Hitoshi Ohno

Summary

Country: Japan

Publications

  1. ncbi request reprint Reappraisal of BCL3 as a molecular marker of anaplastic large cell lymphoma
    Hitoshi Ohno
    Department of Internal Medicine, Takeda General Hospital, 28 1 Mori minami cho, Ishida, Fushimi ku, Kyoto 601 1495, Japan
    Int J Hematol 82:397-405. 2005
  2. ncbi request reprint Polyclonal proliferation of plasma cells associated with marked hypergammaglobulinemia in an elderly patient
    Hitoshi Ohno
    Department of Internal Medicine, Takeda General Hospital, Kyoto, Japan
    Int J Hematol 81:62-5. 2005
  3. ncbi request reprint Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma
    H Ohno
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Histol Histopathol 19:637-50. 2004
  4. ncbi request reprint Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6
    Masayuki Kurata
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
    Cancer Res 62:6224-30. 2002
  5. ncbi request reprint Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma
    Chiyoko Ueda
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Hematol 79:52-4. 2004
  6. ncbi request reprint Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3
    Momoko Nishikori
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara cho, Japan
    Cancer Sci 96:487-97. 2005
  7. ncbi request reprint Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma
    Yoshitomo Maesako
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Sci 94:774-81. 2003
  8. ncbi request reprint The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma
    Chiyoko Ueda
    First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaramachi, Sakyo ku, Kyoto 606 8507, Japan
    Oncogene 21:368-76. 2002
  9. ncbi request reprint High-level expression of BCL3 differentiates t(2;5)(p23;q35)-positive anaplastic large cell lymphoma from Hodgkin disease
    Momoko Nishikori
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
    Blood 101:2789-96. 2003
  10. ncbi request reprint Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications
    Chiyoko Ueda
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Leuk Lymphoma 43:1375-81. 2002

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Reappraisal of BCL3 as a molecular marker of anaplastic large cell lymphoma
    Hitoshi Ohno
    Department of Internal Medicine, Takeda General Hospital, 28 1 Mori minami cho, Ishida, Fushimi ku, Kyoto 601 1495, Japan
    Int J Hematol 82:397-405. 2005
    ..Future studies should identify the relationships among the 3 independent molecules (ie, NPM/ALK, CD30, and Bcl-3) that are activated in t(2;5)+ ALCL...
  2. ncbi request reprint Polyclonal proliferation of plasma cells associated with marked hypergammaglobulinemia in an elderly patient
    Hitoshi Ohno
    Department of Internal Medicine, Takeda General Hospital, Kyoto, Japan
    Int J Hematol 81:62-5. 2005
    ..Abdominal lymphadenopathy, splenomegaly, and a high level of soluble interleukin 2 receptor may have been reflections of an underlying lymphoproliferative disorder, potentially leading to the polyclonal proliferation of plasma cells...
  3. ncbi request reprint Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma
    H Ohno
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Histol Histopathol 19:637-50. 2004
    ....
  4. ncbi request reprint Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6
    Masayuki Kurata
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
    Cancer Res 62:6224-30. 2002
    ..Our study suggested that t(3;6)(q27;p21) leads to BCL6 overexpression; however, the high-level BCL6 expression may not be required to maintain the malignant phenotype of lymphoma cells...
  5. ncbi request reprint Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma
    Chiyoko Ueda
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Hematol 79:52-4. 2004
    ..The lymphoma responded to chemoradiotherapy, and the patient has been well for 2 years, suggesting that multiple oncogene rearrangements may not necessarily be associated with poor clinical outcome...
  6. ncbi request reprint Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3
    Momoko Nishikori
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara cho, Japan
    Cancer Sci 96:487-97. 2005
    ....
  7. ncbi request reprint Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma
    Yoshitomo Maesako
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Sci 94:774-81. 2003
    ..This study has provided new molecular markers, expressions of which are closely associated with B-cell lymphoma subtypes...
  8. ncbi request reprint The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma
    Chiyoko Ueda
    First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaramachi, Sakyo ku, Kyoto 606 8507, Japan
    Oncogene 21:368-76. 2002
    ..This study added to the list of non-IG partners of BCL6 translocations a new class of gene, i.e. cytokine receptor gene, the expression of which is closely associated with lymphoid cells...
  9. ncbi request reprint High-level expression of BCL3 differentiates t(2;5)(p23;q35)-positive anaplastic large cell lymphoma from Hodgkin disease
    Momoko Nishikori
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan
    Blood 101:2789-96. 2003
    ..We propose that BCL3 is overexpressed by genetic and epigenetic modifications, potentially contributing to the development of t(2;5)(+) ALCL...
  10. ncbi request reprint Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications
    Chiyoko Ueda
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Leuk Lymphoma 43:1375-81. 2002
    ..These findings suggested that non-Ig/BCL6 translocation plays a pathogenetic role in a proportion of DLBCL...
  11. ncbi request reprint Angioimmunoblastic T-cell lymphoma initially presenting with replacement of bone marrow and peripheral plasmacytosis
    Hisashi Sakai
    Department of Internal Medicine, Takeda General Hospital, Kyoto, Japan
    Intern Med 46:419-24. 2007
    ..Even in the absence of definitive lymph node biopsy, the appearance of the bone marrow and the peripheral blood can lead to the diagnosis of AITL...
  12. doi request reprint Epstein-Barr virus-positive diffuse large B-cell lymphoma carrying a t(9;14)(p13;q32) translocation
    Hitoshi Ohno
    Department of Hematology, Takeda General Hospital, Kyoto, Japan
    Int J Hematol 89:704-8. 2009
    ..This case report is the first to identify t(9;14)(p13;q32) in EBV(+) DLBCL of the elderly, which was very recently listed among subtypes of DLBCL...
  13. ncbi request reprint Immune pancytopenia associated with a leukemic B-cell tumor carrying t(14;18)(q32;q21) translocation
    Chisaki Mizumoto
    Department of Hematology, Takeda General Hospital, Japan
    Intern Med 50:753-6. 2011
    ..The underlying disease was a leukemic B-cell tumor with t(14;18)(q32;q21), and the pancytopenia was mainly caused by autoimmune mechanisms...
  14. doi request reprint Epstein-Barr virus-associated T-cell lymphoma in an adult patient: prominent infiltrates within the liver portal area revealed by autopsy
    Hitoshi Ohno
    Department of Hematology, Takeda General Hospital, 28 1 Ishida Moriminami cho, Fushimi ku, Kyoto 601 1495, Japan
    Int J Hematol 88:88-94. 2008
    ..These observations indicate that EBV-associated T-cell lymphoma expressing cytotoxic proteins was the underlying disorder. Prominent portal involvement was most likely responsible for the fatal clinical outcome of this patient...
  15. ncbi request reprint Pathogenetic and clinical implications of non-immunoglobulin ; BCL6 translocations in B-cell non-Hodgkin's lymphoma
    Hitoshi Ohno
    Department of Internal Medicine, Takeda General Hospital, Kyoto, Japan
    J Clin Exp Hematop 46:43-53. 2006
    ..The pathogenetic and clinical implications of non-Ig ; BCL6 translocations in B-NHL subtypes may not be identical to those of Ig ; BCL6...
  16. ncbi request reprint t(11;18)(q21;q21)-positive advanced-stage MALT lymphoma associated with monoclonal gammopathy: resistance to rituximab or rituximab-containing chemotherapy
    Hitoshi Ohno
    Department of Hematology, Takeda General Hospital, Kyoto, Japan
    J Clin Exp Hematop 48:47-54. 2008
    ..The lymphoma cells in both cases may have contained two populations, a rituximab-sensitive CD20(+) population and a rituximab-resistant population that had differentiated into the Ig-secreting plasma cell stage...
  17. ncbi request reprint Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases
    Yataro Yoshida
    The Center for Hematological Diseases, Takeda General Hospital, Fushimi, Kyoto, 601 1495, Japan
    Int J Hematol 99:721-5. 2014
    ..In addition, serum M protein levels remained largely unchanged in 4 cases of MGUS for which serial determinations were performed. These findings indicate that MGUS may not affect the prognosis of MDS. ..
  18. ncbi request reprint [Successful treatment of chronic myelogenous leukemia with extramedullary megakaryoblastic tumor by allogeneic bone marrow transplantation (from an unrelated donor)]
    Makiko Jinnai
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto
    Nihon Naika Gakkai Zasshi 91:1598-600. 2002
  19. doi request reprint The duration of functioning of a subcutaneous implantable port for the treatment of hematological tumors: a single institution-based study
    Hitoshi Ohno
    Department of Hematology, Takeda General Hospital, 28 1 Ishida Moriminami cho, Fushimi ku, Kyoto 601 1495, Japan
    Int J Clin Oncol 15:172-8. 2010
    ..Although subcutaneous implantable ports have been indicated as venous access for chemotherapy, these devices have not been used routinely for hematological tumors...
  20. ncbi request reprint Rituximab alone was effective for the treatment of a diffuse large B-cell lymphoma associated with hemophagocytic syndrome
    Takeshi Sano
    Department of Internal Medicine, Takeda General Hospital, 28 1 Ishida, Mori minami cho, Fushimi ku, Kyoto 601 1495, Japan
    Int J Clin Oncol 12:59-62. 2007
    ..After the completion of eight doses of rituximab, the patient remains free of disease with an excellent performance status...
  21. ncbi request reprint Heterogeneous breakpoints on the immunoglobulin genes are involved in fusion with the 5' region of BCL2 in B-cell tumors
    N Yonetani
    First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan
    Jpn J Cancer Res 92:933-40. 2001
    ....
  22. ncbi request reprint The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma
    H Ohno
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Leuk Lymphoma 36:435-45. 2000
    ....
  23. ncbi request reprint Significance of rearrangement of the BCL6 gene in B-cell lymphoid neoplasms
    H Ohno
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Leuk Lymphoma 27:53-63. 1997
    ..At present, limited information is available about the functional consequences of the rearrangements and, in particular, about their ultimate implications for lymphomagenesis...
  24. ncbi request reprint [Significance of soluble interleukin-2 receptor alpha chain in the management of patients with malignant lymphoma: a multi-center study]
    Hitoshi Ohno
    First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto
    Rinsho Ketsueki 43:170-5. 2002
    ..This study confirmed that sIL-2R alpha is a convenient and useful marker in the management of malignant lymphoma...
  25. ncbi request reprint Replacement of the bone marrow with metastatic breast cancer
    Hitoshi Ohno
    Department of Internal Medicine, Takeda General Hospital, Kyoto
    Intern Med 46:531-2. 2007
  26. ncbi request reprint A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene
    T Akasaka
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Cancer Res 57:7-12. 1997
    ..Because H4 gene expression is tightly coupled to DNA replication, this study suggested an immediate mechanism for deregulated expression of BCL6, leading to the development of non-Hodgkin's lymphoma...
  27. ncbi request reprint Establishment and characterization of a new human myeloma cell line, KYdelta-1, producing the delta/kappa type immunoglobulin
    C Ueda
    First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, 54-Shogoin-Kawaramachi, 606-8507, Sakyo-ku, Kyoto, Japan
    Cancer Genet Cytogenet 130:42-50. 2001
    ..Point mutations within the P53 and N-RAS genes were presumably related to the rapidly progressive disease in this particular MM patient...
  28. ncbi request reprint Primary mediastinal large B-cell lymphoma: a comparative study with nodular sclerosis-type Hodgkin's disease
    N Yonetani
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Int J Hematol 74:178-85. 2001
    ..With the exception of 1 patient who was primarily refractory to therapy, 9 patients (90%) achieved complete response and 7 (70%) remain in continuous remission with a mean follow-up of 24 months...
  29. ncbi request reprint Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells
    S Ohka
    Department of Microbiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 287:941-8. 2001
    ..Thus, basolateral sorting of hPVRalpha appears to involve the interaction with mu1B through a tyrosine motif existing in the cytoplasmic domain...
  30. ncbi request reprint Immunoglobulin (Ig)/BCL6 versus non-Ig/BCL6 gene fusion in diffuse large B-cell lymphoma corresponds to a high- versus low-level expression of BCL6 mRNA
    Chiyoko Ueda
    Blood 99:2624-5. 2002
  31. ncbi request reprint Transformation of low-grade B-cell tumor to large cell lymphoma
    Hitoshi Ohno
    Intern Med 43:898-9. 2004
  32. ncbi request reprint [Genetic alterations in malignant lymphoma]
    Hitoshi Ohno
    Department of Medicine, Takeda General Hospital
    Nihon Rinsho 65:146-51. 2007
  33. doi request reprint Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes
    Ako Kikuchi
    Department of Hematology, Tokai University School of Medicine, Isehara, Japan
    Leuk Res 32:1176-82. 2008
    ..These results suggest a heterogeneous immunophenotype and genotype for c-myc/Ig DLBCL, with CD10(-)/BCL6(+)/MUM1(-) cases the most frequent...
  34. ncbi request reprint Successful allogeneic bone marrow transplantation for acute myelogenous leukemia after drug-induced cardiomyopathy
    Mitsuru Itoh
    Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan
    Tohoku J Exp Med 204:85-91. 2004
    ..After BMT, she had severe CHF, which was controlled using pimobendan and amrinone. Patients with cardiomyopathy can receive allogeneic SCT under strict hemodynamic management...