Research Topics
Species | Tomoko SeyaSummaryAffiliation: Nippon Medical School Country: Japan Publications
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Publications
Life-threatening bleeding from gastrointestinal stromal tumor of the stomachTomoko Seya
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
J Nippon Med Sch 75:306-11. 2008..Because the origins and manner of bleeding varies in gastric GISTs, we must decide the methods of hemostasis immediately including the tumor excision...- Left paraduodenal hernia incidentally diagnosed during operation for transverse colon cancerTomoko Seya
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School
J Nippon Med Sch 77:111-4. 2010..In addition to the packing of jejunal loops in the middle of the abdomen, ascending left colic artery was clearly observed at the left edge of the packing of jejunal loops, which indicates left paraduodenal hernia... - Squamous cell carcinoma arising from recurrent anal fistulaTomoko Seya
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, and Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, Japan
J Nippon Med Sch 74:319-24. 2007..e., BAT26 and D2S123). As a result, the tumor was classified as MSI-H (high) according to the Bethesda criteria. Our patient had MSI and one of the smallest reported SCCs arising from recurrent anal fistulae... - Case of rectal malignant melanoma showing immunohistochemical variability in a tumorTomoko Seya
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Japan
J Nippon Med Sch 74:377-81. 2007..Although the patient was treated with immunochemotherapy for metastatic liver tumor, he died because of progression of metastases... - Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatinTomoko Seya
Department of Surgery, Chiba Hokusoh Hospital, Nippon Medical School, Inbamura, Chiba, Japan
Int J Clin Oncol 12:472-7. 2007.... - A case of multiple gastric carcinoids that could not be preoperatively diagnosedTomoko Seya
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Chiba, Japan
J Nippon Med Sch 74:430-3. 2007..Immunohistochemical staining for chromogranin A, synaptophysin, and cytokeratin was positive. However, p53 was absent, and the MIB-1 index was low. Two years after surgery, the patient is alive without recurrence... - Lumican expression in advanced colorectal cancer with nodal metastasis correlates with poor prognosisTomoko Seya
Department of Surgery, Chiba Hokusoh Hospital, Nippon Medical School, Chiba 270 1694, Japan
Oncol Rep 16:1225-30. 2006..048). These results indicate that lumican expression is a potential prognostic factor in patients with advanced colorectal cancer with nodal metastasis... - Pathological and biomolecular analyses of colorectal endocrine carcinomaSeiichi Shinji
Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital
J Nippon Med Sch 74:87-8. 2007 - Neuroendocrine cell differentiation of poorly differentiated colorectal adenocarcinoma correlates with liver metastasisSeiichi Shinji
Department of Surgery for Organ Function and Biological Regulation (Department of Surgery I, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan
Int J Oncol 29:357-64. 2006.... - A study of histopathological assessment criteria for assessing malignancy of gastrointestinal stromal tumor, from a clinical standpointKimiyoshi Yokoi
Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inbamura, Inbagun, Chiba, 270-1694, Japan
J Gastroenterol 40:467-73. 2005..5% in the histologically malignant cases (P = 0.0012). CONCLUSIONS: The new histological malignancy classification for GIST was demonstrated to be useful from a clinical standpoint... - Identification of neovasculature using nestin in colorectal cancerNobuhisa Teranishi
Department of Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Int J Oncol 30:593-603. 2007..071). Nestin is considered a novel angiogenesis marker of proliferating endothelial cells in colorectal cancer tissue... - Correlation between clinical pathologic factors and activity of 5-FU-metabolizing enzymes in colorectal cancerTakeshi Yamada
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Japan
J Nippon Med Sch 75:23-7. 2008..The expression levels and activities of these three enzymes play important roles in the response of cancer patients to 5-FU-based chemotherapy... - Male choriocarcinoma with metastasis to the jejunum: a case report and review of the literatureKimiyoshi Yokoi
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Japan
J Nippon Med Sch 75:116-21. 2008..We report this rare case of a male patient with metastases of choriocarcinoma to the gastrointestinal tract from the mediastinum, together with a review of the literature... - Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastasesSeiichi Shinji
Department of Surgery for Organ and Biological Regulation Department of Surgery I, Graduate School of Medicine, Nippon Medical School, Tokyo 113 8603, Japan
Oncol Rep 15:539-43. 2006..Our results suggest that USP14/TGT60 kD also controls the fate of proteins that regulate tumor invasion and metastasis... - Different expression levels of lumican in human carcinoid tumor and neuroendocrine cell carcinomaSeiichi Shinji
Surgery for Organ and Biological Regulation, Department of Surgery I, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
Int J Oncol 26:873-80. 2005..These results indicate that the higher expression level of cytoplasmic lumican in carcinoid tumors than in NECs may play a role in the slow growth of these tumors... - Case of adenosquamous carcinoma of the ascending colonKimiyoshi Yokoi
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
J Nippon Med Sch 75:242-6. 2008..A search of Japanese literature over the past 25 years yielded 70 patients with adenosquamous carcinoma of the colon, and the clinicopathological features are discussed herein... - Mild hemophilia A diagnosed in a 55-year-old patient after pancreatoduodenectomy for carcinoma of the papilla of vaterNoriyuki Ishikawa
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Japan ac jp
J Nihon Med Sch 74:372-6. 2007..After diagnosis, intermittent administration of a coagulation factor VIII product controlled the bleeding. The patient is currently being treated on an outpatient basis and remains free of cancer recurrence... - A case of extrahepatic bile duct wall recurrence of gastric carcinoma that was treated with pancreaticoduodenectomyTakashi Shirakawa
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba, Japan
J Nippon Med Sch 77:170-4. 2010..The patient has survived for more than 26 months after pancreaticoduodenectomy without recurrence... - A case of rectal metastatic tumor in the soft tissue of the handNoriyuki Ishikawa
Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, and Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, Japan
J Nippon Med Sch 74:309-13. 2007..Fifteen cases of colorectal metastatic tumors in the hand have been documented, of which three were soft-tissue metastases. This report describes the fourth case... - High efficacy of imatinib for recurrent gastrointestinal stromal tumor in the jejunum: a case reportKimiyoshi Yokoi
Department of Surgery, Chiba Hokusoh Hospital Nippon Medical School, 1715 Kamagari, Inba mura, Inba gun, Chiba 270 1694, Japan
J Nippon Med Sch 71:114-9. 2004..9%/M and 49.5%/M, respectively. Whether imatinib is the first choice of treatment for GIST or not, and what is the appropriate dose and period should be resolved... 
Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancerYoko Matsuda
Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School, Tokyo, Japan
Cancer Lett 309:209-19. 2011..Thus, FGFR2 plays important roles in CRC progression in association with tumor cell migration, invasion and growth, and FGFR2 might be a novel therapeutic target for CRC...- External whole-body image of EGFP gene expressionSeiichi Shinji
Department of Surgery I, Nippon Medical School, Tokyo, Japan
J Nippon Med Sch 70:462-3. 2003..This new technology is a useful method for investigating tumor growth in vivo. In the future, this method could be applied to the detection of peritoneal, liver and lung metastasis in living animals... - Antiangiogenic effect of octreotide inhibits the growth of human rectal neuroendocrine carcinomaMichihiro Koizumi
First Department of Surgery, Nippon Medical School, Tokyo, Japan
Digestion 65:200-6. 2002..We examined the effect of the somatostatin analogue, octreotide, on human rectal NE carcinoma... - Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cellsYoko Matsuda
Department of Pathology and Integrative Oncological Pathology, Nippon Medical School, Tokyo, Japan
Mol Cancer Ther 11:2010-20. 2012..In conclusion, FGFR2IIIc plays an important role in colorectal carcinogenesis and tumor progression. Monoclonal antibody against FGFR2IIIc has promising potential in colorectal carcinoma therapy... - A 13-year-old girl with a preoperatively diagnosed solid cystic tumor of the pancreasTakeshi Asano
Department of Pediatrics, Chiba Hokusoh Hospital, Nippon Medical School, Inbu gun, Chiba, Japan
J Nippon Med Sch 73:231-4. 2006..Light microscopy of the tumor confirmed small neoplastic cells. Pathological diagnosis was solid pseudopapillary tumor (solid cystic tumor) of the pancreas. Surgery was successful, and the postoperative course was uneventful... - [Three advanced gastric cancer patients successfully treated by combination therapy of paclitaxel and cisplatin]Takeshi Yamada
Dept of Surgery, Nippon Medical School, Chiba Hokusou Hospital
Gan To Kagaku Ryoho 34:769-72. 2007..Ascites improved only after administration of 1 course in all patients.PTX/CDDP is thought to be an effective chemotherapy showing acceptable toxicity against advanced gastric cancer with ascites... - [Prediction of sensitivity to 5-fluorouracil (5-fu) by metabolic and target enzyme activities in colon cancer]Takeshi Yamada
Dept. of Surgery, Nippon Medical School Chiba Hokusou Hospital
Gan To Kagaku Ryoho 33:1603-9. 2006..To improve its accuracy, the finding of a fourth factor such as P-glycoprotein and multidrug resistance-associated proteins (MRP), to be added to OPRT, DPD and TS, is desired... - [A case of advanced gastric cancer successfully treated by TS-1 and CDDP after jejunostomy]Takashi Shirakawa
Dept. of Surgery, Nippon Medical School Chiba Hokuso Hospital
Gan To Kagaku Ryoho 33:811-5. 2006..The final diagnosis was Stage IIIA and the pathological response to chemotherapy was Grade 2. The patient has survived for over 14 months after surgery and has presented no signs of recurrence... - [Correlation between clinical pathologic factors and enzymatic activity of orotate Phosphoribosyl transferase (OPRT), Dihydropyrimidine dehydrogenase (DPD) and Thymidylate synthase (TS) in colorectal cancer]Takeshi Yamada
Dept. of Surgery, Nippon Medical School Chiba Hokusou Hospital
Gan To Kagaku Ryoho 33:789-93. 2006..With poorly-differentiated adenocarcinoma, it is estimated that many cases would show high DPD and if the enzyme activities can not be measured, so administration of TS-1, which includes DPD inhibitor, may be considered... - [Antitumor effect of paclitaxel for gastric cancer is AUC dependent]Takeshi Yamada
Dept of Surgery, Nippon Medical School, Chiba Hokusou Hospital
Gan To Kagaku Ryoho 35:251-3. 2008..A similar PTX effect was obtained when the AUC was equal. In this study, we demonstrated that the effect of low-dose PTX was equal to the effect of high-dose PTX in gastric cancer... - [Substance P and anticancer drug-induced emesis]Takeshi Yamada
Dept of Surgery, Chiba Hokusoh Hospital
Gan To Kagaku Ryoho 34:903-6. 2007..There were some reports suggesting the role of substance P (SP) and its receptor, neurokinin receptor 1 (NK 1), in the development of emesis...