Affiliation: Oita University of Nursing and Health Sciences
Ban N, Kai M. Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia. Br J Cancer. 2009;101:363-71 pubmed publisher
..The mitotic load after 3 Gy irradiation seems to be heavy enough to accelerate the ageing of HSCs and the hypothesis reasonably explains the leukaemogenic process. ..
Ban N, Yoshida K, Aizawa S, Wada S, Kai M. Cytogenetic analysis of radiation-induced leukemia in Trp53-deficient C3H/He mice. Radiat Res. 2002;158:69-77 pubmed
..These results suggest that loss of Trp53 function triggers the tumorigenic process leading toward SCL through the induction of chromosomal instability, and that SCL and AML are distinct varieties of leukemia. ..