Affiliation: Okayama University
Ochi E, Nosaka K, Tsutaki A, Kouzaki K, Nakazato K. Repeated bouts of fast velocity eccentric contractions induce atrophy of gastrocnemius muscle in rats. J Muscle Res Cell Motil. 2015;36:317-27 pubmed publisher
..05). The level of Bax, a pro-apoptotic protein, was greater (p < 0.05) for 180EC than control. These results support the hypothesis that muscles are atrophied by repeated bouts of fast but not slow velocity eccentric contractions. ..
Lee K, Ochi E, Song H, Nakazato K. Activation of AMP-activated protein kinase induce expression of FoxO1, FoxO3a, and myostatin after exercise-induced muscle damage. Biochem Biophys Res Commun. 2015;466:289-94 pubmed publisher
..Therefore, we conclude that activation of AMPK plays a key role in increasing the level of FoxO1, FoxO3a, and myostatin in gastrocnemius after EIMD. ..