Makoto Noda

Summary

Country: Japan

Publications

  1. ncbi request reprint The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways
    Takao Miki
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Biol Chem 282:12341-52. 2007
  2. ncbi request reprint RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling
    Makoto Noda
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Cancer Metastasis Rev 22:167-75. 2003
  3. doi request reprint The ß1-integrin-dependent function of RECK in physiologic and tumor angiogenesis
    Takao Miki
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Japan
    Mol Cancer Res 8:665-76. 2010
  4. pmc Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
    Ediriweera P S Chandana
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    BMC Dev Biol 10:84. 2010
  5. ncbi request reprint RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity
    Teruyuki Muraguchi
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Nat Neurosci 10:838-45. 2007
  6. doi request reprint The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice
    Huan Wang
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 115:385-98. 2010
  7. ncbi request reprint Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions
    Satoshi Kawashima
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 104:376-85. 2008
  8. ncbi request reprint Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells
    Shunya Kondo
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 120:849-57. 2007
  9. doi request reprint Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts
    Mamiko Hatta
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Cell Signal 21:1885-93. 2009
  10. ncbi request reprint The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors
    Michiko Echizenya
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Japan
    Oncogene 24:5850-7. 2005

Collaborators

Detail Information

Publications28

  1. ncbi request reprint The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways
    Takao Miki
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Biol Chem 282:12341-52. 2007
    ..This modulation was correlated with the accelerated internalization and decay of MT1-MMP and CD13. This study unveils the novel function and target molecules of RECK...
  2. ncbi request reprint RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling
    Makoto Noda
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Cancer Metastasis Rev 22:167-75. 2003
    ....
  3. doi request reprint The ß1-integrin-dependent function of RECK in physiologic and tumor angiogenesis
    Takao Miki
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Japan
    Mol Cancer Res 8:665-76. 2010
    ..Therefore, we propose that RECK in tumor vascular endothelial cells can be an interesting target of cancer treatment via abortion of tumor angiogenesis...
  4. pmc Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
    Ediriweera P S Chandana
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    BMC Dev Biol 10:84. 2010
    ..Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10.5 with halted vascular development; however, the mechanisms by which this phenotype arises remain unclear...
  5. ncbi request reprint RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity
    Teruyuki Muraguchi
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Nat Neurosci 10:838-45. 2007
    ..These findings indicate that RECK is a physiological inhibitor of ADAM10, an upstream regulator of Notch signaling and a critical modulator of brain development...
  6. doi request reprint The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice
    Huan Wang
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 115:385-98. 2010
    ..Our data implicate Reck in protection of ECM/tissue integrity and promotion of functional recovery in the brain after transient cerebral ischemia...
  7. ncbi request reprint Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions
    Satoshi Kawashima
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    J Neurochem 104:376-85. 2008
    ....
  8. ncbi request reprint Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells
    Shunya Kondo
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 120:849-57. 2007
    ....
  9. doi request reprint Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts
    Mamiko Hatta
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Cell Signal 21:1885-93. 2009
    ..Our study has revealed multiple signaling pathways impinging on Reck in cultured mouse embryo fibroblasts and sets a foundation for future studies to find effective Reck inducers of potential value in cancer therapy...
  10. ncbi request reprint The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors
    Michiko Echizenya
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Japan
    Oncogene 24:5850-7. 2005
    ..These findings suggest that MyoD down regulates RECK to facilitate myotube formation, whereas MRF4 up regulates RECK to promote other aspects of myogenesis that require extracellular matrix integrity...
  11. doi request reprint Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation
    Awad Shamma
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Cancer Cell 15:255-69. 2009
    ..Furthermore, Rb heterozygous mice additionally lacking any of Ink4a, Arf, or Suv39h1 generated C cell adenocarcinomas, suggesting that cellular senescence antagonizes Rb-deficient carcinogenesis...
  12. doi request reprint What we learn from transformation suppressor genes: lessons from RECK
    Makoto Noda
    Department of Molecular Oncology and Global COE Program, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Future Oncol 6:1105-16. 2010
    ..In this article we discuss the promise, limitations and recent innovations in this approach, taking one transformation suppressor gene, RECK, as an example...
  13. doi request reprint RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin
    Akira Omura
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Biol Chem 284:3461-9. 2009
    ..Our data demonstrate the ability of RECK to protect fibronectin from MMP-mediated degradation...
  14. pmc A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs
    Ryuya Murai
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Japan
    Oncotarget 1:252-64. 2010
    ..The top-ranking compound, disulfiram, strongly suppressed spontaneous lung-metastasis of human fibrosarcoma cells in nude mice. Our data demonstrate the value of this screen in discovering effective cancer therapeutics...
  15. ncbi request reprint Recklessness as a hallmark of aggressive cancer
    Makoto Noda
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Cancer Sci 98:1659-65. 2007
    ..Here we review the recent advances in RECK research and discuss some of the important issues to be addressed in future studies...
  16. ncbi request reprint Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
    Junseo Oh
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Oncogene 23:5041-8. 2004
    ..In the absence of MMP-2 and MT1-MMP, myoblast fusion in vitro is also significantly retarded. These findings suggest functional overlap in mice between the two MMPs with distinct molecular natures...
  17. ncbi request reprint Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II
    Jiegou Xu
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501 Japan
    Cell Signal 19:1575-82. 2007
    ..These findings raise the possibility that Rgl3 mediates interaction between Ras/Rap-family proteins and profilin II, an important activator of actin polymerization...
  18. ncbi request reprint Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity
    Masafumi Ihara
    Biochemistry and Cell Biology Unit, HMRO, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    Neuron 53:519-33. 2007
    ..Taken together, these data show that Sept4 may be involved in PD as a dual susceptibility factor, as its insufficiency can diminish dopaminergic neurotransmission and enhance alpha-synuclein neurotoxicity...
  19. ncbi request reprint Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents
    Kayoko Nakaji
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Stroke 37:2816-23. 2006
    ..In the present study, we asked whether MMP-2 is involved in the BBB disruption and the subsequent WM lesions after chronic cerebral hypoperfusion...
  20. ncbi request reprint RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis
    Toshihiko Masui
    Department of Surgery, Kyoto University Graduate School of Medicine, Sakyo, Japan
    Clin Cancer Res 9:1779-84. 2003
    ..We also analyzed the correlation between RECK expression and MMP activation...
  21. ncbi request reprint Transcriptional control of the RECK metastasis/angiogenesis suppressor gene
    Regina Maki Sasahara
    Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Sao Paulo 05513 970, SP, Brazil
    Cancer Detect Prev 26:435-43. 2002
    ..Understanding of the mechanisms which control RECK gene transcription may lead to the development of new strategies for cancer prevention and treatment...
  22. ncbi request reprint The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer
    Taku Takeuchi
    Department of Surgery, Nara Medical University, Kashihara City, Nara, Japan
    Clin Cancer Res 10:5572-9. 2004
    ..However, the clinical relevance of these findings remains to be fully documented. Here we examined the expression of RECK and one of its targets, MMP-9, in colorectal cancer tissue...
  23. ncbi request reprint [The membrane-anchored metalloproteinase inhibitor RECK]
    Chiaki Takahashi
    Tanpakushitsu Kakusan Koso 47:1889-95. 2002
  24. ncbi request reprint Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer
    Kazumasa Takenaka
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Eur J Cancer 40:1617-23. 2004
    ..009; Hazard ratio (HR), 0.474 with a 95% Confidence interval (CI) of 0.271-0.830). In conclusion, RECK-status is a significant prognostic factor correlated with tumour angiogenesis in NSCLC patients...
  25. ncbi request reprint Prognostic significance of reversion-inducing cysteine-rich protein with Kazal motifs expression in resected pathologic stage IIIA N2 non-small-cell lung cancer
    Kazumasa Takenaka
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Shogoin kawahara cho 54, Sakyo ku, Kyoto, 606 8507, Japan
    Ann Surg Oncol 12:817-24. 2005
    ..In this study, further analyses focused on pN2 disease were conducted to assess the clinical significance of RECK expression...
  26. doi request reprint TGF-beta signaling preserves RECK expression in activated pancreatic stellate cells
    Hongsik Lee
    Department of Internal Medicine, Ansan Korea University Hospital, Ansan, Gyeonggi Do, Korea
    J Cell Biochem 104:1065-74. 2008
    ....
  27. ncbi request reprint Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor
    Chiaki Takahashi
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:118-23. 2006
    ..These findings suggest that the loss of the proto-oncogene Nras in certain cellular contexts can promote malignant tumor progression...
  28. ncbi request reprint Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK
    Junseo Oh
    National Cancer Institute, Center for Cancer Research, Cell and Cancer Biology Branch, Bethesda, Maryland, USA
    Cancer Res 64:9062-9. 2004
    ..Secondly, TIMP-2 can disrupt VEGF signaling required for initiation of hMVEC migration. Third, TIMP-2 can enhance expression of RECK via Rap1 signaling resulting in an indirect, time-dependent inhibition of endothelial cell migration...