K Yasunari

Summary

Affiliation: Nomura Municipal Hospital
Country: Japan

Publications

  1. ncbi request reprint Oxidative stress in leukocytes is a possible link between blood pressure, blood glucose, and C-reacting protein
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Japan
    Hypertension 39:777-80. 2002
  2. ncbi request reprint Carvedilol inhibits pressure-induced increase in oxidative stress in coronary smooth muscle cells
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Japan
    Hypertens Res 25:419-25. 2002
  3. ncbi request reprint Reactive oxygen species formation by polymorphonuclear cells and mononuclear cells as a risk factor of cardiovascular diseases
    Kenichi Yasunari
    Department of Medicine and Cardiology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Curr Pharm Biotechnol 7:73-80. 2006
  4. ncbi request reprint Pressure promotes angiotensin II--mediated migration of human coronary smooth muscle cells through increase in oxidative stress
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Hypertension 39:433-7. 2002
  5. ncbi request reprint HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress
    K Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 21:937-42. 2001
  6. ncbi request reprint A dopamine-secreting pheochromocytoma
    K Yasunari
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    J Cardiovasc Pharmacol 36:S75-7. 2000
  7. ncbi request reprint Effects of carvedilol on oxidative stress in polymorphonuclear and mononuclear cells in patients with essential hypertension
    Kenichi Yasunari
    Department of General Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Am J Med 116:460-5. 2004
  8. ncbi request reprint Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    J Cardiovasc Pharmacol 41:S33-8. 2003
  9. ncbi request reprint Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients
    T Watanabe
    Department of Medicine and Cardiology, Osaka City University Medical School, Asahimachi, Abeno, Japan
    J Hum Hypertens 20:336-40. 2006
  10. ncbi request reprint Anti-atherosclerotic action of vascular D1 receptors
    K Yasunari
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    Clin Exp Pharmacol Physiol Suppl 26:S36-40. 1999

Detail Information

Publications26

  1. ncbi request reprint Oxidative stress in leukocytes is a possible link between blood pressure, blood glucose, and C-reacting protein
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Japan
    Hypertension 39:777-80. 2002
    ..022 and P=0.006). These results suggest that both hypertension and diabetes lead to increased oxidative stress of PMNs and MNCs, and that CRP is related to MNC oxidative stress...
  2. ncbi request reprint Carvedilol inhibits pressure-induced increase in oxidative stress in coronary smooth muscle cells
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Japan
    Hypertens Res 25:419-25. 2002
    ..These findings suggest that pressure increases oxidative stress and that carvedilol significantly inhibits pressure-induced increase in oxidative stress in cultured human coronary smooth muscle cells...
  3. ncbi request reprint Reactive oxygen species formation by polymorphonuclear cells and mononuclear cells as a risk factor of cardiovascular diseases
    Kenichi Yasunari
    Department of Medicine and Cardiology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Curr Pharm Biotechnol 7:73-80. 2006
    ..ROS formation by MNCs are regulated by vascular inflammation, and that ROS formation by MNCs are also related to various cardiovascular risks such as LV mass, norepinephrine, IMT, and nocturnal blood pressure...
  4. ncbi request reprint Pressure promotes angiotensin II--mediated migration of human coronary smooth muscle cells through increase in oxidative stress
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Hypertension 39:433-7. 2002
    ....
  5. ncbi request reprint HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress
    K Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 21:937-42. 2001
    ....
  6. ncbi request reprint A dopamine-secreting pheochromocytoma
    K Yasunari
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    J Cardiovasc Pharmacol 36:S75-7. 2000
    ..This case shows that excessive excretion of dopamine, a vasodilative hormone, may affect blood pressure...
  7. ncbi request reprint Effects of carvedilol on oxidative stress in polymorphonuclear and mononuclear cells in patients with essential hypertension
    Kenichi Yasunari
    Department of General Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Am J Med 116:460-5. 2004
    ..To compare the effects of carvedilol and propranolol on oxidative stress in leukocytes and C-reactive protein levels in patients with hypertension...
  8. ncbi request reprint Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors
    Kenichi Yasunari
    Department of Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    J Cardiovasc Pharmacol 41:S33-8. 2003
    ..These results suggest that vascular D1A and D1B receptors inhibit migration of vascular smooth muscle cells, possibly through cyclic AMP activation and the suppression of phospholipase D and protein kinase C activities...
  9. ncbi request reprint Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients
    T Watanabe
    Department of Medicine and Cardiology, Osaka City University Medical School, Asahimachi, Abeno, Japan
    J Hum Hypertens 20:336-40. 2006
    ..We propose that ROS formation by MNCs is a marker for prediction of carotid atherosclerosis...
  10. ncbi request reprint Anti-atherosclerotic action of vascular D1 receptors
    K Yasunari
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    Clin Exp Pharmacol Physiol Suppl 26:S36-40. 1999
    ..3. These results suggest that vascular D1-like receptor agonists inhibit migration, proliferation and hypertrophy of VSMC, possibly through the activation of PKA and the suppression of activated PLD, PKC and MAPK activity...
  11. ncbi request reprint Endothelin does not affect intracellular calcium ion concentration in the platelets of rats
    K Murakawa
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    Am J Hypertens 3:307-9. 1990
    ..Our results indicate that [Ca2+]i in rat platelets is not influenced by porcine endothelin...
  12. ncbi request reprint Effect of propranolol on endothelin-induced increase in cytosolic free calcium
    K Yokokawa
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    Am J Hypertens 3:936-8. 1990
    ..The inhibitory action of propranolol on the change in [Ca2+]i induced by ET-1 may be involved in one of the mechanisms of propranolol-induced reduction of vasospasms...
  13. ncbi request reprint Acute effects of alpha- and beta-adrenoceptor blockade on plasma atrial natriuretic peptides during exercise in elderly patients with mild hypertension
    M Kohno
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    Chest 99:847-54. 1991
    ..The observed difference in the ANP response seems to be related to changes in left ventricular function rather than changes in blood pressure or heart rate...
  14. ncbi request reprint Effect on atrial natriuretic peptides of chronic treatment with alpha-methyldopa and hydralazine in spontaneously hypertensive rats
    M Kohno
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    Am J Hypertens 3:111-6. 1990
    ....
  15. ncbi request reprint Left ventricular hypertrophy and angiotensin II receptor blocking agents
    K Yasunari
    Department of Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Curr Med Chem Cardiovasc Hematol Agents 3:61-7. 2005
    ....
  16. ncbi request reprint Acute effects of endothelin on renal hemodynamics and blood pressure in anesthetized rats
    K Yokokawa
    First Department of Internal Medicine, Osaka City University Medical School, Japan
    Am J Hypertens 2:715-7. 1989
    ..0 or 0.5 nM/kg endothelin, renal vascular resistance was significantly elevated. These hemodynamic alterations were dose-dependent. The results show that endothelin has potent hypertensive and renal vasoconstrictive effects in rats...
  17. ncbi request reprint Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension
    Kenichi Yasunari
    Department of General Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Am J Hypertens 19:573-8. 2006
    ..We also studied the role of BP in this effect...
  18. ncbi request reprint Oxidative stress by peripheral blood mononuclear cells is increased in hypertensives with an extreme-dipper pattern and/or morning surge in blood pressure
    Kensaku Maeda
    Department of Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 28:755-61. 2005
    ..These results suggest that both extreme dippers and morning BP surge-type hypertensives may suffer increased ROS formation by MNCs, and that increased ROS formation by MNCs may underlie morning strokes...
  19. ncbi request reprint Benidipine, a long-acting calcium channel blocker, inhibits oxidative stress in polymorphonuclear cells in patients with essential hypertension
    Kenichi Yasunari
    Department of General Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Hypertens Res 28:107-12. 2005
    ....
  20. ncbi request reprint Enhanced oxidative stress in neutrophils from hyperlipidemic guinea pig
    Kensaku Maeda
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, Abeno Ku, Japan
    Atherosclerosis 181:87-92. 2005
    ....
  21. ncbi request reprint Comparative effects of valsartan versus amlodipine on left ventricular mass and reactive oxygen species formation by monocytes in hypertensive patients with left ventricular hypertrophy
    Kenichi Yasunari
    Department of General Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    J Am Coll Cardiol 43:2116-23. 2004
    ....
  22. ncbi request reprint Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation
    Kenichi Yasunari
    Department of General Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Cardiovasc Pharmacol 42:S55-60. 2003
    ....
  23. ncbi request reprint Activation of protein kinase C and nicotinamide adenine dinucleotide phosphate oxidase in leukocytes of spontaneously hypertensive rats
    Kensaku Maeda
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, Osaka, Japan
    Hypertens Res 26:999-1006. 2003
    ..These results suggest that ROS generation by PMN is principally enhanced in SHR through activation of PKCalpha and p47phox...
  24. ncbi request reprint Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile
    Kenichi Yasunari
    Department of General Medicine and Cardiology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cardiovasc Drug Rev 22:189-98. 2004
    ..Temocapril is currently marketed only in Japan. Considering its beneficial effects and unique pharmacokinetics, temocapril, is likely to be introduced in other countries as well...
  25. ncbi request reprint What we learnt from randomized clinical trials and cohort studies of antioxidant vitamin? Focus on vitamin E and cardiovascular disease
    Shinichiro Ueda
    Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus School of Medicine, Okinawa, Japan
    Curr Pharm Biotechnol 7:69-72. 2006
    ..Discrepancy between cohort studies and randomized clinical trials may be partly explained by difference in coronary risk in study participant. However, use of vitamin E supplementation in low risk population has not been justified yet...
  26. ncbi request reprint [Low renin hypertension]
    Kenichi Yasunari
    Department of Cardiology, Osaka City University Graduate School of Medicine
    Nihon Rinsho . 2006