K Abe

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta)
    E Matsubara
    Department of Neurology, Okayama University, Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
    Ann N Y Acad Sci 977:340-8. 2002
  2. ncbi Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins
    Etsuro Matsubara
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Schikata cho, Okayama, Okayama 700 8558, Japan
    Neurobiol Aging 25:833-41. 2004
  3. ncbi Attenuation of oxidative DNA damage with a novel antioxidant EPC-K1 in rat brain neuronal cells after transient middle cerebral artery occlusion
    W R Zhang
    Department of Neurology, Okayama University School of Medicine and Dentistry, Japan
    Neurol Res 23:676-80. 2001
  4. ncbi Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata machi, 700 8558, Okayama, Japan
    Brain Res 907:130-3. 2001
  5. ncbi Temporal and spatial differences of PSA-NCAM expression between young-adult and aged rats in normal and ischemic brains
    K Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 922:135-9. 2001
  6. ncbi DNA fragmentation and HSP72 gene expression by adenovirus-mediated gene transfer in postischemic gerbil hippocampus and ventricle
    H Kitagawa
    Department of Neurology, Okayama University Medical School, Japan
    Metab Brain Dis 13:211-23. 1998
  7. ncbi Protection against ischemic brain damage by GDNF affecting cell survival and death signals
    G Jin
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikatacho, Okayama 700-8558, Japan
    Neurol Res 25:249-53. 2003
  8. ncbi Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion
    C Sasaki
    Department of Neurology, Okayama University Medical School, Japan
    Neurol Res 23:588-92. 2001
  9. ncbi Induction of polysialic acid-neural cell adhesion molecule in surviving motoneurons of transgenic amyotrophic lateral sclerosis mice
    H Warita
    Department of Neurology, Okayama University Medical School, Japan
    Neurosci Lett 300:75-8. 2001
  10. ncbi Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats
    H Kitagawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Stroke 29:1417-22. 1998

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta)
    E Matsubara
    Department of Neurology, Okayama University, Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
    Ann N Y Acad Sci 977:340-8. 2002
  2. ncbi Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins
    Etsuro Matsubara
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Schikata cho, Okayama, Okayama 700 8558, Japan
    Neurobiol Aging 25:833-41. 2004
    ....
  3. ncbi Attenuation of oxidative DNA damage with a novel antioxidant EPC-K1 in rat brain neuronal cells after transient middle cerebral artery occlusion
    W R Zhang
    Department of Neurology, Okayama University School of Medicine and Dentistry, Japan
    Neurol Res 23:676-80. 2001
    ..These results indicate EPC-K1 attenuates oxidative neuronal cell damage and prevents neuronal cell death...
  4. ncbi Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata machi, 700 8558, Okayama, Japan
    Brain Res 907:130-3. 2001
    ....
  5. ncbi Temporal and spatial differences of PSA-NCAM expression between young-adult and aged rats in normal and ischemic brains
    K Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 922:135-9. 2001
    ..PSA-NCAM was induced after ischemia, and the temporal expression was also different after transient MCAO between young and older rats...
  6. ncbi DNA fragmentation and HSP72 gene expression by adenovirus-mediated gene transfer in postischemic gerbil hippocampus and ventricle
    H Kitagawa
    Department of Neurology, Okayama University Medical School, Japan
    Metab Brain Dis 13:211-23. 1998
    ..However, adenovirus-mediated gene transfer may induce indirect apoptotic cell death in the DG and ventricle, in addition to direct traumatic injury around the needle track...
  7. ncbi Protection against ischemic brain damage by GDNF affecting cell survival and death signals
    G Jin
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikatacho, Okayama 700-8558, Japan
    Neurol Res 25:249-53. 2003
    ..These results suggest that GDNF plays a protective role against ischemic injury by controlling the balance between Akt pathway and caspase cascades...
  8. ncbi Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion
    C Sasaki
    Department of Neurology, Okayama University Medical School, Japan
    Neurol Res 23:588-92. 2001
    ....
  9. ncbi Induction of polysialic acid-neural cell adhesion molecule in surviving motoneurons of transgenic amyotrophic lateral sclerosis mice
    H Warita
    Department of Neurology, Okayama University Medical School, Japan
    Neurosci Lett 300:75-8. 2001
    ..The present data suggest that a specific expression of PSA-NCAM may be involved in the survival of spinal motoneurons under pathological conditions such as amyotrophic lateral sclerosis...
  10. ncbi Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats
    H Kitagawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Stroke 29:1417-22. 1998
    ..Therefore, we investigated a possible effect of GDNF on the changes of infarct size, brain edema, DNA fragmentation, and immunoreactivities for caspases after permanent middle cerebral artery occlusion (MCAO) in rats...
  11. ncbi Early decrease of survival signal-related proteins in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene
    H Warita
    Department of Neurology, Okayama University Medical School, Okayama, Japan
    Apoptosis 6:345-52. 2001
    ..The present results suggest that an early decrease of survival signal proteins in the spinal motor neurons may account for the subsequent motor neuronal loss in this animal model of ALS...
  12. ncbi Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite
    Y Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University Medical School, Okayama, Japan
    J Neurosci Res 65:371-7. 2001
    ..The present results suggest that both excitotoxic and oxidative stress play an important role in the upregulation of NT nitration and the apoptotic pathway in cultured rat spinal neurons...
  13. ncbi Inductions of Cu/Zn superoxide dismutase- and nitric oxide synthase-like immunoreactivities in rabbit spinal cord after transient ischemia
    M Watanabe
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Brain Res 732:69-74. 1996
    ..Other factors could be required for NT formation found in degenerative motor neuron death in humans...
  14. ncbi Two Japanese CADASIL families with a R141C mutation in the Notch3 gene
    T Murakami
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry
    Intern Med 40:1144-8. 2001
    ..Although the disease is very rare among the Japanese population, our result suggests a possible relationship of this particular mutation (R141C) with the lesions of the corpus callosum...
  15. ncbi Highly polysialylated neural cell adhesion molecule (PSA-NCAM) positive cells are increased and change localization in rat hippocampus by exposure to repeated kindled seizures
    K Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Acta Neurochir Suppl 86:575-9. 2003
    ..This may contribute to an abnormal reconstruction of the synaptic network in the hippocampus and, thus, epileptogenicity from kindling...
  16. ncbi The protective effect of L-threo-3,4-dihydroxyphenylserine on ischemic hippocampal neuronal death in gerbils
    T H Lee
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Stroke 25:1425-31; discussion 1432. 1994
    ..We evaluated the possible protective effect of DOPS against hippocampal CA1 cell death after transient forebrain ischemia in gerbils...
  17. ncbi Time dependent amelioration against ischemic brain damage by glial cell line-derived neurotrophic factor after transient middle cerebral artery occlusion in rat
    W R Zhang
    Department of Neurology, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700-8558, Japan
    Brain Res 903:253-6. 2001
    ..The effect of GDNF was stronger in suppressing active caspase-3 than active caspase-9...
  18. ncbi Protective effect of ginkgo extract on rat brain with transient middle cerebral artery occlusion
    W R Zhang
    Department of Neurology, Okayama University Medical School, Japan
    Neurol Res 22:517-21. 2000
    ..Immunohistochemical analysis showed that caspase-3 expression was less abundant in Ginkgo treated rats. The present results suggest that Ginkgo extract contains a substance which increases normal CBF and reduces ischemic brain damage...
  19. ncbi Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents ischemic brain injury after transient middle cerebral artery occlusion in rats
    H Kitagawa
    Department of Neurology, Okayama University Medical School, Japan
    J Cereb Blood Flow Metab 19:1336-44. 1999
    ..These results suggest that the successful exogenous GDNF gene transfer ameliorates ischemic brain injury after transient MCAO in association with the reduction of apoptotic signals...
  20. ncbi Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis
    Y Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 935:124-8. 2002
    ..The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS)...
  21. ncbi Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion
    N Omori
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 954:317-22. 2002
    ..These results suggest an important role of p-PTEN for cell survival after ischemia as an upstream regulator for PI3K-Akt...
  22. ncbi Induction of PML immunoreactivity in rat brain neurons after transient middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Okayama University School of Medicine, Japan
    Neurol Res 23:772-6. 2001
    ..The present results suggest that PML protein may be one of the key molecules in ischemic neuronal cell death...
  23. ncbi Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats
    H Kitagawa
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 834:190-5. 1999
    ..This rapid induction of GFRalpha-1 and RET, which correlates with the similar induction of GDNF under these conditions, may play a role in the early response to ischemic brain injury...
  24. ncbi Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia
    M Shiote
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558 Okayama, Japan
    Neuroscience 132:175-82. 2005
    ..These results suggest that VEGF exerts its protective effect on motor neurons against hypoxia-induced toxicity by the Flk-1 receptor through the PI3-K/Akt and the MEK/ERK signaling pathways...
  25. ncbi Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis
    Y Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 25:195-200. 2003
    ....
  26. ncbi Induction of highly polysialylated neural cell adhesion molecule (PSA-NCAM) in postischemic gerbil hippocampus mainly dissociated with neural stem cell proliferation
    M Iwai
    Department of Neurology, Okayama University Medical School, 2-5-1 Shikatacho, 700-8558, Okayama, Japan
    Brain Res 902:288-93. 2001
    ..These results suggest different predominant spatial distribution and chronological change of PSA-NCAM positive and BrdU-labeled cells in DG after transient ischemia...
  27. ncbi EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SOD1 gene
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women's Medical College, Japan
    Neuroreport 12:1359-62. 2001
    ..These findings suggest that EAAT1 and EAAT2 may not play a pivotal role in the degeneration of motoneurons in this animal model...
  28. ncbi Phosphorylation of retinoblastoma protein in rat brain after transient middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Okayama University Medical School, Okayama, Japan
    Neuropathol Appl Neurobiol 26:390-7. 2000
    ..These results suggest that Rb protein is progressively hyper-phosphorylated in the brain after ischaemia, which may activate apoptotic mechanisms in neuronal cells of the brain after ischaemia...
  29. ncbi Functional improvement by electro-acupuncture after transient middle cerebral artery occlusion in rats
    S J Wang
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikatacho, Okayama 700-8558, Japan
    Neurol Res 25:516-21. 2003
    ..These results suggest that the acupoints applied in this study are effective for the functional recovery, and an enhanced expression of VEGF may play a certain role in recovery process after stroke...
  30. ncbi Glutamate enhances DNA fragmentation in cultured spinal motor neurons of rat
    Y Manabe
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    Neurol Res 23:79-82. 2001
    ..The present results show that excessive amount of glutamate enhances DNA fragmentation in developing large motor neuron of cultured spinal cord by involving in apoptotic process of the neurons...
  31. ncbi In vivo adenovirus-mediated gene transfer and the expression in ischemic and reperfused rat brain
    K Abe
    Department of Neurology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Brain Res 763:191-201. 1997
    ..The present study shows an effective gene transfer and the expression in neural cells of ischemic and reperfused brains in vivo, and suggests a great potential of the gene therapy for ischemic stroke patients in the future...
  32. ncbi Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats
    T Hayashi
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Stroke 28:2039-44. 1997
    ..We investigated temporal, spatial, and cellular profiles of the induction of VEGF gene expression after transient focal cerebral ischemia at both mRNA and protein levels...
  33. ncbi Temporal and spacial changes of highly polysialylated neural cell adhesion molecule immunoreactivity in amygdala kindling development
    K Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 25:79-82. 2003
    ..These changes may mainly contribute to the reorganization of neural network in epileptic brain...
  34. ncbi Activation of cell-survival signal Akt by GDNF in normal rat brain
    G Jin
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 958:429-33. 2002
    ..These results indicate that p-Akt is expressed in neuronal cells under physiological conditions, and that topical application of GDNF greatly enhanced the phosphorylation of Akt in normal rat brain...
  35. ncbi Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats
    J M Wang
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikatacho, Okayama, Japan
    Brain Res 859:381-5. 2000
    ..The present results suggest that the treatment with IGF-1 significantly ameliorates brain injury after transient focal brain ischemia associated with the reduction of TUNEL and GSK3beta stainings...
  36. ncbi Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice
    H Warita
    Department of Neurology, Okayama University Medical School, Okayama, Japan
    Brain Res Mol Brain Res 89:147-52. 2001
    ....
  37. ncbi Tardive decrease of astrocytic glutamate transporter protein in transgenic mice with ALS-linked mutant SOD1
    H Warita
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Neurol Res 24:577-81. 2002
    ..The present results show interesting dissociative expressions of astroglial proteins EAAT2 and GFAP in the same ventral horn, but suggest not an early and primary role of EAAT2 in the motoneuronal death of this model...
  38. ncbi Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin
    N Omori
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 25:275-9. 2003
    ..These results indicate that the Tf-PEG-liposome could be utilized as an efficient drug delivery tool to the brain after stroke...
  39. ncbi Impaired retrograde axonal transport of adenovirus-mediated E. coli LacZ gene in the mice carrying mutant SOD1 gene
    T Murakami
    Department of Neurology, Okayama University, Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, Japan
    Neurosci Lett 308:149-52. 2001
    ..1 and 0.05 mm/24 h in non-transgenic and transgenic mice, respectively. These results indicate that the retrograde axonal transport of foreign gene product is impaired in the mice model for familial amyotrophic lateral sclerosis...
  40. ncbi Amelioration of brain edema by topical application of glial cell line-derived neurotrophic factor in reperfused rat brain
    K Abe
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurosci Lett 231:37-40. 1997
    ....
  41. ncbi Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain
    J M Wang
    Department of Neurology, Okayama University Medical School, Japan
    Neurosci Lett 277:17-20. 1999
    ..The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35...
  42. ncbi Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain
    H Kitagawa
    Department of Neurology, Okayama University Medical School, Japan
    Neurosci Lett 274:45-8. 1999
    ..These findings suggest that the signaling for Akt and PI3-K are different from the ERK dependent signal transduction during ischemic brain injury...
  43. ncbi Temporal and spacial changes of BrdU immunoreactivity in amygdala kindling development
    K Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama Univerisity, Japan
    Neurol Res 24:593-6. 2002
    ..Thus, the proliferation of NSC was spacially and temporally different between brain regions depending on different kindling stages...
  44. ncbi Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat
    W R Zhang
    Department of Neurology, Okayama University Medical School, Japan
    Neurosci Lett 276:161-4. 1999
    ..02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions...
  45. ncbi Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia
    K Ohta
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Acta Neurochir Suppl 86:187-9. 2003
    ..These results suggest that the young brain shows a higher potential of proliferation and process branching of OPCs than the aged brain...
  46. ncbi Expression of the glial cell line-derived neurotrophic factor gene in rat brain after transient MCA occlusion
    K Abe
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Brain Res 776:230-4. 1997
    ..The present results indicate that the GDNF gene was expressed in an early stage of reperfusion in neuronal cells of the MCA territory, but that the staining property was different between in the cerebral cortex and caudate...
  47. ncbi [Gene therapy and neurotrophic factor treatment for amyotrophic lateral sclerosis]
    K Abe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University
    Rinsho Shinkeigaku 41:1160-1. 2001
    ..These observations demonstrate that GDNF gene therapy in a mouse model of FALS promotes the survival of motoneurons, suggesting that a similar approach might delay the progression of neurodegeneration of ALS...
  48. ncbi Nocturnal blood pressure dip in CADASIL
    Y Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    J Neurol Sci 193:13-6. 2001
    ..01). This study suggests that a lower nocturnal blood pressure fall may be partly associated with incidence and/or worsening of deep white matter lesions in CADASIL...
  49. ncbi Cognitive and affective impairments of a novel SCA/MND crossroad mutation Asidan
    K Abe
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan
    Eur J Neurol 19:1070-8. 2012
    ..Cognitive and affective changes are one such non-ataxia symptoms, but have been described only in hereditary SCAs with exonic CAG gene expansion...
  50. ncbi Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis
    K Abe
    Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan
    Neuroradiology 43:537-41. 2001
    ..71; P < 0.05), implying frontal lobe dysfunction. These correlations suggest that a reduced NAA/Cr ratio is a marker of cortical neuronal loss and dysfunction in ALS...
  51. ncbi A case of spinocerebellar ataxia accompanied by severe involvement of the motor neuron system
    Y Manabe
    Department of Neurology, Okayama University Medical School, Japan
    Neurol Res 22:567-70. 2000
    ....
  52. ncbi Temporal changes in expression of neuronal nitric oxide synthase mRNA in the rat hippocampus associated with kainate-induced seizures
    K Kashihara
    Department of Neurology, Okayama University Medical School, Japan
    Neurol Res 22:409-12. 2000
    ....
  53. ncbi Dissociative expression of adenoviral-mediated E. coli LacZ gene between ischemic and reperfused rat brains
    K Abe
    Department of Neurology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Neurosci Lett 226:53-6. 1997
    ..The present study showed that an exogenous gene was transferred and expressed in neural cells of ischemic and reperfused brains in vivo, but the temporal profile of the expression is dissociative...
  54. ncbi Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin
    T Kurata
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Kitaku, Okayama 700 8558, Japan
    Neuroscience 197:358-68. 2011
    ..Treatment with atorvastatin or pitavastatin ameliorated the activation of MMP-9. Overall, these data suggest that statins may have therapeutic potential for AD by protecting NVU...
  55. ncbi Proton magnetic resonance spectroscopy of patients with parkinsonism
    K Abe
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
    Brain Res Bull 52:589-95. 2000
    ..The reduction of the NAA/CRE ratio in the putamen correlated well with the severity of parkinsonism. (1)H-MRS may be useful in monitoring patients with various types of parkinsonism...
  56. ncbi Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat
    W R Zhang
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikatacho, Okayama, 700-8558, Japan
    Brain Res 947:140-5. 2002
    ..However, the therapeutic time window was shorter than the effect of GDNF protein itself previously reported...
  57. ncbi Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia
    T Hayashi
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Stroke 29:1007-12; discussion 1013. 1998
    ....
  58. ncbi Induction of platelet derived-endothelial cell growth factor in the brain after ischemia
    T Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 29:463-8. 2007
    ..In the present study, therefore, we investigated the change of PD-ECGF expression in the brain after ischemia...
  59. ncbi Two cases of Japanese CADASIL with corpus callosum lesion
    K Iwatsuki
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Tohoku J Exp Med 195:135-40. 2001
    ....
  60. ncbi A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene
    E Matsubara
    Department of Neurology, Okayama University, Okayama, Japan
    Eur J Neurol 14:819-22. 2007
    ..Asymmetrical wasting of muscles in the extremities exhibited uniform and highly selective CT imaging patterns. RNA and DNA analyses confirmed novel compound heterozygous mutations (R147X/L212F) in the human CAPN3 gene...
  61. ncbi Expression of cyclin-dependent kinase 5 and its activator p35 in rat brain after middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurosci Lett 265:37-40. 1999
    ..These results might suggest that increased cdk5 activity in the brain after ischemia caused depolymerization of neurocytoskeletons, which resulted in neuronal cell death...
  62. ncbi Reduction of ischemic damage by application of insulin-like growth factor-1 in rat brain after transient ischemia
    J M Wang
    Department of Neurology, Okayama University Medical School, Japan
    Acta Med Okayama 55:25-30. 2001
    ..Moreover, this effect is greatly associated with the reduction of Caspase-3 staining, but is only minimally associated with a decreasd stress response at the cellular level...
  63. ncbi Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis
    Yasuhiro Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Apoptosis 7:329-34. 2002
    ..These results indicate that the Ad-GDNF treatment prevented motor neuron loss with preserving survival p-Akt signal and without affecting caspase activations, suggesting a future possibility for the therapy of the disease...
  64. ncbi Glutamate enhances caspase-3 immunoreactivity in cultured spinal cord neurons of newborn rats
    Y Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 25:312-6. 2003
    ..The present results show that excessive amount of glutamate enhances apoptotic pathway through caspase-3 in cultured spinal neurons of newborn rat...
  65. ncbi Sjögren's syndrome with acute transverse myelopathy as the initial manifestation
    Y Manabe
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    J Neurol Sci 176:158-61. 2000
    ..Treatment with prednisone improved motor and sensory symptoms and resulted in improvement of MRI findings. The present case suggests that acute transverse myelopathy can occur as an initial symptom of SS...
  66. ncbi Loss of bag-1 immunoreactivity in rat brain after transient middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Okayama University School of Medicine, Japan
    Brain Res 852:496-500. 2000
    ..The present results suggest that bag-1 plays some roles in normal neuronal function, and its loss may be involved in neuronal cell death after ischemia...
  67. ncbi Preferential expression of HSC70 heat shock mRNA in gerbil heart after transient brain ischemia
    K Abe
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    J Mol Cell Cardiol 25:1131-5. 1993
    ..These results suggest that HSC70 mRNA was preferentially induced in the heart after transient forebrain ischemia that was not only due to the subsequent hyperthermia...
  68. ncbi Enhanced expression of phospho-Akt by electro-acupuncture in normal rat brain
    S J Wang
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Neurol Res 24:719-24. 2002
    ..These results suggest that the EA on D20 and D26 acupoints activates the survival Akt signal pathway, which may be maintaining the neural functions such as cell survival and memory formation in normal brain...
  69. ncbi Reduction of nerve growth factor receptor immunoreactivity in ischaemic gerbil hippocampal CA1 neurons after treatment with L-threo-3,4-dihydroxyphenylserine (DOPS)
    T H Lee
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurol Res 16:201-4. 1994
    ..These data suggest that the protective role of DOPS on the ischaemic hippocampal CA1 cells may act through the NGF and its receptor system...
  70. ncbi Changes of free cholesterol and neutral lipids after transient focal brain ischemia in rats
    H Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Acta Neurochir Suppl 86:177-80. 2003
    ..Macrophages and astrocytes are presumed to play important roles in lipid metabolism for neural reorganization of the ischemic brain injury in the ischemic core and the penumbra, respectively...
  71. ncbi Increases in mRNA levels for Talpha1-tubulin in the rat kindling model of epilepsy
    K Sato
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Brain Res 904:157-60. 2001
    ..These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity...
  72. ncbi Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients
    M Nagai
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurosci Lett 244:165-8. 1998
    ..These results suggest that alternative splicing forms of GLT-1 mRNAs do not play a pathogenetic role in ALS but rather a physiological one in the normal spinal cord and brain...
  73. ncbi Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords of transgenic mice with a G93A mutant SOD1 gene
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women's Medical College, Japan
    J Neuropathol Exp Neurol 60:839-46. 2001
    ....
  74. ncbi Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene
    H Warita
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Brain Res 819:120-31. 1999
    ..This impairment may contribute to subsequent selective motor neuron death in the present model implicated for human FALS...
  75. ncbi Motor neglect following left thalamic hemorrhage: a case report
    Y Manabe
    Department of Neurology, Okayama University Medical School, Okayama, Japan
    J Neurol Sci 171:69-71. 1999
    ..Although unilateral motor neglect is usually associated with right hemispheric lesions, a left thalamic lesion may also result in isolated motor neglect...
  76. ncbi Ventral root avulsion leads to downregulation of GluR2 subunit in spinal motoneurons in adult rats
    I Nagano
    Neurology Service, National Yonezawa Hospital, 26100 1 Misawa, Yamagata, Japan
    Neuroscience 117:139-46. 2003
    ....
  77. ncbi The extracellular matrix in the mouse brain: its reactions to endo-alpha-N-acetylgalactosaminidase and certain other enzymes
    T Murakami
    Department of Anatomy, Faculty of Medicine, Okayama University Medical School, Japan
    Arch Histol Cytol 62:273-81. 1999
    ..It was further demonstrated that hyaluronidase incubation neither digests the collagenous ligands nor revives the lectin VVA or WFA labeling of the nerve cell surface proteoglycans...
  78. ncbi Expression of highly polysialylated neural cell adhesion molecule in rat subventricular zone with exposure to repeated kindled seizures
    K Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 323:244-6. 2002
    ....
  79. ncbi c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata machi, 700 8558, Okayama, Japan
    Neurosci Lett 284:195-9. 2000
    ..This JIP-1 induction got behind the JNK-1 activation, and therefore, may be a vain effort for neurons to survive. Inhibition of JNK-1 activation might become an innovative means of therapy for stroke treatment in the future...
  80. ncbi Intensely positively charged perineuronal nets in the adult rat brain as detected by staining with anionic iron colloid
    T Murakami
    Department of Anatomy, Faculty of Medicine, Okayama University Medical School, Japan
    Arch Histol Cytol 64:45-50. 2001
    ..These findings indicate that the intensely positively charged perineuronal net contains some strongly basic substances such as guanidino compounds, and occupies the perineuronal (perisynaptic) tissue space...
  81. ncbi Genetic variability and diversity of intracellular genome-length hepatitis C virus RNA in long-term cell culture
    Nobuyuki Kato
    Department of Tumor Virology, Okayama University of Graduate School of Medicine, Okayama, Japan
    Arch Virol 154:77-85. 2009
    ..These results suggest that an HCV-RNA-replicating cell culture system would be useful for analysis of the evolutionary dynamics and variations of HCV...
  82. ncbi Inflammatory demyelinating polyradiculoneuropathy associated with interstitial lung disease
    K Kashihara
    Department of Neurology, Okayama University Medical School, Japan
    Clin Rheumatol 19:235-7. 2000
    ..Corticosteroid therapy led to a marked amelioration of both the neuropathy and the lung disease. We suggest that a demyelinating neuropathy is associated with an interstitial lung disease...
  83. ncbi Fluctuating monoplegia due to venous insufficiency by spinal arachnoiditis ossificans
    Y Manabe
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    J Neurol Sci 178:163-6. 2000
    ..Neurological function and MRI improved markedly following an operation on AO. The symptoms seen in the present case were due to posterior venous insufficiency following compressive AO...
  84. ncbi An experimental study on the course of trans-synaptic propagation of neural activity and plasticity in the hippocampus in kainate-induced epilepsy
    K Sato
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Brain Res Bull 55:393-400. 2001
    ..A different mode of hippocampal neural activity and plasticity between kainate and kindling models of epilepsy may be stressed...
  85. ncbi Infarct presenting with a combination of Wallenberg and posterior spinal artery syndromes
    Y Manabe
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    J Neurol Sci 176:155-7. 2000
    ..These lesions were in the territory of the right posterior inferior cerebellar artery (PICA) and the right posterior spinal artery (PSA). The combination was due to severe stenosis of the right vertebral artery...
  86. ncbi Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene
    Y Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 915:104-7. 2001
    ..The present result suggests that an early impairment of DNA repair in the spinal motor neurons may account for the mutant SOD1-mediated motor neuronal death in this model...
  87. ncbi Isolated oculomotor nerve palsy in lymphoma
    Y Manabe
    Department of Neurology, Okayama University Medical School, Japan
    Neurol Res 22:347-8. 2000
    ..Because cranial neuropathy could occur as the first sign of lymphoma, lymphoma is an important differential diagnosis for the partial oculomotor palsy such as our present case...
  88. ncbi Perineuronal nets of proteoglycans in the adult mouse brain are digested by collagenase
    T Murakami
    Department of Anatomy, Faculty of Medicine, Okayama University Medical School, Japan
    Arch Histol Cytol 62:199-204. 1999
    ....
  89. ncbi GABAA receptor-mediated inhibition by ethanol of long-term potentiation in the basolateral amygdala-dentate gyrus pathway in vivo
    K Abe
    Department of Pharmacology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Neuroscience 125:113-7. 2004
    ..p.). The present study demonstrates that ethanol inhibits the induction of long-term potentiation in the basolateral amygdala-dentate gyrus pathway by enhancing GABAA receptor-mediated neurotransmission...
  90. ncbi 2.1 kb 5'-flanking region of the brain type dystrophin gene directs the expression of lacZ in the cerebral cortex, but not in the hippocampus
    S Kimura
    Department of Child Development, Kumamoto University School of Medicine, Japan
    J Neurol Sci 147:13-20. 1997
    ..These results suggest that the 2.1 kb 5'-fragment of the mouse brain type dystrophin gene contains the regulatory element required for its expression in the cerebral cortex, but not in the hippocampus...
  91. ncbi Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice
    K Abe
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Rheumatology (Oxford) 47:292-300. 2008
    ..In this study, we analysed the immune system of Ali18 mice to understand mechanisms underlying the spontaneous inflammation...
  92. ncbi Adaptive response and the influence of ageing: effects of low-dose irradiation on cell growth of cultured glial cells
    Y Miura
    Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    Int J Radiat Biol 78:913-21. 2002
    ..To examine the molecular mechanism of radiation adaptive response (RAR) for the growth of cultured glial cells and to investigate the influence of ageing on the response...
  93. ncbi Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze
    K Mishima
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan
    Eur J Pharmacol 427:43-52. 2001
    ..The activation of these processes by vasopressin-(4-9) is critically involved in the positive effect of vasopressin-(4-9) on scopolamine-induced impairment of spatial memory...
  94. ncbi Establishment of a local cooling model against spinal cord ischemia representing prolonged induction of heat shock protein
    N Motoyoshi
    Departments of Cardiovascular Surgery and Neurology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    J Thorac Cardiovasc Surg 122:351-7. 2001
    ..CONCLUSIONS: These results suggest that local hypothermia extended the production of heat shock protein in spinal cord motor neurons after reperfusion and inhibited their apoptotic change...
  95. ncbi Induction of phosphatidylinositol 3-kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia
    M Sakurai
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan
    Neurosci Lett 302:17-20. 2001
    ..The activation of PI3-k and Akt protein at the early stage of reperfusion may be one of the factors responsible for the delay in neuronal death after spinal cord ischemia...
  96. ncbi Endogenous serotonin contributes to a developmental decrease in long-term potentiation in the rat visual cortex
    Y Edagawa
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
    J Neurosci 21:1532-7. 2001
    ..These results suggest that the induction of visual cortex LTP in 5-week-old rats is suppressed by endogenous 5-HT. 5-HT may be a factor that determines a critical period for synaptic plasticity in the rat visual cortex...
  97. ncbi Identification of a novel inhibitor of LPS-induced TNF-alpha production with antiproliferative activity in monocyte/macrophages
    A Nagahira
    Suntory Biomedical Research Limited, 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka, 618-8503, Japan
    Biochem Biophys Res Commun 281:1030-6. 2001
    ..Compound 1 is likely to have antiinflammatory and antiproliferative effects by acting on some molecule other than p38 MAPK that contributes to both LPS-induced TNF-alpha production and the cell growth of monocyte/macrophages...
  98. ncbi Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson's disease
    K Abe
    Department of Neuroscience, Showa Pharmaceutical University, Higashitamagawagakuen, Machida, Tokyo, Japan
    Brain Res Bull 56:55-60. 2001
    ....
  99. ncbi Doxorubicin-induced DNA intercalation and scavenging by nuclear glutathione S-transferase pi
    S Goto
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan
    FASEB J 15:2702-14. 2001
    ..Nuclear GSTpi protected DNA against damage by anticancer drugs. These results suggest a possible role of GSTpi in the acquisition of resistance to anticancer drugs by cancer cells...
  100. ncbi The complexity of TNF-related apoptosis-inducing ligand
    K Abe
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, RN 270F, Boston, MA 02215, USA
    Ann N Y Acad Sci 926:52-63. 2000
    ..This review will focus on the complexity of TRAIL and the role of c-FLIP in mediating TRAIL function...
  101. ncbi Second transmembrane segment of FtsH plays a role in its proteolytic activity and homo-oligomerization
    S Makino
    Department of Biotechnology, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo
    FEBS Lett 460:554-8. 1999
    ..Therefore, the second transmembrane segment, which neighbors the C-terminal cytoplasmic region of the FtsH, participates in not only its membrane-anchoring, but also its protease activity and homo-oligomerization...