Kenji Matsumoto

Summary

Affiliation: Ogaki Municipal Hospital
Country: Japan

Publications

  1. ncbi request reprint Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 13:6064-9. 2005
  2. doi request reprint Bile acid-binding activity of young persimmon (Diospyros kaki) fruit and its hypolipidemic effect in mice
    Kenji Matsumoto
    Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Minokamo, Gifu, Japan
    Phytother Res 24:205-10. 2010
  3. ncbi request reprint Hypolipidemic effect of young persimmon fruit in C57BL/6.KOR-ApoEshl mice
    Kenji Matsumoto
    Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Gifu, Japan
    Biosci Biotechnol Biochem 72:2651-9. 2008
  4. ncbi request reprint Young persimmon fruits prevent the rise in plasma lipids in a diet-induced murine obesity model
    Kenji Matsumoto
    Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Japan
    Biol Pharm Bull 29:2532-5. 2006
  5. ncbi request reprint Okara, soybean residue, prevents obesity in a diet-induced murine obesity model
    Kenji Matsumoto
    Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology, Minokamo, Gifu, Japan
    Biosci Biotechnol Biochem 71:720-7. 2007
  6. ncbi request reprint Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Nat Prod 66:1124-7. 2003
  7. ncbi request reprint Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biosci Biotechnol Biochem 67:1587-9. 2003
  8. ncbi request reprint Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 12:5799-806. 2004
  9. ncbi request reprint Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal model
    Satoshi Mishima
    API Company Research Institute, Gifu, Japan
    J Exp Ther Oncol 3:283-88. 2003
  10. ncbi request reprint Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell line
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Biosci Biotechnol Biochem 69:353-6. 2005

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 13:6064-9. 2005
    ..These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs...
  2. doi request reprint Bile acid-binding activity of young persimmon (Diospyros kaki) fruit and its hypolipidemic effect in mice
    Kenji Matsumoto
    Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Minokamo, Gifu, Japan
    Phytother Res 24:205-10. 2010
    ..7% condensed tannins, adsorbed approximately 78% of CA in the 2000 microM CA solutions. These results suggest that the ability of YP to bind bile acid contributes to its hypolipidemic effect in mice...
  3. ncbi request reprint Hypolipidemic effect of young persimmon fruit in C57BL/6.KOR-ApoEshl mice
    Kenji Matsumoto
    Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Gifu, Japan
    Biosci Biotechnol Biochem 72:2651-9. 2008
    ..These results indicate that acceleration of fecal bile acid excretion is a major mechanism of the hypolipidemic effect induced by YP in C57BL/6.KOR-ApoEshl mice...
  4. ncbi request reprint Young persimmon fruits prevent the rise in plasma lipids in a diet-induced murine obesity model
    Kenji Matsumoto
    Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, Japan
    Biol Pharm Bull 29:2532-5. 2006
    ..The results indicate that young persimmon fruits are beneficial in the development of preventive and therapeutic agents against dyslipidemia...
  5. ncbi request reprint Okara, soybean residue, prevents obesity in a diet-induced murine obesity model
    Kenji Matsumoto
    Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology, Minokamo, Gifu, Japan
    Biosci Biotechnol Biochem 71:720-7. 2007
    ..We also found that the okara intake caused a marked reduction in the expression of leptin and TNF-alpha genes in EWAT. Our results suggest that okara is beneficial in preventing obesity...
  6. ncbi request reprint Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Nat Prod 66:1124-7. 2003
    ..All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis...
  7. ncbi request reprint Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biosci Biotechnol Biochem 67:1587-9. 2003
    ..The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency...
  8. ncbi request reprint Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 12:5799-806. 2004
    ..It was also shown that the cytotoxicity substantially correlated with deltapsim decrease. These results indicate that alpha-mangostin and its analogs would be candidates for preventive and therapeutic application for cancer treatment...
  9. ncbi request reprint Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal model
    Satoshi Mishima
    API Company Research Institute, Gifu, Japan
    J Exp Ther Oncol 3:283-88. 2003
    ..These results demonstrated that the ethanol extract containing various stilbenoids from the stem bark of V. indica has the potent antitumor activity...
  10. ncbi request reprint Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell line
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Biosci Biotechnol Biochem 69:353-6. 2005
    ..These results suggest that vaticanol C might induce apoptosis via a mechanism involving activation of Bad through disruption of pro-survival signaling pathways...
  11. ncbi request reprint Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C
    Tetsuro Ito
    Gifu International Institute of Biotechnology, Mitake, Kani gun, Gifu 505 0116, Japan
    Carcinogenesis 24:1489-97. 2003
    ..Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential...
  12. ncbi request reprint Human DEAD-box/RNA unwindase rck/p54 contributes to maintenance of cell growth by affecting cell cycle in cultured cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Int J Oncol 29:41-8. 2006
    ..These data suggest that rck/p54 contributes to cell growth possibly by modulating translation-initiation control of the genes involved in the cell proliferation, which is a newly defined mechanism leading to carcinogenesis...
  13. ncbi request reprint Effects of hydroxystilbene derivatives on tyrosinase activity
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biochem Biophys Res Commun 307:861-3. 2003
    ....
  14. doi request reprint Gene expression analysis on the liver of cholestyramine-treated type 2 diabetic model mice
    Kenji Matsumoto
    Department of Applied Microbiology, Gifu Prefectural Research Institute for Bioengineering, 3481 2 Kamihachiya, Hachiya, Minokamo, Gifu 505 0004, Japan
    Biomed Pharmacother 64:373-8. 2010
    ..957, P<0.001). This study provides a valuable basis for further research on the biological functions of bile acid-binding agents in models of type 2 diabetes...
  15. ncbi request reprint Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, Kani gun, Gifu, Japan
    Biol Pharm Bull 26:569-71. 2003
    ..The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative...
  16. ncbi request reprint Gnetol as a potent tyrosinase inhibitor from genus Gnetum
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Mitake, Kani gun, Gifu 505 0116, Japan
    Biosci Biotechnol Biochem 67:663-5. 2003
    ..Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells...
  17. ncbi request reprint Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biol Pharm Bull 26:1057-9. 2003
    ..Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin...
  18. ncbi request reprint Localization of sphingosine kinase-1 in mouse sperm acrosomes
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, Gifu, Japan
    J Histochem Cytochem 53:243-7. 2005
    ..Furthermore, we identified the presence of the S1P receptors S1P1, S1P2, S1P3, and S1P5, in mouse spermatozoa by RT-PCR. These results suggest that S1P produced by SPHK-1 would play a role in the acrosomal reaction through S1P receptors...
  19. ncbi request reprint Expression of rck/p54, a DEAD-box RNA helicase, in gametogenesis and early embryogenesis of mice
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu, Japan
    Dev Dyn 233:1149-56. 2005
    ..These findings indicate that rck/p54 may play an important role in gametogenesis and early embryogenesis in mammals...
  20. ncbi request reprint A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 12:4791-801. 2004
    ..These data suggest that lig-8 is a promising neuroprotector, which affects the signaling pathway of neuronal cell death and that it would be of benefit to delay the progress of neurodegenerative diseases...
  21. ncbi request reprint A tumour-associated DEAD-box protein, rck/p54 exhibits RNA unwinding activity toward c-myc RNAs in vitro
    Yukihiro Akao
    Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Genes Cells 8:671-6. 2003
    ..Our previous data suggested that rck/p54 positively affected the translation initiation of c-myc mRNA...
  22. pmc Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential
    Taisuke Mori
    Department of Reproductive Biology and Pathology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Mol Cell Biol 25:5183-95. 2005
    ..Thus, the results of this study support the possible use of autologous-cell graft systems to treat central nervous system diseases in geriatric patients...
  23. ncbi request reprint Prostaglandin A2 acts as a transactivator for NOR1 (NR4A3) within the nuclear receptor superfamily
    Shinji Kagaya
    Genox Research Inc, Tokyo, Japan
    Biol Pharm Bull 28:1603-7. 2005
    ..These observations suggest that PGA2 can serve as a transactivator of NOR1, and thus suggest a possibility of pharmacological modulation of the NOR1 pathways by PGA2-related compounds...
  24. ncbi request reprint Synthesis, solution behavior, thermal stability, and biological activity of an Fe(III) complex of an artificial siderophore with intramolecular hydrogen bonding networks
    Kenji Matsumoto
    Department of Applied Chemistry, Nagoya Institute of Technology, Gokiso cho, Showa Ku, Nagoya 466 8555, Japan
    Inorg Chem 43:8538-46. 2004
    ..These results indicate that the artificial siderophore with intramolecular hydrogen bonding networks, TAGE, is a good structural and functional model for a natural ferrichrome...
  25. ncbi request reprint NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitro
    Shinji Kagaya
    Genox Research Inc, Bunkyo, Japan
    Int Arch Allergy Immunol 137:35-44. 2005
    ..These results suggest that the expression of the NR4A receptor family genes through CD30 signaling may regulate eosinophil apoptosis in allergic conditions such as AD...
  26. ncbi request reprint Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2)
    Takashi Kubo
    Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Drug Metab Dispos 33:1482-7. 2005
    ..These results suggested that 100C>T (R34W), 424G>A (V142M), and IVS8-2A>G are functionally deficient SNPs...
  27. pmc Gremlin enhances the determined path to cardiomyogenesis
    Daisuke Kami
    Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan
    PLoS ONE 3:e2407. 2008
    ....
  28. ncbi request reprint Prolongation of survival of fully allogeneic cardiac grafts and generation of regulatory cells by a histamine receptor 2 antagonist
    Fumihiko Inoue
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Tokyo, Japan
    Transplantation 84:1288-97. 2007
    ..We examined whether the HR2 antagonist ranitidine affects the alloimmune response in a murine model of cardiac transplantation...
  29. ncbi request reprint Effects of tumor necrosis factor-alpha on cell proliferation, prostaglandins and matrix-metalloproteinases production in rat endometrial stromal cells cultured in vitro
    Toru Gamo
    Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    J Exp Zool A Ecol Genet Physiol 307:699-707. 2007
    ..We believe that these results demonstrate part of the functions of TNF-alpha in endometrium and contribute to the better understanding of endometrial functions...
  30. ncbi request reprint Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesis
    Akio Matsuda
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo, 157 8535, Japan
    Am J Respir Cell Mol Biol 38:168-75. 2008
    ..Of note, the CXCR2 chemokine-induced tube formation was independent of VEGF. Therefore, CXCR2 chemokines may represent potential therapeutic targets for bronchial asthma...
  31. ncbi request reprint Synthesis of multisubstituted furans, pyrroles, and thiophenes via ynolates
    Mitsuru Shindo
    Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan
    Org Lett 9:1963-6. 2007
    ..This novel formal [4 + 1] annulation by C2-C3 and C3-C4 bond formations includes cycloaddition, cyclization, decarboxylation, and dehydration as key steps...
  32. ncbi request reprint Gene expression profiling of human mast cell subtypes: an in silico study
    Hirohisa Saito
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Allergol Int 55:173-9. 2006
    ..e., tryptase- and chymase-positive MCs (MC(TC)) and tryptase-only-positive MCs (MC(T)). However, differences in global molecular expression between these subtypes are unknown...
  33. ncbi request reprint A functional polymorphism in MMP-9 is associated with childhood atopic asthma
    Kazuko Nakashima
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa 230 0045, Japan
    Biochem Biophys Res Commun 344:300-7. 2006
    ..Thus, the MMP-9 gene might be involved in the development of asthma through functional genetic polymorphisms...
  34. ncbi request reprint The implications of the upregulation of ICAM-1/VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic keratopathy
    Naoko Okada
    Department of Ophthalmology, Keio University, Shinanomachi, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:4512-8. 2005
    ..The present study investigated the expression of ICAM-1 and VCAM-1 on fibroblasts with interleukin (IL)-4 and/or tumor necrosis factor (TNF)-alpha stimulation and assessed the effect of eosinophil adhesion on fibroblast viability...
  35. ncbi request reprint Effects of preinjury administration of corticosteroids on pseudointimal hyperplasia and cytokine response in a rat model of balloon aortic injury
    Kazuhito Nagasaki
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku 160 8582, Tokyo, Japan
    World J Surg 28:910-6. 2004
    ..These results suggest that there is an appropriate dosage as well as appropriate timing for MP administration to suppress PIH...
  36. ncbi request reprint Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat
    Viengvansay Nabandith
    Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Asian Pac J Cancer Prev 5:433-8. 2004
    ..This finding that crude alpha-mangostin has potent chemopreventive effects in our short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development...
  37. ncbi request reprint Induction of indefinite survival of fully allogeneic cardiac grafts and generation of regulatory cells by intratracheal delivery of alloantigens under blockade of the CD40 pathway
    Norio Uchida
    Department of Surgery, Keio University, Tokyo, Japan
    Transplantation 75:878-84. 2003
    ..In this study, this treatment protocol was combined with blockade of the CD40 pathway in an attempt to induce operational tolerance...
  38. ncbi request reprint Nutrition during pregnancy may be associated with allergic diseases in infants
    Yuh Ushiyama
    Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770 8503, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:345-51. 2002
    ..05). The results, together with previous reports, suggest that a high intake of energy and lipids (fat and vegetable oil) during pregnancy may accelerate allergic diseases in infants...
  39. ncbi request reprint The role of nitric oxide after a short period of liver ischemia-reperfusion
    Atsushi Morisue
    Department of Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Surg Res 109:101-9. 2003
    ..The present study attempts to clarify the role of NO in liver ischemia-reperfusion injury...
  40. ncbi request reprint High dose of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulatory cells
    Osamu Aramaki
    Department of Surgery, Nihon University, Tokyo, Japan
    Transplantation 75:217-20. 2003
    ..The authors investigated whether antithrombin III (AT-III) could induce unresponsiveness to alloantigens...
  41. ncbi request reprint Transfer of the interleukin-1 receptor antagonist gene into rat liver abrogates hepatic ischemia-reperfusion injury
    Hirohisa Harada
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Transplantation 74:1434-41. 2002
    ..Therefore, we wished to examine the effect of IL-1Ra gene delivery into the rat liver on hepatic ischemia-reperfusion injury...
  42. ncbi request reprint Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison
    Toshiharu Nakajima
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Blood 100:3861-8. 2002
    ..Interspecies comparison studies at the whole genome expression level should be useful for the interpretation of experimental data obtained in animal models of human pathobiology...
  43. ncbi request reprint Pepsin-resistant 16-kD buckwheat protein is associated with immediate hypersensitivity reaction in patients with buckwheat allergy
    Kazuko Tanaka
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Showa University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 129:49-56. 2002
    ..The ingestion of small amounts sometimes provokes an anaphylactic reaction. However, it remains controversial which is the major allergen responsible for such reactions...
  44. ncbi request reprint Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients
    Yukiho Imai
    Genox Research, Inc, Teikyo University Biotech Center, 907 Nogawa, Miyamae, Kawasaki, 216 0001, Kanagawa, Japan
    Biochem Biophys Res Commun 297:1282-90. 2002
    ..The enhanced expression of ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients...
  45. ncbi request reprint B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice
    Yoshinobu Akiyama
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Transplantation 74:732-8. 2002
    ..The mechanism of hyporesponsiveness induced by intratracheal (IT) delivery of alloantigen was examined and its effect on cardiac graft survival was assessed in studies in mice...
  46. ncbi request reprint Tenascin-C expression and splice variant in habu snake venom-induced glomerulonephritis
    Kenji Matsumoto
    Experimental Animal Division, Bio Resource Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Exp Mol Pathol 72:186-95. 2002
    ....
  47. ncbi request reprint Analysis of gene expression in peripheral blood eosinophils from patients with atopic dermatitis by differential display
    Ryoichi Hashida
    Genox Research Inc, Teikyo University Biotechnology Center, 907 Nogawa, Kawasaki, Japan
    Int Arch Allergy Immunol 131:26-33. 2003
    ..The mouse counterpart of one of these genes, intersectin 2, was expressed dramatically, as measured by ear edema, in 1-fluoro-2,4-dinitrobenzene-induced mouse contact dermatitis and in NC/Nga mouse dermatitis...
  48. ncbi request reprint Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen
    Nozomu Shirasugi
    First Department of Surgery, Teikyo University, Tokyo, Japan
    Transplantation 75:1636-9. 2003
    ..In this study, the authors used a CD28-deficient model to evaluate which signal, either through CD28 or cytotoxic T-lymphocyte-associated antigen (CTLA4), is involved in the induction of hyporesponsiveness...
  49. ncbi request reprint Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
    Toshiki Homma
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567, Japan
    Am J Respir Cell Mol Biol 31:463-9. 2004
    ..These results provide evidence for a novel function of corticosteroids in airway inflammatory disorders, and indicate that the use of inhaled corticosteroids in such disorders may have a beneficial role in host defense mechanisms...
  50. ncbi request reprint Expression of a human SOCS protein, HSOCP-1, in peripheral blood eosinophils from patients with atopic dermatitis
    Kaoru Ogawa
    Genox Research Inc, Kawasaki, Kanagawa, Japan
    Int Arch Allergy Immunol 134:2-6. 2004
    ..It is a protein that also interacts with the cyclin-dependent kinase inhibitor p16(INK4), suggesting that HSOCP-1 is involved in cell cycle control and apoptosis...
  51. ncbi request reprint Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 172:6185-94. 2004
    ..This critical role for LBP implies the presence of possible mechanisms linking LBP to the intracellular signaling between Toll-like receptor 4 and IRF-3, leading to the induction of IFN-beta by LPS...
  52. ncbi request reprint TNF-alpha and IL-4 regulate expression of fractalkine (CX3CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts
    Mamoru Yoshikawa
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishidou, Setagaya Ku, Tokyo 154 8567, Japan
    FEBS Lett 561:105-10. 2004
    ..These results suggest that TNF-alpha- and IL-4-stimulated fibroblasts may play an important role in accumulation of monocytes at inflammatory sites...
  53. ncbi request reprint Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region
    Satoru Koyano
    Project Team for Pharmacogenetics, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Drug Metab Dispos 32:149-54. 2004
    ..These data suggest that the R98C, R381W, and I403V hPXR variants, especially R98C, may influence the expression of drug-metabolizing enzymes and transporters, which are transactivated by PXR...
  54. ncbi request reprint TNF-alpha and IL-4 regulate expression of IL-13 receptor alpha2 on human fibroblasts
    Mamoru Yoshikawa
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishidou, Setagaya Ku, 154 8567, Tokyo, Japan
    Biochem Biophys Res Commun 312:1248-55. 2003
    ....
  55. ncbi request reprint The effect of central injection of angiotensin-converting enzyme inhibitor and the angiotensin type 1 receptor antagonist on the induction by lipopolysaccharide of fever and brain interleukin-1beta response in rats
    Hideki Shimizu
    Department of Functional, Morphological, and Regulatory Science, Tottori University Faculty of Medicine, Yonago, Tottori, Japan
    J Pharmacol Exp Ther 308:865-73. 2004
    ..c.v. injection of IL-1beta. These results suggest that in rats, brain ANG II and AT(1) receptors are involved in the LPS-induced production of brain IL-1beta, thus contributing to the fever induced by the presence of LPS within the brain...
  56. ncbi request reprint Antitumor effect of arsenic trioxide in murine xenograft model
    Mariko Kito
    Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Kani gun, Gifu 505 0116
    Cancer Sci 94:1010-4. 2003
    ..Thus, ATO appears to have potential for the treatment of solid tumors, as well as hematopoietic malignancies...
  57. pmc Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    BMC Immunol 4:8. 2003
    ..Although several genes have been reported, no comprehensive study of the gene expression profiles in human cells after stimulation with CpG ODN has been reported...
  58. ncbi request reprint Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor 4 and FcepsilonRI
    Shigeru Okumura
    Laboratory of Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan
    Blood 102:2547-54. 2003
    ..These results reveal that human MCs express tailored pathogen- and antigen-specific immune responses and that human MCs may play important roles in innate and adaptive immunity...
  59. ncbi request reprint PDGF receptor-alpha deficiency in glomerular mesangial cells of tenascin-C knockout mice
    Kenji Matsumoto
    Experimental Animal Division, Bio Resource Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki, 305 0074, Japan
    Biochem Biophys Res Commun 290:1220-7. 2002
    ..These results suggest that failures of both TNC and PDGFR-alpha are a candidate for abnormal restoration of TNKO mice...