Hiroshi Ujike

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint [Overview of genetics and substance use disorders]
    Manabu Takaki
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Nihon Rinsho 68:1451-6. 2010
  2. ncbi request reprint Lack of association between polymorphisms in the 5' upstream region of the DISC1 gene and mood disorders
    Makoto Arai
    Psychiatr Genet 17:357. 2007
  3. ncbi request reprint Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population
    Talal Albalushi
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:392-6. 2008
  4. ncbi request reprint The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 5 1 Shikata cho, Okayama, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:54-8. 2008
  5. ncbi request reprint The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Biol Psychiatry 63:191-6. 2008
  6. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
  7. ncbi request reprint Gene expression related to synaptogenesis, neuritogenesis, and MAP kinase in behavioral sensitization to psychostimulants
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Medical School and Graduate School of Medicine and Dentistry, Okayama, Japan
    Ann N Y Acad Sci 965:55-67. 2002
  8. doi request reprint Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:625-9. 2009
  9. ncbi request reprint Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Clin Psychiatry 69:1416-22. 2008
  10. ncbi request reprint New perspectives in the studies on endocannabinoid and cannabis: cannabinoid receptors and schizophrenia
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Pharmacol Sci 96:376-81. 2004

Collaborators

Detail Information

Publications89

  1. ncbi request reprint [Overview of genetics and substance use disorders]
    Manabu Takaki
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Nihon Rinsho 68:1451-6. 2010
    ..In contrast, some specific genetic risks or protective factors for individual drug are also found. This paper reviews the current status of research into the genetics of substance dependence...
  2. ncbi request reprint Lack of association between polymorphisms in the 5' upstream region of the DISC1 gene and mood disorders
    Makoto Arai
    Psychiatr Genet 17:357. 2007
  3. ncbi request reprint Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population
    Talal Albalushi
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:392-6. 2008
    ..Our data indicate that SNPs previously reported to be associated with schizophrenia do not contribute to genetic susceptibility to schizophrenia...
  4. ncbi request reprint The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 5 1 Shikata cho, Okayama, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:54-8. 2008
    ..000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis...
  5. ncbi request reprint The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Biol Psychiatry 63:191-6. 2008
    ..DTNBP1 may confer susceptibility to psychotic symptoms in various psychiatric disorders besides schizophrenia...
  6. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
    ..We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis...
  7. ncbi request reprint Gene expression related to synaptogenesis, neuritogenesis, and MAP kinase in behavioral sensitization to psychostimulants
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Medical School and Graduate School of Medicine and Dentistry, Okayama, Japan
    Ann N Y Acad Sci 965:55-67. 2002
    ..In contrast, later maintenance process of sensitization may require only limited plastic modification in restricted regions...
  8. doi request reprint Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:625-9. 2009
    ..00037, OR=3.62, 95% CI 2.48-5.28). These findings revealed that genetic variants of DRD2, but not DRD3 or DRD4, confer individual risks for rapid onset, prolonged duration, and spontaneous relapse of methamphetamine psychosis...
  9. ncbi request reprint Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Clin Psychiatry 69:1416-22. 2008
    ..The aim of this investigation was identification of genetic risk factors associated with olanzapine-induced weight gain...
  10. ncbi request reprint New perspectives in the studies on endocannabinoid and cannabis: cannabinoid receptors and schizophrenia
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Pharmacol Sci 96:376-81. 2004
    ..3-fold higher susceptibility to schizophrenia. Recent findings consistently indicate that hyperactivity of the central cannabinoid system is involved in the pathogenesis of schizophrenia or the neural mechanisms of negative symptoms...
  11. ncbi request reprint Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis
    H Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Pharmacogenomics J 3:242-7. 2003
    ..0054, OR=4.24, 95% CI=2.46-7.31). The present study demonstrated that the presence of nine- or fewer repeat alleles of hDAT1 is a strong risk factor for a worse prognosis of METH psychosis...
  12. ncbi request reprint Association study of the dihydropyrimidinase-related protein 2 gene and methamphetamine psychosis
    H Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 1074:90-6. 2006
    ..These findings indicate that a genetic variant of the DRP-2 gene may not affect the risk of METH psychosis or any clinical phenotype of the disorder...
  13. ncbi request reprint Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Ann N Y Acad Sci 1025:279-87. 2004
    ..Molecular findings using animal sensitization models may facilitate a better understanding of, and open the way for innovative therapies for, METH psychosis and also chronic schizophrenia...
  14. ncbi request reprint [Potential genetic predictors for individual vulnerability to substance dependence]
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:11-7. 2008
    ..Odds ratios of these positive or negative risks ranged from about 0.2 to 15. These findings must be informative for drug dependence rehabilitation programs and psycho-education of substance dependence...
  15. pmc The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Behav Brain Funct 4:37. 2008
    ..abstract:..
  16. ncbi request reprint Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder
    H Ujike
    Department of Neuropsychiatry, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Psychiatry Res 101:203-7. 2001
    ..There were no significant differences in the CAG repeat number of longer or shorter alleles among the four diagnostic groups or among the schizophrenia hebephrenic and paranoid subtypes...
  17. ncbi request reprint [Advanced findings on the molecular mechanisms for behavioral sensitization to psychostimulants]
    H Ujike
    Department of Neuropsychiatry, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nihon Yakurigaku Zasshi 117:5-12. 2001
    ..Although in these areas are still in progress, accumulating findings will elucidate the details of the molecular mechanism of behavioral sensitization and dependence...
  18. ncbi request reprint NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder
    H Ujike
    Department of Neuropsychiatry, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Neurosci Lett 301:41-4. 2001
    ..The present study found that the NOTCH4 gene does not confer susceptibility to schizophrenia and schizoaffective disorders, at least in Japanese subjects, in contrast to the findings in British subjects...
  19. ncbi request reprint A family with X-linked dystonia-deafness syndrome with a novel mutation of the DDP gene
    H Ujike
    Department of Neuropsychiatry, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arch Neurol 58:1004-7. 2001
    ..X-linked dystonia-deafness syndrome (DDS) is characterized by early-onset deafness followed by progressive dystonia in adulthood. Only 4 families with the syndrome have been reported, and all were white...
  20. doi request reprint Association study of gender identity disorder and sex hormone-related genes
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:1241-4. 2009
    ..The present findings do not provide any evidence that genetic variants of sex hormone-related genes confer individual susceptibility to MTF or FTM transsexualism...
  21. ncbi request reprint Stimulant-induced psychosis and schizophrenia: the role of sensitization
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Curr Psychiatry Rep 4:177-84. 2002
    ..Accordingly, common molecular mechanisms of sensitization phenomena must develop in these three conditions, and are overviewed in this review..
  22. ncbi request reprint Prevalence of homozygous deletions of the parkin gene in a cohort of patients with sporadic and familial Parkinson's disease
    H Ujike
    Department of Neuropsychiatry, Okayama University Medical School, Japan
    Mov Disord 16:111-3. 2001
    ..On the other hand, deletions were not found in any adult-onset cases (> 40 y). Half of the patients with parkin gene-related Parkinson's disease lacked both heredity and consanguinity...
  23. ncbi request reprint A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 376:182-7. 2005
    ..Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia...
  24. doi request reprint Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
    Kyohei Otani
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 434:88-92. 2008
    ..0212), with an odds ratio of 0.62 (95% confidence interval: 0.51-0.76). The present study demonstrated that reduced CYP2D6 activity was a negative risk factor for methamphetamine dependence...
  25. ncbi request reprint No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans
    Kenji Nakata
    Okayama University Graduate School of Medicine and Dentistry, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 349:171-4. 2003
    ..The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD...
  26. ncbi request reprint The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia
    Takeshi Katsu
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 353:53-6. 2003
    ..Our data suggest that dysregulation of the Wnt-signaling pathway may be involved in the susceptibility to schizophrenia...
  27. doi request reprint G72 gene is associated with susceptibility to methamphetamine psychosis
    Tatsuya Kotaka
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:1046-9. 2009
    ..00085) also showed associations with methamphetamine psychosis. The present findings suggest that the G72 gene may contribute to a predisposition to not only schizophrenia but also to methamphetamine psychosis...
  28. pmc No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies
    Naohiko Uchida
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Shikata cho 2 5 1, Okayama, 700 8558, Japan
    BMC Psychiatry 3:13. 2003
    ..It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia...
  29. doi request reprint Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence
    Yuko Okahisa
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Psychiatry Clin Neurosci 63:417-22. 2009
    ..Accordingly, it was hypothesized that the NPY system may also be involved in methamphetamine dependence or psychosis...
  30. ncbi request reprint Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence
    Akira Nomura
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurosci Lett 400:158-62. 2006
    ..83, 95% ci=1.24-2.68)...
  31. ncbi request reprint The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Japan
    Neurosci Lett 383:194-8. 2005
    ..Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence...
  32. ncbi request reprint The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder
    Kyohei Otani
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 381:108-13. 2005
    ..57, 95% confidence interval: 0.44-0.73). These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder...
  33. ncbi request reprint Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia
    Osamu Yokota
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, 700 8558, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:715-21. 2004
    ..These results suggest that celecoxib may affect the pathophysiology of schizophrenia through COX-2-independent actions rather than by inhibiting activity of up-regulated COX-2 protein...
  34. ncbi request reprint The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia
    Kyohei Otani
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 390:166-70. 2005
    ..These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population...
  35. ncbi request reprint A genetic variant of the serine racemase gene is associated with schizophrenia
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Biol Psychiatry 61:1200-3. 2007
    ..Dysfunction of SRR may reduce the function of NMDA receptors and susceptibility to schizophrenia...
  36. ncbi request reprint A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease
    Naohiko Uchida
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Am J Geriatr Psychiatry 13:1062-6. 2005
    ..The authors provide here genetic evidence that the sigma receptor type 1 (SIGMAR1) gene is involved in susceptibility to AD...
  37. doi request reprint Leukemia inhibitory factor gene is associated with schizophrenia and working memory function
    Yuko Okahisa
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:172-6. 2010
    ..04). The present study indicated that the LIF gene variant may produce susceptibility to hebephrenic schizophrenia and deterioration of working memory function...
  38. ncbi request reprint The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia
    Kenji Nakata
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Biol Psychiatry 53:571-6. 2003
    ..In addition, the DRP-2 gene (Dihydropyrimidinase-like 2; DPYSL2) is located on chromosome 8p21, a region that has been implicated in schizophrenia in genetic linkage studies...
  39. ncbi request reprint Lewy body variant of Alzheimer's disease or cerebral type lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem
    Osamu Yokota
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neuropathology 27:21-35. 2007
    ....
  40. ncbi request reprint Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder
    Kenji Nakata
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Japan
    Neurosci Lett 337:17-20. 2003
    ..Furthermore, no significant association was observed between these polymorphisms and either of two diagnostic subtypes (bipolars I and II disorder). The results suggest that the BDNF gene is unlikely to confer susceptibility to BPD...
  41. ncbi request reprint Variability and heterogeneity in Alzheimer's disease with cotton wool plaques: a clinicopathological study of four autopsy cases
    Osamu Yokota
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Acta Neuropathol 106:348-56. 2003
    ....
  42. ncbi request reprint [The human dihydropyrimidinase-related protein 2 (DRP-2) gene on chromosome 8p21 is associated with paranoid-type schizophrenia]
    Kenji Nakata
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Shikata cho, Okayama, 700 8558 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 24:33-7. 2004
    ..0083). These results suggest that the *2236C allele in the 3'UTR of the DRP-2 gene, or an unknown mutation in linkage disequilibrium with this allele, may reduce the susceptibility to schizophrenia, especially the paranoid subtype...
  43. ncbi request reprint Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans
    Osamu Yokota
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Neurosci Lett 343:175-9. 2003
    ..These findings suggest that unknown factors besides Abeta deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease...
  44. ncbi request reprint Association study between the fibronectin gene and schizophrenia
    Kenji Nakata
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Am J Med Genet B Neuropsychiatr Genet 116:41-4. 2003
    ..These data did not provide evidence for a contribution of the FN1 gene to susceptibility to schizophrenia...
  45. ncbi request reprint No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence
    A Morio
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 1074:411-7. 2006
    ..The present findings suggest that the CART gene may not play a pivotal role in the development of METH dependence and psychosis, at least in a Japanese population...
  46. doi request reprint Association study between casein kinase 1 epsilon gene and methamphetamine dependence
    T Kotaka
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann N Y Acad Sci 1139:43-8. 2008
    ..The present findings suggest that having a genetic variant of the CSNK1E gene did not affect susceptibility to methamphetamine dependence or psychosis, at least in a Japanese population...
  47. ncbi request reprint [Molecular genetics of alcohol dependence]
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 43:87-96. 2008
    ..These unexpected new findings by gene-chip technology, which need to be confirmed by case-control association one by one, must bring about breakthrough in investigation of neural mechanisms of alcohol dependence and innovative therapy...
  48. ncbi request reprint A resistance gene in disguise for schizophrenia?
    Nagafumi Doi
    Department of Neuropsychiatry, University of Tokyo, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 144:165-73. 2007
    ..485 T most likely confers resistance but not susceptibility to schizophrenia. An interaction between a nuclear resistance gene and a presumptive pathogenic gene in the mitochondrial DNA was suggested...
  49. ncbi request reprint CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia
    H Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Japan
    Mol Psychiatry 7:515-8. 2002
    ..011, OR = 0.208, 95% CI (0.098-0.439)). The present findings indicated that certain alleles or genotypes of the CNR1 gene may confer a susceptibility of schizophrenia, especially of the hebephrenic type...
  50. ncbi request reprint Association study of the tumor necrosis factor-alpha gene and its 1A receptor gene with methamphetamine dependence
    A Nomura
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 1074:116-24. 2006
    ..These results suggest that genetic variations in the TNF-alpha gene and its receptor genes may not be involved in individual vulnerability to METH dependence...
  51. ncbi request reprint A robust increase in expression of arc gene, an effector immediate early gene, in the rat brain after acute and chronic methamphetamine administration
    M Kodama
    Department of Neuropsychiatry, Okayama University Medical School, Japan
    Brain Res 796:273-83. 1998
    ....
  52. ncbi request reprint Two kinds of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-3, are differentially activated by acute and chronic methamphetamine treatment in the rat brain
    M Takaki
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama, Japan
    J Neurochem 79:679-88. 2001
    ....
  53. ncbi request reprint A case of adult-onset adrenoleukodystrophy with frontal lobe dysfunction: a novel point mutation in the ABCD1 gene
    Shinichiro Inoue
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Intern Med 51:1403-6. 2012
    ..Severe brain hypoperfusion in the frontal lobes was revealed. We believe that this is a rare case of adult-onset adrenoleukodystrophy with predominant frontal lobe dysfunction...
  54. ncbi request reprint A polymorphism of DRD2 gene and brain atrophy in methamphetamine psychosis
    M Harano
    Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Ann N Y Acad Sci 1025:307-15. 2004
    ..It is suggested that in methamphetamine psychosis the TaqI A polymorphism not only regulates prolongation of psychosis symptoms but also influences the form of the temporal lobe...
  55. ncbi request reprint Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain
    M Takaki
    Department of Neuropsychiatry, Okayama University Medical School, Japan
    Neuroreport 12:1055-60. 2001
    ..Therefore, synaptophysin and stathmin play an important role in the neural plastic changes involved in the early induction process of METH-induced sensitization, but not in the later maintenance process...
  56. ncbi request reprint NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases
    Osamu Yokota
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Acta Neuropathol 104:637-48. 2002
    ....
  57. ncbi request reprint BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats
    K Okumura
    Department of Neuropsychiatry, Okayama University Medical School, Japan
    J Neural Transm 103:1153-61. 1996
    ..Therefore, it is suggested that typical neuroleptics such as haloperidol act agonistic and atypical neuroleptics such as BMY-14802 act antagonistic at rubral sigma receptors in the induction of neck dystonia...
  58. doi request reprint Blonanserin, an antipsychotic and dopamine D(2)/D(3) receptor antagonist, and ameliorated alcohol dependence
    Manabu Takaki
    Department of Neuropsychiatry Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan
    Clin Neuropharmacol 36:68-9. 2013
    ..Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence...
  59. ncbi request reprint [Molecular biology of drug dependence and behavioral sensitization]
    Hiroshi Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
    Seishin Shinkeigaku Zasshi 104:1055-68. 2002
    ..These plastic changes with structural modification of neural networks in the CNS during drug abuse could induce and reinforce psychological dependence and susceptibility to drug-induced psychoses, which become increasingly intractable...
  60. ncbi request reprint No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population
    Ayumu Sakai
    Kasaoka Hospital, Kasaoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 125:87-91. 2004
    ..The present study indicates that the IDE gene polymorphisms do not confer susceptibility to early- or late-onset AD at least in a Japanese population...
  61. doi request reprint Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
    Schizophr Res 101:1-8. 2008
    ..Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases...
  62. doi request reprint Genome-wide association for methamphetamine dependence: convergent results from 2 samples
    George R Uhl
    Molecular Neurobiology Branch, National Institutes of Health Intramural Program, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Arch Gen Psychiatry 65:345-55. 2008
    ..We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent and treat this devastating disorder, by identifying genes whose allelic variants predispose to methamphetamine dependence...
  63. doi request reprint A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia
    Tsuyuka Ohtsuki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Schizophr Res 101:9-16. 2008
    ..The GRM7 gene is located on human chromosome 3p26, which has been suggested by linkage analysis to contain a susceptibility locus for schizophrenia...
  64. doi request reprint Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia
    Ayako Nunokawa
    Psychiatry Clin Neurosci 62:239-40. 2008
  65. ncbi request reprint Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease
    Ayumu Sakai
    Kasaoka Hospital, Kasaoka, Japan
    Dement Geriatr Cogn Disord 17:164-9. 2004
    ..0007). Our findings suggest that the GT-repeat polymorphism in the promoter region of the NEP gene or some other unknown polymorphisms, which are in a linkage disequilibrium, confer a susceptibility to late-onset AD...
  66. doi request reprint Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia
    Masashi Ikeda
    Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Hum Mol Genet 17:3212-22. 2008
    ..Our results suggest that YWHAE is a possible susceptibility gene that functions protectively in schizophrenia...
  67. ncbi request reprint Association between a novel polymorphism in the promoter region of the neuropeptide Y gene and schizophrenia in humans
    Masanari Itokawa
    Department of Schizophrenia Research, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya, 156 8585, Tokyo, Japan
    Neurosci Lett 347:202-4. 2003
    ..These results suggest that the -485T allele in NPY may confer susceptibility to schizophrenia by decreasing the neuropeptide in brains...
  68. ncbi request reprint Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis
    Hideaki Kobayashi
    Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:482-6. 2006
    ..These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis...
  69. ncbi request reprint Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 126:43-5. 2004
    ..007, odds ratio: 2.77, 95% CI 1.30-5.89) higher than that of male abusers with deletion alleles. These findings suggest that GSTM1 gene deletion may contribute to a vulnerability to MAP abuse in female subjects, but not in male subjects...
  70. doi request reprint Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1040-6. 2008
    ..The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population...
  71. ncbi request reprint Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese...
  72. ncbi request reprint Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder
    Nagisa Aoyama
    Department of Medical Technology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Alcohol Clin Exp Res 30:1644-9. 2006
    ..Moreover, SLC22A3 (which encodes OCT3) is a candidate gene for MAP dependence because it is located within a chromosomal region associated with substance dependence...
  73. ncbi request reprint Correlation of tau gene polymorphism with age at onset of Parkinson's disease
    Hideaki Kobayashi
    Department of Psychobiology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Neurosci Lett 405:202-6. 2006
    ..098, P=0.0243). These results suggested that MAPT gene variants may modify the pathogenesis process of PD...
  74. ncbi request reprint An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder
    Atsuko Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, and Ichihara Hospital, Chiba, Japan
    Psychiatr Genet 16:133-8. 2006
    ..This study aimed to investigate whether a functional polymorphism of the catechol-O-methyl transferase gene would be involved in the development of these psychiatric states...
  75. ncbi request reprint Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Genet 120:243-52. 2006
    ..014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis...
  76. ncbi request reprint Association analysis of chromosome 5 GABAA receptor cluster in Japanese schizophrenia patients
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Biol Psychiatry 58:440-5. 2005
    ..A GABA(A) receptor gene cluster on 5q31-35 (beta2 [GABRB2], alpha6 [GABRA6], alpha1 [GABRA1], and gamma2 [GABRG2] subunit genes) is one of the most attractive candidate regions for schizophrenia susceptibility...
  77. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  78. ncbi request reprint NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice
    Hiroki Ishiguro
    Molecular Neurobiology Branch, NIDA IRP, NIH, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:572-84. 2006
    ..These observations support NrCAM as a positionally cloned and drug-regulated gene whose variants are likely to change expression and alter substance abuse vulnerabilities in human addictions and animal models of drug reward...
  79. ncbi request reprint Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Int J Neuropsychopharmacol 9:77-81. 2006
    ..Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition...
  80. ncbi request reprint Identification of a risk haplotype of the alpha-synuclein gene in Japanese with sporadic Parkinson's disease
    Hideaki Kobayashi
    Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mov Disord 21:2157-64. 2006
    ..23 [95% confidence interval, 0.16-0.32] and 1.51 [95% confidence interval, 1.29-1.75]). In conclusion, our findings indicate that genetic variations of the alpha-synuclein gene affect the development of sporadic PD...
  81. ncbi request reprint Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals
    Makoto Arai
    Department of Schizophrenia Research, Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Biol Psychiatry 55:804-10. 2004
    ..Disturbance of these neurodevelopmental processes is proposed as one etiology for mood disorder. We therefore undertook genetic analysis of NCAM1 in mood disorders...
  82. ncbi request reprint Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  83. ncbi request reprint Association study of polymorphisms in the 5' upstream region of human DISC1 gene with schizophrenia
    Thessa T J P Kockelkorn
    Department of Schizophrenia Research, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Neurosci Lett 368:41-5. 2004
    ..These results suggest that the genomic interval of DISC1 probably involved in transcriptional regulation does not display major genetic relevance in Japanese schizophrenia patients...
  84. ncbi request reprint Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 132:70-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  85. ncbi request reprint Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population
    Minori Koga
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Lett 417:326-9. 2007
    ..79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia...
  86. ncbi request reprint Gene polymorphisms of the mu opioid receptor in methamphetamine abusers
    Soichiro Ide
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Ann N Y Acad Sci 1025:316-24. 2004
    ..Further analysis should be capable of identifying associations between the OPRM variations and MAP dependence/psychosis...
  87. ncbi request reprint Study of association between alpha-synuclein gene polymorphism and methamphetamine psychosis/dependence
    Hideaki Kobayashi
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Ann N Y Acad Sci 1025:325-34. 2004
    ..Further analyses are necessary to clarify the gender difference, by using a larger sample size and/or different ethnic groups, as well as functional variations in the alpha-synuclein gene...
  88. ncbi request reprint A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005
    ..Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population...
  89. ncbi request reprint Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia
    Makoto Arai
    Department of Schizophrenia Research, Tokyo Institute of Psychiatry, Tokyo, Japan
    Biol Psychiatry 59:652-9. 2006
    ..Altered levels of the PSA-NCAM1 in the brain of schizophrenics have been reported, suggesting a role for this molecule in the disorder...