K Nasu

Summary

Affiliation: Oita University
Country: Japan

Publications

  1. doi request reprint Ectopic pregnancy after successful treatment with percutaneous transcatheter uterine arterial embolization for congenital uterine arteriovenous malformation: a case report
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Arch Gynecol Obstet 278:171-2. 2008
  2. pmc Tumorigenic effects of tamoxifen on the female genital tract
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Clin Med Pathol 1:17-34. 2008
  3. ncbi request reprint Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    Gynecol Obstet Invest 61:53-5. 2006
  4. ncbi request reprint Tumor necrosis factor-alpha regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 87:220-2. 2007
  5. ncbi request reprint Pregnancy complicated by asymptomatic uterine arteriovenous malformation: a case report
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    J Reprod Med 52:335-7. 2007
  6. ncbi request reprint Granulosa cell tumor associated with secondary amenorrhea and serum luteinizing hormone elevation
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita, 879 5593, Japan
    Int J Clin Oncol 12:228-30. 2007
  7. doi request reprint A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita, Japan
    Arch Gynecol Obstet 279:255-7. 2009
  8. doi request reprint Glassy cell carcinoma arising in the vagina
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Acta Obstet Gynecol Scand 87:982-4. 2008
  9. ncbi request reprint Heparin is a promising agent for the treatment of endometriosis-associated fibrosis
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 94:46-51. 2010
  10. ncbi request reprint Interleukin-1beta regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka, Oita, Japan
    Gynecol Endocrinol 22:495-500. 2006

Detail Information

Publications103 found, 100 shown here

  1. doi request reprint Ectopic pregnancy after successful treatment with percutaneous transcatheter uterine arterial embolization for congenital uterine arteriovenous malformation: a case report
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Arch Gynecol Obstet 278:171-2. 2008
    ..UAE is considered to be a safe and effective procedure, but its long-term effect on fertility has not been fully elucidated. We present a case of ectopic tubal pregnancy after conservative treatment with UAE for uterine AVM...
  2. pmc Tumorigenic effects of tamoxifen on the female genital tract
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Clin Med Pathol 1:17-34. 2008
    ..To prevent tamoxifen from having severe side effects in gynecologic organs, frequent gynecological examination should be performed for both premenopausal and postmenopausal patients with breast cancer who are treated with this drug...
  3. ncbi request reprint Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    Gynecol Obstet Invest 61:53-5. 2006
    ..Therefore, beta-adrenergic agents should be used with great care, especially for patients with myotonic dystrophy, because of these agents' tendency to aggravate or precipitate myotonia and to induce rhabdomyolysis...
  4. ncbi request reprint Tumor necrosis factor-alpha regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 87:220-2. 2007
    ..Tumor necrosis factor-alpha-stimulated vascular endothelial growth factor secretion by these cells may control oviductal fluid secretion by regulating vascular permeability...
  5. ncbi request reprint Pregnancy complicated by asymptomatic uterine arteriovenous malformation: a case report
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    J Reprod Med 52:335-7. 2007
    ..Uterine arteriovenous malformation (AVM) is a rare disease. Percutaneous arterial embolization has been performed for patients who wish to preserve their ability to conceive...
  6. ncbi request reprint Granulosa cell tumor associated with secondary amenorrhea and serum luteinizing hormone elevation
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita, 879 5593, Japan
    Int J Clin Oncol 12:228-30. 2007
    ..Although LH elevation in patients with GCT is rare and its mechanism is unknown, monitoring of serum LH may provide an additional tumor marker after conservative surgery in such patients...
  7. doi request reprint A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita, Japan
    Arch Gynecol Obstet 279:255-7. 2009
    ..Optimum therapy for BML, has not been established. We report here an additional case of BML in the lung that was successfully treated with surgical castration followed by hormonal therapy with anastrozole, an aromatase inhibitor...
  8. doi request reprint Glassy cell carcinoma arising in the vagina
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Acta Obstet Gynecol Scand 87:982-4. 2008
    ..The present case illustrates the potential for glassy cell carcinoma to arise in the Mullerian epithelium throughout the female genital tract...
  9. ncbi request reprint Heparin is a promising agent for the treatment of endometriosis-associated fibrosis
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 94:46-51. 2010
    ..To assess the use of heparin for the medical treatment of endometriosis-associated fibrosis...
  10. ncbi request reprint Interleukin-1beta regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka, Oita, Japan
    Gynecol Endocrinol 22:495-500. 2006
    ....
  11. ncbi request reprint Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection
    K Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Hum Reprod 22:356-61. 2007
    ..The aim of this study was to evaluate the site-specific immunoregulatory mechanisms against viral infection in human Fallopian tubes...
  12. ncbi request reprint Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Am J Physiol Endocrinol Metab 293:E16-23. 2007
    ..Therefore, BAY 11-7085 could be used as a therapeutic agent for the treatment of endometriosis...
  13. ncbi request reprint Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor production by cultured human endometrial stromal cells
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita 879 5593, Japan
    Fertil Steril 82:756-9. 2004
    ..Both mRNA and protein expression of vascular endothelial growth factor were upregulated in a hypoxic condition...
  14. ncbi request reprint Insulin-like growth factor-I regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu Shi, Oita, Japan
    J Soc Gynecol Investig 13:368-71. 2006
    ..The aim of the current study is to evaluate the effect of insulin-like growth factor-I (IGF-I) on the production of vascular endothelial growth factor (VEGF) in the human fallopian tube...
  15. ncbi request reprint Cultured human endometrial epithelial cells produce thymus and activation-regulated chemokine with stimulation of interleukin-4 and interleukin-13
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    Fertil Steril 82:1014-8. 2004
    ....
  16. ncbi request reprint Regulation of proliferation, motility, and contractivity of cultured human endometrial stromal cells by transforming growth factor-beta isoforms
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 84:1114-23. 2005
    ..To evaluate the involvement of transforming growth factor (TGF)-beta isoforms (TGF-beta1, TGF-beta2, and TGF-beta3) on endometrial tissue remodeling during the perimenstrual period...
  17. ncbi request reprint Adenoid cystic carcinoma of Bartholin's Gland. Case report with review of the literature
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Gynecol Obstet Invest 59:54-8. 2005
    ..The patient is now healthy without evidence of recurrence at 5 years after surgery. Adenoid cystic carcinoma of Bartholin's cyst at early stage can be treated by wide local excision as a primary surgery...
  18. ncbi request reprint Squamous cell carcinoma of the cervix producing granulocyte colony-stimulating factor
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Obstet Gynecol 104:1086-8. 2004
    ..Granulocyte colony-stimulating factor (G-CSF) may be responsible for this phenomenon. We report a case of G-CSF-producing squamous cell carcinoma of the cervix that showed marked leukocytosis...
  19. doi request reprint Conservative surgical treatment for early-stage vulvar malignant melanoma
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita, 879 5593, Japan
    Arch Gynecol Obstet 281:335-8. 2010
    ..To investigate the efficacy of wide local excision as a surgical treatment for early-stage vulvar melanomas...
  20. ncbi request reprint Involvement of resistance to apoptosis in the pathogenesis of endometriosis
    K Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Histol Histopathol 24:1181-92. 2009
    ..The role of apoptosis in the pathogenesis of endometriosis and the basic and clinical research on the current medical treatment for endometriosis from the view of apoptosis will be discussed...
  21. doi request reprint Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 92:2097-9. 2009
    ..Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis...
  22. doi request reprint Management of severe cervical stenosis after conization by detention of nylon threads tied up to intrauterine contraceptive device
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita, 879 5593, Japan
    Arch Gynecol Obstet 281:887-9. 2010
    ..To investigate the efficacy of the insertion of intrauterine contraceptive device (IUCD) tied up with nylon threads for the treatment of cervical stenosis after conization...
  23. doi request reprint Multimodal treatment for glassy cell carcinoma of the uterine cervix
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu Shi, Oita, Japan
    J Obstet Gynaecol Res 35:584-7. 2009
    ..Our multimodal treatment protocol may be one of the treatment options for this aggressive disease...
  24. ncbi request reprint Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita University, Hasama machi, Oita, Japan
    Mol Hum Reprod 11:817-23. 2005
    ..Caspase-9-mediated cascade is involved in this mechanism. Therefore, bufalin could be used as a therapeutic agent for the treatment of endometriosis...
  25. pmc Pattern recognition via the toll-like receptor system in the human female genital tract
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    Mediators Inflamm 2010:976024. 2010
    ..Increased understanding of these molecules may provide insight into site-specific immunoregulatory mechanisms in the female reproductive tract...
  26. ncbi request reprint Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Cancer Lett 164:41-9. 2001
    ..Thus, in addition to being of diagnostic value, PLK activity in ovarian tumors may be modulated by chemotherapeutic agents or gene therapy to therapeutic effect...
  27. ncbi request reprint Beta-hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study
    M Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Hum Reprod 21:2850-6. 2006
    ..The aim of this study is to evaluate the effects of beta-HIVS on the proliferation, cell cycle and apoptosis of endometriotic stromal cells...
  28. ncbi request reprint Effects of interleukin-4 on the in-vitro production of cytokines by human endometrial stromal cells
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Mol Hum Reprod 7:265-70. 2001
    ..The increased concentration of these cytokines in the local environment may contribute to the maintenance of early pregnancy by modulating the immune reaction at the feto-maternal interface...
  29. ncbi request reprint Expression of epithelial neutrophil-activating peptide 78 in cultured human endometrial stromal cells
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Mol Hum Reprod 7:453-8. 2001
    ..The modulation of ENA-78 concentration in the local environment by these mediators may contribute to the normal and pathological processes of human reproduction through regulation of leukocyte trafficking into the endometrium...
  30. ncbi request reprint Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, 879 5593, Oita, Japan
    Cancer Lett 165:185-93. 2001
    ..05) and the presence of invasion to >1/2 myometrium (P<0.05). Our results demonstrate that increased Id1 expression in endometrial carcinoma correlates with the malignant potential of this tumor...
  31. ncbi request reprint Expression of c-Ets1 is associated with malignant potential in endometrial carcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Cancer 89:2059-67. 2000
    ..It might play a role in the regulation of physiologic processes such as cell proliferation and differentiation and also is associated with angiogenesis, cell migration, and tumor invasion...
  32. ncbi request reprint Hypoxia regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts
    Hiroko Itoh
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 85:1097-102. 2006
    ..To evaluate the effect of hypoxia on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in the human fallopian tube...
  33. ncbi request reprint Polo-like kinase (PLK) expression in endometrial carcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, 879 5593, Japan
    Cancer Lett 169:41-9. 2001
    ..Thus, in addition to being of diagnostic value, modulation of PLK activity in the tumors by chemotherapeutic agents or gene therapy may prove to be of therapeutic value...
  34. ncbi request reprint Platelet-activating factor induces an imbalance between matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 expression in human uterine cervical fibroblasts
    T Sugano
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Biol Reprod 62:540-6. 2000
    ..Results suggest that PAF may accelerate collagenolysis in the human uterine cervix by inducing an imbalance in the activity between MMP-1 and TIMP-1, thus contributing to the cervical ripening during parturition...
  35. ncbi request reprint Complete response to radiation therapy in a patient with chemotherapy-resistant ovarian clear cell adenocarcinoma
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, 879 5593, Japan
    Arch Gynecol Obstet 267:98-100. 2002
    ..In an effort to maximize salvage potential and quality of life while minimizing toxicity, selected patients with ovarian cancer should be treated with radiation therapy directed to residual or recurrent sites...
  36. ncbi request reprint Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells
    Tami Ueda
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Int J Mol Med 19:301-8. 2007
    ..The findings raise the possibility that apicidin may prove particularly effective in the treatment of endometrial and ovarian cancers...
  37. ncbi request reprint Torsion of a functional ovarian cyst in a premenopausal patient receiving tamoxifen
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, Japan
    Gynecol Obstet Invest 48:200-2. 1999
    ..This ovarian cyst was believed to have developed during tamoxifen administration...
  38. ncbi request reprint Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Oncol Rep 8:567-73. 2001
    ....
  39. ncbi request reprint Expression of hepatocyte growth factor in cultured human endometrial stromal cells is induced through a protein kinase C-dependent pathway
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Biol Reprod 60:1183-7. 1999
    ..HGF secreted by ESC may be involved in the regeneration of the endometrium during the normal menstrual cycle...
  40. ncbi request reprint Effects of platelet-activating factor on cytokine production by human uterine cervical fibroblasts
    T Sugano
    Department of Obstetrics and Gynecology, Oita Medical University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Mol Hum Reprod 7:475-81. 2001
    ..PAF may stimulate local production of cytokines which may induce migration of leukocytes and accelerate collagenolysis in the uterine cervix, thus contributing to cervical ripening during parturition...
  41. ncbi request reprint Possible modulators of IL-8 and GRO-alpha production by granulosa cells
    Kosay Zeineh
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama, Oita, Japan
    Am J Reprod Immunol 50:98-103. 2003
    ....
  42. ncbi request reprint Collagen gel contractility is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis-associated fibrosis
    Akitoshi Yuge
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu Shi, Oita, Japan
    Hum Reprod 22:938-44. 2007
    ....
  43. ncbi request reprint Expression of growth-regulated oncogene beta in an endometrial epithelial cell line, HHUA, and cultured human endometrial cells
    Junichiro Fukuda
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    J Reprod Immunol 59:61-70. 2003
    ..The modulation of the GRO beta concentration in the endometrium by inflammatory mediators may contribute to the normal and pathological processes of human reproduction by regulating the trafficking of neutrophils into the endometrium...
  44. ncbi request reprint Expression of macrophage inflammatory protein-3alpha in an endometrial epithelial cell line, HHUA, and cultured human endometrial stromal cells
    Bing Sun
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Mol Hum Reprod 8:930-3. 2002
    ..MIP-3alpha may contribute to the normal and pathological processes of human reproduction by regulating the trafficking of immature dendritic cells and memory T lymphocytes into the endometrium...
  45. ncbi request reprint Expression of cathepsin L in normal endometrium and endometrial cancer
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Eur J Obstet Gynecol Reprod Biol 99:102-5. 2001
    ..To evaluate the expression of cathepsin L in normal endometrium and endometrial adenocarcinoma...
  46. ncbi request reprint Primary mucinous adenocarcinoma of the vagina
    K Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Eur J Gynaecol Oncol 31:679-81. 2010
    ..We report a case of advanced stage primary mucinous adenocarcinoma of the vagina that showed a highly aggressive course and resistance to combination chemotherapy with paclitaxel and carboplatin...
  47. ncbi request reprint Interleukin-13 stimulates the secretion of vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 by human oviductal epithelial cells
    Hiroko Itoh
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Eur J Obstet Gynecol Reprod Biol 133:208-12. 2007
    ..The aim of this study is to evaluate the effects of interleukin (IL)-13, a Th2 cytokine, on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in human oviductal cells in vitro...
  48. ncbi request reprint Secretion of granulocyte chemotactic protein-2 by cultured human endometrial stromal cells
    Shinichiro Mine
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Fertil Steril 79:146-50. 2003
    ..To evaluate the expression of granulocyte chemotactic protein-2 (GCP-2) in human endometrial stromal cells...
  49. ncbi request reprint Regulation of proliferation, motility, and contractility of human endometrial stromal cells by platelet-derived growth factor
    Harunobu Matsumoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita 879 5593, Japan
    J Clin Endocrinol Metab 90:3560-7. 2005
    ..By regulating ESC function during the perimenstrual period, PDGF may help to protect the endometrium from extensive fibrosis and scarring...
  50. ncbi request reprint Malignant lymphoma of the vagina successfully treated with rituximab, adryamicin, cyclophosphamide, vincristine sulfate, and prednisolone
    K Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Eur J Gynaecol Oncol 33:219-22. 2012
    ..We report a case of vaginal DLBCL successfully treated with chemotherapy consisting of rituximab, adryamicin, cyclophosphamide, vincristine sulfate, and prednisolone (R-CHOP), followed by pelvic irradiation...
  51. ncbi request reprint Endometrioid adenocarcinoma arising from adenomyosis
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita, Japan
    Gynecol Obstet Invest 48:141-4. 1999
    ..We present 2 rare cases of adenocarcinoma arising from adenomyosis. The relationship between prior frequent estrogen use and carcinogenesis and the possible effects of chemotherapy and radiation therapy are reviewed...
  52. ncbi request reprint The effect of epidermal growth factor on vascular endothelial growth factor secretion by endometrial stromal cells
    Y Kawano
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Japan
    Clin Exp Med 2:69-75. 2002
    ..VEGF is believed to be induced by EGF through mechanisms involving tyrosine kinase and phosphatidylinositol 3-kinase. The increase in VEGF may contribute to neovascularization that promotes proliferation of endometrium and placentation...
  53. doi request reprint Erucylphosphocholine shows a strong anti-growth activity in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Gynecol Oncol 111:336-43. 2008
    ..We investigated the effect of ErPC on three endometrial cancer cell lines, two ovarian cancer cell lines, and normal human endometrial epithelial cells...
  54. ncbi request reprint Expression of interferon-gamma-inducible protein-10 in human endometrial stromal cells
    Kengo Kai
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Mol Hum Reprod 8:176-80. 2002
    ..The modulation of IP-10 concentrations in the local environment may contribute to the normal and pathological processes of human reproduction by regulating leukocyte trafficking in the endometrium...
  55. ncbi request reprint Expression and regulation of growth-regulated oncogene alpha in human endometrial stromal cells
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Mol Hum Reprod 7:741-6. 2001
    ..The modulation of GROalpha concentrations in the local environment may contribute to normal and pathological processes in the uterus by regulating leukocyte trafficking in the endometrium...
  56. ncbi request reprint Bowel obstruction due to endometriosis in the rectovaginal septum
    N Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Clin Exp Obstet Gynecol 35:295-6. 2008
    ..Preoperative and postoperative gonadotropin-releasing hormone analog and aromatase inhibitor therapy promote relief of clinical symptoms, a reduction of tumor volume and a better approach to radical surgery...
  57. ncbi request reprint Atypical polypoid adenomyoma in a patient with hyperprolactinemia
    K Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Int J Gynecol Cancer 11:326-8. 2001
    ..It is suggested that ovarian dysfunction caused by hyperprolactinemia may be involved in the pathogenesis of atypical polypoid adenomyoma in the present case...
  58. ncbi request reprint Human oviductal stromal fibroblasts, but not oviductal epithelial cells, express Toll-like receptor 4: the site-specific mucosal immunity of the human fallopian tube against bacterial infection
    Hiroko Itoh
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    Am J Reprod Immunol 56:91-101. 2006
    ..To evaluate the site-specific immunoregulatory mechanisms against bacterial infection in the human fallopian tubes...
  59. doi request reprint Decidualization attenuates the contractility of eutopic and ectopic endometrial stromal cells: implications for hormone therapy of endometriosis
    Akitoshi Tsuno
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    J Clin Endocrinol Metab 94:2516-23. 2009
    ..Decidualization of the endometrium involves the morphological and biochemical reprogramming of the estrogen-primed proliferative endometrial stromal compartment under the continuing influence of progesterone...
  60. ncbi request reprint c-Ets1 is a promising marker in epithelial ovarian cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 9:287-92. 2002
    ..05). Our results demonstrate that c-Ets1 expression in epithelial ovarian cancer correlates to the malignant potential of the tumor...
  61. ncbi request reprint K252a is highly effective in suppressing the growth of human endometrial cancer cells, but has little effect on normal human endometrial epithelial cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Oncol Rep 19:749-53. 2008
    ..These results raise the possibility that K252a may prove to be particularly effective in the treatment of endometrial cancers...
  62. doi request reprint Beta-hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Gynecol Oncol 109:107-14. 2008
    ..We investigated the effect of beta-HIVS on three endometrial cancer cell lines, two ovarian cancer cell lines, and normal human endometrial epithelial cells...
  63. ncbi request reprint Histone deacetylase inhibitors induce growth inhibition, cell cycle arrest and apoptosis in human choriocarcinoma cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Yufu Shi, Oita 879 5593, Japan
    Int J Mol Med 21:109-15. 2008
    ..Furthermore, HDACI treatment of this cell line increased acetylation of H3 and H4 histone tails. These results raise the possibility that HDACIs may prove particularly effective in the treatment of choriocarcinoma...
  64. ncbi request reprint Regulation of contractility of cultured human endometrial stromal cells by tumor necrosis factor-alpha
    Akitoshi Yuge
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu Shi, Oita, Japan
    Eur J Obstet Gynecol Reprod Biol 138:66-70. 2008
    ..The aim of this study is to evaluate the involvement of tumor necrosis factor (TNF)-alpha in endometrial tissue remodeling during the perimenstrual period...
  65. doi request reprint Anti-neoplastic effect of β-hydroxyisovalerylshikonin on a human choriocarcinoma cell line
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Mol Med Report 3:515-8. 2010
    ..These results suggest that β-HIVS may serve as a therapeutic agent for the treatment of choriocarcinoma...
  66. ncbi request reprint PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Yufu Shi, Oita 879 5593, Japan
    Int J Mol Med 25:97-103. 2010
    ..These results suggest that PK11195 alone or in combination with chemotherapeutic drugs might be a new therapeutic option for the treatment of endometrial and ovarian cancers...
  67. ncbi request reprint Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Int J Mol Med 21:637-43. 2008
    ..These results suggest that bufalin may become a useful adjuvant therapy for endometrial and ovarian cancers with minimal side effects...
  68. doi request reprint Erucylphosphocholine induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita 879 5593, Japan
    Tumour Biol 32:569-74. 2011
    ..These results suggest that ErPC may serve as a therapeutic agent for the treatment of choriocarcinoma...
  69. doi request reprint Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaioka, Hasama machi, Yufu Shi, Oita, Japan
    Cancer Lett 277:235-43. 2009
    ..KN-93 induced the G0/G1 arrest and apoptosis, rising hopes that KN-93 may become a useful treatment for endometrial cancers...
  70. doi request reprint Impact of positron emission tomography/computed tomography in the management of patients with epithelial ovarian carcinoma after treatment
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu, Oita 879 5593, Japan
    Arch Gynecol Obstet 283:1121-6. 2011
    ....
  71. ncbi request reprint K252a inhibits proliferation of ovarian cancer cells by upregulating p21WAF1
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Oncol Rep 14:141-3. 2005
    ..This occurred in concert with altered expression of p21WAF1 protein related to the G0/G1 phase of the cell cycle. These results raise the possibility that K252a may prove particularly effective in treatment of ovarian cancer...
  72. ncbi request reprint Interleukin-13 and tumor necrosis factor-beta differentially regulate the production of cytokines by cultured human endometrial stromal cells
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Fertil Steril 79:821-7. 2003
    ..To evaluate the effects of interleukin (IL)-13, a T-helper (Th)2 cytokine, and tumor necrosis factor (TNF)-beta, a Th1 cytokine, on the production of IL-6 family cytokines and chemokines by endometrial stromal cells (ESC)...
  73. ncbi request reprint Production of macrophage inflammatory protein-3alpha in human follicular fluid and cultured granulosa cells
    Yasushi Kawano
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 82:1206-11. 2004
    ..To investigate the role of macrophage inflammatory protein (MIP)-3alpha in human ovulation...
  74. ncbi request reprint C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Oita 879 5593, Japan
    Oncol Rep 14:1287-91. 2005
    ..Furthermore, we demonstrated that the amount of phosphorylated Akt was decreased by C(2)-ceramide. These results raise the possibility that C(2)-ceramide may prove particularly effective in the treatment of endometrial cancers...
  75. ncbi request reprint Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endometrial cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Anticancer Res 26:939-45. 2006
    ..Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest and stimulate apoptosis of cancer cells...
  76. ncbi request reprint Intrauterine growth restriction and the proliferation of smooth muscle cells in umbilical vessels
    Jun Yoshimatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    Aust N Z J Obstet Gynaecol 46:212-6. 2006
    ..The purpose of this study was to investigate the proliferation of smooth muscle cells in umbilical vessels of fetuses affected by intrauterine growth restriction (IUGR) and to compare the findings with gestational age-matched control cases...
  77. ncbi request reprint A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Int J Mol Med 17:323-9. 2006
    ..These results raise the possibility that Scriptaid may prove particularly effective in the treatment of endometrial and ovarian cancers...
  78. ncbi request reprint The relationship between oncogene expression and clinical outcome in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita, 879 5593, Japan
    Curr Cancer Drug Targets 4:511-20. 2004
    ..In this review, we demonstrate the biologic behavior of seven novel molecules (Plks, Eph/ephrin, Id family, CaMK, c-Ets1, Elf-1, and survivin) in the endometrial carcinoma...
  79. ncbi request reprint Differential effects of interferon-alpha and -beta on the secretion of vascular endothelial growth factor by eutopic and ectopic endometrial stromal cells
    Junichiro Fukuda
    Department of Obstetrics and Gynecology, Oita University, Hasama machi, Oita 879 5593, Japan
    Fertil Steril 82:749-51. 2004
    ..Interferon (IFN)-beta, not IFN-alpha, suppresses vascular endothelial growth factor secretion in endometriotic cyst stromal cells. It was suggested that IFN-beta may be more suitable than IFN-alpha as an anti-endometriotic agent...
  80. ncbi request reprint The effect of inflammatory cytokines on secretion of macrophage colony-stimulating factor and monocyte chemoattractant protein-1 in human granulosa cells
    Yasushi Kawano
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Am J Reprod Immunol 52:124-8. 2004
    ..In order to investigate the role of macrophage colony-stimulating factor (M-CSF) and monocyte chemoattractant protein -1 (MCP-1) in human ovulation, we studied the regulation of M-CSF and MCP-1 in cultured human granulosa cells...
  81. ncbi request reprint Endometriotic cells are resistant to interferon-gamma-induced cell growth inhibition and apoptosis: a possible mechanism involved in the pathogenesis of endometriosis
    Masakazu Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita 879 5593, Japan
    Mol Hum Reprod 11:29-34. 2005
    ..Further investigations on the regulation of cell proliferation in both the endometriotic and the normal endometrium may be important for the elucidation of the pathogenesis of endometriosis...
  82. ncbi request reprint Magnetic resonance imaging findings in leiomyoma of the ovary: a case report
    Yasushi Kawano
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Arch Gynecol Obstet 273:298-300. 2006
    ..At laparotomy, total hysterectomy and bilateral salpingo-oophorectomy were performed and histologic examination revealed a leiomyoma arising primarily in the ovary...
  83. ncbi request reprint Adenoid cystic carcinoma of the uterine cervix
    Masakazu Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita 879 5593, Japan
    Int J Clin Oncol 10:198-200. 2005
    ..The patient shows no evidence of recurrent tumor at 5 years after radiotherapy. Generally, radiotherapy and chemotherapy are chosen as the first treatment, because this cancer is seen most commonly in the elderly...
  84. ncbi request reprint Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells
    Yasushi Kawano
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    Fertil Steril 82:1043-7. 2004
    ..To measure the level of interleukin 6 (IL-6), IL-8, and macrophage colony-stimulating factor (M-CSF) induced by IL-1alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues...
  85. ncbi request reprint Expression and regulation of thrombospondin-1 by human endometrial stromal cells
    Yasushi Kawano
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama, Oita 879 5593, Japan
    Fertil Steril 83:1056-9. 2005
    ..Thrombospondin-1 (TSP-1) production was modulated by EGF, IFN-gamma, and in vitro decidualization. It is suggested that TSP-1 may contribute to the regulation of neovascularization in the endometrium and gestational tissues...
  86. ncbi request reprint Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: a possible mechanism for the altered immunological functions in endometriosis
    Masakazu Nishida
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Hasama machi, Oita 879 5593, Japan
    J Clin Endocrinol Metab 89:5094-100. 2004
    ..The alteration of the CXC chemokines expression may be important for elucidation of the pathogenesis of endometriosis...
  87. ncbi request reprint CBHA is a family of hybrid polar compounds that inhibit histone deacetylase, and induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Japan
    Oncology 70:97-105. 2006
    ..We investigated the effect of a novel synthesized histone deacetylase inhibitor (HDACI), CBHA, on three endometrial cancer cell lines, two ovarian cancer cell lines, and normal human endometrial epithelial cells...
  88. ncbi request reprint M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Gynecol Oncol 101:108-13. 2006
    ..Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest, and stimulate apoptosis of cancer cells...
  89. ncbi request reprint Management of patients with carcinoma of the cervix with anuric renal failure
    N Takai
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Int J Gynaecol Obstet 88:156-7. 2005
  90. ncbi request reprint Gastrointestinal stromal tumor arising in the rectovaginal septum
    K Nasu
    Department of Obstetrics and Gynecology, Oita National Hospital, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Int J Gynecol Cancer 14:373-7. 2004
    ..The patient is now healthy without evidence of recurrence at 13 months after surgery. Gynecologists should be aware of rectal GIST arising in the rectovaginal space as a differential diagnosis of vaginal submucosal tumor...
  91. ncbi request reprint Ureteral and sigmoid obstruction caused by pelvic actinomycosis in an intrauterine contraceptive device user
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Gynecol Obstet Invest 54:228-31. 2002
    ..As shown in the present case, pelvic actinomycosis should be considered as a cause of pelvic inflammatory disease in IUCD users, even though Actinomyces was not detected on the IUCD...
  92. ncbi request reprint Secretion of keratinocyte growth factor by cultured human endometrial stromal cells is induced through a cyclic adenosine monophosphate-dependent pathway
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Fertil Steril 77:392-5. 2002
    ..To evaluate the effects of known modulators of endometrial function on the production of keratinocyte growth factor by endometrial stromal cells...
  93. ncbi request reprint Depression and pregnancy-associated death by suicide after spinal cord injury: a case report
    K Kai
    Department of Obstetrics and Gynecology, Kenwakai Otemachi Hospital, Fukuoka, Japan
    Clin Exp Obstet Gynecol 39:532-4. 2012
    ..To report a case of a pregnant woman with traumatic spinal cord injury complicated with a psychiatric disorder...
  94. ncbi request reprint Intrauterine fetal death caused by pit viper venom poisoning in early pregnancy
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Gynecol Obstet Invest 57:114-6. 2004
    ..Consistent with other reports, in the first trimester intrauterine fetal death may especially occur when the mother has systemic symptoms, although its mechanism remains unclear...
  95. ncbi request reprint Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Japan
    Cancer Lett 184:105-16. 2002
    ..01, respectively). We conclude that the survivin protein is a defining diagnostic marker for endometrial carcinomas that may also yield prognostic information...
  96. ncbi request reprint Expression of collagen XVIII mRNA and protein in human umbilical vein and placenta
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Reprod Fertil Dev 15:107-14. 2003
    ..It is therefore considered that vasculature in the feto-placental unit is highly angiogenic, even at the time of parturition...
  97. ncbi request reprint Effects of leptin on the production of cytokines by cultured human endometrial stromal and epithelial cells
    Junichiro Fukuda
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Fertil Steril 80:783-7. 2003
    ..To evaluate the effects of leptin on the production of interleukin (IL)-6 family cytokines and chemokines by human endometrial stromal cells (ESC) and epithelial cells...
  98. ncbi request reprint The significance of Elf-1 expression in epithelial ovarian carcinoma
    Noriyuki Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 12:349-54. 2003
    ..01). Our results demonstrate that Elf-1 expression in ovarian carcinoma correlates with the malignant potential of this tumor...
  99. ncbi request reprint Choledochal cyst diagnosed and conservatively treated during pregnancy
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita National Hospital, Oita, Japan
    Am J Perinatol 21:463-8. 2004
    ....
  100. ncbi request reprint Uterine arteriovenous malformation: ultrasonographic, magnetic resonance and radiological findings
    Kaei Nasu
    Department of Obstetrics and Gynecology, Oita Medical University, Oita, Japan
    Gynecol Obstet Invest 53:191-4. 2002
    ..She was treated by a total hysterectomy and bilateral salpingo-oophorectomy under the diagnosis of uterine AVM. These noninvasive techniques should be performed initially when this rare disease is suspected...
  101. ncbi request reprint CaMKIV expression is associated with clinical stage and PCNA-labeling index in endometrial carcinoma
    Sujie Shang
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 11:181-6. 2003
    ..02). Our results demonstrate that CaMKIV expression in endometrial carcinoma correlates with the malignant potential of this tumor...