Reiko Akagi

Summary

Affiliation: Okayama Prefectural University
Country: Japan

Publications

  1. ncbi request reprint Fundamental role of heme oxygenase in the protection against ischemic acute renal failure
    Reiko Akagi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Japan
    Jpn J Pharmacol 88:127-32. 2002
  2. ncbi request reprint Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient
    Reiko Akagi
    Okayama Prefectural University, Japan
    Br J Haematol 132:237-43. 2006
  3. ncbi request reprint Cytoprotective effects of heme oxygenase in acute renal failure
    Reiko Akagi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama ken, Japan
    Contrib Nephrol 148:70-85. 2005
  4. ncbi request reprint [Gene defects identified in porphyrias and their participation in onset of this disease]
    Reiko Akagi
    Nihon Yakurigaku Zasshi 130:266-9. 2007
  5. ncbi request reprint Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Life Sci 80:1578-85. 2007
  6. ncbi request reprint delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations
    Reiko Akagi
    Department of Nutritional Science, Okayama Prefectural University, Soja, Japan
    Mol Genet Metab 87:329-36. 2006
  7. ncbi request reprint A new ferrochelatase mutation combined with low expression alleles in a Japanese patient with erythropoietic protoporphyria
    Yumiko Yasui
    Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja shi 719 1197, Japan
    Clin Sci (Lond) 102:501-6. 2002
  8. ncbi request reprint Anti-angiogenic effect of pyridoxal 5'-phosphate, pyridoxal and pyridoxamine on embryoid bodies derived from mouse embryonic stem cells
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Int J Mol Med 14:819-23. 2004
  9. ncbi request reprint Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    DNA Cell Biol 25:95-103. 2006
  10. ncbi request reprint [Diversity of physiological functions mediated by heme metabolism]
    Reiko Akagi
    Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Seikagaku 79:441-5. 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Fundamental role of heme oxygenase in the protection against ischemic acute renal failure
    Reiko Akagi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Japan
    Jpn J Pharmacol 88:127-32. 2002
    ..In this review, recent findings concerning the role of HO-1 as a protective response against oxidative stress conditions are summarized, with a particular emphasis on its protective role in ischemic acute renal failure...
  2. ncbi request reprint Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient
    Reiko Akagi
    Okayama Prefectural University, Japan
    Br J Haematol 132:237-43. 2006
    ..This patient thus represents the first case of porphyria where both CPO and ALAD deficiencies were demonstrated at the molecular level...
  3. ncbi request reprint Cytoprotective effects of heme oxygenase in acute renal failure
    Reiko Akagi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama ken, Japan
    Contrib Nephrol 148:70-85. 2005
    ..In addition to these findings, recent evidence on the role of HO-1 in the kidney pathophysiology is summarized, with a particular emphasis on its protective role in the ischemic acute renal failure...
  4. ncbi request reprint [Gene defects identified in porphyrias and their participation in onset of this disease]
    Reiko Akagi
    Nihon Yakurigaku Zasshi 130:266-9. 2007
  5. ncbi request reprint Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Life Sci 80:1578-85. 2007
    ..These results suggest that acylation of epicatechin is an effective chemical modification to improve the anti-cancer activity of epicatechin...
  6. ncbi request reprint delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations
    Reiko Akagi
    Department of Nutritional Science, Okayama Prefectural University, Soja, Japan
    Mol Genet Metab 87:329-36. 2006
    ..This case represents the molecular analysis of the ALAD gene defects in the first case of ADP identified in North America, who is a compound heterozygote for two novel ALAD gene defects...
  7. ncbi request reprint A new ferrochelatase mutation combined with low expression alleles in a Japanese patient with erythropoietic protoporphyria
    Yumiko Yasui
    Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja shi 719 1197, Japan
    Clin Sci (Lond) 102:501-6. 2002
    ..These results indicate that the combination of a 16 base pair deletion and low expression of the wild-type allelic variant is responsible for EPP in this pedigree...
  8. ncbi request reprint Anti-angiogenic effect of pyridoxal 5'-phosphate, pyridoxal and pyridoxamine on embryoid bodies derived from mouse embryonic stem cells
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Int J Mol Med 14:819-23. 2004
    ....
  9. ncbi request reprint Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis
    Kiminori Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    DNA Cell Biol 25:95-103. 2006
    ..These results suggest that acylation of catechin is an effective chemical modification to improve the anticancer activity of catechin...
  10. ncbi request reprint [Diversity of physiological functions mediated by heme metabolism]
    Reiko Akagi
    Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Seikagaku 79:441-5. 2007
  11. pmc Co-synthesis of Human delta-Aminolevulinate Dehydratase (ALAD) Mutants with the Wild-type Enzyme in Cell-free System-Critical Importance of Conformation on Enzyme Activity-
    Rikako Inoue
    Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja city 719 1197, Japan
    J Clin Biochem Nutr 43:143-53. 2008
    ....
  12. ncbi request reprint CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1
    Shuji Takahashi
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Int J Mol Med 11:57-62. 2003
    ....
  13. ncbi request reprint Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
    Tatsuya Sugawara
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Agric Food Chem 54:9805-10. 2006
    ..These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases...
  14. ncbi request reprint Late-onset porphyrias: what are they?
    Shigeru Sassa
    Laboratory of Biochemical Hematology, The Rockefeller University, New York, NY 10021, USA
    Cell Mol Biol (Noisy-le-grand) 48:97-101. 2002
    ....
  15. ncbi request reprint Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity
    Kiichi Nakahira
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Biochem Pharmacol 66:1091-105. 2003
    ..Our findings also suggest that HO-1 induction may play an important role in conferring protection on hepatocytes from oxidative damage caused by free heme...
  16. ncbi request reprint Protective role of heme oxygenase-1 in renal ischemia
    Toru Takahashi
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, 700 8558, Japan
    Antioxid Redox Signal 6:867-77. 2004
    ..In this article, we review the protective role of HO-1 in renal ischemic injury, and its potential therapeutic applications. In addition, we summarize recent findings in the regulatory mechanism of ho-1 gene expression...
  17. ncbi request reprint Increased heme oxygenase-1 and decreased delta-aminolevulinate synthase expression in the liver of patients with acute liver failure
    Hiromi Fujii
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Int J Mol Med 14:1001-5. 2004
    ....
  18. ncbi request reprint [Metabolism of heme and novel drug design]
    Reiko Akagi
    Nihon Yakurigaku Zasshi 130:247. 2007
  19. ncbi request reprint [Protective role of HO-1 in oxidative tissue injuries]
    Toru Takahashi
    Nihon Yakurigaku Zasshi 130:252-6. 2007
  20. doi request reprint Alpha-lipoic acid suppresses 6-hydroxydopamine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1
    Hirofumi Fujita
    Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1206:1-12. 2008
    ..These results suggested that LA suppressed the 6-OHDA induced-apoptosis by the increase in cellular glutathione through stimulation of the GSH synthesis system but not by the expression of HO-1...
  21. ncbi request reprint Protective role of heme oxygenase 1 in the intestinal tissue injury in hemorrhagic shock in rats
    Kazuyoshi Inoue
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan
    Shock 29:252-61. 2008
    ....
  22. ncbi request reprint Tin chloride pretreatment prevents renal injury in rats with ischemic acute renal failure
    Narushi Toda
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan
    Crit Care Med 30:1512-22. 2002
    ..To investigate whether tin chloride pretreatment ameliorates renal injury in rats with ischemic acute renal failure (IARF) by virtue of its kidney-specific heme oxygenase-1 induction...
  23. ncbi request reprint Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells
    Yumiko Yasui
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    Biol Pharm Bull 30:443-6. 2007
    ..We showed that NAC inhibited HO-1 upregulation. These results suggest that oxidative stress in activated RBL-2H3 cells results in the upregulation of HO-1...
  24. ncbi request reprint The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury
    Kenji Uehara
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2 5 1 Shikata cho, Okayama City 700 8558, Japan
    Crit Care Med 33:381-90. 2005
    ..The aim of the present study was to investigate whether glutamine pretreatment improves intestinal injury in rats with endotoxemia by its heme oxygenase-1 induction in the lower intestinal tract...
  25. ncbi request reprint Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity
    Tomoko Kawakami
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Int J Mol Med 18:537-46. 2006
    ..These findings thus demonstrate that rhIL-11 confers significant protection against CCl(4)-induced hepatic injury by virtue of its liver-specific HO-1 induction...
  26. ncbi request reprint Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis
    Hiromi Fujii
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Japan
    Crit Care Med 31:893-902. 2003
    ..The aim of this study was to examine the role of heme oxygenase-1 induction in the intestinal tissue injury in a rat model of sepsis...
  27. ncbi request reprint A protective role of interleukin 11 on hepatic injury in acute endotoxemia
    Kyoichiro Maeshima
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Shock 21:134-8. 2004
    ..In addition, rhIL-11 treatment markedly decreased LPS-induced mortality. These results indicate that rhIL-11 plays a significant protective role in LPS-induced hepatic injury in acute endotoxemia...
  28. ncbi request reprint Prevention of hemorrhagic shock-induced lung injury by heme arginate treatment in rats
    Kyoichiro Maeshima
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Biochem Pharmacol 69:1667-80. 2005
    ..Our findings also indicate that HA pretreatment can significantly suppress the HSR-induced lung injury by virtue of its ability to induce HO-1...
  29. ncbi request reprint Increased pulmonary heme oxygenase-1 and delta-aminolevulinate synthase expression in monocrotaline-induced pulmonary hypertension
    Tatsuo Iwasaki
    Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Curr Neurovasc Res 2:133-9. 2005
    ....