Research Topics
Species | Kenji MatsumotoSummaryAffiliation: Ogaki Municipal Hospital Country: Japan Publications
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Publications
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cellsKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
Bioorg Med Chem 13:6064-9. 2005..These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs...
Bile acid-binding activity of young persimmon (Diospyros kaki) fruit and its hypolipidemic effect in miceKenji Matsumoto
Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Minokamo, Gifu, Japan
Phytother Res 24:205-10. 2010..7% condensed tannins, adsorbed approximately 78% of CA in the 2000 microM CA solutions. These results suggest that the ability of YP to bind bile acid contributes to its hypolipidemic effect in mice...
Hypolipidemic effect of young persimmon fruit in C57BL/6.KOR-ApoEshl miceKenji Matsumoto
Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Gifu, Japan
Biosci Biotechnol Biochem 72:2651-9. 2008..These results indicate that acceleration of fecal bile acid excretion is a major mechanism of the hypolipidemic effect induced by YP in C57BL/6.KOR-ApoEshl mice...
Young persimmon fruits prevent the rise in plasma lipids in a diet-induced murine obesity modelKenji Matsumoto
Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Japan
Biol Pharm Bull 29:2532-5. 2006..The results indicate that young persimmon fruits are beneficial in the development of preventive and therapeutic agents against dyslipidemia...
Okara, soybean residue, prevents obesity in a diet-induced murine obesity modelKenji Matsumoto
Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology, Minokamo, Gifu, Japan
Biosci Biotechnol Biochem 71:720-7. 2007..We also found that the okara intake caused a marked reduction in the expression of leptin and TNF-alpha genes in EWAT. Our results suggest that okara is beneficial in preventing obesity...
Induction of apoptosis by xanthones from mangosteen in human leukemia cell linesKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
J Nat Prod 66:1124-7. 2003..All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis...
Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activityKenji Ohguchi
Gifu International Institute of Biotechnology, Kakamigahara, Japan
Biosci Biotechnol Biochem 67:1587-9. 2003..The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency...
Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cellsKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
Bioorg Med Chem 12:5799-806. 2004..It was also shown that the cytotoxicity substantially correlated with deltapsim decrease. These results indicate that alpha-mangostin and its analogs would be candidates for preventive and therapeutic application for cancer treatment...
Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal modelSatoshi Mishima
API Company Research Institute, Gifu, Japan
J Exp Ther Oncol 3:283-88. 2003..These results demonstrated that the ethanol extract containing various stilbenoids from the stem bark of V. indica has the potent antitumor activity...
Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell lineKenji Ohguchi
Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
Biosci Biotechnol Biochem 69:353-6. 2005..These results suggest that vaticanol C might induce apoptosis via a mechanism involving activation of Bad through disruption of pro-survival signaling pathways...
Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol CTetsuro Ito
Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan
Carcinogenesis 24:1489-97. 2003..Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential...
Human DEAD-box/RNA unwindase rck/p54 contributes to maintenance of cell growth by affecting cell cycle in cultured cellsYukihiro Akao
Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
Int J Oncol 29:41-8. 2006..These data suggest that rck/p54 contributes to cell growth possibly by modulating translation-initiation control of the genes involved in the cell proliferation, which is a newly defined mechanism leading to carcinogenesis...
Effects of hydroxystilbene derivatives on tyrosinase activityKenji Ohguchi
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
Biochem Biophys Res Commun 307:861-3. 2003....
Gene expression analysis on the liver of cholestyramine-treated type 2 diabetic model miceKenji Matsumoto
Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, 3481 2 Kamihachiya, Hachiya, Minokamo, Gifu 505 0004, Japan
Biomed Pharmacother 64:373-8. 2010..957, P<0.001). This study provides a valuable basis for further research on the biological functions of bile acid-binding agents in models of type 2 diabetes...
Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell linesKenji Matsumoto
Gifu International Institute of Biotechnology, Kani-gun, Gifu, Japan
Biol Pharm Bull 26:569-71. 2003..The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative...
Gnetol as a potent tyrosinase inhibitor from genus GnetumKenji Ohguchi
Gifu International Institute of Biotechnology, Mitake, Kani gun, Gifu 505 0116, Japan
Biosci Biotechnol Biochem 67:663-5. 2003..Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells...
Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell linesYukihiro Akao
Gifu International Institute of Biotechnology, Kakamigahara, Japan
Biol Pharm Bull 26:1057-9. 2003..Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin...
Localization of sphingosine kinase-1 in mouse sperm acrosomesKenji Matsumoto
Gifu International Institute of Biotechnology, Gifu, Japan
J Histochem Cytochem 53:243-7. 2005..Furthermore, we identified the presence of the S1P receptors S1P1, S1P2, S1P3, and S1P5, in mouse spermatozoa by RT-PCR. These results suggest that S1P produced by SPHK-1 would play a role in the acrosomal reaction through S1P receptors...
Expression of rck/p54, a DEAD-box RNA helicase, in gametogenesis and early embryogenesis of miceKenji Matsumoto
Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu, Japan
Dev Dyn 233:1149-56. 2005..These findings indicate that rck/p54 may play an important role in gametogenesis and early embryogenesis in mammals...
A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cellsYukihiro Akao
Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
Bioorg Med Chem 12:4791-801. 2004..These data suggest that lig-8 is a promising neuroprotector, which affects the signaling pathway of neuronal cell death and that it would be of benefit to delay the progress of neurodegenerative diseases...
A tumour-associated DEAD-box protein, rck/p54 exhibits RNA unwinding activity toward c-myc RNAs in vitroYukihiro Akao
Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
Genes Cells 8:671-6. 2003..Our previous data suggested that rck/p54 positively affected the translation initiation of c-myc mRNA...
Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potentialTaisuke Mori
Department of Reproductive Biology and Pathology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
Mol Cell Biol 25:5183-95. 2005..Thus, the results of this study support the possible use of autologous-cell graft systems to treat central nervous system diseases in geriatric patients...
Prostaglandin A2 acts as a transactivator for NOR1 (NR4A3) within the nuclear receptor superfamilyShinji Kagaya
Genox Research Inc, Tokyo, Japan
Biol Pharm Bull 28:1603-7. 2005..These observations suggest that PGA2 can serve as a transactivator of NOR1, and thus suggest a possibility of pharmacological modulation of the NOR1 pathways by PGA2-related compounds...
Synthesis, solution behavior, thermal stability, and biological activity of an Fe(III) complex of an artificial siderophore with intramolecular hydrogen bonding networksKenji Matsumoto
Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan
Inorg Chem 43:8538-46. 2004..These results indicate that the artificial siderophore with intramolecular hydrogen bonding networks, TAGE, is a good structural and functional model for a natural ferrichrome...
NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitroShinji Kagaya
Genox Research Inc, Bunkyo, Japan
Int Arch Allergy Immunol 137:35-44. 2005..These results suggest that the expression of the NR4A receptor family genes through CD30 signaling may regulate eosinophil apoptosis in allergic conditions such as AD...
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2)Takashi Kubo
Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Drug Metab Dispos 33:1482-7. 2005..These results suggested that 100C>T (R34W), 424G>A (V142M), and IVS8-2A>G are functionally deficient SNPs...
Gremlin enhances the determined path to cardiomyogenesisDaisuke Kami
Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan
PLoS ONE 3:e2407. 2008....
Prolongation of survival of fully allogeneic cardiac grafts and generation of regulatory cells by a histamine receptor 2 antagonistFumihiko Inoue
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Tokyo, Japan
Transplantation 84:1288-97. 2007..We examined whether the HR2 antagonist ranitidine affects the alloimmune response in a murine model of cardiac transplantation...
Effects of tumor necrosis factor-alpha on cell proliferation, prostaglandins and matrix-metalloproteinases production in rat endometrial stromal cells cultured in vitroToru Gamo
Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School, Kyushu University, Fukuoka, Japan
J Exp Zool A Ecol Genet Physiol 307:699-707. 2007..We believe that these results demonstrate part of the functions of TNF-alpha in endometrium and contribute to the better understanding of endometrial functions...
Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesisAkio Matsuda
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo, 157 8535, Japan
Am J Respir Cell Mol Biol 38:168-75. 2008..Of note, the CXCR2 chemokine-induced tube formation was independent of VEGF. Therefore, CXCR2 chemokines may represent potential therapeutic targets for bronchial asthma...
Synthesis of multisubstituted furans, pyrroles, and thiophenes via ynolatesMitsuru Shindo
Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan
Org Lett 9:1963-6. 2007..This novel formal [4 + 1] annulation by C2-C3 and C3-C4 bond formations includes cycloaddition, cyclization, decarboxylation, and dehydration as key steps...
Gene expression profiling of human mast cell subtypes: an in silico studyHirohisa Saito
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Allergol Int 55:173-9. 2006..e., tryptase- and chymase-positive MCs (MC(TC)) and tryptase-only-positive MCs (MC(T)). However, differences in global molecular expression between these subtypes are unknown...
A functional polymorphism in MMP-9 is associated with childhood atopic asthmaKazuko Nakashima
Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa 230 0045, Japan
Biochem Biophys Res Commun 344:300-7. 2006..Thus, the MMP-9 gene might be involved in the development of asthma through functional genetic polymorphisms...
The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathyNaoko Okada
Department of Ophthalmology, Keio University, Shinanomachi, Tokyo, Japan
Invest Ophthalmol Vis Sci 46:4512-8. 2005..The present study investigated the expression of ICAM-1 and VCAM-1 on fibroblasts with interleukin (IL)-4 and/or tumor necrosis factor (TNF)-alpha stimulation and assessed the effect of eosinophil adhesion on fibroblast viability...
Effects of preinjury administration of corticosteroids on pseudointimal hyperplasia and cytokine response in a rat model of balloon aortic injuryKazuhito Nagasaki
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku 160-8582, Tokyo, Japan
World J Surg 28:910-6. 2004..These results suggest that there is an appropriate dosage as well as appropriate timing for MP administration to suppress PIH...
Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the ratViengvansay Nabandith
Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
Asian Pac J Cancer Prev 5:433-8. 2004..This finding that crude alpha-mangostin has potent chemopreventive effects in our short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development...
Induction of indefinite survival of fully allogeneic cardiac grafts and generation of regulatory cells by intratracheal delivery of alloantigens under blockade of the CD40 pathwayNorio Uchida
Department of Surgery, Keio University, Tokyo, Japan
Transplantation 75:878-84. 2003..CONCLUSIONS: ITD of donor splenocytes or Kb peptide under blockade of the CD40 pathway induced operational tolerance and generated regulatory cells...
Nutrition during pregnancy may be associated with allergic diseases in infantsYuh Ushiyama
Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770-8503, Japan
J Nutr Sci Vitaminol (Tokyo) 48:345-51. 2002..05). The results, together with previous reports, suggest that a high intake of energy and lipids (fat and vegetable oil) during pregnancy may accelerate allergic diseases in infants...
The role of nitric oxide after a short period of liver ischemia-reperfusionAtsushi Morisue
Department of Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
J Surg Res 109:101-9. 2003..CONCLUSIONS: A reduction of the ischemia-reperfusion injury is important in inhibiting the production of high-output NO and peroxynitrite, and in maintaining NO levels necessary for maintenance of microcirculation...
High dose of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulatory cellsOsamu Aramaki
Department of Surgery, Nihon University, Tokyo, Japan
Transplantation 75:217-20. 2003..In vitro, AT-III suppressed proliferation of mixed leukocyte responses and generation of interleukin-2. CONCLUSION: AT-III can be not only an antithrombotic agent but also a strong immunomodulating agent when used at high dose...
Transfer of the interleukin-1 receptor antagonist gene into rat liver abrogates hepatic ischemia-reperfusion injuryHirohisa Harada
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Transplantation 74:1434-41. 2002..CONCLUSIONS: IL-1Ra gene delivery into the liver may be of therapeutic use for abrogating hepatic ischemia-reperfusion injury after transplantation...
Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparisonToshiharu Nakajima
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Blood 100:3861-8. 2002..Interspecies comparison studies at the whole genome expression level should be useful for the interpretation of experimental data obtained in animal models of human pathobiology...
Pepsin-resistant 16-kD buckwheat protein is associated with immediate hypersensitivity reaction in patients with buckwheat allergyKazuko Tanaka
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Showa University School of Medicine, Tokyo, Japan
Int Arch Allergy Immunol 129:49-56. 2002..CONCLUSIONS: The 16-kD buckwheat protein was resistant to pepsin digestion and appeared to be responsible for IHR including anaphylaxis, while the pepsin-sensitive 24-kD protein was responsible for CAP-FEIA but not IHR...
Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patientsYukiho Imai
Genox Research, Inc, Teikyo University Biotech Center, 907 Nogawa, Miyamae, Kawasaki, 216 0001, Kanagawa, Japan
Biochem Biophys Res Commun 297:1282-90. 2002..The enhanced expression of ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients...
B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in miceYoshinobu Akiyama
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Transplantation 74:732-8. 2002..The mechanism of hyporesponsiveness induced by intratracheal (IT) delivery of alloantigen was examined and its effect on cardiac graft survival was assessed in studies in mice...
Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritisKenji Matsumoto
Experimental Animal Division, Bio Resource Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
Exp Mol Pathol 72:186-95. 2002....
Analysis of gene expression in peripheral blood eosinophils from patients with atopic dermatitis by differential displayRyoichi Hashida
Genox Research Inc, Teikyo University Biotechnology Center, 907 Nogawa, Kawasaki, Japan
Int Arch Allergy Immunol 131:26-33. 2003..The mouse counterpart of one of these genes, intersectin 2, was expressed dramatically, as measured by ear edema, in 1-fluoro-2,4-dinitrobenzene-induced mouse contact dermatitis and in NC/Nga mouse dermatitis...
Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigenNozomu Shirasugi
First Department of Surgery, Teikyo University, Tokyo, Japan
Transplantation 75:1636-9. 2003..In this study, the authors used a CD28-deficient model to evaluate which signal, either through CD28 or cytotoxic T-lymphocyte-associated antigen (CTLA4), is involved in the induction of hyporesponsiveness...
Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cellsToshiki Homma
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8567, Japan
Am J Respir Cell Mol Biol 31:463-9. 2004..These results provide evidence for a novel function of corticosteroids in airway inflammatory disorders, and indicate that the use of inhaled corticosteroids in such disorders may have a beneficial role in host defense mechanisms...
Expression of a human SOCS protein, HSOCP-1, in peripheral blood eosinophils from patients with atopic dermatitisKaoru Ogawa
Genox Research Inc, Kawasaki, Kanagawa, Japan
Int Arch Allergy Immunol 134:2-6. 2004..It is a protein that also interacts with the cyclin-dependent kinase inhibitor p16(INK4), suggesting that HSOCP-1 is involved in cell cycle control and apoptosis...
Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytesAtsushi Kato
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
J Immunol 172:6185-94. 2004..This critical role for LBP implies the presence of possible mechanisms linking LBP to the intracellular signaling between Toll-like receptor 4 and IRF-3, leading to the induction of IFN-beta by LPS...
TNF-alpha and IL-4 regulate expression of fractalkine (CX3CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblastsMamoru Yoshikawa
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishidou, Setagaya Ku, Tokyo 154 8567, Japan
FEBS Lett 561:105-10. 2004..These results suggest that TNF-alpha- and IL-4-stimulated fibroblasts may play an important role in accumulation of monocytes at inflammatory sites...
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer regionSatoru Koyano
Project Team for Pharmacogenetics, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Drug Metab Dispos 32:149-54. 2004..These data suggest that the R98C, R381W, and I403V hPXR variants, especially R98C, may influence the expression of drug-metabolizing enzymes and transporters, which are transactivated by PXR...
TNF-alpha and IL-4 regulate expression of IL-13 receptor alpha2 on human fibroblastsMamoru Yoshikawa
Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishidou, Setagaya Ku, 154 8567, Tokyo, Japan
Biochem Biophys Res Commun 312:1248-55. 2003....
The effect of central injection of angiotensin-converting enzyme inhibitor and the angiotensin type 1 receptor antagonist on the induction by lipopolysaccharide of fever and brain interleukin-1beta response in ratsHideki Shimizu
Department of Functional, Morphological, and Regulatory Science, Tottori University Faculty of Medicine, Yonago, Tottori, Japan
J Pharmacol Exp Ther 308:865-73. 2004..c.v. injection of IL-1beta. These results suggest that in rats, brain ANG II and AT(1) receptors are involved in the LPS-induced production of brain IL-1beta, thus contributing to the fever induced by the presence of LPS within the brain...
Antitumor effect of arsenic trioxide in murine xenograft modelMariko Kito
Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Kani-gun, Gifu 505-0116
Cancer Sci 94:1010-4. 2003..Thus, ATO appears to have potential for the treatment of solid tumors, as well as hematopoietic malignancies...
Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006Atsushi Kato
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
BMC Immunol 4:8. 2003..Although several genes have been reported, no comprehensive study of the gene expression profiles in human cells after stimulation with CpG ODN has been reported...
Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor 4 and FcepsilonRIShigeru Okumura
Laboratory of Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan
Blood 102:2547-54. 2003..These results reveal that human MCs express tailored pathogen- and antigen-specific immune responses and that human MCs may play important roles in innate and adaptive immunity...
PDGF receptor-alpha deficiency in glomerular mesangial cells of tenascin-C knockout miceKenji Matsumoto
Experimental Animal Division, Bio Resource Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki, 305 0074, Japan
Biochem Biophys Res Commun 290:1220-7. 2002..These results suggest that failures of both TNC and PDGFR-alpha are a candidate for abnormal restoration of TNKO mice...
