Research Topics
| K NobataSummaryCountry: Japan Publications
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Detail Information
Publications
Comparison of cough reflex sensitivity after an inhaled antigen challenge between actively and passively sensitized guinea pigsJohsuke Hara
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, 920 8641, Japan
Cough 1:6. 2005..The aim of this study was to compare the cough reflex sensitivity to inhaled capsaicin after an inhaled antigen challenge between actively and passively sensitized guinea pigs...
Inhaled lysophosphatidylcholine provokes bronchoconstriction in guinea pigs in vivoKouichi Nobata
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
Eur J Pharmacol 520:150-5. 2005....
Proton pump inhibitor-responsive chronic cough without acid reflux: a case reportKouichi Nobata
The Department of Internal Medicine, Imizu City Hospital, Imizu, JapanAbstract
J Med Case Reports 1:69. 2007..Because 24-h esophageal pH monitoring is quite invasive, the diagnosis of gastroesophageal reflux disease (GERD)-associated cough has usually been made based merely on the clinical efficacy of treatment with proton pump inhibitor (PPI)...
Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators aloneKouichi Nobata
Department of Internal Medicine, Kurobe City Hospital, Kurobe, Japan
Allergy Asthma Proc 27:479-85. 2006..Because bronchial hyperresponsiveness has been shown to be a risk factor for typical asthma onset from CVA, the effect of inhaled corticosteroids on the longitudinal changes in bronchial responsiveness should be examined...
Bronchial asthma showing reduction in FEV1 after inhalation of QvarKouichi Nobata
Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
J Asthma 43:427-8. 2006..These findings would be noteworthy when using Qvar for Japanese patients with asthma known to have a relatively high frequency of the complication of alcohol-induced asthma...
Ambroxol for the prevention of acute upper respiratory diseaseK Nobata
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
Clin Exp Med 6:79-83. 2006..Treatment with ambroxol also significantly reduced the median number of AURD episodes in this assessment (P=0.0028 vs. rebamipide in the second half-year). In conclusion, ambroxol may be useful for preventing AURD...
In vivo airway eosinophil accumulation induced by polymyxin-B reduces bronchial responsiveness in guinea pigsY Ishiura
Third Department of Internal Medicine, Kanazawa University School of Medicine, Takara machi, Kanazawa, Japan
Clin Exp Allergy 31:644-51. 2001..However, it has not been studied whether airway eosinophils enhance or inhibit bronchial responsiveness in vivo...
In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamineYoshihisa Ishiura
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa Graduate University School of Medicine, Kanazawa, Japan
Prostaglandins Other Lipid Mediat 75:1-12. 2005..These results suggest that in vivo airway eosinophils may reduce nonspecific bronchial responsiveness through production of inhibitory or bronchoprotective prostanoids, but not through histaminase production...
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstrictionYoshihisa Ishiura
Kanazawa Graduate University School of Medicine, Kanazawa, Japan
J Investig Allergol Clin Immunol 13:79-86. 2003....
Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivoKouichi Nobata
The Third Department of Internal Medicine, Kanazawa University School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
Eur J Pharmacol 452:97-104. 2002..These results indicate that prevention of antigen-induced bronchoconstriction by blockade of alpha-adrenoceptors is due to the inhibition of mediator release via alpha(1L)-adrenoceptor antagonism...
Lack of adrenomedullin on antigen-induced bronchoconstriction in guinea pigs in vivoYoshihisa Ishiura
Pulmonary Medicine, Cellular Transplantation Biology, Kanazawa, Graduate University School of Medicine, Japan
Life Sci 72:1963-72. 2003..We conclude that an intravenous administration of adrenomedullin does not influence antigen-induced bronchoconstriction or bronchial responsiveness to inhaled methacholine or histamine in vivo...
Th2 cytokine inhibition and cough in asthmatic and bronchitic patientsYoshihisa Ishiura
The Department of Internal Medicine, Toyama City Hospital, Toyama, Japan
Ann Med 36:623-9. 2004....
Pulmonary sarcoidosis with usual interstitial pneumonia distributed predominantly in the lower lung fieldsKouichi Nobata
Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa
Intern Med 45:359-62. 2006..These findings may enlighten the assist in understanding of the process of development of pulmonary sarcoidosis...
Sputum eosinophilia, airway hyperresponsiveness and airway narrowing in young adults with former asthmaJohsuke Hara
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Ishikawa, Japan
Allergol Int 57:211-7. 2008..30-80% of outgrown asthma subjects develop symptoms again later in life. We investigated inflammation and function of lower airway in adolescents with former asthma...
Effect of an orally active Th2 cytokine inhibitor, suplatast on "atopic cough" tosilateYoshihisa Ishiura
Department of Respiratory Medicine, Toyama City Hospital, Toyama, Japan
Arzneimittelforschung 58:297-302. 2008....
Effect of carbocysteine on cough reflex to capsaicin in asthmatic patientsYoshihisa Ishiura
Division of Pulmonary Medicine, Wajima Municipal Hospital, Wajima, Japan
Br J Clin Pharmacol 55:504-10. 2003..This study was designed to investigate the clinical effect of carbocysteine for cough sensitivity in patients with bronchial asthma...
Thromboxane antagonism and cough in chronic bronchitisYoshihisa Ishiura
The Division of Pulmonary Medicine, Wajima Municipal Hospital, Wajima, Japan
Ann Med 35:135-9. 2003..The increased eicosanoid synthesis has been suggested as the underlying mechanism of chronic productive cough in patients with chronic bronchitis...
