Tatsuo Ohira

Summary

Country: Japan

Publications

  1. pmc WNT7a induces E-cadherin in lung cancer cells
    Tatsuo Ohira
    Division of Medical Oncology, Department of Biometrics Preventive Medicine, University of Colorado Health Sciences and Cancer Centers, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:10429-34. 2003
  2. ncbi request reprint Early-stage lung cancer: diagnosis and treatment
    Tatsuo Ohira
    Department of Thoracic Surgery, Tokyo Medical University, 6 7 1 Nishi shinjuku, Tokyo, 160 0023, Japan
    Int J Clin Oncol 11:9-12. 2006
  3. doi request reprint Do tumours located in the left lower lobe have worse outcomes in lymph node-positive non-small cell lung cancer than tumours in other lobes?
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Eur J Cardiothorac Surg 42:414-9. 2012
  4. doi request reprint Breast cancer resistant protein (BCRP) is a molecular determinant of the outcome of photodynamic therapy (PDT) for centrally located early lung cancer
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 67:198-204. 2010
  5. doi request reprint Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways >1.0 cm in diameter
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Clin Cancer Res 16:2198-204. 2010
  6. doi request reprint The prognostic impact of main bronchial lymph node involvement in non-small cell lung carcinoma: suggestions for a modification of the staging system
    Yoshihisa Shimada
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Surg 88:1583-8. 2009
  7. doi request reprint Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery
    Jitsuo Usuda
    Division of Thoracic Surgery, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 74:332-7. 2011
  8. doi request reprint Impact of visceral pleural invasion on the survival of patients with non-small cell lung cancer
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Japan
    Lung Cancer 78:153-60. 2012
  9. doi request reprint Pathological vascular invasion and tumor differentiation predict cancer recurrence in stage IA non-small-cell lung cancer after complete surgical resection
    Yoshihisa Shimada
    First Department of Surgery, Division, Tokyo Medical University Hospital, Shinjyuku ku, Tokyo, Japan
    J Thorac Oncol 7:1263-70. 2012
  10. doi request reprint A proposal for combination of total number and anatomical location of involved lymph nodes for nodal classification in non-small cell lung cancer
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Chest 143:1618-25. 2013

Collaborators

Detail Information

Publications43

  1. pmc WNT7a induces E-cadherin in lung cancer cells
    Tatsuo Ohira
    Division of Medical Oncology, Department of Biometrics Preventive Medicine, University of Colorado Health Sciences and Cancer Centers, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:10429-34. 2003
    ....
  2. ncbi request reprint Early-stage lung cancer: diagnosis and treatment
    Tatsuo Ohira
    Department of Thoracic Surgery, Tokyo Medical University, 6 7 1 Nishi shinjuku, Tokyo, 160 0023, Japan
    Int J Clin Oncol 11:9-12. 2006
  3. doi request reprint Do tumours located in the left lower lobe have worse outcomes in lymph node-positive non-small cell lung cancer than tumours in other lobes?
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Eur J Cardiothorac Surg 42:414-9. 2012
    ..The purpose of this study was to evaluate the impact of tumour lobar location on surgical outcomes as an independent prognostic factor for survival in our non-small cell lung cancer (NSCLC) patient series...
  4. doi request reprint Breast cancer resistant protein (BCRP) is a molecular determinant of the outcome of photodynamic therapy (PDT) for centrally located early lung cancer
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 67:198-204. 2010
    ..Photofrin may be a substrate of BCRP and be pumped out from the cells, therefore, BCRP may be a molecular determinant of the outcome of Photofrin-PDT...
  5. doi request reprint Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways >1.0 cm in diameter
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Clin Cancer Res 16:2198-204. 2010
    ..0 cm in diameter, which are assumed to involve extracartilaginous invasion and to be unsuitable for treatment with Photofrin-PDT...
  6. doi request reprint The prognostic impact of main bronchial lymph node involvement in non-small cell lung carcinoma: suggestions for a modification of the staging system
    Yoshihisa Shimada
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Surg 88:1583-8. 2009
    ..Debate exists about the definition of the borderline between N1 and N2 stations. This study evaluated the prognostic effect of N1 disease, especially focused on the significance of the main bronchial node (No. 10) vs N2 disease...
  7. doi request reprint Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery
    Jitsuo Usuda
    Division of Thoracic Surgery, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 74:332-7. 2011
    ..We investigated whether the expression of Klotho, assessed by immunohistochemistry, can predict survival in patients with resected SCLC...
  8. doi request reprint Impact of visceral pleural invasion on the survival of patients with non-small cell lung cancer
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Japan
    Lung Cancer 78:153-60. 2012
    ..In this study, we investigated visceral pleural invasion (VPI) as a poor prognostic factor in patients with non-small cell lung cancer (NSCLC) according to the 7th edition of the TNM classification...
  9. doi request reprint Pathological vascular invasion and tumor differentiation predict cancer recurrence in stage IA non-small-cell lung cancer after complete surgical resection
    Yoshihisa Shimada
    First Department of Surgery, Division, Tokyo Medical University Hospital, Shinjyuku ku, Tokyo, Japan
    J Thorac Oncol 7:1263-70. 2012
    ..The objective of the current study was to identify the clinicopathological factors that affect overall prognosis and cancer recurrence of stage IA NSCLC...
  10. doi request reprint A proposal for combination of total number and anatomical location of involved lymph nodes for nodal classification in non-small cell lung cancer
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Chest 143:1618-25. 2013
    ..However, it remains unknown whether the total number or anatomic location of involved LNs is a superior prognostic factor...
  11. doi request reprint Prognostic impact of number of resected and involved lymph nodes at complete resection on survival in non-small cell lung cancer
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    J Thorac Oncol 6:1865-71. 2011
    ....
  12. doi request reprint Management of multiple primary lung cancer in patients with centrally located early cancer lesions
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    J Thorac Oncol 5:62-8. 2010
    ....
  13. doi request reprint Molecular determinants of photodynamic therapy for lung cancers
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical Universiry, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lasers Surg Med 43:591-9. 2011
    ....
  14. ncbi request reprint Quantitative p16 and ESR1 methylation in the peripheral blood of patients with non-small cell lung cancer
    Yasuhiro Suga
    Department of Thoracic Surgery, Tokyo Medical University Hospital, Shinjuku ku, Tokyo, Japan
    Oncol Rep 20:1137-42. 2008
    ..Our study results also suggested that comparative evaluation of the methylation ratio before and after surgery might be a powerful tool to predict the prognosis of lung cancer patients...
  15. pmc Retrospective analysis of nodal spread patterns according to tumor location in pathological N2 non-small cell lung cancer
    Yoshihisa Shimada
    First Department of Surgery, Tokyo Medical University Hospital, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    World J Surg 36:2865-71. 2012
    ....
  16. doi request reprint Prognostic factors and the significance of treatment after recurrence in completely resected stage I non-small cell lung cancer
    Yoshihisa Shimada
    Department of Surgery I, Tokyo Medical University Hospital, Tokyo, Japan
    Chest 143:1626-34. 2013
    ....
  17. ncbi request reprint Frequent loss of E-cadherin and/or catenins in intrabronchial lesions during carcinogenesis of the bronchial epithelium
    Yasufumi Kato
    Department of Surgery, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 48:323-30. 2005
    ....
  18. doi request reprint Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lung
    Jitsuo Usuda
    Division of Thoracic Surgery 1, Department of Surgery 1, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Lung Cancer 72:355-9. 2011
    ..In this study, we focused on the Klotho gene, which is an anti-aging gene known to be a potential tumor suppressor. We investigated whether the immunohistochemical expression of Klotho can predict survival patients with resected LCNEC...
  19. ncbi request reprint Training in robotic surgery using the da VinciĀ® surgical system for left pneumonectomy and lymph node dissection in an animal model
    Naohiro Kajiwara
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 17:446-53. 2011
    ..We report and review future possibilities and problems of robotic surgery, especially concerning education, training, safety management and ethical considerations for pneumonectomy and lymph node dissection in clinical practice...
  20. doi request reprint Clinical response of large cell neuroendocrine carcinoma of the lung to perioperative adjuvant chemotherapy
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, Nishishinjuku, Shinjuku ku, Japan
    Anticancer Drugs 21:89-93. 2010
    ..This should be, therefore, evaluated further in prospective multi-institutional phase II trials...
  21. ncbi request reprint Early detection of bronchial lesions using newly developed videoendoscopy-based autofluorescence bronchoscopy
    Norihiko Ikeda
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Lung Cancer 52:21-7. 2006
    ..This videoendoscopy-based autofluorescence system had significantly higher sensitivity for intraepithelial lesions than white light videoendoscopy alone...
  22. ncbi request reprint Individualized adjuvant chemotherapy for surgically resected lung cancer and the roles of biomarkers
    Norihiko Ikeda
    Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 15:144-9. 2009
    ..The extent to which individualized treatment of lung cancer can be provided, especially adjuvant chemotherapy, is discussed in this manuscript...
  23. doi request reprint Recent advances in video-assisted thoracoscopic surgery for lung cancer
    Norihiko Ikeda
    Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Asian J Endosc Surg 6:9-13. 2013
    ..Moreover, the indications for VATS are expanding to encompass complex procedures such as segmentectomy or sleeve resection. Training and dissemination of the technique and the monitoring of outcomes are necessary...
  24. doi request reprint Extended indications for robotic surgery for posterior mediastinal tumors
    Naohiro Kajiwara
    Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Asian Cardiovasc Thorac Ann 20:308-13. 2012
    ..Crucial to the success of these operations were the appropriate placement and angle of the special da Vinci surgical ports in relation to the target and the patient's position, which varied according to the tumor location...
  25. doi request reprint Proposal on incorporating blood vessel invasion into the T classification parts as a practical staging system for stage I non-small cell lung cancer
    Yujin Kudo
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Japan
    Lung Cancer 81:187-93. 2013
    ..We investigated blood vessel invasion (BVI) as a possible negative prognostic factor in patients with stage I non-small cell lung cancer (NSCLC) according to the 7th edition of the TNM classification...
  26. doi request reprint Outcomes of airway stenting for advanced lung cancer with central airway obstruction
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Interact Cardiovasc Thorac Surg 11:425-8. 2010
    ..This study represents a single-institution experience. Although an aggressive strategy of AS is justified in order to improve symptoms and QoL, AS itself did not contribute to survival benefit...
  27. ncbi request reprint Identification of postoperative adjuvant chemotherapy responders in non-small cell lung cancer by novel biomarker
    Takashi Hirano
    Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Int J Cancer 117:460-8. 2005
    ..The evaluation of RCN and GST-pi might provide valuable information concerning postoperatively therapeutic strategy from the standpoint of individualized postoperative therapy...
  28. ncbi request reprint The ratio of the maximum high attenuation area dimension to the maximum tumor dimension may be an index of the presence of lymph node metastasis in lung adenocarcinomas 3 cm or smaller on high-resolution computed tomography
    Ryota Nishio
    Department of Radiology, Tokyo Medical University, Tokyo, Japan
    J Thorac Oncol 2:29-33. 2007
    ....
  29. doi request reprint Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence
    Hisashi Saji
    Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku ku, Tokyo 160 0023, Japan
    Oncol Rep 29:1902-6. 2013
    ..This comprehensive gene expression and functional pathway analysis identified a distinct molecular pathway, CAMs, that correlated with the early relapse of patients with early-stage lung adenocarcinoma...
  30. ncbi request reprint The present status of postoperative adjuvant chemotherapy for completely resected non-small cell lung cancer
    Masahiro Tsuboi
    Department of Thoracic Surgery and Oncology, Tokyo Medical University and Hospital, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 13:73-7. 2007
    ..Further research is needed to define the role of adjuvant platinum-based chemotherapy and its use, in conjunction with chest radiotherapy as the treatment for patients with resected stages IB and IIIA NSCLC...
  31. doi request reprint Cine MRI enables better therapeutic planning than CT in cases of possible lung cancer chest wall invasion
    Naohiro Kajiwara
    Department of Thoracic Surgery, Tokyo Medical University, Japan
    Lung Cancer 69:203-8. 2010
    ..To evaluate the hypothesis that lung cancer treatment planning (whether or not to use induction therapy) can be improved if respiratory dynamic cine magnetic resonance imaging (RD MR) is used...
  32. ncbi request reprint Photodynamic therapy (PDT) for lung cancers
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    J Thorac Oncol 1:489-93. 2006
    ..We also discuss the applications of PDT for advanced lung cancer and combined therapy using PDT and other treatments for lung cancer...
  33. ncbi request reprint [Guidelines for the treatment of lung cancer with lymph node involvement]
    Norihiko Ikeda
    Department of Surgery, Tokyo Medical University, Japan
    Nihon Geka Gakkai Zasshi 105:404-7. 2004
    ..Enrollment of patients in prospective clinical trials is strongly recommended to clarify unresolved issues in this clinical setting...
  34. doi request reprint An intrapericardial foregut cyst: report of a thoracoscopically resected case
    Yujin Kudo
    Department of Surgery, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Surg Today 42:899-902. 2012
    ....
  35. doi request reprint Early experience using the da Vinci Surgical System for the treatment of mediastinal tumors
    Naohiro Kajiwara
    Department of Surgery, Tokyo Medical University, Nishishinjuku, Shinjuku ku, Tokyo, Japan
    Gen Thorac Cardiovasc Surg 59:693-8. 2011
    ..Recently, we used the da Vinci Surgical System for various types of anterior and middle mediastinal tumors in clinical practice. We report our early experience using the da Vinci Surgical System...
  36. pmc Interventional management for benign airway tumors in relation to location, size, character and morphology
    Naohiro Kajiwara
    Department of Surgery, Tokyo Medical University, Tokyo, Japan
    J Thorac Dis 3:221-30. 2011
    ..To select minimally stressful methods for patients with benign bronchial tumors, and evaluate interventional strategies in relation to location, size, character and morphology...
  37. ncbi request reprint Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray
    Tatsuo Ohira
    First Department of Surgery, Tokyo Medical University, Tokyo 106 0023, Japan
    Oncol Rep 9:723-8. 2002
    ..These results suggest that angiogenesis related molecules are suitable candidates for target-based therapeutics and angiogenesis inhibitors are expected to be effective in lung cancer patients pretreated with chemotherapy...
  38. ncbi request reprint Usefulness of TA02 (napsin A) to distinguish primary lung adenocarcinoma from metastatic lung adenocarcinoma
    Takashi Hirano
    Department of Surgery, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku Tokyo 160 0023, Japan
    Lung Cancer 41:155-62. 2003
    ..We concluded that the evaluation of TA02 expression in lung tumorous lesions was very valuable for discriminating between primary and metastatic lung adenocarcinoma, and TA02 was superior to SpA as a discriminating marker...
  39. ncbi request reprint Hypereosinophilia in a patient with invasive thymoma with clonal T-lymphocyte expansion expressing CD4, CD8, and CD25 antigens
    Masahiko Sumi
    First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Int J Hematol 83:243-6. 2006
    ....
  40. doi request reprint Serum heparan sulfate concentration is correlated with the failure of epidermal growth factor receptor tyrosine kinase inhibitor treatment in patients with lung adenocarcinoma
    Makoto Nishio
    Thoracic Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto ku, Tokyo, Japan
    J Thorac Oncol 6:1889-94. 2011
    ....
  41. doi request reprint Isolation of miRNAs that target EGFR mRNA in human lung cancer
    Gaku Yamaguchi
    Department of Surgery, Tokyo Medical University, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Biochem Biophys Res Commun 420:411-6. 2012
    ..Our findings suggest that miR-542-5p may act as an important modulator of EGFR-mediated oncogenesis, with potential applications as a novel therapeutic target in lung cancer...
  42. pmc Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study
    Masaharu Nomura
    Dept, of Surgery I, Tokyo Medical University, Tokyo, Japan
    J Clin Bioinforma 1:23. 2011
    ..abstract:..
  43. ncbi request reprint Quantitative detection of lung cancer cells by fluorescence in situ hybridization: comparison with conventional cytology
    Haruhiko Nakamura
    Department of Chest Surgery, Atami Hospital, International University of Health and Welfare, 13 1 Higashikaigan cho, Atami city, Shizuoka, Japan 413 0012
    Chest 128:906-11. 2005
    ..The aim of this study was to clarify whether fluorescence in situ hybridization (FISH) can diagnose lung cancer in various clinical specimens in comparison with conventional cytology...