N Takai

Summary

Affiliation: Oita Medical University
Country: Japan

Publications

  1. doi Beta-hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Gynecol Oncol 109:107-14. 2008
  2. ncbi Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Japan
    Cancer Lett 184:105-16. 2002
  3. ncbi Endometrioid adenocarcinoma arising from adenomyosis
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, Japan
    Gynecol Obstet Invest 48:141-4. 1999
  4. ncbi c-Ets1 is a promising marker in epithelial ovarian cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 9:287-92. 2002
  5. ncbi Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, 879 5593, Oita, Japan
    Cancer Lett 183:185-93. 2002
  6. ncbi Expression of survivin is associated with malignant potential in epithelial ovarian carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 10:211-6. 2002
  7. ncbi Complete response to radiation therapy in a patient with chemotherapy-resistant ovarian clear cell adenocarcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, 879 5593, Japan
    Arch Gynecol Obstet 267:98-100. 2002
  8. ncbi Successful cerclage in two patients with advanced cervical dilatation in the second trimester
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Arch Gynecol Obstet 268:102-4. 2003
  9. ncbi Clinical relevance of Elf-1 overexpression in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Gynecol Oncol 89:408-13. 2003
  10. ncbi The significance of Elf-1 expression in epithelial ovarian carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 12:349-54. 2003

Collaborators

Detail Information

Publications68

  1. doi Beta-hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Gynecol Oncol 109:107-14. 2008
    ..We investigated the effect of beta-HIVS on three endometrial cancer cell lines, two ovarian cancer cell lines, and normal human endometrial epithelial cells...
  2. ncbi Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Japan
    Cancer Lett 184:105-16. 2002
    ..01, respectively). We conclude that the survivin protein is a defining diagnostic marker for endometrial carcinomas that may also yield prognostic information...
  3. ncbi Endometrioid adenocarcinoma arising from adenomyosis
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, Japan
    Gynecol Obstet Invest 48:141-4. 1999
    ..We present 2 rare cases of adenocarcinoma arising from adenomyosis. The relationship between prior frequent estrogen use and carcinogenesis and the possible effects of chemotherapy and radiation therapy are reviewed...
  4. ncbi c-Ets1 is a promising marker in epithelial ovarian cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 9:287-92. 2002
    ..05). Our results demonstrate that c-Ets1 expression in epithelial ovarian cancer correlates to the malignant potential of the tumor...
  5. ncbi Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, 879 5593, Oita, Japan
    Cancer Lett 183:185-93. 2002
    ..05). Our results demonstrate that CaMKIV expression in epithelial ovarian cancer correlates with the malignant potential of this tumor...
  6. ncbi Expression of survivin is associated with malignant potential in epithelial ovarian carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 10:211-6. 2002
    ..01, respectively). We conclude that the survivin protein is a defining diagnostic marker for epithelial ovarian carcinomas that may also yield prognostic information...
  7. ncbi Complete response to radiation therapy in a patient with chemotherapy-resistant ovarian clear cell adenocarcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, 879 5593, Japan
    Arch Gynecol Obstet 267:98-100. 2002
    ..In an effort to maximize salvage potential and quality of life while minimizing toxicity, selected patients with ovarian cancer should be treated with radiation therapy directed to residual or recurrent sites...
  8. ncbi Successful cerclage in two patients with advanced cervical dilatation in the second trimester
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Arch Gynecol Obstet 268:102-4. 2003
    ..We had two rare cases of successful cerclage at advanced cervical dilatation in the second trimester and both delivered healthy babies at full term...
  9. ncbi Clinical relevance of Elf-1 overexpression in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Gynecol Oncol 89:408-13. 2003
    ..Elf-1 is a member of the Ets transcription factor family that regulates the genes involved in cellular growth and differentiation. Enhanced expression of Elf-1 has been reported in prostate cancer, breast cancer, and osteosarcoma...
  10. ncbi The significance of Elf-1 expression in epithelial ovarian carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 12:349-54. 2003
    ..01). Our results demonstrate that Elf-1 expression in ovarian carcinoma correlates with the malignant potential of this tumor...
  11. ncbi Polo-like kinase (PLK) expression in endometrial carcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, 879 5593, Japan
    Cancer Lett 169:41-9. 2001
    ..Thus, in addition to being of diagnostic value, modulation of PLK activity in the tumors by chemotherapeutic agents or gene therapy may prove to be of therapeutic value...
  12. ncbi Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Oncol Rep 8:567-73. 2001
    ....
  13. ncbi Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, 879 5593, Oita, Japan
    Cancer Lett 165:185-93. 2001
    ..05) and the presence of invasion to >1/2 myometrium (P<0.05). Our results demonstrate that increased Id1 expression in endometrial carcinoma correlates with the malignant potential of this tumor...
  14. ncbi Intraplacental choriocarcinoma with fetomaternal transfusion
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, Japan
    Pathol Int 50:258-61. 2000
    ..Primary intraplacental choriocarcinoma may frequently be overlooked or missed, and choriocarcinoma may possibly arise in the placenta more often than in retained or persistent trophoblast following pregnancy...
  15. ncbi Polo-like kinase expression in normal human endometrium during the menstrual cycle
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Japan
    Reprod Fertil Dev 12:59-67. 2000
    ....
  16. ncbi Treatment with a metallic endovascular stent in a patient with iliac venous stenosis due to endometrial cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Japan
    Arch Gynecol Obstet 264:51-3. 2000
    ..In addition, this procedure dramatically improved the patient's quality of life...
  17. ncbi Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Cancer Lett 164:41-9. 2001
    ..Thus, in addition to being of diagnostic value, PLK activity in ovarian tumors may be modulated by chemotherapeutic agents or gene therapy to therapeutic effect...
  18. ncbi Expression of c-Ets1 is associated with malignant potential in endometrial carcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Cancer 89:2059-67. 2000
    ..It might play a role in the regulation of physiologic processes such as cell proliferation and differentiation and also is associated with angiogenesis, cell migration, and tumor invasion...
  19. ncbi Immunohistochemical localization of polo like kinase in early human placenta
    J Yoshimatsu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama, Japan
    Res Commun Mol Pathol Pharmacol 106:3-12. 1999
    ..These results suggest that PLK plays a different role in syncytiotrophoblastic cells than it does in other proliferating cells...
  20. ncbi Expression of polo-like kinase (PLK) in the mouse placenta and ovary
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Japan
    Reprod Fertil Dev 11:31-5. 1999
    ..Nevertheless, in ovarian stroma and lutein bodies where PCNA was not expressed, PLK was strongly expressed. This finding indicates that PLK may have some post mitotic functions in certain specialized cell types...
  21. ncbi Primary mucinous adenocarcinoma of the vagina
    K Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Eur J Gynaecol Oncol 31:679-81. 2010
    ..We report a case of advanced stage primary mucinous adenocarcinoma of the vagina that showed a highly aggressive course and resistance to combination chemotherapy with paclitaxel and carboplatin...
  22. ncbi Expression of cathepsin L in normal endometrium and endometrial cancer
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Eur J Obstet Gynecol Reprod Biol 99:102-5. 2001
    ..To evaluate the expression of cathepsin L in normal endometrium and endometrial adenocarcinoma...
  23. ncbi Beta-hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study
    M Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Hum Reprod 21:2850-6. 2006
    ..The aim of this study is to evaluate the effects of beta-HIVS on the proliferation, cell cycle and apoptosis of endometriotic stromal cells...
  24. ncbi Villoglandular papillary adenocarcinoma of the uterine cervix diagnosed during pregnancy
    N Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Japan
    Eur J Gynaecol Oncol 31:573-4. 2010
    ..A successful pregnancy can be completed in patients with VPA without lymph-vascular invasion, when treated conservatively. This management is particularly desirable in young women to preserve reproductive capability...
  25. ncbi Malignant lymphoma of the vagina successfully treated with rituximab, adryamicin, cyclophosphamide, vincristine sulfate, and prednisolone
    K Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Eur J Gynaecol Oncol 33:219-22. 2012
    ..We report a case of vaginal DLBCL successfully treated with chemotherapy consisting of rituximab, adryamicin, cyclophosphamide, vincristine sulfate, and prednisolone (R-CHOP), followed by pelvic irradiation...
  26. ncbi Bowel obstruction due to endometriosis in the rectovaginal septum
    N Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Clin Exp Obstet Gynecol 35:295-6. 2008
    ..Preoperative and postoperative gonadotropin-releasing hormone analog and aromatase inhibitor therapy promote relief of clinical symptoms, a reduction of tumor volume and a better approach to radical surgery...
  27. ncbi Atypical polypoid adenomyoma in a patient with hyperprolactinemia
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Int J Gynecol Cancer 11:326-8. 2001
    ..It is suggested that ovarian dysfunction caused by hyperprolactinemia may be involved in the pathogenesis of atypical polypoid adenomyoma in the present case...
  28. ncbi Angiomyofibroblastoma of the vulva
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Int J Gynecol Cancer 12:228-31. 2002
    ....
  29. ncbi Management of patients with carcinoma of the cervix with anuric renal failure
    N Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Int J Gynaecol Obstet 88:156-7. 2005
  30. ncbi FTIR spectroscopic analyses of human placental membranes
    Y Nishida
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama-machi, Oita 879-5593, Japan
    Biopolymers 62:22-8. 2001
    ..Our data suggested that this IR technique is applicable to the clinical diagnosis of diseases in the gynecological field...
  31. ncbi Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Int J Mol Med 21:637-43. 2008
    ..These results suggest that bufalin may become a useful adjuvant therapy for endometrial and ovarian cancers with minimal side effects...
  32. ncbi PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Yufu Shi, Oita 879 5593, Japan
    Int J Mol Med 25:97-103. 2010
    ..These results suggest that PK11195 alone or in combination with chemotherapeutic drugs might be a new therapeutic option for the treatment of endometrial and ovarian cancers...
  33. ncbi CBHA is a family of hybrid polar compounds that inhibit histone deacetylase, and induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    Oncology 70:97-105. 2006
    ..We investigated the effect of a novel synthesized histone deacetylase inhibitor (HDACI), CBHA, on three endometrial cancer cell lines, two ovarian cancer cell lines, and normal human endometrial epithelial cells...
  34. ncbi A successful pregnancy and delivery after resectoscopic surgery for early invasive endometrial cancer
    H Matsumoto
    Department of Obstetrics and Gynecology, Oita Prefectural Hospital, Oita, Japan
    Eur J Gynaecol Oncol 30:689-90. 2009
    ..She underwent cesarean section at 33 weeks and five days of gestation and had a healthy baby. Resectscopic surgery can help to preserve fertility among young women who have early invasive endometrial cancer...
  35. doi Erucylphosphocholine shows a strong anti-growth activity in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Gynecol Oncol 111:336-43. 2008
    ..We investigated the effect of ErPC on three endometrial cancer cell lines, two ovarian cancer cell lines, and normal human endometrial epithelial cells...
  36. ncbi Human endometrial and ovarian cancer cells: histone deacetylase inhibitors exhibit antiproliferative activity, potently induce cell cycle arrest, and stimulate apoptosis
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Curr Med Chem 14:2548-53. 2007
    ..These results raise the possibility that HDACIs may prove particularly effective in the treatment of endometrial cancers and ovarian cancers...
  37. doi Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells
    Haili Li
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Cancer Lett 297:198-206. 2010
    ..We found a strong anticancer activity of TPL and identified some potential target genes of this drug, raising hopes that TPL may become a useful therapy for endometrial and ovarian cancers...
  38. ncbi A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Int J Mol Med 17:323-9. 2006
    ..These results raise the possibility that Scriptaid may prove particularly effective in the treatment of endometrial and ovarian cancers...
  39. ncbi M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Gynecol Oncol 101:108-13. 2006
    ..Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest, and stimulate apoptosis of cancer cells...
  40. ncbi CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma
    Sujie Shang
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 11:181-6. 2003
    ..02). Our results demonstrate that CaMKIV expression in endometrial carcinoma correlates with the malignant potential of this tumor...
  41. ncbi C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Oita 879 5593, Japan
    Oncol Rep 14:1287-91. 2005
    ..Furthermore, we demonstrated that the amount of phosphorylated Akt was decreased by C(2)-ceramide. These results raise the possibility that C(2)-ceramide may prove particularly effective in the treatment of endometrial cancers...
  42. ncbi K252a is highly effective in suppressing the growth of human endometrial cancer cells, but has little effect on normal human endometrial epithelial cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Oncol Rep 19:749-53. 2008
    ..These results raise the possibility that K252a may prove to be particularly effective in the treatment of endometrial cancers...
  43. ncbi Primary malignant melanoma of the vagina
    N Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Eur J Gynaecol Oncol 29:558-9. 2008
    ..We report a case of a 70-year-old woman with primary malignant melanoma of the vagina, and discuss the importance of prognostic factors and the efficacy of adjuvant chemotherapy...
  44. doi Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaioka, Hasama machi, Yufu Shi, Oita, Japan
    Cancer Lett 277:235-43. 2009
    ..KN-93 induced the G0/G1 arrest and apoptosis, rising hopes that KN-93 may become a useful treatment for endometrial cancers...
  45. ncbi K252a inhibits proliferation of ovarian cancer cells by upregulating p21WAF1
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Oncol Rep 14:141-3. 2005
    ..This occurred in concert with altered expression of p21WAF1 protein related to the G0/G1 phase of the cell cycle. These results raise the possibility that K252a may prove particularly effective in treatment of ovarian cancer...
  46. doi Metastatic uterine cervical cancer originating in the lung: a case report
    Kentaro Kai
    Department of Obstetrics and Gynecology, Oita University, Japan
    Gynecol Obstet Invest 68:269-71. 2009
    ..Although rare, the respiratory tract should be considered as a possible primary site of uterine cervical metastatic carcinoma...
  47. ncbi Granulosa cell tumor associated with secondary amenorrhea and serum luteinizing hormone elevation
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita, 879 5593, Japan
    Int J Clin Oncol 12:228-30. 2007
    ..Although LH elevation in patients with GCT is rare and its mechanism is unknown, monitoring of serum LH may provide an additional tumor marker after conservative surgery in such patients...
  48. ncbi Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endometrial cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Anticancer Res 26:939-45. 2006
    ..Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest and stimulate apoptosis of cancer cells...
  49. ncbi Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells
    Tami Ueda
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Int J Mol Med 19:301-8. 2007
    ..The findings raise the possibility that apicidin may prove particularly effective in the treatment of endometrial and ovarian cancers...
  50. ncbi Magnetic resonance imaging findings in leiomyoma of the ovary: a case report
    Yasushi Kawano
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Arch Gynecol Obstet 273:298-300. 2006
    ..At laparotomy, total hysterectomy and bilateral salpingo-oophorectomy were performed and histologic examination revealed a leiomyoma arising primarily in the ovary...
  51. ncbi Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita University, Hasama machi, Oita, Japan
    Mol Hum Reprod 11:817-23. 2005
    ..Caspase-9-mediated cascade is involved in this mechanism. Therefore, bufalin could be used as a therapeutic agent for the treatment of endometriosis...
  52. ncbi Adenoid cystic carcinoma of Bartholin's Gland. Case report with review of the literature
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Gynecol Obstet Invest 59:54-8. 2005
    ..The patient is now healthy without evidence of recurrence at 5 years after surgery. Adenoid cystic carcinoma of Bartholin's cyst at early stage can be treated by wide local excision as a primary surgery...
  53. ncbi Spontaneous pregnancy in a 45,X/46,X,r (X) Turner's mosaic patient
    Akitoshi Yuge
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Acta Obstet Gynecol Scand 82:775-6. 2003
  54. doi Multimodal treatment for glassy cell carcinoma of the uterine cervix
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu Shi, Oita, Japan
    J Obstet Gynaecol Res 35:584-7. 2009
    ..Our multimodal treatment protocol may be one of the treatment options for this aggressive disease...
  55. doi Lymphoepithelioma-like carcinoma of the uterine cervix
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Prefectural Hospital, Oita, Japan
    Arch Gynecol Obstet 280:725-7. 2009
    ..To elucidate the clinicopathologic features of lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, we examined three Japanese cases...
  56. doi Conservative surgical treatment for early-stage vulvar malignant melanoma
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita, 879 5593, Japan
    Arch Gynecol Obstet 281:335-8. 2010
    ..To investigate the efficacy of wide local excision as a surgical treatment for early-stage vulvar melanomas...
  57. ncbi Endometriotic cells are resistant to interferon-gamma-induced cell growth inhibition and apoptosis: a possible mechanism involved in the pathogenesis of endometriosis
    Masakazu Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita 879 5593, Japan
    Mol Hum Reprod 11:29-34. 2005
    ..Further investigations on the regulation of cell proliferation in both the endometriotic and the normal endometrium may be important for the elucidation of the pathogenesis of endometriosis...
  58. ncbi The relationship between oncogene expression and clinical outcome in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita, 879 5593, Japan
    Curr Cancer Drug Targets 4:511-20. 2004
    ..In this review, we demonstrate the biologic behavior of seven novel molecules (Plks, Eph/ephrin, Id family, CaMK, c-Ets1, Elf-1, and survivin) in the endometrial carcinoma...
  59. ncbi Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Am J Physiol Endocrinol Metab 293:E16-23. 2007
    ..Therefore, BAY 11-7085 could be used as a therapeutic agent for the treatment of endometriosis...
  60. ncbi Histone deacetylase inhibitors induce growth inhibition, cell cycle arrest and apoptosis in human choriocarcinoma cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Int J Mol Med 21:109-15. 2008
    ..Furthermore, HDACI treatment of this cell line increased acetylation of H3 and H4 histone tails. These results raise the possibility that HDACIs may prove particularly effective in the treatment of choriocarcinoma...
  61. ncbi Placenta percreta invading the urinary bladder
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Arch Gynecol Obstet 271:274-5. 2005
    ..Placenta percreta is a rare obstetric complication causing life-threatening hemorrhage...
  62. doi A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita, Japan
    Arch Gynecol Obstet 279:255-7. 2009
    ..Optimum therapy for BML, has not been established. We report here an additional case of BML in the lung that was successfully treated with surgical castration followed by hormonal therapy with anastrozole, an aromatase inhibitor...
  63. ncbi Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells
    Takashi Kumagai
    Division of Hematology Oncology, UCLA School of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Int J Cancer 121:656-65. 2007
    ..SAHA is a novel, promising therapeutic agent for human pancreatic cancers...
  64. ncbi Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells
    Noriyuki Takai
    Division of Hematology Oncology, Cedars Sinai Medical Center University of California at Los Angeles School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Clin Cancer Res 10:1141-9. 2004
    ..Our purpose was to investigate the antiproliferative effects of the HDACIs [suberoyl anilide bishydroxamine, valproic acid (VPA), trichostatin A, and sodium butyrate] against six endometrial cancer cell lines...
  65. ncbi Discovery of epigenetically masked tumor suppressor genes in endometrial cancer
    Noriyuki Takai
    Division of Hematology Oncology, Cedars Sinai Medical Center University of California at Los Angeles School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Mol Cancer Res 3:261-9. 2005
    ..Our data suggest that C/ebpalpha and Tig1 function as tumor suppressor proteins in endometrial cancers and that their reexpression may be a therapeutic target...
  66. ncbi Polo-like kinases (Plks) and cancer
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Oncogene 24:287-91. 2005
    ..In contrast to Plk1, several studies have observed that Plk3 expression is negatively correlated with the development of certain cancers...
  67. ncbi Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis
    Noriyuki Takai
    Division of Hematology Oncology, Cedars Sinai Medical Center University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Cancer 101:2760-70. 2004
    ..Histone deacetylase inhibitors (HDACIs) can inhibit proliferation, stimulate apoptosis, and induce cell cycle arrest in malignant cells...
  68. ncbi 2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth
    Noriyuki Takai
    Division of Hematology Oncology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, CA 90048, USA
    Cancer 104:2701-8. 2005
    ..HER2 is a ligand-less member of the HER family that functions as the preferred coreceptor for epidermal growth factor receptor (EGFR), HER3, and HER4...