transplant 16:125-32. 2007
    ....
  5. doi request reprint Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts
    T Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    J Cell Mol Med 14:914-21. 2010
    ..These findings extend the utility of blood-brain barrier permeabilization in facilitating cell therapy for treating neonatal HI injury...
  6. pmc Regenerative medicine for epilepsy: from basic research to clinical application
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Int J Mol Sci 14:23390-401. 2013
    ..Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data. ..
  7. pmc Neuroprotective effects of liraglutide for stroke model of rats
    Kenichiro Sato
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama 700 8558, Japan
    Int J Mol Sci 14:21513-24. 2013
    ..In conclusion, this is the first study to demonstrate neuroprotective effects of liraglutide on cerebral ischemia through anti-oxidative effects and VEGF upregulation...
  8. ncbi request reprint Proximal vertebral body fracture after 4-level fusion using l1 as the upper instrumented vertebra for lumbar degenerative disease: report of 2 cases with literature review
    Takao Yasuhara
    Department of Spinal Surgery, Shinkomonji Hospital, Kitakyushu, Fukuoka 800 0057, Japan
    Acta Med Okayama 67:197-202. 2013
    ..In consideration of multi-level fusion, L1 should be avoided as an upper instrumented vertebra to prevent junctional kyphosis, especially in cases with osteoporosis and flat back posture. ..
  9. doi request reprint Posterior reversible encephalopathy syndrome
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Kita ku, Okayama 700 8558, Japan
    J Clin Neurosci 18:406-9. 2011
    ..In previous reports, delayed diagnosis might have affected the prognosis. Further work on the clinical manifestations of PRES and its therapy is required...
  10. ncbi request reprint Chiari malformation with thick occipital bone
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 65:59-61. 2011
    ..This case gives us the essence of the occurrence mechanisms of Chiari malformation and foramen magnum decompression...
  11. ncbi request reprint Primary germinoma in the medulla oblongata - case report -
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurol Med Chir (Tokyo) 51:326-9. 2011
    ..Germinoma should be included in the differential diagnosis of midline medullary lesion in young patients, and biopsy should be considered...
  12. ncbi request reprint Development of cervical subarachnoid hematoma following coronal artery stenting for angina pectoris
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurol Med Chir (Tokyo) 51:664-6. 2011
    ..The hemiparesis was ameliorated after surgery. Spinal hematoma should be considered in the differential diagnosis in patients receiving anti-platelet or anti-coagulant drugs with rapid progression of pain...
  13. ncbi request reprint Ex vivo gene therapy: transplantation of neurotrophic factor-secreting cells for cerebral ischemia
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Front Biosci 11:760-75. 2006
    ..Neurotrophic factor delivery, combined with ex vivo method, poses as novel treatment for stroke, although additional safety and efficacy studies remain to be examined...
  14. ncbi request reprint Toxicity of semaphorin3A for dopaminergic neurons
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 382:61-5. 2005
    ..Optimizing the dosage and infusion location (i.e., nigra) and timing (more than 1 week post-transplantation) might further reveal the contribution of Sema3A to the pathogenesis of Parkinson's disease...
  15. ncbi request reprint Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan
    Eur J Neurosci 19:1494-504. 2004
    ..Further, VEGF is likely to promote neuroprotection indirectly by activating the proliferation of glia and by promoting angiogenesis. Our results support a potential neuroprotective role for VEGF in the treatment of Parkinson's disease...
  16. ncbi request reprint Wegener granulomatosis manifesting as meningitis. Case report
    Takao Yasuhara
    Department of Neurosurgery, Kagawa Rosai Hospital, Marugame City, Kagawa, Japan
    J Neurosurg 97:1229-32. 2002
    ..With treatment, the meningeal enhancement resolved and the cANCA titer normalized. Meningeal granulomatosis as the sole lesion in WG has never been reported in the literature. This atypical course of WG should be noted...
  17. ncbi request reprint Glioblastoma with metastasis to the spleen--case report
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Neurol Med Chir (Tokyo) 43:452-6. 2003
    ..Glioblastoma with metastases to the spleen is very rare. The prognosis for patients is poor. Excessive therapy should not be used for patients with extracranial metastases from glioblastoma...
  18. ncbi request reprint Pseudoxanthoma elasticum with carotid rete mirabile
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Neurol Neurosurg 106:114-7. 2004
    ..Only three cases have been reported previously in the literature. Although the relation between P. elasticum and carotid rete mirabile is unclear, both disorders are believed to be major risk factors for cerebrovascular disease...
  19. ncbi request reprint The potential role of vascular endothelial growth factor in the central nervous system
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Rev Neurosci 15:293-307. 2004
    ....
  20. ncbi request reprint Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Neurosurg 102:80-9. 2005
    ..The authors investigated the effects of GDNF on 6-hydroxydopamine (6-OHDA)-treated dopaminergic neurons in vitro and in vivo...
  21. ncbi request reprint The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine Dentistry, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Brain Res 1038:1-10. 2005
    ..Our results demonstrate the importance of administration dose of VEGF, suggesting that low-dose administration of VEGF might be desirable for Parkinson's disease...
  22. pmc Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alpha
    Feifei Wang
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    BMC Neurosci 11:52. 2010
    ..Additionally, to explore the underlying mechanisms, neuroprotective effects of SDF-1alpha were explored using 6-OHDA-exposed PC12 cells by using dopamine (DA) assay and TdT-mediated dUTP-biotin nick-end labeling (TUNEL) staining...
  23. doi request reprint Exercise exerts neuroprotective effects on Parkinson's disease model of rats
    Naoki Tajiri
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1310:200-7. 2010
    ..The results suggest that exercise exerts neuroprotective effects or enhances the neuronal differentiation in Parkinson's disease model of rats with subsequent improvement in deteriorated motor function...
  24. doi request reprint The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting
    Meng Jing
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Brain Res 1295:203-17. 2009
    ..This study might shed light on the cytoarchitectural mechanisms of temporal lobe epilepsy as well as clarify the effect of adult NSC transplantation with intracerebroventricular EPO infusion for temporal lobe epilepsy...
  25. doi request reprint Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion
    Yoichiro Kikuchi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cell Physiol 226:1390-8. 2011
    ..The present results demonstrate that alterations in urinary 8-OHdG level closely approximate onset and disease progression in PD...
  26. doi request reprint Intrapallidal metabotropic glutamate receptor activation in a rat model of Parkinson's disease: behavioral and histological analyses
    Takashi Agari
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan, 700 8558
    Brain Res 1203:189-96. 2008
    ..The results indicate that the blockade of amphetamine-induced rotations might be at least partially mediated by group I mGluR activation. This study advances the use of selective group I mGluRs directed toward the GP for PD treatment...
  27. doi request reprint The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease
    Judith Thomas Tayra
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1502:55-70. 2013
    ..CEPO-Fc might be a therapeutic tool for patients with Parkinson's disease...
  28. doi request reprint Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats demonstrated potent therapeutic effects, compared to adult neural stem cells
    Kazuya Takahashi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1234:172-82. 2008
    ..Transplantation of NPCs will be a hopeful strategy for stroke patients, although further studies are required for the patient safety and underlying mechanisms...
  29. pmc Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons
    Wen Ji Yuan
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    BMC Neurosci 9:75. 2008
    ..In parallel, edaravone or saline was intravenously administered for PD model of rats receiving intrastriatal 6-OHDA lesion with subsequent behavioral and histological analyses...
  30. ncbi request reprint Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat
    Kazuki Kobayashi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Japan
    Brain Res 1102:1-11. 2006
    ....
  31. ncbi request reprint Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Cell Transplant 15:231-8. 2006
    ..An equally major finding is the observation lending support to the hippocampus as an excellent target brain region for stem cell therapy in treating HI injury...
  32. ncbi request reprint Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: in vitro evidence of expedited neuronal differentiation and GDNF secretion
    Koichi Hara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Neurosci Res 85:1240-51. 2007
    ..Nurr1 cell grafts in ischemic stroke, with in vitro evidence suggesting the cells' excellent neuronal differentiation capability and ability to secrete GDNF as likely mechanisms mediating the observed therapeutic benefits...
  33. pmc Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
    Noriyuki Matsukawa
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    BMC Neurosci 10:126. 2009
    ..Assessment of the mechanism underlying minocycline neuroprotection should clarify the drug's clinical value in acute stroke setting...
  34. pmc Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912 3200, USA
    J Cereb Blood Flow Metab 28:1804-10. 2008
    ..These results show that intravenous delivery of MAPCs is a feasible and efficacious cell therapy with potential for clinical use...
  35. doi request reprint Injection of muscimol, a GABAa agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdala-kindled rats
    Satoshi Kuramoto
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurol Res 31:407-13. 2009
    ....
  36. doi request reprint Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesis
    Tomohito Kadota
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Brain Res 1254:120-7. 2009
    ..These results suggest that continuous low dose infusion of EPO exerts neuroprotective/rescue effects with neurogeneic potentials. EPO might be a strong tool for PD therapy, although the further experiments should be added...
  37. doi request reprint BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats
    Satoshi Kuramoto
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, Japan
    Brain Res 1368:281-9. 2011
    ..These results might suggest the importance of the dose and administrative way of this neurotrophic factor to the epilepsy model of animals...
  38. doi request reprint Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats
    Akihiko Kondo
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Brain Res 1296:127-36. 2009
    ....
  39. ncbi request reprint Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: a pilot study
    Koichi Hara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res Bull 74:164-71. 2007
    ..Additional studies are warranted to reveal behavioral deficits associated with this ischemia model...
  40. ncbi request reprint Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia
    Akimasa Yano
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Neurosurg 103:104-14. 2005
    ..The authors evaluated the neuroprotective and angiogenic effects of a continuous and low-dose infusion of vascular endothelial growth factor (VEGF)-165 on cerebral ischemia in rats...
  41. doi request reprint Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/Akt signaling pathway
    Tanefumi Baba
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Stroke 40:e598-605. 2009
    ..Neuroprotective effects of electric stimulation have been recently shown in ischemic stroke, but the underlying mechanisms remain poorly understood...
  42. doi request reprint Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia, USA
    Stem Cells Dev 18:1501-14. 2009
    ..The present study demonstrates the potential of Notch-induced BMSC cell therapy for patients presenting with fixed ischemic stroke...
  43. doi request reprint Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke
    Koichi Hara
    Department of Neurology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Prog Neurobiol 85:318-34. 2008
    ..Such highly potent neuronal lineage commitment and neurotrophic factor secretory function of NT2.Nurr1 cells make them an appealing graft source for transplantation therapy...
  44. ncbi request reprint Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 26:12497-511. 2006
    ..These results suggest that HB1.F3 cell transplantation exerts neuroprotective effects against dopaminergic depletion in vitro and in vivo because of trophic factor secretion and neuronal differentiation...
  45. doi request reprint Striatal stimulation nurtures endogenous neurogenesis and angiogenesis in chronic-phase ischemic stroke rats
    Takamasa Morimoto
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Cell Transplant 20:1049-64. 2011
    ..These results provide evidence that SS affords neurorestoration at the chronic phase of stroke by stimulating endogenous neurogenesis and angiogenesis...
  46. ncbi request reprint Transplantation of bone marrow-derived stem cells: a promising therapy for stroke
    Yamei Tang
    Department of Neurology, Medical College of Georgia, Augusta 30912 3200, USA
    Cell Transplant 16:159-69. 2007
    ..The phenotypic features of MSCs and MAPCs, as well as their application in stroke, are described...
  47. doi request reprint Comparison of the therapeutic potential of adult and embryonic neural precursor cells in a rat model of Parkinson disease
    Kenichiro Muraoka
    Department of Neurosurgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
    J Neurosurg 108:149-59. 2008
    ..The therapeutic effects of adult and embryonic neural precursor cells (NPCs) were evaluated and their therapeutic potential compared in a rat model of Parkinson disease...
  48. ncbi request reprint Spinal Cord Stimulation Exerts Neuroprotective Effects against Experimental Parkinson's Disease
    Aiko Shinko
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan
    PLoS ONE 9:e101468. 2014
    ..SCS is supposed to suppress or delay PD progression and might become a less invasive option for PD patients, although further preclinical and clinical investigations are needed to confirm the effectiveness and safety. ..
  49. ncbi request reprint [Autologous transplantation of adult derived neural stem cells]
    Tetsuro Shingo
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    No Shinkei Geka 35:823-9. 2007
  50. doi request reprint Dietary supplementation exerts neuroprotective effects in ischemic stroke model
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Rejuvenation Res 11:201-14. 2008
    ..These data demonstrate the remarkable neuroprotective effects of NT-020 when given prior to stroke, possibly acting via its neurogenic potential...
  51. ncbi request reprint Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury
    Yu Okuma
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurosci Lett 554:156-61. 2013
    ..Intra-arterial transplantation of MSCs combined with mannitol is an effective treatment in a TBI model of rats. This technique might be used for patients with diseases of the central nervous system including TBI. ..
  52. ncbi request reprint Cognitive functions in Parkinson's disease: relation to disease severity and hallucination
    Takaaki Wakamori
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Parkinsonism Relat Disord 20:415-20. 2014
    ..We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF)...
  53. pmc Laterality of cervical disc herniation
    Yuichi Takahashi
    Department of Spine and Spinal Surgery, Shinkomonji Hospital, 2 5, Dairishinmachi, Moji, Kitakyushu, Fukuoka 800 0057, Japan
    Eur Spine J 22:178-82. 2013
    ..Cervical disc herniation (CDH) is found more frequently at the lower cervical spine than at the upper or middle level. However, there is scarcity of data about the laterality of CDH. The aim of this study is to detect the laterality of CDH...
  54. ncbi request reprint Transplantation of cryopreserved human bone marrow-derived multipotent adult progenitor cells for neonatal hypoxic-ischemic injury: targeting the hippocampus
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Rev Neurosci 17:215-25. 2006
    ..Seven-day old Sprague-Dawley rats were initially subjected to unilateral HI injury, that involved permanent ligation of the right common carotid artery and subsequent exposure to hypoxic environment. At day 7 after HI..
  55. ncbi request reprint [Spontaneous thrombosis of a fusiform aneurysm arising from the distal posterior cerebral artery: case report]
    Akihiko Kondo
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan
    No Shinkei Geka 31:189-93. 2003
    ..This is the first case of complete spontaneous thrombosis of an aneurysm of the distal posterior cerebral artery. The mechanism of its development and spontaneous thrombosis in a fusiform aneurysm is discussed...
  56. ncbi request reprint Nanotechnology as an adjunct tool for transplanting engineered cells and tissues
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30904, USA
    Curr Mol Med 7:609-18. 2007
    ..This review article discusses recent progress in the field of nanotechnology as a tool for tissue engineering, gene therapy, cell immunoisolation, and cell imaging, highlighting its direct applications in cell transplantation therapy...
  57. doi request reprint Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse
    Tadashi Masuda
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    Brain Res 1355:228-39. 2010
    ....
  58. ncbi request reprint Multiple intracranial hemorrhages after cervical spinal surgery
    Yuichi Takahashi
    Department of Spine and Spinal Surgery, Shinkomonji Hospital, Fukuoka, Japan
    Neurol Med Chir (Tokyo) 52:643-5. 2012
    ..Wound drainage should be controlled thoroughly even in patients without intraoperative liquorrhea...
  59. ncbi request reprint Gene therapy, cell transplantation and stroke
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30904, USA
    Front Biosci 11:1090-101. 2006
    ..This chapter will also highlight some of the most recent findings regarding NT2N cells...
  60. doi request reprint Neurological disorders and neural regeneration, with special reference to Parkinson's disease and cerebral ischemia
    Isao Date
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Okayama, Japan
    J Artif Organs 12:11-6. 2009
    ..The biological features of various types of stem cells have been widely investigated and will be applied to the treatment of neurological disorders through cell transplantation...
  61. ncbi request reprint Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats
    Takao Yasuhara
    Movement Disorders Program, Department of Neurology, Medical College of Georgia, 1429 Harper Street, HF 1121, Augusta, GA 30912, USA
    Brain Res 1133:49-52. 2007
    ..The present results support 8-OHdG as a biomarker that may aid both in the diagnosis and in the documentation of progression in PD...
  62. ncbi request reprint Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemia
    M Kameda
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho Okayama, Okayama, 700 8558, Japan
    Eur J Neurosci 26:1462-78. 2007
    ..Moreover, the NSPC-GDNF group showed more effective inhibition of microglial invasion and apoptosis. These findings suggest that NSPC-GDNF may be useful in treatment of cerebral ischemia...
  63. ncbi request reprint Noonan syndrome with occipito-atlantal dislocation and upper cervical cord compression due to C1 dysplasia and basilar invagination
    Yasuyuki Miyoshi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurol Med Chir (Tokyo) 51:463-6. 2011
    ..CT demonstrated solid bony fusion between the occipital bone and C2 at 8 months after surgery. Cervical neuraxial malformations are rare in patients with Noonan syndrome...
  64. ncbi request reprint Posterior decompression of far-out foraminal stenosis caused by a lumbosacral transitional vertebra--case report
    Yasuyuki Miyoshi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama, Japan
    Neurol Med Chir (Tokyo) 51:153-6. 2011
    ..This case illustrates the effectiveness and some refinements of posterior decompression for radicular pain caused by far-out foraminal stenosis below a TV and compression of the L5 spinal nerve...
  65. doi request reprint Overheated and melted intracranial pressure transducer as cause of thermal brain injury during magnetic resonance imaging: case report
    Reiichiro Tanaka
    Department of Critical Care and Emergency Medicine, Okayama University Hospital, Okayama, Japan
    J Neurosurg 117:1100-9. 2012
    ..Strict adherence to the manufacturer's guidelines is very important for preventing serious complications in patients with ICP monitors undergoing MRI examinations...
  66. ncbi request reprint The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke
    Feifei Wang
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 66:429-34. 2012
    ..In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke...
  67. ncbi request reprint [Mist irrigation system at drilling in spinal surgery]
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Kita ku, Okayama, Japan
    No Shinkei Geka 38:1103-7. 2010
    ..As a conclusion, MIS might help surgeons to drill in the deep and narrow operative field. Additionally it might help to reduce the risks of heat injury to neuronal tissue by cooling efficiently...
  68. ncbi request reprint The high integration and differentiation potential of autologous neural stem cell transplantation compared with allogeneic transplantation in adult rat hippocampus
    K Muraoka
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700 8558, Japan
    Exp Neurol 199:311-27. 2006
    ....
  69. ncbi request reprint De novo formation and rupture of an aneurysm. Case report
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Neurosurg 97:697-700. 2002
    ..Aneurysms can enlarge considerably in 2 to 4 weeks and can rupture at or soon after their formation. This case provides insight into aneurysm formation and rupture...
  70. ncbi request reprint Infantile cervical intramedullary cavernous angioma manifesting as hematomyelia. Case report
    Yasuyuki Miyoshi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okaya, Japan
    Neurol Med Chir (Tokyo) 50:677-82. 2010
    ..This case of infantile intramedullary spinal cord cavernous angioma presenting with cervical hematomyelia shows osteoplastic laminotomy of the cervical spine might be helpful to prevent consequent cervical deformity in pediatric cases...
  71. ncbi request reprint Overexpression of D2/D3 receptors increases efficacy of ropinirole in chronically 6-OHDA-lesioned Parkinsonian rats
    N Matsukawa
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res 1160:113-23. 2007
    ..These data support the use of the subtherapeutic dose of ropinirole in a chronic model of PD...
  72. ncbi request reprint Grafting of glial cell line-derived neurotrophic factor secreting cells for hypoxic-ischemic encephalopathy in neonatal rats
    Shinji Katsuragi
    Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake cho, Miyazaki, Japan
    Am J Obstet Gynecol 192:1137-45. 2005
    ..The aim of this study was to examine the neuroprotective effect of glial cell line-derived neurotrophic factor with the use of this delivery system...
  73. ncbi request reprint Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats
    Shinji Katsuragi
    Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake cho, Miyazaki, Japan
    Am J Obstet Gynecol 192:1028-37. 2005
    ..We examined the effect of glial cell line-derived neurotrophic factors on long-term learning and memory impairment and morphological changes up to 18 weeks after hypoxic-ischemic stress in neonatal rats...
  74. ncbi request reprint Cell transplantation: stem cells in the spotlight
    Cesar V Borlongan
    Neurology, Institute of Molecular Medicine and Genetics, School of Graduate Studies, Medical College of Georgia, Augusta 30912 3200, USA
    Cell Transplant 14:519-26. 2005