Takako Hattori

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
  2. ncbi CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes
    Gen Yosimichi
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Biochem Biophys Res Commun 299:755-61. 2002
  3. ncbi Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9
    Takako Hattori
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:14417-28. 2006
  4. pmc Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmacy, 5 1 Shikata cho, 2 chome, Okayama 700 8525, Japan Email
    Nucleic Acids Res 36:3011-24. 2008
  5. ncbi Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Cell Physiol 202:191-204. 2005
  6. pmc Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth
    Nao Tomita
    Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan
    PLoS ONE 8:e59226. 2013
  7. doi Novel chondrogenic and chondroprotective effects of the natural compound harmine
    Emilio Satoshi Hara
    Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Biochimie 95:374-81. 2013
  8. doi Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes
    Mitsuhiro Hoshijima
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    FEBS J 279:3584-97. 2012
  9. ncbi CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1
    Mitsuhiro Hoshijima
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 5 1 Shikata cho, 2 chome, Okayama 700 8525, Japan
    FEBS Lett 580:1376-82. 2006
  10. ncbi Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line
    Harumi Kawaki
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    DNA Cell Biol 22:641-8. 2003

Collaborators

Detail Information

Publications19

  1. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
    ..These findings imply that downregulation of Sox9 in the hypertrophic zone of the normal growth plate is essential for allowing vascular invasion, bone marrow formation and endochondral ossification...
  2. ncbi CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes
    Gen Yosimichi
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Biochem Biophys Res Commun 299:755-61. 2002
    ..These findings suggest that a significant portion of intracellular CTGF/Hcs24 may regulate certain cell biological events in chondrocytes through the interaction with this particular cytoskeletal protein...
  3. ncbi Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9
    Takako Hattori
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:14417-28. 2006
    ..Our results suggest that, by controlling the cellular concentrations of SOX9, PIAS proteins and sumoylation may be part of a major regulatory system of SOX9 functions...
  4. pmc Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmacy, 5 1 Shikata cho, 2 chome, Okayama 700 8525, Japan Email
    Nucleic Acids Res 36:3011-24. 2008
    ..Our results support the hypothesis that Tip60 is a coactivator of Sox9 in chondrocytes...
  5. ncbi Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Cell Physiol 202:191-204. 2005
    ..The surface-exposed RA-A47 may induce autoantibodies and inflammatory reactions in autoimmune disease situations such as rheumatoid arthritis...
  6. pmc Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth
    Nao Tomita
    Department of Biochemistry and Molecular Dentistry, Okayama University Dental School, Okayama, Japan
    PLoS ONE 8:e59226. 2013
    ..Our results also indicate the possible involvement of locally enhanced IGF-I or IGF-II in this extended bone growth...
  7. doi Novel chondrogenic and chondroprotective effects of the natural compound harmine
    Emilio Satoshi Hara
    Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Biochimie 95:374-81. 2013
    ..These findings uncover novel chondrogenic effects of harmine and indicate harmine as a potential drug for prevention and/or repair of cartilage degradation...
  8. doi Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes
    Mitsuhiro Hoshijima
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    FEBS J 279:3584-97. 2012
    ..Strengthening the binding between CCN2 and CCN3 with the 11H3 antibody had an enhancing effect on aggrecan expression in chondrocytes, suggesting that CCN2 had an antagonizing effect by binding to CCN3...
  9. ncbi CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1
    Mitsuhiro Hoshijima
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 5 1 Shikata cho, 2 chome, Okayama 700 8525, Japan
    FEBS Lett 580:1376-82. 2006
    ..These findings suggest for the first time that CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and that alpha5beta1 is involved in this adhesion...
  10. ncbi Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line
    Harumi Kawaki
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    DNA Cell Biol 22:641-8. 2003
    ..Since CTGF is actually processed into subfragments, and functional assignment of each module is of interest, these systems are expected to contribute to the progress of CTGF investigations...
  11. doi The regenerative effects of CCN2 independent modules on chondrocytes in vitro and osteoarthritis models in vivo
    Tarek Abd El Kader
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan Department of Dental Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Bone 59:180-8. 2014
    ..These results indicate the utility of TSP1 in the regenerative therapeutics of OA. Possible molecular mechanism that enables conditional reconstruction of CCN2 by 4 modules is discussed as well. ..
  12. ncbi Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Cell Physiol 197:94-102. 2003
    ..Furthermore, the stimulation of bFGF and CTGF release from chondrocytes may stimulate the proliferation of adjacent endothelial and/or synovial cells...
  13. pmc CCN family member 2/connective tissue growth factor (CCN2/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes
    Shinsuke Itoh
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 8:e71156. 2013
    ..Thus CCN2 may play a role as an anti-aging factor by stabilizing articular cartilage. ..
  14. ncbi [Autoantigen and molecular chaperone in rheumatoid arthritis--their roles in metabolism of chondrocytes]
    Takako Hattori
    Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Biochemistry and Molecular Dentistry
    Clin Calcium 16:1553-56. 2006
    ..Extracellular HSP47/RA-A47 may act as an autoantigen, but also regulate autoimmune inflammation. It is, therefore, a potential new biologic therapy for rheumatoid arthritis...
  15. pmc Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family
    Tarek Abd El Kader
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8525, Japan
    J Cell Commun Signal 7:11-8. 2013
    ..These findings indicate that fibrotic gene induction is under the control of a complex molecular network conducted by CCN family members functioning together...
  16. pmc BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054, Erlangen, Germany
    Histochem Cell Biol 127:183-94. 2007
    ..The Col10a1 specific BAC recombination vector described here will enable the specific analysis of effector gene functions in hypertrophic cartilage during skeletal development, endochondral ossification, and fracture callus healing...
  17. ncbi Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo
    Martina Schmidl
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 281:31790-800. 2006
    ..The data suggest that TSG is an important modulator of BMP-regulated cartilage development and chondrocyte differentiation...
  18. ncbi A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, D 91054, Germany
    Matrix Biol 23:309-22. 2004
    ..These established transgenic lines should facilitate the genetic analysis of regulatory pathways of chondrocyte maturation and Col10a1 gene expression in the future...
  19. ncbi Fibroblast growth factor-2 promotes the repair of partial thickness defects of articular cartilage in immature rabbits but not in mature rabbits
    Tetsuya Yamamoto
    Department of Orthopaedic Surgery, Osaka Minami National Hospital, Kawachinagano, Japan
    Osteoarthritis Cartilage 12:636-41. 2004
    ..To investigate cartilage response to fibroblast growth factor-2 (FGF-2) with increasing age in vivo, we examined the effect of FGF-2 on partial thickness defects of immature and mature rabbits...