Tohru Ohnuma

Summary

Country: Japan

Publications

  1. pmc No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 2:496-502. 2012
  2. ncbi request reprint No correlation between plasma NMDA-related glutamatergic amino acid levels and cognitive function in medicated patients with schizophrenia
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University, School of Medicine, Tokyo, Japan
    Int J Psychiatry Med 44:17-27. 2012
  3. ncbi request reprint Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Brain Res Mol Brain Res 112:90-4. 2003
  4. doi request reprint Changes in plasma glycine, L-serine, and D-serine levels in patients with schizophrenia as their clinical symptoms improve: results from the Juntendo University Schizophrenia Projects (JUSP)
    Tohru Ohnuma
    Juntendo University Schizophrenia Projects JUSP, Department of Psychiatry, Juntendo University, School of Medicine, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1905-12. 2008
  5. ncbi request reprint Hypothesis: minimal changes in neural transmission in schizophrenia: decreased glutamatergic and GABAergic functions in the prefrontal cortex
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University, School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:889-94. 2005
  6. doi request reprint Significance of NMDA receptor-related glutamatergic amino acid levels in peripheral blood of patients with schizophrenia
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University Schizophrenia Projects, Juntendo University, School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:29-39. 2011
  7. doi request reprint Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia
    Tohru Ohnuma
    Juntendo University Schizophrenia Projects JUSP, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:511-8. 2009
  8. pmc Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6
    Tohru Ohnuma
    Department of Psychiatry, Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya shi Saitama, 343 0032 Japan
    Br J Clin Pharmacol 56:315-20. 2003
  9. ncbi request reprint No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 343 0032, Japan
    Neurosci Lett 343:70-2. 2003
  10. ncbi request reprint Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421 Japan
    J Gerontol A Biol Sci Med Sci 61:660-2. 2006

Collaborators

Detail Information

Publications52

  1. pmc No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 2:496-502. 2012
    ..However, no Japanese patients were examined in these studies. The aim of the present study was to replicate the previous finding in Japanese AD cases...
  2. ncbi request reprint No correlation between plasma NMDA-related glutamatergic amino acid levels and cognitive function in medicated patients with schizophrenia
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University, School of Medicine, Tokyo, Japan
    Int J Psychiatry Med 44:17-27. 2012
    ....
  3. ncbi request reprint Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Brain Res Mol Brain Res 112:90-4. 2003
    ..8% P<0.05). In addition, the cellular Fyn mRNA signal was negatively correlated with the age of onset (r=-0.94, P=0.0026). These results suggest that an increase in Fyn expression may contribute to the pathophysiology of schizophrenia...
  4. doi request reprint Changes in plasma glycine, L-serine, and D-serine levels in patients with schizophrenia as their clinical symptoms improve: results from the Juntendo University Schizophrenia Projects (JUSP)
    Tohru Ohnuma
    Juntendo University Schizophrenia Projects JUSP, Department of Psychiatry, Juntendo University, School of Medicine, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1905-12. 2008
    ..The plasma levels of these amino acids during the clinical course of schizophrenia were also compared...
  5. ncbi request reprint Hypothesis: minimal changes in neural transmission in schizophrenia: decreased glutamatergic and GABAergic functions in the prefrontal cortex
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University, School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:889-94. 2005
    ..But these changes are small and failed to be statistically significant. The "receptors/transporters ratio" for each case magnified these changes, such that they became statistically significant...
  6. doi request reprint Significance of NMDA receptor-related glutamatergic amino acid levels in peripheral blood of patients with schizophrenia
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University Schizophrenia Projects, Juntendo University, School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:29-39. 2011
    ..Finally, for future therapies with glutamatergic agents still being examined in animal studies, the results of these biological marker studies may lay the foundation for the development of next-generation antipsychotics...
  7. doi request reprint Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia
    Tohru Ohnuma
    Juntendo University Schizophrenia Projects JUSP, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:511-8. 2009
    ..None of the genotypes studied was associated with changes in the plasma glycine and l- and d-serine levels during the schizophrenic clinical course. The DAO gene may be a susceptibility locus for schizophrenia...
  8. pmc Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6
    Tohru Ohnuma
    Department of Psychiatry, Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya shi Saitama, 343 0032 Japan
    Br J Clin Pharmacol 56:315-20. 2003
    ....
  9. ncbi request reprint No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 343 0032, Japan
    Neurosci Lett 343:70-2. 2003
    ..The present study reports that there is no indication that the three polymorphisms in the Fyn gene are associated with the age of schizophrenic onset...
  10. ncbi request reprint Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421 Japan
    J Gerontol A Biol Sci Med Sci 61:660-2. 2006
    ..For the USF 2 gene, the two SNPs did not show significant association with onset of AD. Our study suggests that the three SNPs of the USF 1 gene and two SNPs of the USF 2 gene presented here are not associated with onset of AD...
  11. ncbi request reprint Genetic association between Notch4 polymorphisms and Japanese schizophrenics
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Psychiatr Genet 16:77-9. 2006
    ..The linkage disequilibrium of this locus indicates that there is genetic heterogeneity in the Notch4 gene. Linkage disequilibrium may differ among ethnic groups, and so a larger study should be performed in this region...
  12. ncbi request reprint Genetic association between Notch4 polymorphisms and Alzheimer's disease in the Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine Hongo, Bunkyo ku, Tokyo, Japan
    J Gerontol A Biol Sci Med Sci 62:350-1. 2007
    ..Potential markers nearby the 5' untranslated region polymorphism might affect risk for AD...
  13. doi request reprint Association study between Disrupted-in-Schizophrenia-1 (DISC1) and Japanese patients with treatment-resistant schizophrenia (TRS)
    Yuri Hotta
    Juntendo University Schizophrenia Projects, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:636-9. 2011
    ..Taken together, results showed that DISC1 had no apparent degree of association with Japanese patients with schizophrenia as a candidate susceptibility gene for disease per se or TRS...
  14. doi request reprint Plasma alanine levels increase in patients with schizophrenia as their clinical symptoms improve-Results from the Juntendo University Schizophrenia Projects (JUSP)
    Tokiko Hatano
    Juntendo University Schizophrenia Projects JUSP, Department of Psychiatry, Juntendo University, School of Medicine, Tokyo, Japan
    Psychiatry Res 177:27-31. 2010
    ..Drug-naïve patients did not show a significant difference in plasma alanine levels when compared with healthy controls. The measurement of plasma alanine levels may be a therapeutic marker for schizophrenia...
  15. ncbi request reprint No genetic association between SLC7A10 and Japanese patients with schizophrenia
    Yuto Takebayashi
    Juntendo University Schizophrenia Projects JUSP, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1965-8. 2011
    ..Results showed no association. In conclusion, SLC7A10 had no apparent degree of association with schizophrenia as a candidate susceptibility gene in the disease per se...
  16. ncbi request reprint Genetic association between APOA1 and APOD polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neural Transm 120:1599-603. 2013
    ..Our results suggest that the variation of the APOD gene modifies the risk for AD. Further association studies for APOD 3' UTR polymorphisms with other ethnic groups would be needed. ..
  17. doi request reprint No association between glutathione-synthesis-related genes and Japanese schizophrenia
    Ryo Hanzawa
    Juntendo University Schizophrenia Projects, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 65:39-46. 2011
    ..Thus, in this study, we investigated the association between the GSH synthesis genes (GCLM, GCLC, and GSS) and schizophrenia in Japanese individuals...
  18. doi request reprint Genetic association between PLTP gene polymorphisms and Alzheimer's disease in a Japanese population
    Bolati Kuerban
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 30:78-82. 2010
    ..PLTP also affects apolipoprotein E (APOE) secretion from glial cells. This study aimed to investigate whether single nucleotide polymorphisms (SNPs) of the PLTP gene are associated with AD...
  19. ncbi request reprint Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Am J Med Genet 114:436-9. 2002
    ..These findings suggest that the IL-6prom G allele which may affect plasma IL-6 concentration might be a risk factor for sporadic AD in Japanese...
  20. ncbi request reprint Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP)
    Hitoshi Maeshima
    Department of Psychiatry, Juntendo University, School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1410-8. 2007
    ..Although GLS and GLS2 are not likely genetic risk factors for schizophrenia, changes in plasma glutamate concentration might be connected with clinical course of schizophrenia...
  21. ncbi request reprint No genetic association between tumour necrosis factor receptor II 196R polymorphism and Japanese sporadic Alzheimer's disease
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Psychiatr Genet 14:53-5. 2004
    ..The results showed no genetic association between TNFRII 196R polymorphism and Alzheimer's disease. The TNFRII 196R G allele does not appear to be associated with Alzheimer's disease susceptibility in a Japanese population...
  22. ncbi request reprint Genetic analysis of the TrkB gene and schizophrenia in the Japanese population: Juntendo University Schizophrenia Projects (JUSP)
    Maiko Higashi
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neurosci Lett 425:1-5. 2007
    ..025), the significance did not remain after Bonferroni correction. Thus, these results do not support a significant role for TrkB sequence variation in the etiology of schizophrenia...
  23. ncbi request reprint No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease
    Tomoko Watanabe
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 343 0032, Japan
    Neurosci Lett 360:109-11. 2004
    ..These results suggest that the Fyn polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) investigated here have no genetic association with sporadic AD...
  24. ncbi request reprint No genetic association between PCSK9 polymorphisms and Alzheimer's disease and plasma cholesterol level in Japanese patients
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Psychiatr Genet 15:239. 2005
  25. doi request reprint No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia
    Maiko Kitazawa
    Juntendo University Schizophrenia Projects, Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:456-64. 2012
    ..Taken together these results indicate that the genes HIST1H2BJ, PRSS16, and PGBD1 were not associated with Japanese patients with schizophrenia...
  26. doi request reprint Genetic association between ghrelin polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan nshibata juntendo ac jp
    Dement Geriatr Cogn Disord 32:178-81. 2011
    ..The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the ghrelin gene are associated with AD...
  27. ncbi request reprint No genetic association between ATP binding cassette proteins and Japanese sporadic Alzheimer's disease
    Taku Ohkubo
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 20:95-8. 2005
    ..Furthermore, we observed weak linkage disequilibrium between these two single nucleotide polymorphisms. These results indicate that the common polymorphisms of the ABCG5 and ABCA12 genes investigated here are not associated with AD...
  28. doi request reprint Genetic association analysis between TDP-43 polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 28:325-9. 2009
    ..In addition, it has been shown that TDP-43 may play a role in the pathogenesis of Alzheimer's disease (AD). This study aims to investigate whether single nucleotide polymorphisms (SNPs) of the TDP-43 gene are associated with AD...
  29. doi request reprint Association analysis between functional polymorphism of the rs4606 SNP in the RGS2 gene and antipsychotic-induced Parkinsonism in Japanese patients with schizophrenia: results from the Juntendo University Schizophrenia Projects (JUSP)
    Masayuki Higa
    Juntendo University Schizophrenia Projects JUSP, Department of Psychiatry, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neurosci Lett 469:55-9. 2010
    ..Taken together, these results, although preliminary, suggest that rs4606 does not affect AIEPSs in Japanese subjects...
  30. ncbi request reprint Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    J Alzheimers Dis 20:417-21. 2010
    ..Although rs729211 showed marginal association in the APOE4 negative group, the linkage disequilibrium analysis results suggest this to be a false positive...
  31. ncbi request reprint No genetic association between tryptophan hydroxylase 2 gene polymorphisms and Japanese schizophrenia
    Shinji Higashi
    Department of Psychiatry, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Psychiatr Genet 17:123. 2007
  32. ncbi request reprint No genetic association between the myeloperoxidase gene -463 polymorphism and estrogen receptor-alpha gene polymorphisms and Japanese sporadic Alzheimer's disease
    Chie Usui
    Department of Psychiatry, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Dement Geriatr Cogn Disord 21:296-9. 2006
    ....
  33. doi request reprint The relationship between the response of clinical symptoms and plasma olanzapine concentration, based on pharmacogenetics: Juntendo University Schizophrenia Projects (JUSP)
    Motohiro Nozawa
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Ther Drug Monit 30:35-40. 2008
    ..Long-term olanzapine treatment with adequate plasma olanzapine concentrations could be more effective in improving some symptoms than treatment with conventional antipsychotics...
  34. doi request reprint Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:405-13. 2012
    ....
  35. ncbi request reprint Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421 Japan
    Neurobiol Aging 26:1011-4. 2005
    ..LD of the 5A/6A polymorphism with rs679620 was relatively strong. These results suggest that the common polymorphisms of MMP-9 and MMP-3 investigated here are not associated with AD...
  36. doi request reprint Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 26:161-4. 2008
    ..It has recently been shown that the neuronal sortilin-related receptor (SORL1) plays an important role in the pathogenesis of Alzheimer's disease (AD)...
  37. doi request reprint No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 27:273-7. 2009
    ..Recently, it has been shown that the heme oxygenases HMOX1 and HMOX2 might play a role in the pathogenesis of Alzheimer's disease (AD)...
  38. pmc Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia
    Nobuto Shibata
    Departments of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 3:161-7. 2013
    ..The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the PPAR-γ gene and the PGC-1α gene affect the onset of AD and PDD genetically...
  39. doi request reprint No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia
    Yasuhito Nagai
    Juntendo University School of Medicine, Tokyo, Japan
    Neurosci Lett 463:223-7. 2009
    ..SCL1A2 appears not to be a genetic risk factor for schizophrenia...
  40. doi request reprint Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 33:250-4. 2012
    ..The aim of this study was to investigate whether polymorphisms of both genes are associated with AD and PD with dementia (PDD)...
  41. doi request reprint Genetic association between clusterin polymorphisms and Alzheimer's disease in a Japanese population
    Miwa Komatsu
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Psychogeriatrics 11:14-8. 2011
    ..The present study aimed to investigate whether common single nucleotide polymorphisms (SNP) of the CLU gene are associated with AD...
  42. ncbi request reprint The effect of IL4 +33C/T polymorphism on risk of Japanese sporadic Alzheimer's disease
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neurosci Lett 323:161-3. 2002
    ..We could not find any relationship between the IL4 +33C/T polymorphism and plasma IL4 concentration...
  43. doi request reprint Polymorphisms in the aldehyde dehydrogenase 2 and dopamine β hydroxylase genes are not associated with Alzheimer's disease
    Miwa Komatsu
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neural Transm 121:427-32. 2014
    ..ALDH2*2 and functional SNPs of the DBH gene did not modify the risk for AD. Since our data set was constructed only with AD in a Japanese population, further detailed genetic analyses with other ethnic groups would be needed. ..
  44. ncbi request reprint No genetic association between postsynaptic density-95 gene polymorphisms and schizophrenia
    Ritsuko Kawashima
    Department of Psychiatry, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Neurosci Lett 400:168-71. 2006
    ..The results suggested that these six polymorphisms did not affect risk for schizophrenia...
  45. doi request reprint Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 109:80-5. 2009
    ..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population...
  46. pmc Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int J Alzheimers Dis 2011:762471. 2011
    ..We failed to detect any synergetic association among Akt1 polymorphisms, Apolipoprotein E (APO E), and AD. Further genetic studies are needed to clarify the relationship between the Akt1 and AD...
  47. doi request reprint Low-dose lamotrigine augmentation therapy improves residual symptoms in treatment-resistant schizophrenia: a report of five cases
    Tohru Ohnuma
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Asia Pac Psychiatry 5:336-43. 2013
    ..Thus, detailed case reports examining the efficacy of LTG may help to shed light on various treatments for complex, heterogeneous diseases such as schizophrenia...
  48. pmc Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Tokyo, Japan Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 3:66-73. 2013
    ..In the present study, we investigated whether apolipoprotein E (APOE) polymorphisms influenced the cognitive function of Japanese patients with Alzheimer's disease (AD) at certain ages...
  49. ncbi request reprint Case reports and literature review: the association between reactivation of human herpes virus-6 and peripheral white blood cell count in patients with carbamazepine-induced hypersensitivity syndrome
    Kentaro Matsuda
    Department of Psychiatry, Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya shi, Saitama 343 0032, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:751-4. 2006
    ..When an increase in white blood cells are observed in HS cases at onset, immediate discontinuation of cause drug and intensive care are necessary to avoid the more severe symptoms of HS...
  50. ncbi request reprint Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating
    Kazuhiro Nakamura
    Department of Pathology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Mol Biol 363:345-54. 2006
    ..Thus, maintaining proper serotonin levels during childhood may be important for mature sensorimotor gating in adulthood...
  51. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  52. ncbi request reprint Visual and auditory hallucinations with excessive intake of paroxetine
    Ryo Kumagai
    Psychiatry Clin Neurosci 57:548-9. 2003