H Makino

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. pmc Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease
    Yuko Kurose
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    BMC Nephrol 14:23. 2013
  2. pmc The serum vaspin levels are reduced in Japanese chronic hemodialysis patients
    Junko Inoue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    BMC Nephrol 13:163. 2012
  3. pmc A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood
    Kenji Tsuji
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    BMC Nephrol 13:46. 2012
  4. pmc Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis
    Keiichi Takiue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Kita ku, Okayama 700 8558, Japan
    BMC Nephrol 13:14. 2012
  5. pmc Angiogenesis and chronic kidney disease
    Yohei Maeshima
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Fibrogenesis Tissue Repair 3:13. 2010
  6. pmc Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis
    Tomoko Kawabata
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Okayama, Japan
    Arthritis Res Ther 12:R133. 2010
  7. pmc Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis
    Koji Takasugi
    Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry, Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Res Ther 8:R126. 2006
  8. pmc Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis
    Jiro Yamana
    Department of Medicine and Clinical Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Arthritis Res Ther 6:R567-77. 2004
  9. pmc The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis
    Katsue Sunahori
    Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Res Ther 8:R69. 2006
  10. ncbi request reprint The telmisartan renoprotective study from incipient nephropathy to overt nephropathy--rationale, study design, treatment plan and baseline characteristics of the incipient to overt: angiotensin II receptor blocker, telmisartan, Investigation on Type 2 Dia
    H Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    J Int Med Res 33:677-86. 2005

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. pmc Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease
    Yuko Kurose
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    BMC Nephrol 14:23. 2013
    ....
  2. pmc The serum vaspin levels are reduced in Japanese chronic hemodialysis patients
    Junko Inoue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    BMC Nephrol 13:163. 2012
    ..Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients...
  3. pmc A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood
    Kenji Tsuji
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    BMC Nephrol 13:46. 2012
    ..Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause...
  4. pmc Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis
    Keiichi Takiue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Kita ku, Okayama 700 8558, Japan
    BMC Nephrol 13:14. 2012
    ..A functional catalase deficiency was hypothesized to exacerbate albuminuria and the progression of glomerulosclerosis in this model...
  5. pmc Angiogenesis and chronic kidney disease
    Yohei Maeshima
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Fibrogenesis Tissue Repair 3:13. 2010
    ..Determining the disease stage at which therapy is most effective and developing an effective drug delivery system targeting the kidney will be essential for pro-or anti-angiogenic strategies for patients with CKD...
  6. pmc Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis
    Tomoko Kawabata
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Okayama, Japan
    Arthritis Res Ther 12:R133. 2010
    ....
  7. pmc Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis
    Koji Takasugi
    Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry, Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Res Ther 8:R126. 2006
    ..These results suggest that IL-10 may contribute to the inflammatory process by facilitating monocyte differentiation into TNF-alpha-responsive macrophages in the presence of M-CSF in RA...
  8. pmc Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis
    Jiro Yamana
    Department of Medicine and Clinical Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Arthritis Res Ther 6:R567-77. 2004
    ....
  9. pmc The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis
    Katsue Sunahori
    Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Res Ther 8:R69. 2006
    ..These results indicate that the S100A8/A9 heterodimer, secreted extracellularly from activated tissue macrophages, may amplify proinflammatory cytokine responses through activation of NF-kappaB and p38 MAPK pathways in RA...
  10. ncbi request reprint The telmisartan renoprotective study from incipient nephropathy to overt nephropathy--rationale, study design, treatment plan and baseline characteristics of the incipient to overt: angiotensin II receptor blocker, telmisartan, Investigation on Type 2 Dia
    H Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    J Int Med Res 33:677-86. 2005
    ..6) and 77.5 (10.3) mmHg. The INNOVATION study will determine whether telmisartan, an angiotensin II receptor blocker, provides clinical benefits in hypertensive or normotensive patients with diabetes mellitus and diabetic nephropathy...
  11. doi request reprint Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: a post-hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATI
    Hirofumi Makino
    Department of Medicine and Clinical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hypertens Res 31:657-64. 2008
    ..Telmisartan is shown to be safe and well tolerated in these patients...
  12. ncbi request reprint Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes
    Hirofumi Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 Okayama, Japan
    Diabetes Care 30:1577-8. 2007
  13. ncbi request reprint Glomerular cell apoptosis in human lupus nephritis
    Hirofumi Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    Virchows Arch 443:67-77. 2003
    ..These data suggest that apoptosis is increased, but not decreased in glomeruli from patients with lupus nephritis. The signals that could induce glomerular cell apoptosis in lupus nephritis will need to be identified...
  14. ncbi request reprint Remission and regression of diabetic nephropathy
    Hirofumi Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Hypertens Res 26:515-9. 2003
    ..In this population, pharmacological therapy targeting hyperglycemia, hypertension (including ARB/ACE inhibitor), and hyperlipidemia in cases of type 2 diabetes is also necessary...
  15. ncbi request reprint Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury
    T Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Soc Nephrol 12:2652-63. 2001
    ..The present study opens a possibility of a novel therapeutic potential of natriuretic peptides for treating immune-mediated renal injury...
  16. ncbi request reprint Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats
    M Hashimoto
    Third Department of Medicine, Okayama University Medical School, Okayama, Japan
    Am J Nephrol 19:615-21. 1999
    ..Thus, the stable reduction in systemic blood pressure by barnidipine is associated with a reduction in PDGF B-chain mRNA expression in the glomerulus and reduction in urinary protein excretion in SHR...
  17. ncbi request reprint Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis
    H Yokoi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Kidney Dis 38:S134-8. 2001
    ..These results indicate that CTGF has a crucial role in the profibrotic action of TGF-beta in renal fibroblasts, providing a potential therapeutic target against tubulointerstitial fibrosis...
  18. ncbi request reprint Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats
    T Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    J Hypertens 19:1095-103. 2001
    ..The altered EP4 signaling may play a critical role in the exaggerated mesangial growth in SHRSPs...
  19. ncbi request reprint Plasma adrenomedullin levels in patients on hemodialysis
    H Yamasaki
    Department of Medicine III, Okayama University Medical School, 251, Shikata-cho, Okayama-city, Okayama, Japan
    Nephron 89:20-5. 2001
    ..In conclusion, elevation in plasma AM level causes a fall in MBP in patients on HD, therefore, removal of AM by HD treatment using a high-flux dialyzer contributes to the stability of blood pressure during HD...
  20. ncbi request reprint Oxidative stress is reduced by the long-term use of vitamin E-coated dialysis filters
    M Satoh
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Kidney Int 59:1943-50. 2001
    ..Here we investigated the effects of a vitamin E-coated regenerated cellulose hollow fiber dialyzer (CL-EE) on oxidative stress compared with a polysulfone hollow fiber (CL-PS)...
  21. ncbi request reprint Gene expression profile in streptozotocin-induced diabetic mice kidneys undergoing glomerulosclerosis
    J Wada
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Kidney Int 59:1363-73. 2001
    ..To elucidate the molecular mechanism of diabetic nephropathy, a high-density DNA filter array was employed to survey the gene expression profile of streptozotocin-induced diabetic CD-1 (ICR) mouse kidneys...
  22. doi request reprint Intermittent administration of a sustained-release prostacyclin analog ONO-1301 ameliorates renal alterations in a rat type 1 diabetes model
    H Yamasaki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Prostaglandins Leukot Essent Fatty Acids 84:99-107. 2011
    ..Taken together, these results suggest the potential therapeutic efficacy of intermittent administration of SR-ONO in treating diabetic nephropathy potentially via inducing HGF, thus counteracting the pro-fibrotic effects of TGF-beta1...
  23. ncbi request reprint Methylprednisolone accelerates the resolution of glomerulonephritis by sensitizing mesangial cells to apoptosis
    K Maruyama
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Exp Nephrol 9:317-26. 2001
    ..These results suggest that methylprednisolone may accelerate the resolution phase of Thy-1.1 nephritis in part by sensitizing mesangial cells to apoptosis...
  24. doi request reprint Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
    R Kodera
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Diabetologia 54:965-78. 2011
    ..Here we demonstrate that a GLP-1 receptor agonist, exendin-4, exerts renoprotective effects through its anti-inflammatory action via the GLP-1 receptor without lowering blood glucose...
  25. ncbi request reprint Malignant hypertension with a rare complication of pulmonary alveolar hemorrhage
    K Hida
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Am J Nephrol 20:64-7. 2000
    ..The authors report a case of malignant hypertension with a rare complication of pulmonary alveolar hemorrhage and speculate that it may be related to vascular injuries at the alveolar capillary level caused by malignant hypertension...
  26. ncbi request reprint Differential effect of chronic inhibition of calcium channel and angiotensin II type 1-receptor on aldosterone synthesis in spontaneously hypertensive rats
    F Otsuka
    Department of Medicine III, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    J Steroid Biochem Mol Biol 74:125-36. 2000
    ..Our results indicate that chronic treatment with different antihypertensive agents directly modulates adrenocortical aldosterone synthesis in SHR in vivo via different mechanisms...
  27. ncbi request reprint Ultrastructure of glomerular basement membrane in active heymann nephritis rats revealed by tissue-negative staining method
    Y Hayashi
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Am J Nephrol 21:249-55. 2001
    ..The density of the tunnels also increased at 15 weeks. In conclusion, immune deposits may affect the GBM biosynthesis and induce the defect of size barrier of the GBM, which is responsible for proteinuria in active Heymann nephritis...
  28. ncbi request reprint Determination of bisphenol a in effluents of hemodialyzers
    H Yamasaki
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Nephron 88:376-8. 2001
    ..77 ppb). This is the first report of BPA elution from hemodialyzers in which polycarbonate and polysulfone are used, and also the first report of detection of BPA in whole blood samples from patients on hemodialysis...
  29. ncbi request reprint Apoptosis and extracellular matrix-cell interactions in kidney disease
    H Makino
    Department of Medicine III, Okayama University Medical School, Japan
    Kidney Int Suppl 77:S67-75. 2000
    ..Diabetic nephropathy is characterized by the abnormal ECM accumulation and the phenotypic change of MC. Some speculations on the possible involvement of apoptosis in diabetic nephropathy are also discussed...
  30. ncbi request reprint Galectins, galactoside-binding mammalian lectins: clinical application of multi-functional proteins
    J Wada
    Department of Medicine III, Okayama University Medical School, Japan
    Acta Med Okayama 55:11-7. 2001
    ....
  31. ncbi request reprint The role of nitric oxide and the renin-angiotensin system in salt-restricted Dahl rats
    H Kataoka
    Department of Medicine III, Okayama University Medical School, Japan
    Am J Hypertens 14:276-85. 2001
    ..These data suggest that endogenous NO is an essential determinant of salt-sensitive hypertension in DS rats...
  32. ncbi request reprint Antisense oligonucleotides
    N Kashihara
    Department of Medicine III, Okayama University Medical School, Japan
    Exp Nephrol 6:84-8. 1998
    ..This technique was originally used to elucidate the function of a target gene, but may also have therapeutic applications, provided it is designed carefully and properly...
  33. ncbi request reprint Chronic treatment with amlodipine modulates adrenocortical angiotensin II receptors in spontaneously hypertensive rats
    M Kishida
    Department of Medicine III, Okayama University Medical School, Okayama University, Japan
    Life Sci 69:113-22. 2001
    ..Thus, chronic amlodipine treatment differently modulates both adrenocortical AT1R and AT2R in SHR in a possibly direct manner...
  34. ncbi request reprint Japanese family with glucocorticoid-remediable aldosteronism diagnosed by long-polymerase chain reaction
    K Yokota
    Department of Medicine III, Okayama University Medical School, Japan
    Hypertens Res 24:589-94. 2001
    ..Our clinical data and genetic investigation confirmed the presence of GRA in this Japanese family...
  35. ncbi request reprint Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients
    M Maruyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    Clin Nephrol 68:73-80. 2007
    ..We also investigated these parameters in patients with minimal-change nephrotic syndrome (MCNS), minor glomerular abnormalities (MGA), and normal kidneys as age-matched controls...
  36. ncbi request reprint Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model
    K Tanabe
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Kidney Int 71:227-38. 2007
    ..These results demonstrate the potential use of antiangiogenic endostatin peptide as a novel therapeutic agent in preventing peritoneal sclerosis, a severe complication in patients undergoing long-term PD...
  37. ncbi request reprint The frequency of Fabry disease with the E66Q variant in the α-galactosidase A gene in Japanese dialysis patients: a case report and a literature review
    Y Kikumoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Clin Nephrol 78:224-9. 2012
    ..We reviewed previous studies and found E66Q mutation in 36% of Japanese FD patients on HD including the present case. The clinical characteristics of E66Q variant are also discussed...
  38. ncbi request reprint Relationships of serum levels of insulinlike growth factors with indices of bone metabolism and nutritional conditions in hemodialysis patients
    K Nanba
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Nephron 89:145-52. 2001
    ..However, the serum IGF-I level cannot be used as a marker of bone metabolism in hemodialysis patients...
  39. ncbi request reprint Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice
    H Makino
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    Diabetologia 49:2514-24. 2006
    ..Based on the suggested involvement of increased endogenous natriuretic peptides, the aim of this study was to investigate their role in the development and progression of diabetic nephropathy...
  40. ncbi request reprint Erythromycin ameliorates renal injury via anti-inflammatory effects in experimental diabetic rats
    A Tone
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Diabetologia 48:2402-11. 2005
    ..The aim of this study was to investigate the renoprotective effects of erythromycin in streptozotocin (STZ)-induced diabetic rats...
  41. ncbi request reprint Delayed neuronal death in hippocampal CA1 pyramidal neurons after forebrain ischemia in hyperglycemic gerbils: amelioration by indomethacin
    F Kondo
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, 2 5 1 Shikatacho, Okayama, Japan
    Brain Res 853:93-8. 2000
    ..Our results also showed that indomethacin provides a neuroprotective effect in normo- and hyperglycemic conditions...
  42. ncbi request reprint Disruption of klotho gene causes an abnormal energy homeostasis in mice
    K Mori
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 278:665-70. 2000
    ..The present study elucidates the importance of klotho gene expression for the maintenance of normal energy homeostasis...
  43. ncbi request reprint Good response of membranous lupus nephritis to tacrolimus
    M Maruyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Japan
    Clin Nephrol 65:276-9. 2006
    ..By changing to tacrolimus and higher doses of steroids, the serum complement titer improved and proteinuria disappeared. This case indicates that tacrolimus can be an effective therapeutic agent for membranous lupus nephritis...
  44. doi request reprint Beta-blocker prescription and outcomes in hemodialysis patients from the Japan Dialysis Outcomes and Practice Patterns Study
    Kazushi Nakao
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Nephron Clin Pract 113:c132-9. 2009
    ..Since the outcomes associated with the use of beta-blockers are not fully known, we investigated their effect on mortality among a cohort of hemodialysis patients...
  45. ncbi request reprint Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys
    H Zhang
    Department of Medicine III, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 780 8558, Japan
    J Biol Chem 276:17132-9. 2001
    ....
  46. ncbi request reprint Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins
    Y Shikata
    Department of Medicine III, Okayama University Medical School, Okayama, 700 8558, Japan
    Biochem Biophys Res Commun 257:234-8. 1999
    ..These results suggest that the formation of focal adhesion complexes accelerated by accumulation of mesangial matrices may inhibit the proliferation of HMCs by modulating MAP kinase activity and be related to mesangial cell depletion...
  47. ncbi request reprint Changes in serum leptin concentrations in overweight Japanese men after exercise
    N Miyatake
    Okayama Southern Institute of Health, Okayama, Japan
    Diabetes Obes Metab 6:332-7. 2004
    ..To investigate the link between serum leptin concentrations and exercise...
  48. ncbi request reprint A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy
    A Nakatsuka
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Nephrol 64:221-7. 2005
    ..This case clearly demonstrates that the earlier and accurate diagnosis and initiation of chemotherapy at the early stage with serum creatinine level below 4.0 mg/dl are necessary to improve renal and patient outcome...
  49. ncbi request reprint Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy
    T Nagae
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 270:89-93. 2000
    ..Thus, RAMPs are regulated differently in obstructive nephropathy, suggesting their distinct roles in renal pathophysiology...
  50. ncbi request reprint Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation
    Hitomi Kataoka Usui
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Diabetes 56:363-72. 2007
    ..SR-A may be a key molecule for the inflammatory process in pathogenesis of diabetic nephropathy and a novel therapeutic target for diabetic vascular complications...
  51. ncbi request reprint Olmesartan reducing incidence of endstage renal disease in diabetic nephropathy trial (ORIENT): rationale and study design
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:703-9. 2006
    ..0 mg/dl, the need for chronic dialysis, or renal transplantation) or death. The average follow-up period is 4 years and the study ends in 2009...
  52. ncbi request reprint Enhanced TGF-beta/Smad signaling in the early stage of diabetic nephropathy is independent of the AT1a receptor
    Yuko Okazaki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Exp Nephrol 11:77-87. 2007
    ..The aim of this study was to clarify the role of AII in the regulation of the TGF-beta system in the early stage of DN using AII type1a receptor-deficient(AT1a(-/-)) mice...
  53. ncbi request reprint Comparison of ventilatory threshold and exercise habits between Japanese men with and without metabolic syndrome
    Nobuyuki Miyatake
    Okayama Southern Institute of Health, 408 1 Hirata, Okayama 700 0952, Japan
    Diabetes Res Clin Pract 77:314-9. 2007
    ..We compared the levels of ventilatory threshold (VT) and exercise habits in subjects with metabolic syndrome with those in age, sex-matched subjects without metabolic syndrome...
  54. ncbi request reprint CD14+,CD16+ blood monocytes and joint inflammation in rheumatoid arthritis
    Norikuni Kawanaka
    Department of Medicine and Clinical Science, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Rheum 46:2578-86. 2002
    ..We undertook this study to investigate the relevance of this phenotype to joint inflammation in rheumatoid arthritis (RA)...
  55. ncbi request reprint [Diabetic nephropathy]
    Motofumi Sasaki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Nihon Rinsho . 2006
  56. ncbi request reprint Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus
    Ken Ei Sada
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Rheumatol 33:1545-52. 2006
    ..We evaluated IR in association with plasma concentrations of adipocytokines in patients with SLE...
  57. ncbi request reprint Circulating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen
    Kazuko Kobayashi
    Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Lipid Res 44:716-26. 2003
    ..Further, these same Abs correlated with IgG immune complexes containing beta2-GPI or LDL. Thus, the beta2-GPI-oxLDL complexes acting as an autoantigen are closely associated with autoimmune-mediated atherogenesis...
  58. doi request reprint Slower decline of glomerular filtration rate in the Japanese general population: a longitudinal 10-year follow-up study
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:433-41. 2008
    ..Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR...
  59. ncbi request reprint Anti-beta 2-glycoprotein I autoantibodies and atherosclerosis
    Eiji Matsuura
    Department of Cell Chemistry, Department of Medicine III, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int Rev Immunol 21:51-66. 2002
    ..All of these observations strongly suggest that autoimmune atherogenesis linked to beta 2-GPI interaction with oxLDL and autoantibodies may be present in APS...
  60. ncbi request reprint Changes of gene expression profiles in macrophages stimulated by angiotensin II--angiotensin II induces MCP-2 through AT1-receptor
    Atsuhito Tone
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Renin Angiotensin Aldosterone Syst 8:45-50. 2007
    ..It has recently been reported that Ang II exerts proinflammatory actions in vivo and in vitro. This study was aimed to clarify the direct effects of Ang II on monocytes/macrophages...
  61. ncbi request reprint Expression of Fc gamma receptor III (CD16) on monocytes during hemodialysis in patients with chronic renal failure
    Norikuni Kawanaka
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Nephron 90:64-71. 2002
    ..In this study, changes in the population of CD14+CD16+ monocytes were analyzed during a single session of HD therapy, and the influence of dialyzer membrane materials on these monocytes was investigated...
  62. doi request reprint Chronic Kidney Disease Japan Cohort (CKD-JAC) study: design and methods
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:1101-7. 2008
    ..Insights from the CKD-JAC study will provide a basis for future interventional trials focused on reducing the burden of ESRD and CVD in patients with CKD in Japan...
  63. ncbi request reprint Gene expression and identification of gene therapy targets in diabetic nephropathy
    Jun Wada
    Department of Medicine III, Okayama University Medical School, Okayama, Japan
    Kidney Int 61:S73-8. 2002
    ..e., mitochondria. In this review, these novel differentially regulated genes that respond to hyperglycemic stress are described, and they may serve as possible targets for gene therapy in the treatment of diabetic nephropathy...
  64. doi request reprint Impact of blood pressure control on cardiovascular events in 26,512 Japanese hypertensive patients: the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study, a prospective nationwide observational study
    Kazuaki Shimamoto
    Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 31:469-78. 2008
    ..BP was controlled below 140/90 mmHg in a half of the very elderly hypertensive patients in this study, and these patients also had a lower incidence of CV events...
  65. ncbi request reprint Intravenous vitamin D therapy reduces PTH-(1-84)/large C fragments ratio in chronic hemodialysis patients
    Takashi Kihara
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Nephron Clin Pract 98:c93-100. 2004
    ..The PTH-(1-84)/large C-PTH fragments ratio reflects both biosynthesis and processing of PTH; however the alteration of the ratio under vitamin D therapy has not been investigated...
  66. doi request reprint Glycated albumin levels predict long-term survival in diabetic patients undergoing haemodialysis
    Kousuke Fukuoka
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Shigei Medical Research Hospital, Okayama, Japan
    Nephrology (Carlton) 13:278-83. 2008
    ..Here, we investigated the impact of GA levels on long-term survival in diabetic patients with ESRD...
  67. doi request reprint The MUSCAT study: a Multicenter PROBE Study Comparing the Effects of Angiotensin II Type-1 Receptor Blockers on Self-Monitored Home Blood Pressure in Patients with Morning Hypertension: study design and background characteristics
    Haruhito Uchida
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Hypertens Res 31:51-8. 2008
    ..MHBPs and surrogate markers will be examined at baseline and after 1 year of follow-up. In the stratified analysis, we will determine the significance of MHBP reduction on cardiovascular risk management...
  68. doi request reprint Increased susceptibility to oxidant-mediated tissue injury and peritoneal fibrosis in acatalasemic mice
    Naomi Fukuoka
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan
    Am J Nephrol 28:661-8. 2008
    ..Peritoneal fibrosis is a major complication leading to the loss of peritoneal function in patients undergoing peritoneal dialysis. However, the effect of catalase depletion on peritoneal fibrosis has not yet been investigated...
  69. doi request reprint Chronic kidney disease perspectives in Japan and the importance of urinalysis screening
    Kunihiro Yamagata
    Department of Nephrology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Clin Exp Nephrol 12:1-8. 2008
    ..For an effective screening strategy to reduce the ESRD population in Japanese and Asians, universal screening with the urine dip-stick test for proteinuria could be one solution...
  70. ncbi request reprint Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Japan
    Am J Kidney Dis 50:927-37. 2007
    ..The Modification of Diet in Renal Disease (MDRD) Study equation was developed in whites and African Americans, but performance was not evaluated in Japanese...
  71. ncbi request reprint Plasma orexin concentrations in patients on hemodialysis
    Taro Sugimoto
    Department of Medicine and Clinical Science, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Nephron 90:379-83. 2002
    ..In this study, we investigated the relationship between plasma orexin concentrations and nutritional states in patients on hemodialysis...
  72. ncbi request reprint Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects
    Izumi Hashimoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Obesity (Silver Spring) 14:799-811. 2006
    ..Chronic inflammation observed in obesity has been reported to be implicated in the development of atherosclerosis. We screened candidate chemokines that link chronic inflammation and obesity...
  73. ncbi request reprint Regulation of angiogenic factors in angiotensin II infusion model in association with tubulointerstitial injuries
    Hiroyuki Kitayama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Hypertens 19:718-27. 2006
    ..In the present study we investigated the renal expression of VEGF, Ang1, Ang2, and corresponding receptors in association with tubulointerstitial lesions in a rat ang II infusion model...
  74. ncbi request reprint 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice
    Kunihiro Ichinose
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Diabetes 55:1232-42. 2006
    ..Taken together, these results demonstrate the potential use of NM-3 as a novel therapeutic agent for renal alterations in type 2 diabetes...
  75. ncbi request reprint [Nephrotic syndrome due to metabolic disease--special reference to diabetic nephropathy]
    Sakiko Ohga
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 62:1907-13. 2004
    ..However further studies are necessary for the clinical guidline in patients with diabetic nephropathy manifesting with nephrotic syndrome...
  76. ncbi request reprint Practical efficacy of telmisartan for decreasing morning home blood pressure and pulse wave velocity in patients with mild-to-moderate hypertension
    Haruhito Uchida
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Japan
    Hypertens Res 27:545-50. 2004
    ..In conclusion, telmisartan 40 mg/day was found to be effective for reducing MHBP and arterial wall stiffness in patients with mild-to-moderate hypertension, and thus may also be effective for improving cerebrocardiovascular mortality...
  77. ncbi request reprint Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells
    Tomoko Tsukinoki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Exp Nephrol 8:196-205. 2004
    ..Fas ligand (FasL) is a well-known death factor; however, the role of FasL in the regulation of human glomerulonephritis remains unclear...
  78. ncbi request reprint Clinical significance of serum oxidized low-density lipoprotein/beta2-glycoprotein I complexes in patients with chronic renal diseases
    Junko Kasahara
    Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Nephron Clin Pract 98:c15-24. 2004
    ..In the present study, the prevalence and clinical significance of oxLDL/beta2GPI complexes were evaluated in patients with chronic renal disorders...
  79. ncbi request reprint Bone assessment of female long-distance runners
    Masaru Kaga
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 3 1 1 Naka, Tsushima, 700 8530, Okayama, Japan
    J Bone Miner Metab 22:509-13. 2004
    ..We concluded that the effect of long-distance training on bone metabolism in the female high school athletes (i.e., during puberty) was different from that in the adult athletes...
  80. ncbi request reprint Aldosterone regulation for 18 years in a case of primary aldosteronism
    Tomoko Miyoshi
    Department of Medicine, Okayama, Japan
    Am J Hypertens 17:546-8. 2004
  81. ncbi request reprint Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis
    Mitsuhiro Iwahashi
    Department of Medicine and Clinical Science, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Rheum 50:1457-67. 2004
    ....
  82. ncbi request reprint [Early diagnosis of and therapy for patients with diabetic nephropathy]
    Hirofumi Makino
    Nihon Naika Gakkai Zasshi 93:471-6. 2004
  83. ncbi request reprint Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction
    Reiko Sunami
    Okayama Univ Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Am J Physiol Renal Physiol 286:F1030-8. 2004
    ..This study demonstrates that catalase deficiency enhanced tubulointerstitial injury and fibrosis in a murine model of UUO and thus supports the protective role of catalase in this model...
  84. ncbi request reprint The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats
    Keita Hiragushi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Kidney Int 65:540-50. 2004
    ....
  85. ncbi request reprint Pathogenesis of IgA nephropathy
    Jun Wada
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Semin Nephrol 23:556-63. 2003
    ....
  86. ncbi request reprint Overexpression of angiotensin type 2 receptor ameliorates glomerular injury in a mouse remnant kidney model
    Naoko Hashimoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 286:F516-25. 2004
    ..Taken together, our findings suggest that AT(2)R-mediated signaling may protect from glomerular injuries induced by (5/6)Nx and that overexpression of AT(2)R may serve as a potential therapeutic strategy for glomerular disorders...
  87. ncbi request reprint Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model
    Tsunetatsu Namba
    Division of Clinical Gene Therapy, Osaka University Medical School, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    Circulation 108:2250-7. 2003
    ....
  88. ncbi request reprint Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes
    Shinichi Okada
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Diabetes 52:2586-93. 2003
    ..Moreover, expressions of TGF-beta and type IV collagen in glomeruli were also suppressed in diabetic ICAM-1(-/-) mice. These results suggest that ICAM-1 is critically involved in the pathogenesis of diabetic nephropathy...
  89. ncbi request reprint [Prevention and remission of diabetic nephropathy]
    Taro Sugimoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 61:1167-71. 2003
    ..Thus, simultaneous adjustment on hyperglycemia, hypertension, and dyslipidemia may lead to prevention and remission of diabetic nephropathy...
  90. ncbi request reprint Successful treatment of necrotizing fasciitis associated with diabetic nephropathy
    Daisuke Ogawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Diabetes Res Clin Pract 60:213-6. 2003
    ....
  91. ncbi request reprint An extra-adrenal abdominal pheochromocytoma causing ectopic ACTH syndrome
    Fumio Otsuka
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Am J Hypertens 18:1364-8. 2005
    ..This is the first report of ectopic ACTH syndrome induced by an extra-adrenal abdominal paraganglioma...
  92. ncbi request reprint Hypokalemic paralysis and osteomalacia secondary to renal tubular acidosis in a case with primary Sjögren's syndrome
    Masanori Kawashima
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Mod Rheumatol 16:48-51. 2006
    ..Hypokalemic paralysis and osteomalacia should be taken into consideration in the diagnosis of SS with RTA1...
  93. ncbi request reprint Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia
    Tosjio Ogura
    Health and Medical Center, Okayama University, Okayama, Japan
    Horm Res 59:30-4. 2003
    ..The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated...
  94. ncbi request reprint Role of bradykinin in renoprotective effects by angiotensin II type 1 receptor antagonist in salt-sensitive hypertension
    Kazuaki Yokota
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Hypertens Res 26:265-72. 2003
    ..Collectively, these data show that when AT1 action is chronically blocked, endogenous bradykinin plays a pivotal role in preventing the progression of glomerular injury in salt-sensitive hypertension...
  95. ncbi request reprint Serum interleukin-18 levels are associated with nephropathy and atherosclerosis in Japanese patients with type 2 diabetes
    Akihiko Nakamura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Diabetes Care 28:2890-5. 2005
    ..This study aimed to test the hypothesis that the serum level of IL-18 is a common predictor of nephropathy and atherosclerosis in patients with type 2 diabetes...
  96. ncbi request reprint [Revised criteria for the early diagnosis of diabetic nephropathy]
    Shigeki Inomat
    Japanese Society of Nephrology
    Nihon Jinzo Gakkai Shi 47:767-9. 2005
    ..4) Renal hypertrophy and elevated urinary type IV collagen may indicate the existence of diabetic renal disease. 5) Microalbuminuria originating in non-diabetic diseases should be excluded...
  97. ncbi request reprint Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients
    Hisanori Morimoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Nephrol Dial Transplant 20:2775-82. 2005
    ..In the present study, we compared the effects of a vitamin E-coated polysulfone membrane (PSE) and a non-vitamin E-coated polysulfone membrane (PS) on oxidative stress markers such as ADMA...
  98. ncbi request reprint Antiangiogenic endostatin peptide ameliorates renal alterations in the early stage of a type 1 diabetic nephropathy model
    Kunihiro Ichinose
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Diabetes 54:2891-903. 2005
    ..These results demonstrate the potential use of antiangiogenic endostatin peptide as a novel therapeutic agent in diabetic nephropathy...
  99. ncbi request reprint Increase of serum angiopoietin-2 during pregnancy is suppressed in women with preeclampsia
    Kumiko Hirokoshi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Am J Hypertens 18:1181-8. 2005
    ....
  100. ncbi request reprint Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nephrol Dial Transplant 20:2670-80. 2005
    ....
  101. ncbi request reprint Catalase deficiency renders remnant kidneys more susceptible to oxidant tissue injury and renal fibrosis in mice
    Mizuho Kobayashi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Kidney Int 68:1018-31. 2005
    ..Catalase is one of the important antioxidant enzymes regulating the levels of intracellular hydrogen peroxide and hydroxyl radical. The effect of catalase deficiency on progressive renal fibrosis has not been fully elucidated...