Hidenori Toyoda

Summary

Affiliation: Ogaki Municipal Hospital
Country: Japan

Publications

  1. pmc The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis
    Yoshiki Murakami
    Department of Hepatology, Graduate School of Medicine Osaka City University, Osaka 545 8585, Japan
    BMC Cancer 13:99. 2013
  2. doi request reprint Characteristics and prognosis of patients with hepatocellular carcinoma after the year 2000 in Japan
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Gastroenterol Hepatol 26:1765-71. 2011
  3. doi request reprint Novel method to measure serum levels of des-gamma-carboxy prothrombin for hepatocellular carcinoma in patients taking warfarin: a preliminary report
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Cancer Sci 103:921-5. 2012
  4. pmc Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C
    Yoshiki Murakami
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, 53 Shogoinkawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    BMC Med Genomics 3:48. 2010
  5. ncbi request reprint Prognostic significance of simultaneous measurement of three tumor markers in patients with hepatocellular carcinoma
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Gifu, Japan
    Clin Gastroenterol Hepatol 4:111-7. 2006
  6. doi request reprint Prevalence of hepatitis E virus IgG antibody in Japanese patients with hemophilia
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Intervirology 51:21-5. 2008
  7. ncbi request reprint Prevalence of low-level hepatitis B viremia in patients with HBV surface antigen-negative hepatocellular carcinoma with and without hepatitis C virus infection in Japan: analysis by COBAS TaqMan real-time PCR
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    Intervirology 50:241-4. 2007
  8. doi request reprint Eight-week regimen of antiviral combination therapy with peginterferon and ribavirin for patients with chronic hepatitis C with hepatitis C virus genotype 2 and a rapid virological response
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Liver Int 29:120-5. 2009
  9. doi request reprint Amino acid substitutions in the hepatitis C virus core region are associated with postoperative recurrence and survival of patients with HCV genotype 1b-associated hepatocellular carcinoma
    Hidenori Toyoda
    Department of Gastroenterology and Surgery, Ogaki Municipal Hospital, Ogaki, Japan
    Ann Surg 254:326-32. 2011
  10. doi request reprint Prognostic value of pretreatment levels of tumor markers for hepatocellular carcinoma on survival after curative treatment of patients with HCC
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    J Hepatol 49:223-32. 2008

Collaborators

Detail Information

Publications88

  1. pmc The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis
    Yoshiki Murakami
    Department of Hepatology, Graduate School of Medicine Osaka City University, Osaka 545 8585, Japan
    BMC Cancer 13:99. 2013
    ..In hepatocellular carcinoma (HCC), malignancy level is related to the degree of histological differentiation...
  2. doi request reprint Characteristics and prognosis of patients with hepatocellular carcinoma after the year 2000 in Japan
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Gastroenterol Hepatol 26:1765-71. 2011
    ..We investigated how the characteristics of patients with HCC changed and whether this trend is continuing after the year 2000...
  3. doi request reprint Novel method to measure serum levels of des-gamma-carboxy prothrombin for hepatocellular carcinoma in patients taking warfarin: a preliminary report
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Cancer Sci 103:921-5. 2012
    ..The novel NX-DCP ratio identifies patients on warfarin with elevated DCP due to HCC and is useful as a tumor marker for HCC in this patient subpopulation...
  4. pmc Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C
    Yoshiki Murakami
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, 53 Shogoinkawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    BMC Med Genomics 3:48. 2010
    ..In this study we administered the standard combination treatment to CHC patients. We then examined their miRNA expression profiles in order to identify the miRNAs that were associated with each patient's drug response...
  5. ncbi request reprint Prognostic significance of simultaneous measurement of three tumor markers in patients with hepatocellular carcinoma
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Gifu, Japan
    Clin Gastroenterol Hepatol 4:111-7. 2006
    ..We conducted a prospective study to evaluate the significance of simultaneous measurement of 3 currently used tumor markers in the evaluation of tumor progression and prognosis of patients with hepatocellular carcinoma (HCC)...
  6. doi request reprint Prevalence of hepatitis E virus IgG antibody in Japanese patients with hemophilia
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Intervirology 51:21-5. 2008
    ..We investigated the prevalence of antibody against hepatitis E virus (HEV) in Japanese patients with hemophilia...
  7. ncbi request reprint Prevalence of low-level hepatitis B viremia in patients with HBV surface antigen-negative hepatocellular carcinoma with and without hepatitis C virus infection in Japan: analysis by COBAS TaqMan real-time PCR
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    Intervirology 50:241-4. 2007
    ..We investigated the prevalence of low-level HBV in the serum of HBsAg-negative patients with HCC using a newly developed, sensitive method based on real-time polymerase chain reaction...
  8. doi request reprint Eight-week regimen of antiviral combination therapy with peginterferon and ribavirin for patients with chronic hepatitis C with hepatitis C virus genotype 2 and a rapid virological response
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Liver Int 29:120-5. 2009
    ....
  9. doi request reprint Amino acid substitutions in the hepatitis C virus core region are associated with postoperative recurrence and survival of patients with HCV genotype 1b-associated hepatocellular carcinoma
    Hidenori Toyoda
    Department of Gastroenterology and Surgery, Ogaki Municipal Hospital, Ogaki, Japan
    Ann Surg 254:326-32. 2011
    ..We researched the molecular marker for prognosis of postoperative patients with hepatocellular carcinoma (HCC)...
  10. doi request reprint Prognostic value of pretreatment levels of tumor markers for hepatocellular carcinoma on survival after curative treatment of patients with HCC
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    J Hepatol 49:223-32. 2008
    ..We evaluated the prognostic value of the pretreatment elevation of tumor markers for hepatocellular carcinoma (HCC) in patients who underwent curative treatment...
  11. doi request reprint Long-term follow-up of patients with hepatitis C with a normal alanine aminotransferase
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    J Med Virol 81:446-51. 2009
    ..010), and high total bilirubin level (8.309 [2.235-30.888], P = 0.002). In patients with hepatitis C with a normal ALT level initially, an ALT level of 21-35 IU/L is a risk factor for an increased ALT level and hepatocarcinogenesis...
  12. doi request reprint Impact of genetic polymorphisms near the IL28B gene and amino acid substitutions in the hepatitis C virus core region on interferon sensitivity/resistance in patients with chronic hepatitis C
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Med Virol 83:1203-11. 2011
    ..In HCV genotype 1b, genetic variations near the IL28B gene affected the sensitivity/resistance to IFN strongly. Genetic polymorphisms near the IL28B gene did not affect the sensitivity/resistance to IFN in HCV genotype 2...
  13. pmc Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum
    Akira Kanamori
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki 503 8502, Japan
    World J Gastroenterol 15:1138-40. 2009
    ..The patient has been asymptomatic without recurrence of tumor or stenosis of the Santorini orifice upon endoscopic examination for the past 2 years...
  14. doi request reprint Late-onset colonic occlusion after emergent selective embolization of sigmoid artery with N-butyl cyanoacrylate for life-threatening traumatic bleeding
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    J Vasc Interv Radiol 20:1376-9. 2009
    ..Because complications of mesenteric artery embolization may be delayed for months, an extended follow-up period is prudent to monitor the embolization site even in the absence of clinical symptoms...
  15. doi request reprint Outcome in partial early virologic responders to combination therapy with peginterferon and ribavirin in patients infected with hepatitis C virus genotype 1b
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    J Med Virol 83:101-7. 2011
    ..The outcome of partial early virologic responders varied greatly, and close monitoring of serum HCV RNA is required for predicting the outcome of treatment in these patients...
  16. ncbi request reprint Clearance of GB virus C during highly active antiretroviral therapy and course of HIV disease progression in HIV-infected patients with hemophilia
    H Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Eur J Clin Microbiol Infect Dis 24:645-6. 2005
  17. ncbi request reprint Assessment of tumor hemodynamics in small hepatocellular carcinoma: comparison of Doppler ultrasonography, angiography-assisted computed tomography, and pathological findings
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    Liver Int 24:425-31. 2004
    ..We evaluated the usefulness of Doppler ultrasonography (DUS) for the analysis of tumor hemodynamics in small hepatocellular carcinoma (HCC)...
  18. doi request reprint B-mode ultrasound with algorithm based on statistical analysis of signals: evaluation of liver fibrosis in patients with chronic hepatitis C
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    AJR Am J Roentgenol 193:1037-43. 2009
    ..The method includes an algorithm for removing small structures, such as cross sections of the thin vessels, in the background texture to minimize differences in analysis results between users...
  19. doi request reprint Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Liver Int 31:1359-65. 2011
    ..The aim of this study was to investigate whether the SNP of IL28B (rs8099917) and amino acid substitutions in the core and NS5A region affect the response to IFN therapy...
  20. ncbi request reprint Characteristics and prognosis of patients in Japan with viral marker-negative hepatocellular carcinoma
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Gastroenterol Hepatol 23:459-66. 2008
    ..We investigated the characteristics and prognosis of HCC patients in whom no markers for hepatitis virus infection were detected, in comparison with those of HCC patients with hepatitis virus infection...
  21. doi request reprint Prevalence and clinical characterization of patients with acute hepatitis B induced by lamivudine-resistant strains
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 25:745-9. 2010
    ..The aim of this study was to investigate the molecular and clinical characteristics of patients with acute hepatitis B caused by LMV-resistant strains...
  22. ncbi request reprint Prevalence and clinical implications of occult hepatitis B viral infection in hemophilia patients in Japan
    Hidenori Toyoda
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya, Japan
    J Med Virol 73:195-9. 2004
    ..The genotype of the occult HBV in the present study was exclusively the domestic type indigenous to Japan (genotype C), suggesting a different route of transmission for HBV in comparison to HCV and HIV in this population...
  23. doi request reprint Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C
    Takashi Honda
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Liver Int 30:527-37. 2010
    ..The aim of this study was to evaluate the efficacy and indication of combination therapy with ribavirin plus peginterferon-alpha-2b in chronic hepatitis C virus (HCV) patients aged 65 years and older...
  24. doi request reprint An early viral response to standard interferon-alpha identifies resistance to combination therapy with peginterferon and ribavirin in patients infected by HCV genotype 1
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu 503 8502 Japan
    J Med Virol 82:1537-44. 2010
    ....
  25. doi request reprint Mutations in the interferon sensitivity-determining region of hepatitis C virus genotype 2a correlate with response to pegylated-interferon-alpha 2a monotherapy
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Med Virol 81:459-66. 2009
    ..Rapid virologic response and the ISDR sequence variations are significantly associated with response to pegylated-IFN-alpha 2a monotherapy in Japanese patients with HCV genotype 2a...
  26. doi request reprint Association between HCV amino acid substitutions and outcome of peginterferon and ribavirin combination therapy in HCV genotype 1b and high viral load
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    J Gastroenterol Hepatol 25:1072-8. 2010
    ....
  27. ncbi request reprint Prospective study of a high-intensity interferon-alpha regimen for chronic hepatitis C virus genotype 1b infection
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu, 503 8502 Japan
    Hepatogastroenterology 49:1619-24. 2002
    ..To evaluate efficacy of high-intensity interferon administration for patients chronically infected with hepatitis C virus genotype 1b, we administered interferon-alpha with different regimens according to viral load...
  28. ncbi request reprint Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma
    Teiji Kuzuya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Gastroenterol Hepatol 22:1929-35. 2007
    ..The aim of this study was to determine whether antiviral therapy with lamivudine is beneficial in patients after initial treatment for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)...
  29. doi request reprint Transient reappearance of serum hepatitis C virus RNA observed by real-time PCR during antiviral therapy with peginterferon and ribavirin in patients with HCV genotype 1b
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu 503 8502, Japan
    J Clin Virol 47:258-62. 2010
    ..However, the sensitivity of previous assays for serum HCV RNA is limited...
  30. doi request reprint Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Med Virol 84:438-44. 2012
    ..In conclusion, HCV genotype 1a is rare in Japan. The presence of IL28B genotype TT, and more than two mutations, in the ISDR are associated with a good response to IFN therapy in patients with HCV genotype 1a...
  31. doi request reprint Predictive value of early viral dynamics during peginterferon and ribavirin combination therapy based on genetic polymorphisms near the IL28B gene in patients infected with HCV genotype 1b
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Med Virol 84:61-70. 2012
    ..In contrast, lack of early virologic response at 12 weeks retains a strong predictive value for the failure of sustained virologic response regardless of IL28B polymorphisms, which remains useful as a factor to stop therapy...
  32. doi request reprint Antiviral combination therapy with peginterferon and ribavirin does not induce a therapeutically resistant mutation in the HCV core region regardless of genetic polymorphism near the IL28B gene
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Med Virol 83:1559-64. 2011
    ..Antiviral combination therapy with PEG-IFN and ribavirin does not appear to induce mutation of HCV core region residue 70 regardless of genetic polymorphism near the IL28B gene in Japanese patients infected with HCV genotype 1b...
  33. ncbi request reprint Comparison of biochemical safety between PEG-IFN alpha-2a and PEG-IFN alpha-2b
    Yoshiaki Katano
    Department of Gastroenterology, Nagoya University Graduate School of Medicine 65 Tsurumai cho, Showa Ku, Nagoya 466 8560, Japan
    Hepatogastroenterology 56:485-91. 2009
    ..To compare the effects of two PEG-IFN products on blood cell profile...
  34. doi request reprint Association between hepatic steatosis and hepatic expression of genes involved in innate immunity in patients with chronic hepatitis C
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    Cytokine 63:145-50. 2013
    ....
  35. doi request reprint Characteristics of elderly hepatitis C virus-associated hepatocellular carcinoma patients
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    J Gastroenterol Hepatol 28:357-64. 2013
    ..We evaluate characteristics of HCV-positive patients who develop HCC in older age to determine an optimal surveillance strategy...
  36. ncbi request reprint Staging hepatocellular carcinoma by a novel scoring system (BALAD score) based on serum markers
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, and Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Clin Gastroenterol Hepatol 4:1528-36. 2006
    ..Previously proposed staging systems for hepatocellular carcinoma (HCC) involve clinical, imaging, or pathologic factors in the evaluation. We established and validated a novel staging system for HCC that is based on simply serum markers...
  37. doi request reprint Predictive value of tumor markers for hepatocarcinogenesis in patients with hepatitis C virus
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86, Minaminokawa cho, Ogaki, Gifu 503 8052, Japan
    J Gastroenterol 46:536-44. 2011
    ....
  38. doi request reprint Incidence of hepatocellular carcinoma in hepatitis C carriers with normal alanine aminotransferase levels
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86, Minaminokawa cho, Ogaki, Gifu 503 8052, Japan
    J Hepatol 50:729-35. 2009
    ..This study sought to identify the independent risk factors involved in the development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection who have normal alanine aminotransferase (ALT) levels...
  39. doi request reprint Incidence of hepatocellular carcinoma in patients with chronic hepatitis B virus infection who have normal alanine aminotransferase values
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    J Med Virol 82:539-45. 2010
    ..Therefore, maintenance of low HBV-DNA levels is important for the prevention of HCC in patients with low platelet counts, particularly in patients whose ALT values fall within the current normal range...
  40. doi request reprint High ability to predict the treatment outcome of peginterferon and ribavirin combination therapy based on the reduction in HCV RNA levels at 4 weeks after starting therapy and amino acid substitutions in the hepatitis C virus in patients infected with HCV
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    J Gastroenterol 46:501-9. 2011
    ....
  41. doi request reprint Association of hepatitis B virus subgenotypes and basal core promoter/precore region variants with the clinical features of patients with acute hepatitis
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Gastroenterol 43:558-64. 2008
    ..The aim of this study was to investigate the distributions of subgenotypes and BCP/PC variants to identify clinical differences in acute hepatitis B patients...
  42. doi request reprint Differences in viral kinetics between genotypes 1 and 2 of hepatitis C virus after single administration of standard interferon-alpha
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Japan
    J Med Virol 81:1354-62. 2009
    ..Within genotype 2, HCV genotype 2A was more sensitive to IFN than genotype 2B...
  43. ncbi request reprint Changes in hepatitis C virus (HCV) antibody status in patients with chronic hepatitis C after eradication of HCV infection by interferon therapy
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Nagoya, Japan
    Clin Infect Dis 40:e49-54. 2005
    ..Changes in hepatitis C virus (HCV) antibody status were followed for 10 years after the eradication of HCV by interferon (IFN) therapy in 30 patients with chronic hepatitis C who showed a sustained virological response...
  44. pmc Significance of a reduction in HCV RNA levels at 4 and 12 weeks in patients infected with HCV genotype 1b for the prediction of the outcome of combination therapy with peginterferon and ribavirin
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    BMC Infect Dis 12:324. 2012
    ..We conducted a multicenter study to validate this importance along with baseline predictive factors in this patient subpopulation...
  45. ncbi request reprint Impact of surveillance on survival of patients with initial hepatocellular carcinoma: a study from Japan
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Clin Gastroenterol Hepatol 4:1170-6. 2006
    ..We investigated trends in the prediagnostic surveillance of patients in whom hepatocellular carcinoma (HCC) was diagnosed, and evaluated the impact of these trends on early detection of HCC and on patient survival...
  46. ncbi request reprint Relationship between Lens culinaris agglutinin-reactive alpha-fetoprotein and pathologic features of hepatocellular carcinoma
    Toshifumi Tada
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Liver Int 25:848-53. 2005
    ..We investigated pathological features of Lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3)-positive hepatocellular carcinoma (HCC) in order to seek a pathological basis of poor prognosis of HCC patients with elevated AFP-L3...
  47. doi request reprint Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis B patients: a propensity score analysis
    Takashi Kumada
    Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan
    J Hepatol 58:427-33. 2013
    ..Some patients with chronic hepatitis B virus (HBV) infection progress to hepatocellular carcinoma (HCC). However, the long-term effect of nucleos(t)ide analogue (NA) therapy on progression to HCC is unclear...
  48. doi request reprint Non-hypervascular hypointense nodules detected by Gd-EOB-DTPA-enhanced MRI are a risk factor for recurrence of HCC after hepatectomy
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Hepatol 58:1174-80. 2013
    ..We conducted a prospective observational study to investigate the impact of the presence of non-hypervascular hypointense hepatic nodules on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI on the recurrence of HCC after hepatectomy...
  49. doi request reprint Prognostic significance of a combination of pre- and post-treatment tumor markers for hepatocellular carcinoma curatively treated with hepatectomy
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Hepatol 57:1251-7. 2012
    ..We investigated the prognostic value of a combination of these tumor markers for HCC, measured before and after treatment, on survival and recurrence in patients treated with hepatectomy...
  50. ncbi request reprint Changes in the characteristics and survival rate of hepatocellular carcinoma from 1976 to 2000: analysis of 1365 patients in a single institution in Japan
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    Cancer 100:2415-21. 2004
    ..The authors analyzed changes in the characteristics and survival rate of patients with hepatocellular carcinoma (HCC) in the past 25 years...
  51. ncbi request reprint Comparison of the usefulness of three staging systems for hepatocellular carcinoma (CLIP, BCLC, and JIS) in Japan
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Am J Gastroenterol 100:1764-71. 2005
    ....
  52. ncbi request reprint Treatment of chronic hepatitis C with interferon alone or combined with ribavirin in Japan
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    Intervirology 49:112-8. 2006
    ..3 vs. 42.6%, p = 0.0003). A decrease in SVR was observed with an increased body mass index in patients who received combination therapy...
  53. ncbi request reprint Efficacy of ribavirin plus interferon-alpha in patients aged >or=60 years with chronic hepatitis C
    Takashi Honda
    Department of Gastroenterology, Nagoya University School of Medicine, Showa Ku, Nagoya, Japan
    J Gastroenterol Hepatol 22:989-95. 2007
    ..The aim of the present study was to evaluate the efficacy and tolerability of combination therapy in such patients...
  54. ncbi request reprint Contrast-enhanced ultrasonographic assessment of the response of Ménétrier disease to Helicobacter pylori eradication therapy
    Teiji Kuzuya
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu 503 8502, Japan
    J Ultrasound Med 25:1099-103. 2006
  55. ncbi request reprint Incidence of hepatocellular carcinoma in chronic hepatitis C after interferon therapy
    Kazuhiko Hayashi
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Hepatogastroenterology 49:508-12. 2002
    ..We investigated the rate of occurrence and the risk factors for hepatocellular carcinoma in chronic hepatitis C patients who received interferon therapy...
  56. ncbi request reprint Evaluation of pathological features of hepatocellular carcinoma by contrast-enhanced ultrasonography: comparison with pathology on resected specimen
    Sadanobu Ogawa
    Department of Imaging Diagnosis, Ogaki Municipal Hospital, Ogaki, Japan
    Eur J Radiol 59:74-81. 2006
    ..Some pathological characteristics of HCC might be evaluated preoperatively and non-invasively, by means of combined analysis of three phases of CEUS findings...
  57. doi request reprint Transarterial chemoembolization for hepatitis B virus-associated hepatocellular carcinoma: improved survival after concomitant treatment with nucleoside analogues
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    J Vasc Interv Radiol 23:317-22.e1. 2012
    ..To determine whether nucleoside analogue therapy is associated with improved survival in patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) who are treated solely with transarterial chemoembolization...
  58. ncbi request reprint Comparison of hepatitis B virus subgenotypes in patients with acute and chronic hepatitis B and absence of lamivudine-resistant strains in acute hepatitis B in Japan
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Nagoya, Japan
    J Med Virol 79:366-73. 2007
    ..In conclusion, the prevalence of uncommon Japanese HBV subgenotypes is expected to increase, although lamivudine-resistant strains have not yet been found in patients with acute hepatitis B...
  59. ncbi request reprint Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Gifu, Japan
    J Hepatol 48:43-50. 2008
    ..We analyzed hepatitis B virus (HBV) X gene integration in hepatocytes of HBV-negative, chronic hepatitis C (CH-C) patients with mild fibrosis, and prospectively followed these patients for the development of hepatocellular carcinoma (HCC)...
  60. ncbi request reprint Influence of age, sex, and degree of liver fibrosis on the association between serum alanine aminotransferase levels and liver inflammation in patients with chronic hepatitis C
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan
    Dig Dis Sci 49:295-9. 2004
    ..Age, sex, and degree of liver fibrosis independently influenced serum ALT levels in patients with chronic hepatitis C...
  61. doi request reprint Higher hepatic gene expression and serum levels of matrix metalloproteinase-2 are associated with steatohepatitis in non-alcoholic fatty liver diseases
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Biomarkers 18:82-7. 2013
    ....
  62. doi request reprint Impact of a unified CT angiography system on outcome of patients with hepatocellular carcinoma
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    AJR Am J Roentgenol 192:766-74. 2009
    ..The purpose of our study was to evaluate the impact of a unified CT angiography (CTA) system for the management of patients with hepatocellular carcinoma (HCC)...
  63. doi request reprint Clinical and molecular characteristics of hepatitis A virus infections during the years 1992-2003 in Ogaki, a centrally located city of Japan
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Manaminokawa, Ogaki, Gifu 503 8502, Japan
    J Clin Virol 44:145-8. 2009
    ..The emergence of imported hepatitis A virus (HAV) strains from other regions is a feature of acute hepatitis A in developed countries as well as the decrease in number of cases...
  64. ncbi request reprint [Ruptured aneurysm of a posterior inferior pancreaticoduodenal artery associated with duodenal stenosis after transcatheter arterial embolization]
    Kenta Yamamoto
    Department of Gastroenterology, Ogaki Municipal Hospital
    Nihon Shokakibyo Gakkai Zasshi 108:978-86. 2011
    ..As a result, we inferred that this case without pancreatitis or pancreas surgery was a true aneurysm made by the bloodstream changes caused by the celiac artery stenosis...
  65. ncbi request reprint [Hepatic arterial infusion chemotherapy for colorectal liver metastases]
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa cho, Ogaki, Gifu 503 8502, Japan
    Gan To Kagaku Ryoho 31:700-5. 2004
    ..Furthermore, in order to finally determine the position of HAI for colorectal liver metastases, it is necessary to conduct a comparative study versus systemic chemotherapy, using the survival time as the primary end point...
  66. doi request reprint Pharmacotherapy of chronic hepatitis C virus infection - the IDEAL trial: '2b or not 2b (= 2a), that is the question'
    Hidenori Toyoda
    Ogaki Municipal Hospital, Department of Gastroenterology, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    Expert Opin Pharmacother 10:2845-57. 2009
    ..There has been no direct comparison of the antiviral efficacy and the adverse effects of peginterferon (PEG-IFN) alfa-2a and PEG-IFN alfa-2b when used in combination therapy with ribavirin for chronic hepatitis C virus (HCV) infection...
  67. doi request reprint Baseline factors and early viral response (week 4) to antiviral therapy with peginterferon and ribavirin for predicting sustained virologic response in patients infected with hepatitis C virus genotype 1: a multicenter study
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Med Virol 85:65-70. 2013
    ..However, the cut-off levels should be modified based on the baseline predictive variables...
  68. doi request reprint Clinical utility of highly sensitive Lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein <20 ng/mL
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Cancer Sci 102:1025-31. 2011
    ..001). In patients with AFP <20 ng/mL, measurements of AFP-L3% by the highly sensitive method before treatment were more useful for diagnosis and prognosis of HCC than by the conventional method...
  69. doi request reprint Evolution of hypointense hepatocellular nodules observed only in the hepatobiliary phase of gadoxetate disodium-enhanced MRI
    Takashi Kumada
    Department of Gastroenterology, Ogaki Municipal Hospital, Gifu, Japan
    AJR Am J Roentgenol 197:58-63. 2011
    ....
  70. pmc Markedly lower follow-up rate after liver biopsy in patients with non-alcoholic fatty liver diseases than those with viral hepatitis in Japan
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    BMC Res Notes 4:341. 2011
    ..abstract:..
  71. ncbi request reprint Comparison of IV contrast-enhanced sonography and histopathology of pancreatic cancer
    Kenji Takeshima
    Department of Imaging Diagnosis, Ogaki Municipal Hospital, 4 86 Minaminhokawa, Ogaki, Gifu 503 8502, Japan
    AJR Am J Roentgenol 185:1193-200. 2005
    ..We compared contrast-enhanced sonography findings with pathologic findings in pancreatic cancer to evaluate the ability of contrast-enhanced sonography to depict the pathologic changes associated with pancreatic cancer...
  72. doi request reprint Survival benefit of hepatopancreatoduodenectomy for cholangiocarcinoma in comparison to hepatectomy or pancreatoduodenectomy
    Yuji Kaneoka
    Department of Surgery, Ogaki Municipal Hospital, 4 86 Minaminokawa cho, Ogaki, 503 8502, Japan
    World J Surg 34:2662-70. 2010
    ..We conducted a retrospective study of patients with cholangiocarcinoma to examine whether hepatopancreatoduodenectomy, in comparison to standard surgeries, provides a survival benefit...
  73. ncbi request reprint Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma
    Shinji Takai
    Department of Pharmacology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Japan
    Life Sci 81:585-91. 2007
    ..SB203580, an inhibitor of p38 MAPK, suppressed the TPA-induced HSP27 phosphorylation. Our results strongly suggest that activation of PKCdelta regulates the phosphorylation of HSP27 via p38 MAPK in human HCC...
  74. ncbi request reprint Evaluation for clinical utility of GPC3, measured by a commercially available ELISA kit with Glypican-3 (GPC3) antibody, as a serological and histological marker for hepatocellular carcinoma
    Eisuke Yasuda
    Department of Medical Technology, Ogaki Municipal Hospital, Ogaki, Japan
    Hepatol Res 40:477-85. 2010
    ..This lack of utility could have been due to the measuring procedure used in the present study. Further evaluation of GPC3 in HCC with other measuring procedures is needed...
  75. doi request reprint Eradicating Helicobacter pylori in peptic ulcer disease reduces medical costs in the community
    Yasuhiro Sone
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Helicobacter 13:346-51. 2008
    ....
  76. ncbi request reprint [Recent advances in biochemical diagnosis and assessment of severity in acute pancreatitis]
    Seiki Kiriyama
    Department of Gastroenterology, Ogaki Municipal Hospital
    Nihon Rinsho 62:2035-9. 2004
    ..Increasing knowledge of the inflammatory process in AP has led to possibly useful biochemical indicators of severity, such as cytokines, nonpancreatic synovial type group II PLA2 or granulocyte elastase...
  77. ncbi request reprint Conserved balance of hepatocyte nuclear DNA content in mononuclear and binuclear hepatocyte populations during the course of chronic viral hepatitis
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, 4 86 Minaminokawa, Ogaki, Gifu 503 8502, Japan
    World J Gastroenterol 12:4546-8. 2006
    ..To analyze the percentages of hepatocytes with increased nuclear DNA content, i.e., tetraploid (4n) and octoploid (8n) nuclei, and then compared mononuclear and binuclear hepatocyte populations...
  78. ncbi request reprint Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma
    Eisuke Yasuda
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 337:337-42. 2005
    ..Levels of phosphorylated HSP27 gradually decreased in parallel with HCC progression. Our findings suggest that phosphorylated HSP27 may have a suppressive role in progression of human HCC...
  79. ncbi request reprint Characteristics and prognosis of hepatocellular carcinoma detected in sustained responders to interferon therapy for chronic hepatitis C
    Hidenori Toyoda
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Cancer Detect Prev 27:498-502. 2003
    ..0494). HCC detected in sustained responders often appear more advanced when detected than HCC in non-sustained responders, but recurrence seems to be less frequent when the initial HCC is treated sufficiently...
  80. ncbi request reprint Impact of tumor factors on the prognosis of patients with advanced cirrhosis (Child-Pugh class C) and hepatocellular carcinoma
    Hidenori Toyoda
    J Gastroenterol Hepatol 20:963-5. 2005
  81. ncbi request reprint Emergent transcatheter arterial embolization of ruptured inferior phrenic artery aneurysm with N-butyl cyanoacrylate
    Hidenori Toyoda
    J Vasc Interv Radiol 15:886-7. 2004
  82. ncbi request reprint Mutations of the interferon sensitivity-determining region (ISDR) correlate with the complexity of hypervariable region (HVR)-1 in the Japanese variant of hepatitis C virus (HCV) type 1b
    Isao Nakano
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Med Virol 74:54-61. 2004
    ..This suggests that the ISDR is not directly related to IFN responsiveness, but the degree of HVR-1 complexity may be more important...
  83. ncbi request reprint Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma
    Takahiro Noda
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 17:1309-14. 2007
    ..01), presence of microvascular invasion (p<0.05), and tumor size (p<0.05). Our findings strongly suggest that HSP20 may play a role against the progression of human HCC...
  84. ncbi request reprint 'Yes, now you are free from chronic HCV infection, but . . .'
    Hidenori Toyoda
    J Gastroenterol Hepatol 21:9-10. 2006
  85. ncbi request reprint Serum carboxypeptidase A activity as a biomarker for early-stage pancreatic carcinoma
    Shinji Matsugi
    New Diagnostics Business and Technology Development Department, Wako Pure Chemical Industries, Ltd, 6 1 Takada cho, Amagasaki, Hyogo, Japan
    Clin Chim Acta 378:147-53. 2007
    ..We developed an assay for active form of serum carboxypeptidase A (F-CPA) and its zymogen precursor pro CPA, and evaluated them as a marker for early-stage pancreatic carcinoma...
  86. doi request reprint Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase
    Rie Matsushima-Nishiwaki
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 283:18852-60. 2008
    ..These findings strongly suggest that the control of the phosphorylated heat shock protein 27 levels could be a new therapeutic strategy especially to counter the recurrence of hepatocellular carcinoma...
  87. pmc Relation between incidence of hepatic carcinogenesis and integration value of alanine aminotransferase in patients with hepatitis C virus infection
    Takashi Kumada
    Gut 56:738-9. 2007
  88. ncbi request reprint Risk of HCV transmission after needlestick injury, and the efficacy of short-duration interferon administration to prevent HCV transmission to medical personnel
    Hobyung Chung
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama 589 8511, Japan
    J Gastroenterol 38:877-9. 2003
    ..We carried out this study to assess the risk of hepatitis C virus (HCV) transmission after needlestick injuries in medical personnel, and to evaluate the efficacy of short-duration interferon administration to prevent HCV transmission...