Michihiro Fukushima

Summary

Affiliation: Obihiro University of Agriculture and Veterinary Medicine
Country: Japan

Publications

  1. ncbi request reprint Amylomyces rouxii strain CBS 438.76 affects cholesterol metabolism in cholesterol-fed rats
    Michihiro Fukushima
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:453-9. 2005
  2. doi request reprint Feeding potato flakes affects cecal short-chain fatty acids, microflora and fecal bile acids in rats
    Kyu Ho Han
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Ann Nutr Metab 52:1-7. 2008
  3. ncbi request reprint Comparative hypocholesterolemic effects of five animal oils in cholesterol-fed rats
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    Biosci Biotechnol Biochem 63:202-5. 1999
  4. ncbi request reprint Low density lipoprotein receptor mRNA in rat liver is affected by resistant starch of beans
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    Lipids 36:129-34. 2001
  5. ncbi request reprint Effects of diets enriched in n-6 or n-3 fatty acids on cholesterol metabolism in older rats chronically fed a cholesterol-enriched diet
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Lipids 36:261-6. 2001
  6. ncbi request reprint Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Exp Biol Med (Maywood) 226:758-65. 2001
  7. ncbi request reprint Investigation of gene expressions related to cholesterol metabolism in rats fed diets enriched in n-6 or n-3 fatty acid with a cholesterol after long-term feeding using quantitative-competitive RT-PCR analysis
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:228-35. 2001
  8. ncbi request reprint Some bovine proteins behave as dietary fibres and reduce serum lipids in rats
    Liyanage Ruvini
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Br J Nutr 97:898-905. 2007
  9. ncbi request reprint Potato pulps lowered the serum cholesterol and triglyceride levels in rats
    Naoto Hashimoto
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:445-50. 2006
  10. ncbi request reprint Adzuki resistant starch lowered serum cholesterol and hepatic 3-hydroxy-3-methylglutaryl-CoA mRNA levels and increased hepatic LDL-receptor and cholesterol 7alpha-hydroxylase mRNA levels in rats fed a cholesterol diet
    Kyu Ho Han
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Br J Nutr 94:902-8. 2005

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Amylomyces rouxii strain CBS 438.76 affects cholesterol metabolism in cholesterol-fed rats
    Michihiro Fukushima
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:453-9. 2005
    ..The results of this study demonstrate that feeding of A. rouxii lowers the serum total cholesterol level by enhancement of the cecal SCFA concentration and the hepatic LDL receptor mRNA...
  2. doi request reprint Feeding potato flakes affects cecal short-chain fatty acids, microflora and fecal bile acids in rats
    Kyu Ho Han
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Ann Nutr Metab 52:1-7. 2008
    ..The present study was designed to investigate the effects of the consumption of various colored potato (white, red and purple) flakes on cecal fermentation and fecal bile acid excretions in rats...
  3. ncbi request reprint Comparative hypocholesterolemic effects of five animal oils in cholesterol-fed rats
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    Biosci Biotechnol Biochem 63:202-5. 1999
    ....
  4. ncbi request reprint Low density lipoprotein receptor mRNA in rat liver is affected by resistant starch of beans
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    Lipids 36:129-34. 2001
    ..8-2.0 times higher than that in the CS group. The results of this study demonstrate that AS, KS, and TS lowered the serum total cholesterol level by enhancing the hepatic LDL receptor mRNA level...
  5. ncbi request reprint Effects of diets enriched in n-6 or n-3 fatty acids on cholesterol metabolism in older rats chronically fed a cholesterol-enriched diet
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Lipids 36:261-6. 2001
    ....
  6. ncbi request reprint Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Exp Biol Med (Maywood) 226:758-65. 2001
    ..The results of this study demonstrate that MAF and EF lowered the serum total cholesterol level by enhancement of fecal cholesterol excretion, and in particular, by enhancement of hepatic LDL receptor mRNA in EF group...
  7. ncbi request reprint Investigation of gene expressions related to cholesterol metabolism in rats fed diets enriched in n-6 or n-3 fatty acid with a cholesterol after long-term feeding using quantitative-competitive RT-PCR analysis
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:228-35. 2001
    ....
  8. ncbi request reprint Some bovine proteins behave as dietary fibres and reduce serum lipids in rats
    Liyanage Ruvini
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Br J Nutr 97:898-905. 2007
    ..Moreover, favourable amino acid compositions in the AR and AC preparations may also have a lowering effect on plasma lipid concentration in bovine protein diet-fed groups...
  9. ncbi request reprint Potato pulps lowered the serum cholesterol and triglyceride levels in rats
    Naoto Hashimoto
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:445-50. 2006
    ..On the other hand, HK pulp inhibited the synthesis of fatty acids at the mRNA levels of FAS and SREBP-1c, which might lead to a reduction of the serum TG level...
  10. ncbi request reprint Adzuki resistant starch lowered serum cholesterol and hepatic 3-hydroxy-3-methylglutaryl-CoA mRNA levels and increased hepatic LDL-receptor and cholesterol 7alpha-hydroxylase mRNA levels in rats fed a cholesterol diet
    Kyu Ho Han
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Br J Nutr 94:902-8. 2005
    ....
  11. ncbi request reprint Resistant starches of beans reduce the serum cholesterol concentration in rats
    Kyu Ho Han
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:281-6. 2003
    ..658, p < 0.001). The results suggest that AS, KS, and TS elevate cecal SCFA concentration, in particular butyric acid concentration, and fecal neutral sterol excretion, and lower the serum total cholesterol level...
  12. ncbi request reprint Japanese butterbur (Petasites japonicus) leaves increase hepatic oxidative stress in male rats
    Kyu Ho Han
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Biosci Biotechnol Biochem 76:2026-31. 2012
    ..Our findings suggest that feeding 5% butterbur leaf powder to rats can cause adverse effects by increasing oxidative stress...
  13. ncbi request reprint Red potato extract protects from D-galactosamine-induced liver injury in rats
    Kyu Ho Han
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Biosci Biotechnol Biochem 70:2285-8. 2006
    ....
  14. ncbi request reprint Effects of anthocyanin-rich purple potato flakes on antioxidant status in F344 rats fed a cholesterol-rich diet
    Kyu Ho Han
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Br J Nutr 98:914-21. 2007
    ....
  15. ncbi request reprint Effects of dietary supplementation with betaine on a nonalcoholic steatohepatitis (NASH) mouse model
    Sakura Kawakami
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    J Nutr Sci Vitaminol (Tokyo) 58:371-5. 2012
    ..82 ± 0.85%) was significantly (p<0.001) smaller than that in the HF group (9.06 ± 2.24%). These results indicate the potential of betaine to serve as an agent for amelioration of hepatic steatosis in NASH model mice...
  16. ncbi request reprint Cholesterol metabolism in rat is affected by protocatechuic acid
    Akiko Tamura
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:13-8. 2004
    ..The results of this study suggest the possibility that the increase in the hepatic LDL receptor, apo E, LCAT and HTGL guessed by these mRNAs increase in the protocatechuic acid group lowers the serum total cholesterol level...
  17. ncbi request reprint Anthocyanin-rich purple potato flake extract has antioxidant capacity and improves antioxidant potential in rats
    Kyu Ho Han
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080, Japan
    Br J Nutr 96:1125-33. 2006
    ....
  18. ncbi request reprint Amelioration of D-galactosamine-induced acute liver injury in rats by dietary supplementation with betaine derived from sugar beet molasses
    Tomoko Okada
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Biosci Biotechnol Biochem 75:1335-41. 2011
    ..These results indicate that 1% betaine has a hepatoprotective effect by increasing hepatic and serum glutathione levels along with glutathione-related enzyme activities in rats...
  19. ncbi request reprint Effect of white wheat bread containing sugar beet fiber on serum lipids and hepatic mRNA in rats fed on a cholesterol-free diet
    Yumi Nakamura
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Biosci Biotechnol Biochem 73:1280-5. 2009
    ..These results indicate that the observed changes in serum lipid levels in the BP and BBP groups were due to the increased fecal lipid and CYP7A1 mRNA levels...
  20. ncbi request reprint Potato and soy peptide diets modulate lipid metabolism in rats
    Ruvini Liyanage
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Biosci Biotechnol Biochem 72:943-50. 2008
    ..These results indicate that the observed changes in the serum cholesterol levels in rats fed on soy and potato peptide appear to have been due to different mechanisms...
  21. ncbi request reprint Enzyme-resistant fractions of beans lowered serum cholesterol and increased sterol excretions and hepatic mRNA levels in rats
    Kyu Ho Han
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Lipids 38:919-24. 2003
    ..05) higher than in the CP group. These results suggest that AS and TS have a serum cholesterol-lowering function due to the enhanced levels of hepatic SR-B1 and cholesterol 7alpha-hydroxylase mRNA...
  22. ncbi request reprint Effect of fermented bean paste on serum lipids in rats fed a cholesterol-free diet
    Yumi Nakamura
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Biosci Biotechnol Biochem 73:2506-12. 2009
    ..These effects might be related not only to the resistant starch but also to the protein or peptide in the fermented bean paste...
  23. ncbi request reprint Effect of an adzuki bean extract on hepatic anti-oxidant enzyme mRNAs in D-galactosamine-treated rats
    Kiyoshi Ohba
    Hokkaido Tokachi Area Regional Food Processing Technology Center, Obihiro, Japan
    Biosci Biotechnol Biochem 69:1988-91. 2005
    ....
  24. ncbi request reprint Hepatoprotective effects of purple potato extract against D-galactosamine-induced liver injury in rats
    Kyu Ho Han
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido
    Biosci Biotechnol Biochem 70:1432-7. 2006
    ..This suggests that PPE has hepatoprotective effects against GalN-induced hepatotoxicity via inhibition lipid peroxidation and/or inflammation in rats...
  25. ncbi request reprint Anthocyanin-rich red potato flakes affect serum lipid peroxidation and hepatic SOD mRNA level in rats
    Kyu Ho Han
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    Biosci Biotechnol Biochem 71:1356-9. 2007
    ..These results suggest that RPF might improve the antioxidant system by enhancing hepatic SOD mRNA...
  26. ncbi request reprint Raw Chinese yam (Dioscorea opposita) promotes cecal fermentation and reduces plasma non-HDL cholesterol concentration in rats
    Naomichi Nishimura
    Department of Nutritional Sciences, Faculty of Health and Welfare Science, Nayoro City University, Nayoro, Hokkaido, Japan
    J Nutr Sci Vitaminol (Tokyo) 57:340-7. 2011
    ..In addition, RY has a plasma-cholesterol lowering effect, possibly due to the inhibited release of VLDL...
  27. ncbi request reprint Hepatoprotective effects of the water extract from adzuki bean hulls on acetaminophen-induced damage in rat liver
    Kyu Ho Han
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:380-3. 2004
    ..These findings suggest that the adzuki extract will serve as a prophylactic against oxidative damage to the liver...
  28. doi request reprint Anti-obesity role of adzuki bean extract containing polyphenols: in vivo and in vitro effects
    Tomoko Kitano-Okada
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    J Sci Food Agric 92:2644-51. 2012
    ..The aim of this work was to evaluate the effects of polyphenol-rich adzuki bean extract on lipid metabolism, triglyceride accumulation and proinflammatory cytokine secretion in vivo and in vitro...
  29. ncbi request reprint Ingestion of gelatinized potato starch containing a high level of phosphorus decreases serum and liver lipids in rats
    Takumi Kanazawa
    Faculty of Human Life Sciences, Fuji Women s University, Ishikari, Hokkaido, Japan
    J Oleo Sci 57:335-43. 2008
    ..Thus, we conclude that dietary gelatinized potato starch reduces free fatty acid and triglyceride in serum and hepatic triglyceride, but does not affect cecal fermentation...
  30. ncbi request reprint Resistant starch fraction prepared from kintoki bean affects gene expression of genes associated with cholesterol metabolism in rats
    Kyu Ho Han
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Exp Biol Med (Maywood) 229:787-92. 2004
    ..05) higher than in the control group. The results suggest that resistant starch of kintoki bean reduces serum cholesterol level by increasing hepatic LDL receptor, SR-B1, and cholesterol 7alpha-hydroxylase mRNAs...
  31. doi request reprint Yam contributes to improvement of glucose metabolism in rats
    Naoto Hashimoto
    Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region, Memuro, Hokkaido, Japan
    Plant Foods Hum Nutr 64:193-8. 2009
    ..In conclusion, yam may contribute to improvement of glucose metabolism. Additionally, we speculated that leptin level is possibly involved in the insulin-response to yam diets...
  32. doi request reprint Inulin-type fructans with different degrees of polymerization improve lipid metabolism but not glucose metabolism in rats fed a high-fat diet under energy restriction
    Kyu Ho Han
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080 8555, Japan
    Dig Dis Sci 58:2177-86. 2013
    ..However, relatively little information is available on the comparative effects of inulins with different degree of polymerization (DP) on the lipid or glucose metabolism...
  33. doi request reprint Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS
    Masahito Hagio
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan
    J Lipid Res 50:173-80. 2009
    ..Analyzing detailed BA profiles, including conjugation status, in a single run is possible using UPLC/ESI-MS. This method will be useful for investigating the roles of BA metabolism under physiological and pathological conditions...
  34. ncbi request reprint Dietary L-cysteine improves the antioxidative potential and lipid metabolism in rats fed a normal diet
    Seulki Lee
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Biosci Biotechnol Biochem 77:1430-4. 2013
    ..05) than in the control rats. These results suggest that dietary L-cysteine dose-dependently affected the antioxidative enzyme activities, and the lipid levels in the serum and liver which might be related to the reduced food intake...
  35. ncbi request reprint Composition and oligosaccharides of a milk sample of the giant panda, Ailuropoda melanoleuca
    Tadashi Nakamura
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido, 080 8555, Japan
    Comp Biochem Physiol B Biochem Mol Biol 135:439-48. 2003
    ....
  36. ncbi request reprint A mixture of organisms affects cholesterol metabolism together with rat cecal flora
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    Biosci Biotechnol Biochem 63:1160-4. 1999
    ....
  37. ncbi request reprint Tartary buckwheat sprout powder lowers plasma cholesterol level in rats
    Tomoko Kuwabara
    The United Graduate School of Agriculture Sciences, Iwate University, Iwate, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:501-7. 2007
    ....
  38. ncbi request reprint Resistant starch as a prebiotic and synbiotic: state of the art
    David L Topping
    CSIRO Health Sciences and Nutrition, Adelaide, Australia
    Proc Nutr Soc 62:171-6. 2003
    ..More emphasis needs to be given to the investigation of the effects of complex carbohydrates, including RS, on the autochthonous microflora of the human large bowel...