M Funahashi

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. pmc Role of the hyperpolarization-activated cation current (Ih) in pacemaker activity in area postrema neurons of rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    J Physiol 552:135-48. 2003
  2. ncbi request reprint The sensitivity of hyperpolarization-activated cation current (Ih) to propofol in rat area postrema neurons
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1015:198-201. 2004
  3. ncbi request reprint Electrophysiological properties of the rat area postrema neurons displaying both the transient outward current and the hyperpolarization-activated inward current
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama, Japan
    Brain Res Bull 58:337-43. 2002
  4. ncbi request reprint Two distinct types of transient outward currents in area postrema neurons in rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 942:31-45. 2002
  5. ncbi request reprint Long-term enhancement of excitatory synaptic inputs to layer V parahippocampal neurons by low frequency stimulation in rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Neurosci Res 42:65-77. 2002
  6. ncbi request reprint Propofol suppresses a hyperpolarization-activated inward current in rat hippocampal CA1 neurons
    M Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Neurosci Lett 311:177-80. 2001
  7. ncbi request reprint Nicotinic modulation of area postrema neuronal excitability in rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1017:227-33. 2004
  8. ncbi request reprint Activation of presynaptic 5-HT3 receptors facilitates glutamatergic synaptic inputs to area postrema neurons in rat brain slices
    M Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Methods Find Exp Clin Pharmacol 26:615-22. 2004
  9. ncbi request reprint Propagation of synchronous burst discharges from entorhinal cortex to morphologically and electrophysiologically identified neurons of rat lateral amygdala
    M Funahashi
    Department of Physiology, Okayama University Dental School, 2 5 1 Shikata cho, 700 8525, Okayama, Japan
    Brain Res 884:104-15. 2000
  10. ncbi request reprint Development of inhibitory synaptic transmission to the superior salivatory nucleus in rats
    Yoshihiro Mitoh
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama 700 8525, Japan
    Brain Res 1191:47-54. 2008

Detail Information

Publications23

  1. pmc Role of the hyperpolarization-activated cation current (Ih) in pacemaker activity in area postrema neurons of rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    J Physiol 552:135-48. 2003
    ..Our findings indicate that Ih contributes to the subthreshold membrane and firing properties of rat area postrema neurons and may regulate their resting membrane potential and firing patterns...
  2. ncbi request reprint The sensitivity of hyperpolarization-activated cation current (Ih) to propofol in rat area postrema neurons
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1015:198-201. 2004
    ....
  3. ncbi request reprint Electrophysiological properties of the rat area postrema neurons displaying both the transient outward current and the hyperpolarization-activated inward current
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama, Japan
    Brain Res Bull 58:337-43. 2002
    ..We discuss the functional significance of the specific subset of area postrema neurons whose cells have both I(H) and I(TO) channels...
  4. ncbi request reprint Two distinct types of transient outward currents in area postrema neurons in rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 942:31-45. 2002
    ..We discuss the role of I(to) as the ionic current underlying neuronal excitability...
  5. ncbi request reprint Long-term enhancement of excitatory synaptic inputs to layer V parahippocampal neurons by low frequency stimulation in rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Neurosci Res 42:65-77. 2002
    ..It is suggested that stable changes in excitatory inputs to layer V parahippocampal neurons involve the activation of NMDA and metabotropic glutamate receptors, but requires AMPA receptor activation and postsynaptic cell firing...
  6. ncbi request reprint Propofol suppresses a hyperpolarization-activated inward current in rat hippocampal CA1 neurons
    M Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Neurosci Lett 311:177-80. 2001
    ..We suggest that the effectiveness of propofol as an anticonvulsant or an antiemetic is associated with the blockade of the I(H) channel...
  7. ncbi request reprint Nicotinic modulation of area postrema neuronal excitability in rat brain slices
    Makoto Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1017:227-33. 2004
    ..We conclude that nicotinic receptors in the rat area postrema can excite cells via (1) a direct post- and/or extrasynaptic mechanism; and (2) an indirect enhancement of glutamate release...
  8. ncbi request reprint Activation of presynaptic 5-HT3 receptors facilitates glutamatergic synaptic inputs to area postrema neurons in rat brain slices
    M Funahashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Methods Find Exp Clin Pharmacol 26:615-22. 2004
    ..Such a mechanism may contribute to the chemosensitive function of area postrema neurons...
  9. ncbi request reprint Propagation of synchronous burst discharges from entorhinal cortex to morphologically and electrophysiologically identified neurons of rat lateral amygdala
    M Funahashi
    Department of Physiology, Okayama University Dental School, 2 5 1 Shikata cho, 700 8525, Okayama, Japan
    Brain Res 884:104-15. 2000
    ..We conclude that other synchronous events such as sharp waves and interictal spikes can spread from entorhinal cortex to amygdala in the same manner...
  10. ncbi request reprint Development of inhibitory synaptic transmission to the superior salivatory nucleus in rats
    Yoshihiro Mitoh
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama 700 8525, Japan
    Brain Res 1191:47-54. 2008
    ..The development of SS neurons is discussed as compared with the development of peripheral salivary gland tissue and brainstem neurons that participate in oral motor and sensory functions...
  11. ncbi request reprint Postnatal development of inhibitory synaptic transmission to superior salivatory neurons in rats
    Yoshihiro Mitoh
    Department of Oral Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Med Invest 56:270-2. 2009
    ..The period at which GABA responses change from excitatory to inhibitory in SS neurons was discussed compared with those of the forebrain, brainstem, and spinal neurons...
  12. ncbi request reprint Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation
    T Sugimoto
    Department of Oral Anatomy II, Okayama University Dental School, 2 5 1 Shikata cho, Okayama 700, Japan
    Brain Res 794:353-8. 1998
    ..These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268...
  13. ncbi request reprint Noxious tooth pulp stimulation suppresses c-fos expression in the rat hippocampal formation
    M Funahashi
    Department of Oral Physiology, Okayama University Dental School, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 827:215-20. 1999
    ....
  14. ncbi request reprint Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxide-cyclic guanosine monophosphate pathway modulation in rabbits
    A Kohjitani
    Department of Dental Anesthesiology, Okayama University School of Dentistry, Japan
    Anesthesiology 95:176-83. 2001
    ..Nonadrenergic noncholinergic (NANC) nerves have important roles in the regulation of the lower esophageal sphincter (LES) motility and function. The effects of thiopental, ketamine, and midazolam on NANC LES relaxation were investigated...
  15. ncbi request reprint Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits
    Atsushi Kohjitani
    Department of Dental Anaesthesiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Eur J Pharmacol 465:145-51. 2003
    ..These findings suggest that mexiletine inhibits NANC relaxation via NO-cGMP pathway modulation, possibly by inhibiting myenteric nitrergic neurotransmission in the lower oesophageal sphincter in rabbits...
  16. ncbi request reprint Purinergic modulation of area postrema neuronal excitability in rat brain slices
    Naoki Kodama
    Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1165:50-9. 2007
    ..It is well known that P2X(7) subunit forms only homomultimeric P2X receptors. Finally, the present study suggests that purinoceptor activation may contribute to the control of several autonomic functions by area postrema neurons...
  17. ncbi request reprint Peripheral N-methyl-D-aspartate receptors modulate nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits
    Atsushi Kohjitani
    Department of Dental Anesthesiology, Okayama University Hospital of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Anesth Analg 101:1681-8. 2005
    ....
  18. ncbi request reprint Suppression of the hyperpolarization-activated inward current contributes to the inhibitory actions of propofol on rat CA1 and CA3 pyramidal neurons
    Hitoshi Higuchi
    Department of Dental Anesthesiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Neurosci Res 45:459-72. 2003
    ..The present study suggests that various actions including suppressive effects on I(H) contribute to the anesthetic and anti-convulsant properties of propofol...
  19. ncbi request reprint Ketamine and midazolam differentially inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits: role of superoxide anion and nitric oxide synthase
    Atsushi Kohjitani
    Department of Dental Anesthesiology, Okayama University Hospital of Dentistry, Shikata cho, Japan
    Anesthesiology 98:449-58. 2003
    ..The mechanisms inhibiting the NANC relaxation by ketamine and midazolam were investigated...
  20. ncbi request reprint Excitatory and inhibitory postsynaptic currents of the superior salivatory nucleus innervating the salivary glands and tongue in the rat
    Yoshihiro Mitoh
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama 700 8525, Japan
    Brain Res 999:62-72. 2004
    ..These characteristics of the excitatory and inhibitory inputs may be involved in determining the firing properties of the SS neurons innervating the salivary glands and the tongue...
  21. ncbi request reprint Role of parabrachial nucleus in submandibular salivary secretion induced by bitter taste stimulation in rats
    R Matsuo
    Department of Oral Physiology, Okayama University Dental School, Japan
    Auton Neurosci 88:61-73. 2001
    ..These results suggest that aversive taste information from the parabrachial taste area reaches the salivary secretory center via the reticular formation ventral to the parabrachial nucleus...
  22. ncbi request reprint The origin of sensory nerve fibers that innervate the submandibular salivary gland in the rat
    Miyuki Kobashi
    Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1060:184-7. 2005
    ..The labeled neurons in these ganglia were of various sizes compared to unlabeled neurons, suggesting that the sensory nerves of the gland conduct various modalities of sensory information...
  23. ncbi request reprint Variety of morphological and electrophysiological properties of area postrema neurons in adult rat brain slices
    Makoto Funahashi
    Department of Oral Physiology and Cellular Function, Hokkaido University, Graduate School of Dental Medicine, North 13 West 7 Kita ku, Sapporo 060 8586, Japan
    Neurosci Res 54:43-8. 2006
    ....