J Kodama

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. pmc Role of emmprin in endometrial cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    BMC Cancer 12:191. 2012
  2. ncbi request reprint Stage IB1 cervical cancer patients with an MRI-measured tumor size < or = 2 cm might be candidates for less-radical surgery
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Gynaecol Oncol 34:39-41. 2013
  3. ncbi request reprint Vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression are implicated in the angiogenesis of endometrial cancer
    N Seki
    Department of Obstetrics and Gynaecology, Okayama University Medical School, Japan
    Eur J Cancer 36:68-73. 2000
  4. ncbi request reprint Prognostic significance of stromal versican expression in human endometrial cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Oncol 18:269-74. 2007
  5. ncbi request reprint Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and Inner Mongolia Agriculture University Hospital, Huhehaote, China
    Ann Oncol 18:70-6. 2007
  6. ncbi request reprint Prognostic factors in node-positive patients with stage IB-IIB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Gynaecol Obstet 93:130-5. 2006
  7. ncbi request reprint Loss of basement membrane heparan sulfate expression is associated with pelvic lymph node metastasis in invasive cervical cancer
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Oncol Rep 14:89-92. 2005
  8. ncbi request reprint Conservative treatment of cervical intraepithelial neoplasia using a cold-knife section technique
    Chafika Mazouni
    Department of Oncologic Gynecology, Marseille Public Hospital System APHM, Hopital de la Conception, Service de gynécologie A, Marseille, France
    Eur J Obstet Gynecol Reprod Biol 121:86-93. 2005
  9. ncbi request reprint Risk factors for early and late postoperative complications of patients with endometrial cancer
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Obstet Gynecol Reprod Biol 124:222-6. 2006
  10. ncbi request reprint Phase I study of weekly nedaplatin and concurrent pelvic radiotherapy as adjuvant therapy after radical surgery for cervical cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Gynecol Cancer 18:1037-41. 2008

Collaborators

Detail Information

Publications60

  1. pmc Role of emmprin in endometrial cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    BMC Cancer 12:191. 2012
    ..Enriched on the surface of many tumor cells, emmprin promotes tumor growth, invasion, metastasis and angiogenesis. We evaluated the clinical importance of emmprin and investigated its role in endometrial cancer...
  2. ncbi request reprint Stage IB1 cervical cancer patients with an MRI-measured tumor size < or = 2 cm might be candidates for less-radical surgery
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Gynaecol Oncol 34:39-41. 2013
    ....
  3. ncbi request reprint Vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression are implicated in the angiogenesis of endometrial cancer
    N Seki
    Department of Obstetrics and Gynaecology, Okayama University Medical School, Japan
    Eur J Cancer 36:68-73. 2000
    ..In addition, VEGF and PD-ECGF might contribute to the aggressive potential of high grade tumours or certain histological subtypes with unfavourable prognosis through the induction of angiogenesis...
  4. ncbi request reprint Prognostic significance of stromal versican expression in human endometrial cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Oncol 18:269-74. 2007
    ..However, the expression of versican in human endometrial cancer has seldom been characterized. The aim of this study was to investigate versican expression in endometrial cancers...
  5. ncbi request reprint Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and Inner Mongolia Agriculture University Hospital, Huhehaote, China
    Ann Oncol 18:70-6. 2007
    ..The chemokine receptors CXCR4 and CCR7 have been suggested to play an important role in cancer invasion and metastasis. The expression of these receptors in human cervical cancer, however, has seldom been characterized...
  6. ncbi request reprint Prognostic factors in node-positive patients with stage IB-IIB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Gynaecol Obstet 93:130-5. 2006
    ..The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB-IIB cervical cancers, who also presented with positive pelvic nodes...
  7. ncbi request reprint Loss of basement membrane heparan sulfate expression is associated with pelvic lymph node metastasis in invasive cervical cancer
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Oncol Rep 14:89-92. 2005
    ..033). Heparanase mRNA expression is associated with the loss of BM HS-GAG expression, which is closely related to lymph node metastasis in invasive cervical cancers...
  8. ncbi request reprint Conservative treatment of cervical intraepithelial neoplasia using a cold-knife section technique
    Chafika Mazouni
    Department of Oncologic Gynecology, Marseille Public Hospital System APHM, Hopital de la Conception, Service de gynécologie A, Marseille, France
    Eur J Obstet Gynecol Reprod Biol 121:86-93. 2005
    ..This procedure can be adapted to patient age, preservation of childbearing potential and extent of dysplasia...
  9. ncbi request reprint Risk factors for early and late postoperative complications of patients with endometrial cancer
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Obstet Gynecol Reprod Biol 124:222-6. 2006
    ..The aim of this study was to investigate the risk factors for the occurrence of early and late postoperative complications in patients managed primarily by surgery in our institution...
  10. ncbi request reprint Phase I study of weekly nedaplatin and concurrent pelvic radiotherapy as adjuvant therapy after radical surgery for cervical cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Gynecol Cancer 18:1037-41. 2008
    ..Weekly administration of nedaplatin may be more tolerable and less toxic than weekly administration of cisplatin...
  11. ncbi request reprint Correlation of presenting symptoms and patient characteristics with endometrial cancer prognosis in Japanese women
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int J Gynaecol Obstet 91:151-6. 2005
    ..To determine whether patient characteristics and presenting symptoms could be prognostic indicators for endometrial cancer in Japanese women...
  12. ncbi request reprint Prognostic significance of the thymidine phosphorylate/dihydropyrimidine dehydrogenase ratio in invasive cervical cancer
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Eur J Obstet Gynecol Reprod Biol 121:81-85. 2005
  13. ncbi request reprint Chemotherapy for high-risk early-stage endometrial cancer
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Okayama, Japan
    Curr Opin Obstet Gynecol 19:42-7. 2007
    ..To discuss the usefulness of chemotherapy in high-risk early-stage endometrial cancer and the best chemotherapy regimen...
  14. ncbi request reprint Prognostic factors in pathologic parametrium-positive patients with stage IB-IIB cervical cancer treated by radical surgery and adjuvant therapy
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Gynecol Oncol 105:757-61. 2007
    ..The purpose of the present study was to identify prognostic factors and recurrent patterns in pathologic parametrium-positive patients with stage IB-IIB cervical cancers treated by radical surgery and adjuvant therapy...
  15. ncbi request reprint Versican expression in human cervical cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Cancer 43:1460-6. 2007
    ..Versican enrichment of the tumour tissue may be associated with progression in cervical cancer. Versican expression can serve as an indicator of poor prognosis in patients with cervical cancer...
  16. ncbi request reprint Factors associated with parametrial involvement in stage IB1 cervical cancer and identification of patients suitable for less radical surgery
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho Kita ku, Okayama 700 8558, Japan
    Gynecol Oncol 122:491-4. 2011
    ....
  17. ncbi request reprint Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama 700 8558, Japan
    Clin Cancer Res 7:2826-31. 2001
    ..TSP association with clinicopathological features, including microvessel count, regarding prognostic significance was examined in patients presenting with invasive cervical cancer...
  18. ncbi request reprint Thrombospondin-1 and -2 messenger RNA expression in epithelial ovarian tumor
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Medical School, Japan
    Anticancer Res 21:2983-7. 2001
    ..The role of thrombospondin (TSP) in tumor progression remains controversial. The association of TSP with clinicopathological features regarding prognostic significance was examined in patients with epithelial ovarian tumor...
  19. ncbi request reprint Optimal surgery and diagnostic approach of stage IA2 squamous cell carcinoma of the cervix
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Eur J Obstet Gynecol Reprod Biol 101:192-5. 2002
    ..Most patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA2 squamous cell carcinoma of the cervix, opt for radical surgery at present...
  20. ncbi request reprint D-dimer level as a risk factor for postoperative venous thromboembolism in Japanese women with gynecologic cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Oncol 21:1651-6. 2010
    ..The purpose of the present study was to evaluate whether early postoperative D-dimer levels and certain pre-, intra-, and postoperative parameters can be used to predict venous thromboembolism (VTE) in gynecologic cancer patients...
  21. ncbi request reprint Prognostic factors in stage IB-IIB cervical adenocarcinoma patients treated with radical hysterectomy and pelvic lymphadenectomy
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Surg Oncol 101:413-7. 2010
    ....
  22. doi request reprint Phase I study of chemoradiation with nedaplatin and ifosfamide in patients with advanced squamous cell carcinoma of the uterine cervix
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Gynecol Cancer 18:1300-4. 2008
    ..With the ifosfamide dose fixed to 1 g/m(2), the recommended nedaplatin dosage was determined to be 80 mg/m(2) to be administered for three cycles...
  23. ncbi request reprint Heparanase messenger RNA expression in epithelial ovarian tumor
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int J Mol Med 12:961-4. 2003
    ..006, respectively). There was no association between heparanase expression and patient outcome. These findings provide evidence that heparanase expression may be associated with a high grade phenotype in this class of neoplasm...
  24. ncbi request reprint Efficacy and prognostic implications of administering adjuvant chemotherapy to patients with endometrial cancer that is confined to the uterus
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama, Japan
    Eur J Obstet Gynecol Reprod Biol 131:76-80. 2007
    ..The purpose of this study was to determine the value of prognostic factors and to assess the efficacy of adjuvant chemotherapy in patients with endometrial cancer confined to the uterus...
  25. pmc Vascular endothelial growth factor-C expression and its relationship to pelvic lymph node status in invasive cervical cancer
    I Hashimoto
    Department of Obstetrics and Gynecology and, Okayama University Medical School, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Br J Cancer 85:93-7. 2001
    ..Furthermore, examination of VEGF-C expression in biopsy specimens may be beneficial in the prediction of pelvic lymph node metastasis...
  26. ncbi request reprint Heparanase expression in both normal endometrium and endometrial cancer
    - Hasengaowa
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int J Gynecol Cancer 16:1401-6. 2006
    ..004 and P= .002, respectively). Heparanase may participate in normal endometrial remodeling and can serve as an indicator of the aggressive potential and poor prognosis of endometrial cancers...
  27. ncbi request reprint Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer
    - Hasengaowa
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Eur J Gynaecol Oncol 26:403-6. 2005
    ..Decreased HS-GAG expression of BM is associated with tumor progression, but is not be a useful prognostic factor in patients presenting with endometrial cancer...
  28. ncbi request reprint Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis
    N Seki
    Department of Obstetrics and Gynecology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
    Int J Oncol 19:305-10. 2001
    ..Our findings provide evidence that elevated TSP expression may be associated with an angiogenic phenotype in endometrial cancer. In addition, TSP-2 expression is a marker for poor prognosis in this disease...
  29. ncbi request reprint Cytocidal effect and DNA damage of nedaplatin: a mathematical model and analysis of experimental data
    Y Miyagi
    Department of Obstetrics and Gynecology, Okayama University Medical School, Shikata cho 2 5 1, Okayama City, Okayama 700 8558, Japan
    Cancer Chemother Pharmacol 47:229-35. 2001
    ..Therefore, we developed a new mathematical model to explain these phenomena...
  30. doi request reprint Hepatocyte growth factor activator inhibitor-2 (HAI-2) is a favorable prognosis marker and inhibits cell growth through the apoptotic pathway in cervical cancer
    K Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medical, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Oncol 20:63-70. 2009
    ..We investigated the role of hepatocyte growth factor activator inhibitor-2 (HAI-2) and evaluated its clinical importance in cervical cancer...
  31. ncbi request reprint Prognostic significance of syndecan-1 expression in human endometrial cancer
    - Hasengaowa
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Ann Oncol 16:1109-15. 2005
    ..Syndecan-1 binds to various extracellular matrix components via its heparan sulfate glycosaminoglycans. The aim of this study was to investigate syndecan-1 expression in endometrial cancers...
  32. ncbi request reprint Cytocidal effect and DNA damage of nedaplatin in vitro by simulating pharmacokinetic parameters
    K Kawanishi
    Department of Obstetrics and Gynecology, Okayama University Medical School, Shikata-cho 2-5-1, Okayama City, Okayama 700-8558, Japan
    Cancer Chemother Pharmacol 47:303-8. 2001
    ..Therefore, a new pharmacokinetic-pharmacodynamic model for nedaplatin must be constructed to investigate the most effective administration procedure in vivo...
  33. ncbi request reprint Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer
    Y Shinyo
    Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan
    Ann Oncol 14:1505-10. 2003
    ..Endoglycosidic heparanase degrades heparan sulfate glycosaminoglycans, and may be important in cancer invasion and metastasis, although its expression in human cervical cancer has not been characterized...
  34. ncbi request reprint Complications and obstetric outcomes after laser conization during pregnancy
    N Seki
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Gynaecol Oncol 31:399-401. 2010
    ..The purpose of the present study was to evaluate the efficacy of diagnostic laser conization and the obstetric outcomes of patients undergoing diagnostic laser conization during pregnancy...
  35. ncbi request reprint Expression of the CXCR4 and CCR7 chemokine receptors in human endometrial cancer
    J Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Gynaecol Oncol 28:370-5. 2007
    ..The aim of this study was to investigate CXCR4 and CCR7 expression in endometrial cancers...
  36. ncbi request reprint Expression of the serine protease hepsin and clinical outcome of human endometrial cancer
    Tamaki Matsuo
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Anticancer Res 28:159-64. 2008
    ..g. prostate, renal, ovarian carcinoma). The purpose of the present study was to examine hepsin expression and to evaluate its clinicopathological significance in endometrial cancer...
  37. ncbi request reprint Expression of hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) in ovarian cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Int J Oncol 34:345-53. 2009
    ..These findings indicate that low HAI-1 and HAI-2 expression in ovarian cancer may be associated with poor prognosis. HAI-1 and HAI-2 could be considered a therapeutic target for treatment approaches in ovarian cancer...
  38. ncbi request reprint Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) are potential targets in uterine leiomyosarcoma
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Oncol 37:605-14. 2010
    ..These findings indicate that HAI-1 and HAI-2 may be possible tumor suppressor genes for uterine LMS and thus, both could be considered therapeutic agents for the treatment of LMS...
  39. doi request reprint The SUVmax of 18F-FDG PET correlates with histological grade in endometrial cancer
    Keiichiro Nakamura
    Department of Gynecologic Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int J Gynecol Cancer 20:110-5. 2010
    ....
  40. ncbi request reprint The predictive value of measurement of SUVmax and SCC-antigen in patients with pretreatment of primary squamous cell carcinoma of cervix
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama, Japan
    Gynecol Oncol 119:81-6. 2010
    ..Use of positron emission tomography/computed tomography (PET/CT) and serum squamous cell carcinoma (SCC) antigen (SCC-ag) as predictors for poor prognosis of pretreatment of primary SCC of cervix...
  41. doi request reprint A pilot study of combination chemotherapy with paclitaxel, pirarubicin, and carboplatin (TPC) for endometrial carcinoma
    Atsushi Hongo
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Kita ku, Okayama, 700 8558, Japan
    Int J Clin Oncol 15:476-83. 2010
    ..We retrospectively evaluated the efficacy and feasibility of combined paclitaxel, pirarubicin, and carboplatin (TPC) therapy for endometrial carcinoma...
  42. ncbi request reprint The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Int J Oncol 35:239-48. 2009
    ..022 and p=0.011, respectively). The present study proposes that these findings may be considered HAI-1 as a therapeutic target for treatment and identify as a favorable prognostic marker for cancer patients of cervical cancer...
  43. ncbi request reprint Hepsin inhibits the cell growth of endometrial cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Int J Mol Med 22:389-97. 2008
    ....
  44. ncbi request reprint Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Int J Oncol 28:393-8. 2006
    ..Our findings in this study identify Hepsin as a target for new approaches in ovarian cancer treatment...
  45. doi request reprint The role of hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 in endometrial cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Cancer 128:2613-24. 2011
    ..These findings indicate that HAI-1 and HAI-2 could be considered as therapeutic targets and used as favorable prognosis markers for endometrial cancer...
  46. ncbi request reprint Antitumor effects of a soluble insulin-like growth factor I receptor in human ovarian cancer cells: advantage of recombinant protein administration in vivo
    Atsushi Hongo
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata, Okayama 700 8558, Japan
    Cancer Res 63:7834-9. 2003
    ..Because 486/STOP cells result in massive apoptosis in vivo within 48 h, usage of a recombinant protein has a great advantage to use its unique bystander effect in vivo for clinical application...
  47. ncbi request reprint Secretory leukoprotease inhibitor inhibits cell growth through apoptotic pathway on ovarian cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medical, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Oncol Rep 19:1085-91. 2008
    ..021), lymph node metastasis (p=0.011). We propose that SLPI could be considered a therapeutic target for the treatment of ovarian cancer...
  48. ncbi request reprint Expression of matriptase and clinical outcome of human endometrial cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medical, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Anticancer Res 29:1685-90. 2009
    ..The purpose of the present study was to examine matriptase expression and evaluate its clinicopathological significance in endometrial cancer...
  49. ncbi request reprint Neoadjuvant treatment with docetaxel and the effects of irradiation for human ovarian adenocarcinoma and cervical squamous cell carcinoma in vitro
    Shinako Araki
    Department of Obstetrics and Gynecology, Okayama University Medical School, Japan
    Acta Med Okayama 56:13-8. 2002
    ..The DNA single-strand breaks induced by the irradiation were enhanced in both cell lines (BG-1; P < 0.01, SiHa; P < 0.05). The synergistic cytocidal effect cannot be explained quantitatively only by the single-strand breaks...
  50. ncbi request reprint Clinical significance of syndecan-1 and versican expression in human epithelial ovarian cancer
    Tomoyuki Kusumoto
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Oncol Rep 23:917-25. 2010
    ..Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer...
  51. ncbi request reprint Loss of cell-surface heparan sulfate expression in both cervical intraepithelial neoplasm and invasive cervical cancer
    Yasuhiro Shinyo
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Gynecol Oncol 96:776-83. 2005
    ..The aims of this study are to investigate its expression in cervical neoplasms...
  52. ncbi request reprint A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis
    Kosei Hasegawa
    Department of Immunology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Cancer 108:86-90. 2004
    ..In Cox multivariate analysis, AKAP3 mRNA expression was found to be a significant predictor of both overall and progression-free survival in patients with poorly differentiated tumors...
  53. ncbi request reprint SSX expression in gynecological cancers and antibody response in patients
    Kosei Hasegawa
    Department of Immunology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Cancer Immun 4:16. 2004
    ..This suggests that SSX4 is a potential target for cancer vaccines in gynecological cancer patients...
  54. ncbi request reprint [Mechanism of metastasis in cervical cancer]
    Junichi Kodama
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 62:78-81. 2004
  55. ncbi request reprint Parathyroid hormone-related protein as a potential tumor marker: a case report of ovarian clear cell carcinoma
    Naoko Suwaki
    Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan
    J Obstet Gynaecol Res 32:94-8. 2006
    ....
  56. ncbi request reprint Eradication of HPV post-surgical treatments, its correlation with specific types, types of surgery and the physical status
    Jin Fen
    Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama 700 8558, Japan
    Oncol Rep 12:375-9. 2004
    ..Type 33 is most frequently persistent among types 16, 18 and 33. Persistent high-risk HPVs increase the risk for recurrence of post-surgical treatments of CIN, but the incidence is not high as long as the lesion is completely removed...
  57. ncbi request reprint Immunohistochemical evaluation of insulin-like growth factor I receptor status in cervical cancer specimens
    Hiroyuki Kuramoto
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 62:251-9. 2008
    ..This IGF-IR overexpression pattern may be utilized in the diagnosis of HPV infection status in CIN lesions...
  58. ncbi request reprint [Paclitaxel and carboplatin with or without pirarubicin (THP-ADR) as first line chemotherapy in elderly patients]
    Shoji Nagao
    Dept of Obstetrics and Gynecology, Okayama University Medical School
    Gan To Kagaku Ryoho 30:243-9. 2003
    ..The overall response rates were equivalent among elderly and younger patients (69% and 78%), respectively. The regimen consisting of paclitaxel and carboplatin without THP-ADR was applied safely to elderly patients...
  59. pmc Rapid and sensitive detection of physical status of human papillomavirus type 16 DNA by quantitative real-time PCR
    Shoji Nagao
    Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan
    J Clin Microbiol 40:863-7. 2002
    ..Four of 11 cervical intraepithelial neoplasia involved integrated forms of HPV-16 DNA partially or exclusively. This rapid, sensitive technique is useful in the analysis of the physical status of HPV DNA...