Kiminori Matsubara

Summary

Affiliation: Okayama Prefectural University
Country: Japan

Publications

  1. ncbi request reprint Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Life Sci 80:1578-85. 2007
  2. ncbi request reprint A fibrinolytic enzyme from a marine green alga, Codium latum
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Phytochemistry 52:993-9. 1999
  3. ncbi request reprint Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    DNA Cell Biol 25:95-103. 2006
  4. ncbi request reprint Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    J Agric Food Chem 53:6272-5. 2005
  5. ncbi request reprint Inhibitory effect of glycolipids from spinach on in vitro and ex vivo angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Oncol Rep 14:157-60. 2005
  6. ncbi request reprint Anti-angiogenic effect of pyridoxal 5'-phosphate, pyridoxal and pyridoxamine on embryoid bodies derived from mouse embryonic stem cells
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Int J Mol Med 14:819-23. 2004
  7. ncbi request reprint Recent advances in marine algal anticoagulants
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Curr Med Chem Cardiovasc Hematol Agents 2:13-9. 2004
  8. ncbi request reprint Petasiphenol which inhibits DNA polymerase lambda activity is an inhibitor of in vitro angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Oncol Rep 11:447-51. 2004
  9. ncbi request reprint Purification and characterization of a fibrinolytic enzyme and identification of fibrinogen clotting enzyme in a marine green alga, Codium divaricatum
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Comp Biochem Physiol B Biochem Mol Biol 125:137-43. 2000
  10. ncbi request reprint Inhibitory effect of pyridoxal 5'-phosphate on endothelial cell proliferation, replicative DNA polymerase and DNA topoisomerase
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719 119, Japan
    Int J Mol Med 12:51-5. 2003

Detail Information

Publications19

  1. ncbi request reprint Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Life Sci 80:1578-85. 2007
    ..These results suggest that acylation of epicatechin is an effective chemical modification to improve the anti-cancer activity of epicatechin...
  2. ncbi request reprint A fibrinolytic enzyme from a marine green alga, Codium latum
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Phytochemistry 52:993-9. 1999
    ..Protease activity peaked at pH 10, and was completely inhibited by diisopropyl fluorophosphate (DFP). Therefore, we conclude that CLP is a trypsin-like serine protease...
  3. ncbi request reprint Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    DNA Cell Biol 25:95-103. 2006
    ..These results suggest that acylation of catechin is an effective chemical modification to improve the anticancer activity of catechin...
  4. ncbi request reprint Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    J Agric Food Chem 53:6272-5. 2005
    ..These results imply that nasunin with both antioxidant and antiangiogenic activities might be useful to prevent angiogenesis-related diseases...
  5. ncbi request reprint Inhibitory effect of glycolipids from spinach on in vitro and ex vivo angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Oncol Rep 14:157-60. 2005
    ..These results demonstrate that glycolipids from spinach would suppress tumor growth by suppressing angiogenesis and might be candidates for anti-cancer or anti-angiogenic materials...
  6. ncbi request reprint Anti-angiogenic effect of pyridoxal 5'-phosphate, pyridoxal and pyridoxamine on embryoid bodies derived from mouse embryonic stem cells
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Int J Mol Med 14:819-23. 2004
    ....
  7. ncbi request reprint Recent advances in marine algal anticoagulants
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Curr Med Chem Cardiovasc Hematol Agents 2:13-9. 2004
    ..This article provides a short review of algal anticoagulants and recent developments in this area. It focuses on their biological activities, structures, and potent uses as medical agents...
  8. ncbi request reprint Petasiphenol which inhibits DNA polymerase lambda activity is an inhibitor of in vitro angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Oncol Rep 11:447-51. 2004
    ..Taken together, petasiphenol could act as a potent antiangiogenic compound for preventing tumor and be useful to design therapeutic agents...
  9. ncbi request reprint Purification and characterization of a fibrinolytic enzyme and identification of fibrinogen clotting enzyme in a marine green alga, Codium divaricatum
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Comp Biochem Physiol B Biochem Mol Biol 125:137-43. 2000
    ..Analysis of clots formed by the enzyme and by thrombin by SDS-PAGE showed that the fibrinogen clotting enzyme would act like thrombin and have high substrate specificity...
  10. ncbi request reprint Inhibitory effect of pyridoxal 5'-phosphate on endothelial cell proliferation, replicative DNA polymerase and DNA topoisomerase
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719 119, Japan
    Int J Mol Med 12:51-5. 2003
    ..These results suggest that vitamin B6 suppresses endothelial cell proliferation and angiogenesis at least in part by inhibiting DNA polymerase and DNA topoisomerases...
  11. ncbi request reprint Pyridoxal 5'-phosphate and pyridoxal inhibit angiogenesis in serum-free rat aortic ring assay
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Int J Mol Med 8:505-8. 2001
    ..These results indicated the antiangiogenic effect of PLP and pyridoxal, and suggested that the antitumor effect of high levels of vitamin B6 might be mediated through suppression of angiogenesis...
  12. ncbi request reprint Anticoagulant properties of a sulfated galactan preparation from a marine green alga, Codium cylindricum
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, 719 1197, Okayama, Japan
    Int J Biol Macromol 28:395-9. 2001
    ..The anticoagulant did not potentiate antithrombin III (AT III) and heparin cofactor II (HC II), thus the anticoagulant mechanism would be different from that of other anticoagulants isolated so far from the genus Codium...
  13. ncbi request reprint Pyridoxal 5'-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon
    Yoshiyuki Mizushina
    Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, 651 2180, Hyogo, Japan
    Biochem Biophys Res Commun 312:1025-32. 2003
    ....
  14. ncbi request reprint Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719 1197, Japan
    Int J Mol Med 15:695-9. 2005
    ..Thus, 15-20 kDa fucoidan would have proangiogenic effect on angiogenesis. These results elucidate that 20-30 kDa would be a critical point to characterize the role of fucoidans on angiogenesis...
  15. ncbi request reprint Acylated catechin derivatives: inhibitors of DNA polymerase and angiogenesis
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo, Japan
    Front Biosci (Elite Ed) 3:1337-48. 2011
    ..Moreover, the results suggest that acylation of catechin is an effective chemical modification to improve the anti-cancer activity of catechin...
  16. ncbi request reprint Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis (review)
    Kiminori Matsubara
    Faculty of Health and Welfare Science, Okayama Prefectual University, Okayama, Japan
    J Nutr Biochem 14:246-50. 2003
    ..Potential mechanisms underlying the preventive effect of dietary vitamin B(6) have been suggested to include the suppression of cell proliferation, oxidative stress, nitric oxide (NO) synthesis, and angiogenesis...
  17. ncbi request reprint PTHrP regulates angiogenesis and bone resorption via VEGF expression
    Sachiko Isowa
    Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama, 700 8525, Japan
    Anticancer Res 30:2755-67. 2010
    ..This study investigated whether/how PTHrP (1-34) signaling regulates expression of vascular endothelial growth factor (VEGF) produced by BC cells...
  18. ncbi request reprint Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
    Tatsuya Sugawara
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Agric Food Chem 54:9805-10. 2006
    ..These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases...
  19. ncbi request reprint Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Human Life Sciences Education, Graduate School of Education, Hiroshima University, Higashi Hiroshima, Hiroshima 739 8524, Japan
    Int J Mol Med 22:381-7. 2008
    ..These results suggest that vitamin K3 may be a potential anti-cancer agent like vitamin K2...