Masahiro Nishibori

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint The regulation of ICAM-1 and LFA-1 interaction by autacoids and statins: a novel strategy for controlling inflammation and immune responses
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Pharmacol Sci 92:7-12. 2003
  2. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Sci 97:25-30. 2005
  3. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): Preface
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Sci 97:7. 2005
  4. pmc Effect of ciprofloxacin-induced prostaglandin E2 on interleukin-18-treated monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Antimicrob Agents Chemother 49:3228-33. 2005
  5. ncbi request reprint Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 63:65-9. 2009
  6. ncbi request reprint Allergy to carboxymethylcellulose
    N Muroi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Allergy 57:1212-3. 2002
  7. ncbi request reprint The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction
    Goutarou Katsuno
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Clin Immunol 119:110-9. 2006
  8. ncbi request reprint Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Pharmacol 512:223-30. 2005
  9. ncbi request reprint Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Immunol 123:324-32. 2007
  10. ncbi request reprint Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama City 700 8558, Japan
    Clin Immunol 115:85-92. 2005

Collaborators

Detail Information

Publications69

  1. ncbi request reprint The regulation of ICAM-1 and LFA-1 interaction by autacoids and statins: a novel strategy for controlling inflammation and immune responses
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Pharmacol Sci 92:7-12. 2003
    ..The regulation of interaction mediated by adhesion molecules may provide a new target for controlling inflammatory and immune responses...
  2. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Sci 97:25-30. 2005
    ..Thus, MEK-ERK activation plays major role in the PAR-2-mediated proliferative response. The coupling of PARs to calcium signaling and MEK-ERK activation may be independent, and varied dependent on cell types...
  3. ncbi request reprint Physiology and pathophysiology of proteinase-activated receptors (PARs): Preface
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Sci 97:7. 2005
  4. pmc Effect of ciprofloxacin-induced prostaglandin E2 on interleukin-18-treated monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Antimicrob Agents Chemother 49:3228-33. 2005
    ....
  5. ncbi request reprint Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column
    Masahiro Nishibori
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 63:65-9. 2009
    ..The specific removal of monocytes from septic patients may produce beneficial effects by reducing the interaction between monocytes and functionally associated cells including vascular endothelial cells...
  6. ncbi request reprint Allergy to carboxymethylcellulose
    N Muroi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Allergy 57:1212-3. 2002
  7. ncbi request reprint The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction
    Goutarou Katsuno
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Clin Immunol 119:110-9. 2006
    ..Thereby, the inhibitors were found to abolish the actions of CIP. These results therefore suggest that CIP might exert its immune modulatory effects via the production of PGE2...
  8. ncbi request reprint Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Pharmacol 512:223-30. 2005
    ..In conclusion, the mechanism responsible for the effect of prostaglandin E1 on lipopolysaccharide-induced responses is distinct from that of prostaglandin E2...
  9. ncbi request reprint Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Immunol 123:324-32. 2007
    ..Thus, the action mechanism of stain is different from that of calcineurin inhibitors...
  10. ncbi request reprint Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama City 700 8558, Japan
    Clin Immunol 115:85-92. 2005
    ..The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect...
  11. doi request reprint Prostaglandin E2 inhibits advanced glycation end product-induced adhesion molecule expression, cytokine production, and lymphocyte proliferation in human peripheral blood mononuclear cells
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Exp Ther 331:656-70. 2009
    ..These results as a whole indicated that PGE(2) inhibited the actions of AGE-2 and AGE-3 via EP(2)/EP(4) receptors and the cAMP/PKA pathway...
  12. ncbi request reprint Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Immunol 116:211-6. 2005
    ..The effects of simvastatin were abolished by the addition of the product of the HMG-CoA reductase, mevalonate, indicating the involvement of HMG-CoA reductase in the action of simvastatin...
  13. ncbi request reprint The immunosuppressive effects of nicotine during human mixed lymphocyte reaction
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Pharmacol 559:69-74. 2007
    ..The inhibitors of cyclooxygenase (COX)-2 and protein kinase A (PKA) at 100 microM inhibited the actions of nicotine, suggesting that the endogenous prostaglandin E(2) might be, at least, partially involved the actions of nicotine...
  14. doi request reprint Prostaglandin E2 inhibits advanced glycation end product-induced adhesion molecule expression on monocytes, cytokine production, and lymphocyte proliferation during human mixed lymphocyte reaction
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Pharmacol Exp Ther 334:964-72. 2010
    ..These results as a whole indicate that PGE2 inhibited the actions of AGE-2 and AGE-3 via EP2/EP4 receptors and the cAMP/PKA pathway...
  15. ncbi request reprint Stimulation of adenosine A2A receptor inhibits LPS-induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells
    Ryosuke Hamano
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama, Japan
    Shock 29:154-9. 2008
    ..Thus, adenosine differentially regulates the expression of ICAM-1 and the production of TNF-alpha through plural subtypes of receptors...
  16. doi request reprint Effect of nicotine on advanced glycation end product-induced immune response in human monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Pharmacol Exp Ther 332:1013-21. 2010
    ..These results indicate that the mechanism of action of nicotine may be partially via endogenous PGE(2) production...
  17. ncbi request reprint Effect of adenosine receptor subtypes stimulation on mixed lymphocyte reaction
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    Eur J Pharmacol 564:204-10. 2007
    ..These results suggest that adenosine inhibits the immune responses during mixed lymphocyte reaction via adenosine A(2A) receptor...
  18. ncbi request reprint alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Immunother 28:40-3. 2005
    ..The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin...
  19. ncbi request reprint Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners
    Masanori Yoshii
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    J Pharmacol Sci 98:450-8. 2005
    ..These results as a whole indicated that tryptase has proliferative effects on DLD-1 through cyclooxygenase- and MAP kinase-dependent manners acting on PAR-2 by its proteolytic activity...
  20. ncbi request reprint Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama City
    J Pharmacol Sci 97:447-50. 2005
    ..Anti-ICAM-1 and B7 Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection...
  21. ncbi request reprint The effect of ciprofloxacin on CD14 and toll-like receptor-4 expression on human monocytes
    Goutaro Katsuno
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Shock 25:247-53. 2006
    ..Therefore, CIP might regulate the TNF-alpha production induced by LPS by inhibiting the expression of LPS receptor complex, which seems to be mediated by COX-2 but not the cAMP/PKA pathway...
  22. ncbi request reprint Prostaglandins E1 and E2 inhibit lipopolysaccharide-induced interleukin-18 production in monocytes
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Pharmacol 517:252-6. 2005
    ..Therefore, prostanoid IP, EP2- and EP4-receptors might be involved in the decrease in interleukin-18 production during sepsis...
  23. ncbi request reprint Histamine downregulates CD14 expression via H2 receptors on human monocytes
    Hideo Kohka Takahashi
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    Clin Immunol 108:274-81. 2003
    ..Such inhibition might be due to the down-regulation of CD14 expression on monocytes by histamine...
  24. ncbi request reprint Effect of nicotine on IL-18-initiated immune response in human monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Leukoc Biol 80:1388-94. 2006
    ....
  25. ncbi request reprint E-prostanoid (EP)2/EP4 receptor-dependent maturation of human monocyte-derived dendritic cells and induction of helper T2 polarization
    Shinichiro Kubo
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Pharmacol Exp Ther 309:1213-20. 2004
    ..The matured MoDCs under such conditions preferably induced Th2 polarization, indicating the importance of EP2 and EP4 receptors in the determination of Th1/Th2 development of naive T cells...
  26. ncbi request reprint Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Leukoc Biol 77:400-7. 2005
    ..It was concluded that LFA703 has the inhibitory effect on an IL-18-initiated immune response without any activation on monocytes...
  27. ncbi request reprint Effect of prostaglandin E2 on intercellular adhesion molecule-1 and B7 expression in mixed lymphocyte reaction
    Toshihiko Morichika
    Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
    Transplantation 75:2100-5. 2003
    ..We examined the effect of PGE2 on the expression of ICAM-1 and B7 in the human mixed leukocyte reaction (MLR) in the presence or absence of IL-18...
  28. doi request reprint Histamine inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes
    Hidenori Wake
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Pharmacol Exp Ther 330:826-33. 2009
    ..These results as a whole indicated that histamine inhibited the AGE-2- and AGE-3-induced adhesion molecule expression and cytokine production via H2 receptors and the cAMP/PKA pathway...
  29. doi request reprint Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction
    Katsuhisa Ohashi
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Clin Immunol 134:345-53. 2010
    ..AGE-2 and AGE-3 up-regulated the expression of RAGE on monocytes; therefore, the AGEs may activate monocytes, leading to the up-regulation of adhesion molecule expression, cytokine production and T-cell proliferation...
  30. ncbi request reprint Adenosine A2A-receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 production in monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    J Pharmacol Sci 104:183-6. 2007
    ..A PKA inhibitor prevented the actions of A2AR stimulation, indicating that the action mechanism of A2AR stimulation may be via the activation of the cAMP/PKA pathway...
  31. doi request reprint Beta2-adrenoceptor stimulation inhibits advanced glycation end products-induced adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    Eur J Pharmacol 627:313-7. 2010
    ....
  32. pmc Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses
    Yuji Sugata
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Immunology 121:266-75. 2007
    ....
  33. ncbi request reprint Effect of beta2-adrenergic receptor agonists on intercellular adhesion molecule (ICAM)-1, B7, and CD40 expression in mixed lymphocyte reaction
    Ryuji Tamura
    Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
    Transplantation 77:293-301. 2004
    ..1, B7.2, CD40, and CD40 ligand (CD40L) in human mixed lymphocyte reaction (MLR) and in an in vitro model of acute rejection in the presence or absence of IL-18...
  34. ncbi request reprint High mobility group box 1 complexed with heparin induced angiogenesis in a matrigel plug assay
    Hidenori Wake
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 63:249-62. 2009
    ..Taken together, these results suggested that HMGB1 in complex with heparin possesses remarkable angiogenic activity, probably through the induction of TNF-alpha and VEGF-A120...
  35. doi request reprint Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Kinki University, Osaka Sayama, Osaka, Japan
    Eur J Pharmacol 701:194-202. 2013
    ..1, B7.2 and CD40. These results together indicated that HMGB1 could induce an intimate cellular interplay between monocytes and T-cells in PBMCs through the stimulation and up-regulation of RAGE and other adhesive molecules on monocytes...
  36. ncbi request reprint Beta2-adrenergic receptor stimulation inhibits LPS-induced IL-18 and IL-12 production in monocytes
    Kenji Mizuno
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Immunol Lett 101:168-72. 2005
    ..Therefore, the stimulation of beta2-AR might be beneficial in the treatment of sepsis through inhibiting LPS-elicited IL-18...
  37. doi request reprint Advanced glycation end products subspecies-selectively induce adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Pharmacol Exp Ther 330:89-98. 2009
    ..These results indicated that AGE-2 and AGE-3 activated monocytes via RAGE, leading to the up-regulation of adhesion molecule expression and cytokine production...
  38. ncbi request reprint Histamine inhibits lipopolysaccharide-induced interleukin (IL)-18 production in human monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Clin Immunol 112:30-4. 2004
    ..Therefore, the stimulation of H2 receptor might be beneficial in the treatment of sepsis through inhibiting LPS-elicited IL-18...
  39. ncbi request reprint Effect of beta 2-adrenergic receptor stimulation on interleukin-18-induced intercellular adhesion molecule-1 expression and cytokine production
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Exp Ther 304:634-42. 2003
    ....
  40. ncbi request reprint Unique regulation profile of prostaglandin e1 on adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Pharmacol Exp Ther 307:1188-95. 2003
    ..In conclusion, IP receptor and EP2/EP4 receptor play an important role in the action of PGE1 on the expression of adhesion molecules on monocytes and cytokine production...
  41. ncbi request reprint Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1- and B7.1-dependent manner
    Toshihiko Morichika
    Department of Tumour Biology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Exp Ther 304:624-33. 2003
    ..These results as a whole indicated that histamine via H2-receptor inhibited the LPS-induced TNF-alpha production through the regulation of ICAM-1 and B7.1 expression, leading to the reduction of innate immune response stimulated by LPS...
  42. ncbi request reprint Beta 2-adrenergic receptor agonist induces IL-18 production without IL-12 production
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Neuroimmunol 151:137-47. 2004
    ..The sympathetic innervating lymphoid organs may be under the control of beta2-AR stimulation, maintaining the basal cytokine environment in the tissues...
  43. ncbi request reprint Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18
    Hideyuki Itoh
    Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
    Transplantation 74:864-70. 2002
    ..We also investigated the modulatory effects of histamine on IL-18 action because histamine has been demonstrated to be a modulator of IL-18 effect and a mediator of inflammation...
  44. doi request reprint Histidine-rich glycoprotein inhibited high mobility group box 1 in complex with heparin-induced angiogenesis in matrigel plug assay
    Hidenori Wake
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Eur J Pharmacol 623:89-95. 2009
    ..These results strongly suggested that HRG might be an inhibitor of angiogenesis induced by growth factors with heparin binding activity and that HRG may be a potential drug for angiogenic diseases, including tumor growth...
  45. ncbi request reprint Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes
    Hideo Kohka Takahashi
    Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Mol Pharmacol 70:450-3. 2006
    ..In conclusion, cimetidine, a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers...
  46. ncbi request reprint Prostaglandin E(2) inhibits IL-18-induced ICAM-1 and B7.2 expression through EP2/EP4 receptors in human peripheral blood mononuclear cells
    Hideo K Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Immunol 168:4446-54. 2002
    ..2 as well as anti-ICAM-1 Ab inhibited IL-18-induced cytokine production implies that PGE(2) may modulate the immune response through regulation of the expression of particular adhesion molecules on monocytes via EP2 and EP4Rs...
  47. ncbi request reprint Essential role of ICAM-1/LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC
    Atsushi Yoshida
    Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:181-6. 2002
    ....
  48. ncbi request reprint Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells
    Goutarou Katsuno
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700 8558, Japn
    J Pharmacol Sci 98:463-6. 2005
    ..The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate...
  49. doi request reprint Anti-high mobility group box-1 antibody therapy for traumatic brain injury
    Yu Okuma
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Ann Neurol 72:373-84. 2012
    ..In this study, we examined the involvement of HMGB1 in traumatic brain injury (TBI) and evaluated the ability of intravenously administered neutralizing anti-HMGB1 monoclonal antibody (mAb) to attenuate brain injury...
  50. ncbi request reprint Stimulation of alpha7 nicotinic acetylcholine receptor inhibits CD14 and the toll-like receptor 4 expression in human monocytes
    Ryosuke Hamano
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Shock 26:358-64. 2006
    ..These results suggested that the nuclear factor-kappaB and p38 mitogen-activated protein kinase might be involved in the actions of nicotine...
  51. ncbi request reprint Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation
    Minori Yokoyama
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Gastroenterology 127:892-902. 2004
    ..Inducible histamine and histamine H2-receptors have been suggested to be involved in innate immune response...
  52. ncbi request reprint alpha7 Nicotinic acetylcholine receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 and -12 production in monocytes
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Japan
    J Pharmacol Sci 102:143-6. 2006
    ..PGE(2) is known to increase cAMP levels and to activate protein kinase A (PKA). COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production...
  53. ncbi request reprint Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice
    Akira Yokoyama
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Pharmacol 558:179-84. 2007
    ..In conclusion, the present findings suggested that the elevation of endogenous histamine by amodiaquine may thus play a protective role through the regulation of TNF-alpha production in endotoxin-induced hepatic injury mice...
  54. ncbi request reprint Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells
    Hideo Kohka Takahashi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Exp Ther 300:227-35. 2002
    ....
  55. doi request reprint Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats
    Jiyong Zhang
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmacological Sciences, Okayama 700 8558, Japan
    Stroke 42:1420-8. 2011
    ..In the present study, we focused on the protective effects of the mAb on the marked translocation of HMGB1 in the brain, the disruption of the blood-brain barrier (BBB), and the resultant brain edema...
  56. ncbi request reprint Effects of HMGB1 on ischemia-reperfusion injury in the rat heart
    Susumu Oozawa
    Department of Cardiovascular Surgery, University of Okayama Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Circ J 72:1178-84. 2008
    ..In the present study a neutralizing monoclonal antibody (mAb) for HMGB1 was used to clarify the role of HMGB1 in cardiac I/R injury...
  57. ncbi request reprint MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2
    Atsushi Jikuhara
    Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Life Sci 73:2817-29. 2003
    ....
  58. ncbi request reprint Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats
    Keyue Liu
    Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    FASEB J 21:3904-16. 2007
    ..Intravenous injection of neutralizing anti-HMGB1 mAb provides a novel therapeutic strategy for ischemic stroke...
  59. ncbi request reprint Gene expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1)in human osteoarthritic cartilage
    Chuji Terada
    Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 65:369-77. 2011
    ..IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA...
  60. pmc E prostanoid 2 (EP2)/EP4-mediated suppression of antigen-specific human T-cell responses by prostaglandin E2
    Mitsuhiro Okano
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Immunology 118:343-52. 2006
    ..These results suggest that PGE2 suppresses both Th1- and Th2-polarized antigen-specific human T-cell responses via a cAMP-dependent EP2/EP4-mediated pathway...
  61. ncbi request reprint Histidine-rich glycoprotein plus zinc reverses growth inhibition of vascular smooth muscle cells by heparin
    Shuji Mori
    Department of Pharmacology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Cell Tissue Res 312:353-9. 2003
    ....
  62. ncbi request reprint High affinity binding of serum histidine-rich glycoprotein to nickel-nitrilotriacetic acid: the application to microquantification
    Shuji Mori
    Department of Pharmacology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Life Sci 73:93-102. 2003
    ..These findings indicate the potential usefulness of this method for the specific measurement of small amounts of rHRG and for understanding the roles of abundant histidine residues in rHRG-metal cation interaction...
  63. ncbi request reprint Role of recA/RAD51 family proteins in mammals
    Masahiro Kawabata
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 59:1-9. 2005
    ..In addition, identification of alternative transcripts of some RAD51 paralogs may reflect the complexity of the homologous recombination system...
  64. ncbi request reprint [Immunologic tests: Anti-Sp100 antibody]
    Shuji Mori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 63:640-2. 2005
  65. ncbi request reprint Nafamostat mesilate is an extremely potent inhibitor of human tryptase
    Shuji Mori
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Pharmacol Sci 92:420-3. 2003
    ..1 nM). These results strongly indicated that nafamostat mesilate is an extremely potent inhibitor of tryptase and suggested that some of its beneficial effects in the treatment of clinical status may be due to tryptase inhibition...
  66. ncbi request reprint Hypothesis: the antitumor activities of statins may be mediated by IL-18
    Hideo Kohka Takahashi
    J Leukoc Biol 80:215-6. 2006
    ..We present a new hypothesis that the production of IL-18 might play roles in the action of statins on cancer...
  67. doi request reprint Suppression of ischaemia-induced cytokine release by dimaprit and amelioration of liver injury in rats
    Atsuko Motoki
    Department of Anaesthesiology and Resuscitology, Ehime University Graduate School of Medicine, Shitsukawa, Touon shi, Ehime, Japan
    Basic Clin Pharmacol Toxicol 102:394-8. 2008
    ..Since interleukin-12 facilitates cell-mediated cytotoxicity, the protective effect of dimaprit may be attributed to regulation of cytokine release during reperfusion...
  68. ncbi request reprint Involvement of proteinase-activated receptor-2 in mast cell tryptase-induced barrier dysfunction in bovine aortic endothelial cells
    Toshiaki Sendo
    Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cell Signal 15:773-81. 2003
    ..Therefore, it is suggested that mast cell tryptase impairs endothelial barrier function through activation of endothelial PAR-2 in a manner dependent on the phospholipase C activity...