Atsushi Watanabe

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. doi request reprint Perinatal hypophosphatasia caused by uniparental isodisomy
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan Electronic address
    Bone 60:93-7. 2014
  2. doi request reprint Prevalence of c.1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasia in Japanese and effects of the mutation on heterozygous carriers
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan
    J Hum Genet 56:166-8. 2011
  3. ncbi request reprint Genetic aspects of the vascular type of Ehlers-Danlos syndrome (vEDS, EDSIV) in Japan
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Main Hospital, Tokyo, Japan
    Circ J 71:261-5. 2007
  4. ncbi request reprint Prenatal genetic diagnosis of severe perinatal (lethal) hypophosphatasia
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Hospital
    J Nippon Med Sch 74:65-9. 2007
  5. ncbi request reprint Vascular type of Ehlers-Danlos syndrome
    Atsushi Watanabe
    Department of Molecular and Medical Genetics, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    J Nippon Med Sch 75:254-61. 2008
  6. ncbi request reprint Osteogenic and chondrogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice
    Rei Ogawa
    Department of Plastic and Reconstructive Surgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Toky 113 8603, Japan
    Biochem Biophys Res Commun 313:871-7. 2004
  7. doi request reprint Expression of cochlin mRNA splice variants in the inner ear
    Kuwon Sekine
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Audiol Neurootol 15:88-96. 2010
  8. ncbi request reprint Expression of full-length Cochlin p63s is inner ear specific
    Lishu Li
    Department of Otorhinolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 32:219-23. 2005
  9. doi request reprint Cochlin-tomoprotein: a novel perilymph-specific protein and a potential marker for the diagnosis of perilymphatic fistula
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Sendagi, Tokyo 113 8603, Japan
    Audiol Neurootol 14:338-44. 2009
  10. doi request reprint The performance of Cochlin-tomoprotein detection test in the diagnosis of perilymphatic fistula
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Audiol Neurootol 15:168-74. 2010

Collaborators

Detail Information

Publications36

  1. doi request reprint Perinatal hypophosphatasia caused by uniparental isodisomy
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan Electronic address
    Bone 60:93-7. 2014
    ....
  2. doi request reprint Prevalence of c.1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasia in Japanese and effects of the mutation on heterozygous carriers
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan
    J Hum Genet 56:166-8. 2011
    ..Our results indicate that the only way to reliably detect whether individuals are pl-HPP carriers is to perform the ALPL mutation analysis...
  3. ncbi request reprint Genetic aspects of the vascular type of Ehlers-Danlos syndrome (vEDS, EDSIV) in Japan
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Main Hospital, Tokyo, Japan
    Circ J 71:261-5. 2007
    ..Affected individuals with vEDS are at risk of arterial rupture, aneurysm, and/or dissection; gastrointestinal perforation or rupture; and uterine rupture during pregnancy, which may lead to sudden death...
  4. ncbi request reprint Prenatal genetic diagnosis of severe perinatal (lethal) hypophosphatasia
    Atsushi Watanabe
    Division of Clinical Genetics, Nippon Medical School Hospital
    J Nippon Med Sch 74:65-9. 2007
    ..As a result, prenatal genetic counseling for hypophosphatasia with collaboration between obstetricians and clinical genetics teams...
  5. ncbi request reprint Vascular type of Ehlers-Danlos syndrome
    Atsushi Watanabe
    Department of Molecular and Medical Genetics, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    J Nippon Med Sch 75:254-61. 2008
    ....
  6. ncbi request reprint Osteogenic and chondrogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice
    Rei Ogawa
    Department of Plastic and Reconstructive Surgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Toky 113 8603, Japan
    Biochem Biophys Res Commun 313:871-7. 2004
    ..Since this cell population can be easily identified through fluorescence microscopy, it may be an ideal source of ASCs for further experiments on stem cell biology and tissue engineering...
  7. doi request reprint Expression of cochlin mRNA splice variants in the inner ear
    Kuwon Sekine
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Audiol Neurootol 15:88-96. 2010
    ..The short mRNA was detected only in the inner ear, and this variant may provide a clue to understanding the formation and function of cochlin isoforms...
  8. ncbi request reprint Expression of full-length Cochlin p63s is inner ear specific
    Lishu Li
    Department of Otorhinolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 32:219-23. 2005
    ..To study the specificity of expression of Cochlin isoforms in various organs, here we have investigated expression of the COCH gene at both the transcriptional and translational level...
  9. doi request reprint Cochlin-tomoprotein: a novel perilymph-specific protein and a potential marker for the diagnosis of perilymphatic fistula
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Sendagi, Tokyo 113 8603, Japan
    Audiol Neurootol 14:338-44. 2009
    ..The aim of this study was to determine whether CTP, a novel perilymph-specific protein, could be used as a marker for the diagnosis of PLF...
  10. doi request reprint The performance of Cochlin-tomoprotein detection test in the diagnosis of perilymphatic fistula
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Audiol Neurootol 15:168-74. 2010
    ..To establish a definite diagnostic test for PLF using CTP as a biochemical marker, we examined the diagnostic performance of the CTP detection test...
  11. ncbi request reprint Transient cardiomyopathy in a patient with congenital contractural arachnodactyly (Beals syndrome)
    Tae Matsumoto
    Department of Pediatrics, Nippon Medical School Graduate School of Medicine, Tokyo, Japan
    J Nippon Med Sch 73:285-8. 2006
    ..This is the first report of CCA with transient cardiomyopathy. We discuss the mechanism of the spontaneous improvement of cardiomyopathy in this case on the basis of expression of the responsible gene...
  12. ncbi request reprint Expression of cochlin in the vestibular organ of rats
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 67:252-8. 2005
    ..These findings support the theory that deposition of acidophilic substance in the inner ear caused by mutation of cochlin can induce a secondary retrograde dendritic degeneration of the vestibular nerves...
  13. ncbi request reprint Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differences
    Rei Ogawa
    Department of Plastic and Reconstructive Surgery, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8603, Japan
    Biochem Biophys Res Commun 319:511-7. 2004
    ..89 times greater than those harvested from male mice. This suggests that the adipogenic differentiation of ASCs is closely related to sex differences...
  14. ncbi request reprint Identification of a novel Cochlin isoform in the perilymph: insights to Cochlin function and the pathogenesis of DFNA9
    Tetsuo Ikezono
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Biochem Biophys Res Commun 314:440-6. 2004
    ..The pathogenesis of DFNA9 is not fully clarified as yet, and this novel perilymph-associated CTP isoform might provide mechanistic clues to how mutations in the COCH gene damage the inner ear function...
  15. ncbi request reprint Chondrogenic and osteogenic differentiation of adipose-derived stem cells isolated from GFP transgenic mice
    Rei Ogawa
    Department of Plastic and Reconstructive Surgery, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 71:240-1. 2004
    ..This cell population can be easily identified through fluorescence microscope, it should be an ideal source of ASCs for further experiments of stem cell biology and tissue engineering...
  16. pmc Successful gene therapy in utero for lethal murine hypophosphatasia
    Hanako Sugano
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, 113 8602 Japan
    Hum Gene Ther 23:399-406. 2012
    ..Our data clearly demonstrate that systemic injection of AAV9 in utero is an effective strategy for the treatment of lethal HPP mice. Fetal gene therapy may be an important choice after prenatal diagnosis of life-threatening HPP...
  17. doi request reprint A novel mutation screening system for Ehlers-Danlos Syndrome, vascular type by high-resolution melting curve analysis in combination with small amplicon genotyping using genomic DNA
    Banyar Than Naing
    Department of Biochemistry and Molecular Biology, Nippon Medical School, and Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan
    Biochem Biophys Res Commun 405:368-72. 2011
    ..A better understanding of the genotype-phenotype correlation in COL3A1 using this method will lead to improve in diagnosis and treatment...
  18. ncbi request reprint Biological effects of cellular stretch on human dermal fibroblasts
    Chenyu Huang
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan Department of Plastic Surgery, Meitan General Hospital, Beijing, China
    J Plast Reconstr Aesthet Surg 66:e351-61. 2013
    ..A better understanding of such fibroblast mechanoresponses in vitro will help the development of novel interventions that can prevent, reduce or even reverse pathological scar formation and/or progression in vivo. ..
  19. doi request reprint Identical germline mutations in the TMEM127 gene in two unrelated Japanese patients with bilateral pheochromocytoma
    Naomi Takeichi
    Division of Endocrinology and Metabolism, Department of Medicine, Nippon Medical School, Tsukuba, Japan
    Clin Endocrinol (Oxf) 77:707-14. 2012
    ..The aim of the present study was to determine whether TMEM127 mutations are involved in the pathogenesis of pheochromocytomas/paragangliomas in Japanese subjects...
  20. ncbi request reprint Conservative management of hyperreactio luteinalis: a case report
    Takashi Abe
    Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Japan
    J Nippon Med Sch 78:241-5. 2011
    ..The present report describes case of HL in a woman with a normal singleton pregnancy in whom conservative management allowed the preservation of both ovaries...
  21. ncbi request reprint Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads
    Tomohiro Miyasaka
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Neuropathol Exp Neurol 64:665-74. 2005
    ..Based on TM4-positive NFT counts and total NFT counts, we speculate that NFTs in the human hippocampus are produced at a constant rate irrespective of the disease stage...
  22. doi request reprint Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno-associated viral vector serotype 1
    Naotaka Iwamoto
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    J Gene Med 11:498-505. 2009
    ..As an alternative approach, we examined the feasibility of intrathecal (IT) injection of adeno-associated viral vector serotype 1 (AAV1)...
  23. ncbi request reprint Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy model
    Tsutomu Igarashi
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy, Research Center for Advanced Medical Technology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Gene Ther 10:219-26. 2003
    ..These data suggest that the anti-angiogenic activity of angiostatin has therapeutic potential for the treatment of retinal neovascularization...
  24. ncbi request reprint Interchromosomal duplication of major histocompatibility complex class I regions in rainbow trout (Oncorhynchus mykiss), a species with a presumably recent tetraploid ancestry
    Takashi Shiina
    Department of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Immunogenetics 56:878-93. 2005
    ..The interchromosomal duplication and the homology levels are supportive of the tetraploid model...
  25. ncbi request reprint Bovine hepatocyte growth factor and its receptor c-Met: cDNA cloning and expression analysis in the mammary gland
    Daisuke Yamaji
    Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Domest Anim Endocrinol 30:239-46. 2006
    ..These results suggest pivotal roles of HGF and c-Met in the development of bovine mammary gland...
  26. ncbi request reprint Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats
    Shin ichi Satoh
    First Laboratory for Pharmacology, Institute of Life Science Research, Asahi Kasei Corporation, 632 1, Mifuku, Ohito cho, Tagata gun, 410 2321, Japan
    Life Sci 72:103-12. 2002
    ..Inhibition of Rho-kinase is efficacious in preventing the ECG change and development of fibrosis induced by vasopressin in this model...
  27. ncbi request reprint [Case of systemic mastocytosis with hemophagocytic syndrome]
    Atsushi Watanabe
    Third Department of Internal Medicine, Akita University School of Medicine, Akita
    Nihon Naika Gakkai Zasshi 92:874-6. 2003
  28. ncbi request reprint Cloning and characterization of the promoter region of the bovine membrane tethering protein p115 gene and its regulation in mammary epithelial cells
    Atsushi Watanabe
    Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Sapporo 062 0045, Japan
    Biochim Biophys Acta 1629:60-72. 2003
    ..Furthermore, the results suggested that p115 gene transcription is activated by E(2), by insulin, or by both in association with the stimulation of mammary epithelial cell proliferation...
  29. ncbi request reprint Multidisciplinary treatment by pneumonectomy, PMX and CHDF in a case of pulmonary suppuration complicated with septic shock
    Noriyuki Takahashi
    Department of Thoracic Surgery, Sapporo Medical University, Sapporo, Japan
    Ann Thorac Cardiovasc Surg 9:319-22. 2003
    ..Ann Thorac Cardiovasc Surg 2003; 9: 319-22)..
  30. pmc Complete nucleotide sequence of the Cryptomeria japonica D. Don. chloroplast genome and comparative chloroplast genomics: diversified genomic structure of coniferous species
    Tomonori Hirao
    Institute of Wood Technology, Akita Prefectural University, 11 1 Kaieisaka, Noshiro, Akita 016 0876, Japan
    BMC Plant Biol 8:70. 2008
    ....
  31. pmc Effects of intramammary infusions of interleukin-8 on milk protein composition and induction of acute-phase protein in cows during mammary involution
    Atsushi Watanabe
    Hokkaido Research Station, National Institute of Animal Health, Sapporo 062 0045, Japan
    Can J Vet Res 72:291-6. 2008
    ..In the cows infused with 25 microg of rbIL-8, the rectal temperature and serum haptoglobin level were transiently elevated after the infusion, showing that intramammary infusion of rbIL-8 could elicit systemic inflammation...
  32. ncbi request reprint Leptin inhibits hepatocyte growth factor-induced ductal morphogenesis of bovine mammary epithelial cells
    Daisuke Yamaji
    Laboratories of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 54:183-9. 2007
    ..These results suggest that stroma-derived factors intricately regulate mammary epithelial morphogenesis...
  33. pmc Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity
    Takashi Shiina
    Department of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Japan
    Genetics 173:1555-70. 2006
    ..This is most likely reminiscent of the fact that these hsSNV and hv1SNV have been selected in adaptation to the constantly evolving microbial antigenic repertoire...
  34. ncbi request reprint Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo
    Atsushi Watanabe
    Biomolecular Characterization Division, Characterization Center, RIKEN The Institute of Physical and Chemical Research, Wako, Japan
    J Neurochem 90:1302-11. 2004
    ..Similar degradation products starting from the bulky residues next to asparaginyl residues were found in the smeared tau in vivo partially purified from the homogenates from Alzheimer's disease brains...
  35. ncbi request reprint Mating communication systems of four Plusiinae species distributed in Japan: identification of the sex pheromones and field evaluation
    Shin ichi Inomata
    Graduate School of Bio Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184 8588, Japan
    J Chem Ecol 31:1429-42. 2005
    ..Using previously published chemical and biosynthetic data, together with the finding from this study, we propose a classification of the Plusiinae sex pheromones...
  36. pmc CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV
    Tadafumi Hashimoto
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033
    EMBO J 21:1524-34. 2002
    ..Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD...