Fusanori Nishimura

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Periodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expression
    F Nishimura
    Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    Horm Metab Res 38:530-5. 2006
  2. ncbi request reprint Periodontal disease as part of the insulin resistance syndrome in diabetic patients
    Fusanori Nishimura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    J Int Acad Periodontol 7:16-20. 2005
  3. ncbi request reprint Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship
    Fusanori Nishimura
    Department of Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Periodontol 74:97-102. 2003
  4. pmc Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice
    Fusanori Nishimura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Am J Pathol 161:2047-52. 2002
  5. doi request reprint IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts
    Tomoko Yamaguchi
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cell Physiol 217:423-32. 2008
  6. ncbi request reprint High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts
    Kazuhiro Omori
    Department of Pathophysiology, Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8525, Japan
    J Biol Chem 279:6643-9. 2004
  7. doi request reprint Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation
    Yuko Sugiura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Support Care Cancer 18:395-8. 2010
  8. ncbi request reprint Macrophage-adipocyte interaction: marked interleukin-6 production by lipopolysaccharide
    Akiko Yamashita
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Obesity (Silver Spring) 15:2549-52. 2007
  9. ncbi request reprint Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts
    Mayumi Yamaguchi
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Periodontal Res 39:320-6. 2004
  10. ncbi request reprint Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice
    Milan Petelin
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8525, Japan
    Exp Mol Pathol 76:76-81. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Periodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expression
    F Nishimura
    Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    Horm Metab Res 38:530-5. 2006
    ..It can be concluded that Pg infection is associated with increased LDL-cholesterol in diabetic subjects, which may be accompanied by increased cholesterol synthesis by inflammatory cytokines...
  2. ncbi request reprint Periodontal disease as part of the insulin resistance syndrome in diabetic patients
    Fusanori Nishimura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    J Int Acad Periodontol 7:16-20. 2005
    ..Here, we summarize current knowledge supporting this concept primarily based on data obtained from our own studies and propose a new concept that periodontal disease should be considered as part of the insulin resistance syndrome...
  3. ncbi request reprint Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship
    Fusanori Nishimura
    Department of Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Periodontol 74:97-102. 2003
    ..We believe that this interaction is a possible mechanism accounting for a 2-way relationship between type 2 diabetes and periodontal disease...
  4. pmc Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice
    Fusanori Nishimura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Am J Pathol 161:2047-52. 2002
    ..In addition, reduced cathepsin-L activity may play an important role in inducing drug-induced gingival overgrowth...
  5. doi request reprint IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts
    Tomoko Yamaguchi
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cell Physiol 217:423-32. 2008
    ..Our findings indicate that Cav-1 might be a therapeutic target for IL-6-mediated tissue degradation in periodontitis...
  6. ncbi request reprint High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts
    Kazuhiro Omori
    Department of Pathophysiology, Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8525, Japan
    J Biol Chem 279:6643-9. 2004
    ..Thus, elevated VEGF secretion in HGFs under the HG condition may play a role in the development of the severe periodontitis observed in diabetic patients...
  7. doi request reprint Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation
    Yuko Sugiura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Support Care Cancer 18:395-8. 2010
    ..This study was performed to determine the in vivo effects of Oralbalance on oral mucosal total bacterial counts in patients undergoing HCT...
  8. ncbi request reprint Macrophage-adipocyte interaction: marked interleukin-6 production by lipopolysaccharide
    Akiko Yamashita
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Obesity (Silver Spring) 15:2549-52. 2007
    ..We hypothesized a ligand for toll-like receptor 4 (TLR4), bacterial lipopolysaccharide (LPS), would further exaggerate macrophage-adipocyte interaction...
  9. ncbi request reprint Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts
    Mayumi Yamaguchi
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Periodontal Res 39:320-6. 2004
    ....
  10. ncbi request reprint Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice
    Milan Petelin
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8525, Japan
    Exp Mol Pathol 76:76-81. 2004
    ..These results may suggest that systemically produced sTNFR2 and IL-6 could be a key role to modulate proinflammatory activities of TNF-alpha in Pg-induced lung inflammation simulated aspiration pneumonia...
  11. doi request reprint Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population
    Kazu Takeuchi-Hatanaka
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Clin Periodontol 35:317-23. 2008
    ....
  12. doi request reprint Evaluation of xerostomia in hematopoietic cell transplantation by a simple capacitance method device
    Yuko Sugiura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8525, Japan
    Support Care Cancer 16:1197-200. 2008
    ..We investigated moisture in the oral mucosa in patients undergoing HCT by the capacitance method using a convenient device, Moisture Checker for Mucus (MCM; Life Co., Ltd., Saitama, Japan)...
  13. ncbi request reprint Chronic periodontitis with multiple risk factor syndrome: a case report
    Masayuki Shimoe
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Int Acad Periodontol 13:40-7. 2011
    ..This report describes the clinical course of a patient suffering from severe periodontitis with multiple risk factor syndrome, and discusses the association between periodontal infection and systemic health...
  14. ncbi request reprint High glucose up-regulates lipopolysaccharide-stimulated inflammatory cytokine production via c-jun N-terminal kinase in the monocytic cell line THP-1
    Hirotaka Iwata
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Endotoxin Res 13:227-34. 2007
    ..Therefore, we suggest that this may be one of the mechanisms by which sub-clinical infection by Gram-negative bacteria promotes atherosclerosis in diabetic subjects...
  15. ncbi request reprint Periodontal treatment in severe aplastic anemia
    Kosuke Oyaizu
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    J Periodontol 76:1211-6. 2005
    ..However, treatment of periodontitis in the AA patient is significantly complicated by the bleeding disorder. We present a case report of the successful periodontal treatment of an AA patient with spontaneous gingival bleeding...
  16. ncbi request reprint Oligonucleotide array analysis of cyclic tension-responsive genes in human periodontal ligament fibroblasts
    Keisuke Yamashiro
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Int J Biochem Cell Biol 39:910-21. 2007
    ..Mechanical stress was found to effect the expression of numerous genes, in particular, expression of an early responsive gene; FOS initiates alteration of HPLF behaviors to control homeostasis of the periodontal ligament...
  17. ncbi request reprint Detection of periodontal pathogen Porphyromonas gingivalis by loop-mediated isothermal amplification method
    Hiroshi Maeda
    Division of Periodontal Science, Department of Patho physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    FEMS Immunol Med Microbiol 43:233-9. 2005
    ..These findings indicate the potential usefulness of LAMP for detecting and quantifying P. gingivalis, especially in its rapidity and simplicity...
  18. doi request reprint Rapid and simple detection of eight major periodontal pathogens by the loop-mediated isothermal amplification method
    Junko Miyagawa
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    FEMS Immunol Med Microbiol 53:314-21. 2008
    ..These findings suggest the usefulness of the LAMP method for the rapid and simple microbiological diagnosis of periodontitis, and the possibility of LAMP examination without the DNA extraction step...
  19. doi request reprint Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation
    Yoshihiko Soga
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8525, Japan
    Support Care Cancer 19:995-1000. 2011
    ..Here, we examined the bacteria on the buccal mucosa after HCT...
  20. ncbi request reprint Appearance of multidrug-resistant opportunistic bacteria on the gingiva during leukemia treatment
    Yoshihiko Soga
    Department of Pathophysiology, Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Periodontol 79:181-6. 2008
    ..Here, we report a patient with an abnormal increase in multidrug-resistant opportunistic bacteria in the gingiva during hematopoietic cell transplantation (HCT)...
  21. ncbi request reprint C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect
    Koji Naruishi
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Japan
    Transplantation 76:1380-2. 2003
    ..The results indicate that although both SP600125 and CsA are anti-angiogenic by inhibiting VEGF production by way of a JNK-dependent pathway, the inhibitory effect was much stronger with the novel inhibitor of JNK than with CsA...
  22. doi request reprint Febrile neutropenia and periodontitis: lessons from a case periodontal treatment in the intervals between chemotherapy cycles for leukemia reduced febrile neutropenia
    Yoshihiko Soga
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Support Care Cancer 17:581-7. 2009
    ....
  23. ncbi request reprint Tumor necrosis factor-alpha gene (TNF-alpha) -1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese
    Yoshihiko Soga
    Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Clin Periodontol 30:524-31. 2003
    ....
  24. ncbi request reprint Ligation of IFN-gamma-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun N-terminal kinase (JNK) pathway
    Michio Meguro
    Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Cytokine 22:107-15. 2003
    ..Furthermore, ligation of GF HLA-DR with L243 induced selective phosphorylation of JNK-2. We concluded that JNK-2 was one of the HLA-DR-mediated signal transduction pathways...
  25. ncbi request reprint Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis
    Yoshihiro Iwamoto
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Periodontol 74:1231-6. 2003
    ..Since periodontal disease has been suggested to act as a risk factor for atherosclerosis, we examined the effects of antimicrobial periodontal treatment on CRP, adiponectin, and TNF-alpha levels...
  26. ncbi request reprint Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells
    Junji Mineshiba
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    FEMS Immunol Med Microbiol 45:37-44. 2005
    ..Our results suggest that the two NF-(kappa)B binding sites contribute to LPS-mediated hBD-2 transcription while the NF-IL6 binding site represses LPS-independent hBD-2 transcription in the HeLa cells...
  27. ncbi request reprint CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects
    Yoshihiko Soga
    Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Life Sci 74:827-34. 2004
    ....
  28. ncbi request reprint Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria
    Hiroshi Maeda
    Department of Patho physiology, Division of Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    FEMS Immunol Med Microbiol 39:81-6. 2003
    ....
  29. ncbi request reprint Unique genes induced by mechanical stress in periodontal ligament cells
    Fumio Myokai
    Department of Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama, Japan
    J Periodontal Res 38:255-61. 2003
    ..The aim of this study is to isolate mechanical stress-induced genes (MSGens) from human periodontal ligament (PDL) cells and to analyze profiles of the mRNA expression of these genes...
  30. doi request reprint Antimicrobial effects of the saliva substitute, Oralbalance, against microorganisms from oral mucosa in the hematopoietic cell transplantation period
    Yuko Sugiura
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8525, Japan
    Support Care Cancer 16:421-4. 2008
    ..However, HCT patients are severely compromised, and saliva substitute must therefore not promote infection. This study was performed to determine the effects of Oralbalance on microbial species identified during HCT...
  31. ncbi request reprint Counter-antigen presentation: fibroblasts produce cytokines by signalling through HLA class II molecules without inducing T-cell proliferation
    Hideki Ohyama
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8525, Japan
    Cytokine 17:175-81. 2002
    ....
  32. ncbi request reprint Prevalence of blood pressure levels and hypertension-related diseases in Japanese dental patients
    Takuya Miyawaki
    Department of Dental Anesthesiology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Community Dent Health 21:134-7. 2004
    ..To investigate the prevalence of blood pressure levels and hypertension-related diseases and to evaluate the risks associated with dental patients in Japan...
  33. ncbi request reprint A proposed model linking inflammation to obesity, diabetes, and periodontal infections
    Robert J Genco
    Department of Oral Biology, School of Dental Medicine, Office of Science, Technology Transfer, and Economic Outreach STOR, University at Buffalo, Buffalo, NY 14228, USA
    J Periodontol 76:2075-84. 2005
    ....
  34. ncbi request reprint Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka 553 0003, Japan
    Metabolism 55:258-62. 2006
    ..300, P = .003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients...
  35. ncbi request reprint Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes, Kansai Denryoku Hospital, Osaka, Japan
    Metabolism 52:142-5. 2003
    ..4%, P =.009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients...
  36. ncbi request reprint [Diabetes mellitus and periodontal disease]
    Fusanori Nishimura
    Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 60:404-9. 2002
  37. ncbi request reprint Porphyromonas gingivalis infection is associated with elevated C-reactive protein in nonobese Japanese type 2 diabetic subjects
    Fusanori Nishimura
    Diabetes Care 25:1888. 2002
  38. ncbi request reprint The periodontal host response with diabetes
    Fusanori Nishimura
    Department of Dental Science for Health Promotion, Division of Cervico Gnathostomatology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Periodontol 2000 43:245-53. 2007