Atsuhiro Sakamoto

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. ncbi request reprint Influence of inhalation anesthesia assessed by comprehensive gene expression profiling
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Gene 356:39-48. 2005
  2. ncbi request reprint [Mechanism of intractable low back pain and neural blockade]
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 69:588-92. 2002
  3. ncbi request reprint [Nerve block therapy for intractable pain: 3 cases of erythlomelalgia]
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 70:66-8. 2003
  4. ncbi request reprint The influences of propofol and dexmedetomidine on circadian gene expression in rat brain
    Yuko Yoshida
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Brain Res Bull 79:441-4. 2009
  5. ncbi request reprint Expressions of genes encoding drug-metabolizing enzymes are altered after sevoflurane, isoflurane, propofol or dexmedetomidine anesthesia
    Keiko Nakazato
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Biomed Res 30:17-24. 2009
  6. pmc Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus
    Megumi Anzai
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e59454. 2013
  7. doi request reprint Electroconvulsive stimulation (ECS) increases the expression of neuropeptide Y (NPY) in rat brains in a model of neuropathic pain: a quantitative real-time polymerase chain reaction (RT-PCR) study
    Tadashi Okabe
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Pain Med 10:1460-7. 2009
  8. ncbi request reprint Incessant non-sustained ventricular tachycardia after stimulus of electroconvulsive therapy with atropine premedication?
    Chol Kim
    Department of Anesthesiology, Nippon Medical School, Sendagi, Tokyo, Japan
    Psychiatry Clin Neurosci 61:564-7. 2007
  9. ncbi request reprint Proteomic analysis of rat brains in a model of neuropathic pain following exposure to electroconvulsive stimulation
    Chihiro Kamagata
    Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Biomed Res 32:91-102. 2011
  10. doi request reprint Postoperative intensive care unit drug fever caused by dexmedetomidine
    Tadashi Okabe
    Department of Anesthesiology and Intensive Care Medicine, Nippon Medical School, Tokyo, Japan
    Anesth Analg 108:1589-91. 2009

Detail Information

Publications84

  1. ncbi request reprint Influence of inhalation anesthesia assessed by comprehensive gene expression profiling
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Gene 356:39-48. 2005
    ..Our findings provide the first assessment for the influence of inhalation anesthesia by approaches of experimental biology and genome science...
  2. ncbi request reprint [Mechanism of intractable low back pain and neural blockade]
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 69:588-92. 2002
    ..In this article, the mechanisms of passing into the chronic state, especially the development of neuropathic pain, and the utilities of diagnostic and therapeutic neural blockade for low back pain are discussed...
  3. ncbi request reprint [Nerve block therapy for intractable pain: 3 cases of erythlomelalgia]
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 70:66-8. 2003
    ..In this article, the mechanisms of passing into the chronic pain state as well as the efficacy of neural blockade for intractable pain such as erythromelalgia are discussed...
  4. ncbi request reprint The influences of propofol and dexmedetomidine on circadian gene expression in rat brain
    Yuko Yoshida
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Brain Res Bull 79:441-4. 2009
    ..There are circadian genes whose expressions were affected by sevoflurane. We hypothesized that propofol and dexmedetomidine also have influences on the expressions of circadian genes...
  5. ncbi request reprint Expressions of genes encoding drug-metabolizing enzymes are altered after sevoflurane, isoflurane, propofol or dexmedetomidine anesthesia
    Keiko Nakazato
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Biomed Res 30:17-24. 2009
    ..There were differences between inhalation and intravenous anesthesia, and interestingly, between sevoflurane and isoflurane and between propofol and dexmedetomidine...
  6. pmc Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus
    Megumi Anzai
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e59454. 2013
    ..We aimed to examine whether sevoflurane directly affects the SCN...
  7. doi request reprint Electroconvulsive stimulation (ECS) increases the expression of neuropeptide Y (NPY) in rat brains in a model of neuropathic pain: a quantitative real-time polymerase chain reaction (RT-PCR) study
    Tadashi Okabe
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Pain Med 10:1460-7. 2009
    ..Electroconvulsive shock therapy (ECT) has been widely used as an effective and established treatment for refractory depression and schizophrenia. Some reports have shown that ECT is also effective for treating refractory neuropathic pain...
  8. ncbi request reprint Incessant non-sustained ventricular tachycardia after stimulus of electroconvulsive therapy with atropine premedication?
    Chol Kim
    Department of Anesthesiology, Nippon Medical School, Sendagi, Tokyo, Japan
    Psychiatry Clin Neurosci 61:564-7. 2007
    ..But ventricular tachycardia is rare. Reported herein is a case of incessant non-sustained ventricular tachycardia, possibly triggered by atropine premedication...
  9. ncbi request reprint Proteomic analysis of rat brains in a model of neuropathic pain following exposure to electroconvulsive stimulation
    Chihiro Kamagata
    Department of Anesthesiology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Biomed Res 32:91-102. 2011
    ..This trend suggests an association of ECS with improved hypersensitivity, and these results may help elucidate the mechanism of this effect...
  10. doi request reprint Postoperative intensive care unit drug fever caused by dexmedetomidine
    Tadashi Okabe
    Department of Anesthesiology and Intensive Care Medicine, Nippon Medical School, Tokyo, Japan
    Anesth Analg 108:1589-91. 2009
    ..This symptom improved rapidly 7 h after stopping dexmedetomidine hydrochloride. Other possible causes (such as infection) were sequentially eliminated...
  11. doi request reprint A transient inflammatory reaction in the lung after experimental hemorrhagic shock and resuscitation with a hemoglobin-vesicles solution compared with rat RBC transfusion
    Yoshitaka Yamanashi
    Department of Anesthesiology, Nippon Medical School, Bunkyo, Tokyo, Japan
    ASAIO J 55:478-83. 2009
    ....
  12. doi request reprint microRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: A TaqMan® Low Density Array study
    Yuuki Genda
    Department of Anaesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo 113 8603, Japan
    Int J Mol Med 31:129-37. 2013
    ..These results provide a step toward elucidation of the mechanisms underlying neuropathic pain...
  13. doi request reprint The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study
    Shinji Akada
    Department of Anesthesiology and Intensive Care, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Anesth Analg 107:167-70. 2008
    ..Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV...
  14. doi request reprint Clinical role and efficacy of landiolol in the intensive care unit
    Yuko Yoshida
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    J Anesth 22:64-9. 2008
    ....
  15. ncbi request reprint Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock
    Yoshitugu Goto
    Department of Anesthesiology, Nippon Medical School, Sendagi, Tokyo, Japan
    Biomed Res 27:283-8. 2006
    ..Our results suggest that resuscitation from hemorrhagic shock with HbV did not increase hypoxic or inflammatory effects in major organs, compared with resuscitation using LR solution, despite prolonged elevation of blood lactate...
  16. pmc Aggressive treatment with noninvasive ventilation for mild acute hypoxemic respiratory failure after cardiovascular surgery: retrospective observational study
    Keiko Nakazato
    Department of Anesthesiology, Nippon Medical School, and Division of Intensive Care Unit and Coronary Care Unit, Nippon Medical School Hospital, 1 1 5 Sendagi, Tokyo 113 8603, Japan
    J Cardiothorac Surg 7:41. 2012
    ..The aim of this study was to investigate the effectiveness of NIV in the early stage of mild AHRF after cardiovascular surgery...
  17. doi request reprint Differences in microRNA changes of healthy rat liver between sevoflurane and propofol anesthesia
    Masashi Ishikawa
    Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Anesthesiology 117:1245-52. 2012
    ..The authors hypothesized that anesthetics influence miRNA expression in the liver, and performed miRNA screening tests using TaqMan low-density arrays...
  18. doi request reprint Factors predicting successful noninvasive ventilation in acute lung injury
    Yuko Yoshida
    Department of Anesthesiology, Nippon Medical School Hospital, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Anesth 22:201-6. 2008
    ..The aims of this study were to determine factors predicting the need for endotracheal intubation in ALI patients treated with NIV, and to promote the selection of patients suitable for NIV...
  19. ncbi request reprint Noninvasive positive pressure ventilation in patients with perioperative negative pressure pulmonary edema
    Masayuki Furuichi
    Department of Anesthesiology, Nippon Medical School Hospital, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Anesth 24:464-8. 2010
    ..Favorable outcomes in these cases suggest that NPPV could be a feasible and safe alternative for treating NPPE if the patency of the airway is restored...
  20. ncbi request reprint Changes in neuropeptide Y gene expression in the spinal cord of chronic constrictive injury model rats after electroconvulsive stimulation
    Tadashi Okabe
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Biomed Res 31:287-92. 2010
    ....
  21. ncbi request reprint Atrial natriuretic peptide alleviates cardiovascular and metabolic disorders in a rat endotoxemia model: a possible role for its anti-inflammatory properties
    Masaki Mori
    Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:296-305. 2010
    ....
  22. ncbi request reprint The impact on renal function of fluid resuscitation with hemoglobin vesicle solution in moderate hemorrhagic shock
    Yuka Saito
    Department of Urology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    J Artif Organs 16:376-81. 2013
    ..In conclusion, HbV transfusion improved blood pressure in a manner equivalent to RBC transfusion when administered during hemorrhagic shock, and no renal dysfunction was apparent after 24 h. ..
  23. pmc Postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting or cardiac valve surgery: intraoperative use of landiolol
    Kazuhiro Nakanishi
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    J Cardiothorac Surg 8:19. 2013
    ..This study aimed to investigate whether intraoperative administration of landiolol could reduce the incidence of atrial fibrillation (AF) after cardiac surgery...
  24. ncbi request reprint Differential expression of rat hippocampal microRNAs in two rat models of chronic pain
    Yoko Hori
    Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Int J Mol Med 32:1287-92. 2013
    ..Further research is required to determine the correlation among miRNAs, messenger RNAs (mRNAs) and proteins. ..
  25. doi request reprint The miRNA and mRNA changes in rat hippocampi after chronic constriction injury
    Masae Arai
    Department of Anesthesiology and Pain Medicine, Graduate School of Nippon Medical School, Tokyo, Japan
    Pain Med 14:720-9. 2013
    ..We elaborated the rat hippocampi in order to assess for central nervous system changes following a peripheral neuropathic injury...
  26. pmc Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis
    Yoshiaki Tsuboko
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Drug Des Devel Ther 6:273-8. 2012
    ..In part, this is due to the wide variety of factors involved in the etiology of ALI/ARDS. In this study, we examined the efficacy of sivelestat in patients with ALI/ARDS associated with abdominal sepsis...
  27. pmc A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain
    Shigeru Toda
    Department of Pharmacology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Mol Pain 7:2. 2011
    ..In recent years, spinal glial cells, microglia and astrocytes, have been shown to play critical roles in neuropathic pain, but their participation in the analgesic effects of local anesthetics remains largely unknown...
  28. ncbi request reprint The reciprocal relationship between heme oxygenase and nitric oxide synthase in the organs of lipopolysaccharide-treated rodents
    Masayuki Furuichi
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Biomed Res 30:235-43. 2009
    ..These data suggest that the CO/HO system modifies the NO/NOS system in endotoxic organs, and that there were only minor organ-specific behaviors in terms of the relationship between these systems in the organs examined...
  29. ncbi request reprint Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction
    Kazuhiro Nakanishi
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Crit Care Med 34:1351-7. 2006
    ..To examine the association between decreased release of proinflammatory cytokines in response to urinary trypsin inhibitor pretreatment and decreased myocardial and lung injury after cardiopulmonary bypass...
  30. pmc Epigenetic suppression of mouse Per2 expression in the suprachiasmatic nucleus by the inhalational anesthetic, sevoflurane
    Keisuke Mori
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    PLoS ONE 9:e87319. 2014
    ..However, the molecular mechanisms underlying this suppression remain unclear. In this study, we examined the possibility that sevoflurane suppresses Per2 expression via epigenetic modification of the Per2 promoter...
  31. pmc Proton nuclear magnetic resonance and pattern recognition analysis of liver extracts from rats under different anesthetics
    Tomoyuki Tajima
    Department of Anesthesiology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    BMC Med Imaging 12:28. 2012
    ....
  32. doi request reprint Time-dependent repression of mPer2 expression in the suprachiasmatic nucleus by inhalation anesthesia with sevoflurane
    Kana Kadota
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Neurosci Lett 528:153-8. 2012
    ..Further investigation into the molecular events caused by anesthesia are required to explain atypical clinical signs observed in patients after surgical procedures, such as fatigue, sleep disorder, mood alteration and delirium...
  33. doi request reprint A subset of μ-opioid receptor-expressing cells in the rostral ventromedial medulla contribute to thermal hyperalgesia in experimental neuropathic pain
    Hiroshi Mase
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Neurosci Res 70:35-43. 2011
    ..These results suggest that a subset of RVM neurons expressing μ-opioid receptors contribute to the maintenance of thermal hyperalgesia in neuropathic pain...
  34. ncbi request reprint [Use of cardiovascular drugs for cardiac surgery--based on recent studies]
    Chol Kim
    Department of Anesthesiology, Nippon Medical School, Tokyo 113 8602
    Masui 58:272-8. 2009
    ..To maintain hypotension in a certain situation, prostaglandin E1 is better to use than nicardipine, diltiazem, and nitroglycerin. It is important to administer the drugs focusing on postoperative complications and outcome...
  35. ncbi request reprint The effects of dexmedetomidine on human neutrophil apoptosis
    Hiroaki Kishikawa
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Biomed Res 29:189-94. 2008
    ..The mechanisms of dexmedetomidine-induced apoptosis are associated with the caspase cascade and loss of MTP...
  36. doi request reprint Effect of administration of pre-warmed intravenous fluids on the frequency of hypothermia following spinal anesthesia for Cesarean delivery
    Kenji Yokoyama
    Department of Anesthesiology, Musashikosugi Hospital, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki, 211 8533 Japan
    J Clin Anesth 21:242-8. 2009
    ..To determine whether administration of pre-warmed colloid followed by pre-warmed crystalloid solution prevents the development of hypothermia in patients undergoing Cesarean delivery...
  37. doi request reprint The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain
    Chiyo Sato
    Department of Pharmacology, Nippon Medical School, Tokyo, Japan
    Anesth Analg 106:313-20, table of contents. 2008
    ..We also analyzed changes in the expression of nerve growth factor (NGF), which is involved in plasticity of the nociceptive circuit after nerve injury...
  38. ncbi request reprint Repair of an infrarenal abdominal aortic aneurysm is associated with persistent left ventricular diastolic dysfunction
    Hiroyasu Bitoh
    Department of Anesthesia and Pain Control, Graduate School of Medicine, Nippon Medical School, Japan
    J Nihon Med Sch 74:393-401. 2007
    ..The aim of this study was to elucidate perioperative changes in diastolic function using tissue Doppler imaging (TDI) in patients undergoing repair of an infrarenal abdominal aortic aneurysm (AAA)...
  39. ncbi request reprint Effects of atrial natriuretic peptide at a low dose on water and electrolyte metabolism during general anesthesia
    Mariko Koda
    Department of Anesthesiology, Nippon Medical School, Tokyo 113 8603, Japan
    J Clin Anesth 17:3-7. 2005
    ..To assess the hemodynamic, renal, and endocrine effects of small continuous doses of atrial natriuretic peptide (ANP) in patients anesthetized with sevoflurane for gastrectomy...
  40. doi request reprint Low-dose dexmedetomidine facilitates the carotid body response to low oxygen tension in vitro via α2-adrenergic receptor activation in rabbits
    Hidehiko Nakatani
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Eur J Anaesthesiol 29:570-6. 2012
    ..Some anaesthetics exert an inhibitory effect on the response of the carotid body to low oxygen tension. However, the effect of dexmedetomidine on the carotid body response has not been reported...
  41. ncbi request reprint Landiolol, an ultra-short-acting β₁-blocker, more effectively terminates atrial fibrillation than diltiazem after open heart surgery: prospective, multicenter, randomized, open-label study (JL-KNIGHT study)
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Circ J 76:1097-101. 2012
    ..The aim of the present study was to investigate whether landiolol was effective for both rate control and conversion to normal sinus rhythm (NSR)...
  42. ncbi request reprint Inflation of the distal cuff by saline reduces the incidence of malposition of the bronchial tube during lung separation in patients receiving nitrous oxide
    Manzo Suzuki
    Department of Anesthesiology, Second Hospital Nippon Medical School, Kanagawa, Japan
    J Cardiothorac Vasc Anesth 21:838-42. 2007
    ..A common problem during lung separation is malposition of the double-lumen tube (DLT). It was hypothesized that inflation of the distal cuff with saline instead of air may reduce the incidence of malposition of the endobronchial tube...
  43. ncbi request reprint Circadian gene expression is suppressed during sevoflurane anesthesia and the suppression persists after awakening
    Katsuya Kobayashi
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Brain Res 1185:1-7. 2007
    ..This suggests that sevoflurane anesthesia may have effects at the molecular level and that these effects are long lasting...
  44. ncbi request reprint Changes in the gene expression levels of microRNAs in the rat hippocampus by sevoflurane and propofol anesthesia
    Gentaro Goto
    Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo 113 8603, Japan
    Mol Med Rep 9:1715-22. 2014
    ..One miRNA was common between the two anesthesia groups, whereas 14 miRNAs were significantly differentially expressed. In conclusion, sevoflurane and propofol exerted different effects on miRNA expression in the rat hippocampus...
  45. doi request reprint The general anesthetic sevoflurane affects the expression of clock gene mPer2 accompanying the change of NAD+ level in the suprachiasmatic nucleus of mice
    Yumiko Ohe
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Sendagi 1 1 5, Bunkyo ku, Tokyo 113 8602, Japan
    Neurosci Lett 490:231-6. 2011
    ..Furthermore, the modification of mPer2 expression by the anesthesia is considered to affect various gene expressions...
  46. ncbi request reprint A case of cancer pain management by long-term intrathecal PCA
    Chiyo Sato
    Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:333-7. 2010
    ..There were no signs of motor paralysis, psychomimetic alteration, neurological dysfunction, or infection related to the intrathecal route during treatment. Intrathecal therapy is an effective treatment in terminally ill patients...
  47. ncbi request reprint Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats
    Shusuke Koda
    Department of Anesthesiology and Intensive Care, Nippon Medical School, Tokyo, Japan
    Biomed Res 26:241-7. 2005
    ..9+/- 4.0 sec vs. 4.7+/- 2.1 sec, P> 0.01). Our results suggest that administration of an appropriate dose of cannabinoid receptor agonist WIN 55,212-2 has an anticonvulsant effect but does not cause respiratory depression...
  48. ncbi request reprint Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy
    Manzo Suzuki
    Department of Anesthesiology, Second Hospital Nippon Medical School, Kanagawa, Japan
    Anesthesiology 105:111-9. 2006
    ..Ketamine potentiates intravenous or epidural morphine analgesia. The authors hypothesized that very-low-dose ketamine infusion reduces acute and long-term postthoracotomy pain...
  49. ncbi request reprint Repeated dexmedetomidine infusions, a postoperative living-donor liver transplantation patient
    Katsuyuki Terajima
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Anesth 20:234-6. 2006
    ..However, all of the measurements were within the therapeutic range for DEX. Thus, DEX infusion could be safely used in the postoperative LDLT patient by employing a simple consciousness scale...
  50. ncbi request reprint Free radicals in phacoemulsification and aspiration procedures
    Hiroshi Takahashi
    Department of Ophthalmology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Ophthalmol 120:1348-52. 2002
    ..To detect free radicals in phacoemulsification and aspiration procedures using electron-spin resonance and to observe the effect of ophthalmic viscosurgical devices (viscoelastic agents) on free radical intensity...
  51. ncbi request reprint Cardiac marker responses to coronary artery bypass graft surgery with cardiopulmonary bypass and aortic cross-clamping
    Shinhiro Takeda
    Department of Anesthesiology and Intensive Care Medicine, Nippon Medical School, Tokyo, Japan
    J Cardiothorac Vasc Anesth 16:421-5. 2002
    ..To study several markers of myocardial injury in relation to aortic cross-clamping and cardiopulmonary bypass (CPB) after coronary artery bypass graft (CABG) surgery...
  52. ncbi request reprint Effect of L-canavanine, an Inhibitor of inducible nitric oxide synthase, on myocardial dysfunction during septic shock
    Norihito Suzuki
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 69:13-8. 2002
    ..L-canavanine shows selective inhibition of inducible nitric oxide synthase unlike the vasopressor action of L-NAME in cytokine-treated hearts...
  53. ncbi request reprint Inhibition of inducible nitric oxide synthase attenuates interleukin-1 beta induced vascular hyporeactivity in the rabbit
    Toru Shimizu
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Nippon Med Sch 69:149-53. 2002
    ..These data suggest that the selective inhibition of iNOS attenuates the direct endothelial damage induced by IL-1 beta in vitro...
  54. ncbi request reprint Preoperative administration of methylprednisolone attenuates cytokine-induced respiratory failure after esophageal resection
    Shinhiro Takeda
    Division of Intensive Care Unit and Coronary Care Unit, Nippon Medical School Hospital and Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 70:16-20. 2003
    ..We conclude that preoperative administration of methylprednisolone may attenuate postoperative reduction of arterial oxygen saturation by suppressing the release of cytokines...
  55. ncbi request reprint [Present status of therapeutic angiogenesis by autologous bone marrow cell implantation for refractory chronic peripheral arterial disease and ischemic heart disease]
    Masaaki Miyamoto
    First Department of Internal Medicine, Nippon Medical School, Japan
    J Nippon Med Sch 70:436-41. 2003
  56. ncbi request reprint Alteration of free radical development by ophthalmic viscosurgical devices in phacoemulsification
    Hiroshi Takahashi
    Departments of Ophthalmology, Nippon Medical School, Tokyo, Japan
    J Cataract Refract Surg 32:1545-8. 2006
    ..To determine the effect of ophthalmic viscosurgical devices (OVDs) and irrigation/aspiration (I/A) settings on free radical development during phacoemulsification...
  57. ncbi request reprint Continuous infusion of dexmedetomidine improves renal ischemia-reperfusion injury in rat kidney
    Shinji Sugita
    Department of Anesthesiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 80:131-9. 2013
    ..Dexmedetomidine has shown beneficial effects in several inflammatory models, including ischemia-reperfusion injury (IRI). This study investigated whether the continuous infusion of dexmedetomidine could improve renal IRI in rats...
  58. ncbi request reprint Changes in microRNA expression in rat lungs caused by sevoflurane anesthesia: a TaqMan® low-density array study
    Shunsuke Tanaka
    Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Biomed Res 33:255-63. 2012
    ....
  59. ncbi request reprint Fluid resuscitation with hemoglobin vesicles in a rabbit model of acute hemorrhagic shock
    Katsuyuki Terajima
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Shock 25:184-9. 2006
    ..HbV solution offers the advantages of systemic oxygenation without impairing microcirculation in the treatment of hemorrhagic shock...
  60. ncbi request reprint [Anesthesia management for laparoscopic prostatectomy and open prostatectomy]
    Tadashi Okabe
    Department of Anesthesiology, Nippon Medical School, Tokyo 113 8603
    Masui 56:1404-7. 2007
    ..However, it has been considered that the amount of bleeding under laparoscopic prostatectomy is less than that of traditional open surgery...
  61. ncbi request reprint Propofol anaesthesia alters the cerebral proteome differently from sevoflurane anaesthesia
    Yoshiaki Tsuboko
    Department of Anaesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Biomed Res 32:55-65. 2011
    ..This study highlights the power of proteomic studies in assessing the effects of certain anaesthetics on the integrity of neuronal structure and function...
  62. ncbi request reprint Halothane modulates NMDA and non-NMDA excitatory synaptic transmission in rat cortical neurons
    Akira Kitamura
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 9603, Japan
    J Anesth 19:66-72. 2005
    ..We investigated and compared the effects of halothane on N-methyl-D-asparate (NMDA) and non-NMDA receptor-mediated postsynaptic currents...
  63. ncbi request reprint Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion
    Keiko Nakazato
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8602, Tokyo, Japan
    J Cancer Res Clin Oncol 133:741-7. 2007
    ..This study examines the loading volume required for preservation of renal function during anesthesia of NIPP...
  64. ncbi request reprint An epidural initial dose is unnecessary in combined spinal epidural anesthesia for Caesarean section
    Takashi Hongo
    Department of Anesthesiology, Nippon Medical School, Sendagi, Tokyo, Japan
    J Nippon Med Sch 73:70-4. 2006
    ..This finding suggests that an epidural initial dose is unnecessary for postoperative pain relief in combined spinal epidural anesthesia for Caesarean section...
  65. ncbi request reprint Does carboxy-hemoglobin serve as a stress-induced inflammatory marker reflecting surgical insults?
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Bunkyo ku, Tokyo 113 8603, Japan
    J Nippon Med Sch 72:19-28. 2005
    ....
  66. ncbi request reprint Differences in the leukocyte response to incision during upper abdominal surgery with epidural versus general anesthesia
    Chol Kim
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8603, Japan
    J Nippon Med Sch 73:4-9. 2006
    ..Thus, anesthesia modifies the early response of leukocytes to surgical stress. The link between the early leukocyte response to surgery and postoperative outcome is the next subject of investigation...
  67. pmc Pattern recognition analysis of proton nuclear magnetic resonance spectra of brain tissue extracts from rats anesthetized with propofol or isoflurane
    Hiroshi Kawaguchi
    Department of Anesthesiology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    PLoS ONE 5:e11172. 2010
    ....
  68. pmc Safety and efficacy of oral rehydration therapy until 2 h before surgery: a multicenter randomized controlled trial
    Kenji Itou
    Department of Anesthesiology, Tokai University School of Medicine, Tokai University Hospital, 143 Shimokasuya, Isehara, Kanagawa, 259 1193, Japan
    J Anesth 26:20-7. 2012
    ..In Japan, long preoperative fasting is still common practice. To shorten the preoperative fasting period in Japan, we tested the safety and efficacy of oral rehydration therapy until 2 h before surgery...
  69. ncbi request reprint Effect of bicarbonated Ringer's solution on the acid-base balance in patients undergoing abdominal aortic aneurysm repair
    Yoichi Shimada
    Department of Anesthesiology, Nippon Medical School Second Hospital, Kanagawa, Japan
    J Nippon Med Sch 72:364-9. 2005
    ..The present study was designed to assess whether prophylactic use of bicarbonated Ringer's solution ameliorates metabolic acidosis in patients undergoing aortic surgery...
  70. ncbi request reprint Unmasking of Brugada syndrome by an antiarrhythmic drug in a patient with septic shock
    Katsuyuki Terajima
    Division of Intensive Care and Coronary Care Unit, Nippon Medical School, Tokyo, Japan
    Anesth Analg 102:233-6. 2006
    ..This case report suggests that some drugs used in the treatment of septic shock can unmask the Brugada-type electrocardiogram pattern and induce lethal ventricular tachyarrhythmia...
  71. ncbi request reprint Increases in central retinal artery blood flow in humans following carotid artery and stellate ganglion irradiation with 0.6 to 1.6 microm irradiation
    Seiji Mii
    Department of Anesthesiology, Nippon Medical School
    J Nihon Med Sch 74:23-9. 2007
    ..031). These data suggest that LLLI to the SG or to the CCA is a useful therapy for increasing the retrobulbar blood flow, with irradiation directed to the CCA being more effective than that directed to the SG in clinical settings...
  72. doi request reprint A new curved laryngoscope blade for routine and difficult tracheal intubation
    Koji Nishikawa
    Department of Anesthesiology, Nippon Medical School Tama Nagayama Hospital, Nagayama 1 7 1, Tama shi, Tokyo 206 8512, Japan
    Anesth Analg 107:1248-52. 2008
    ..The new curved blade can also effectively move the U-shaped epiglottis out of the laryngeal view to facilitate intubation in pediatric patients aged 2 mo-13 yr...
  73. ncbi request reprint Systemic ATP infusion improves spontaneous pain and tactile allodynia, but not tactile hypesthesia, in patients with postherpetic neuralgia
    Michiru Moriyama
    Department of Anesthesia, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8603 Tokyo, Japan
    J Anesth 18:177-80. 2004
    ..Activation of purinoceptors may improve neuropathic pain. Accordingly, the effects of systemic ATP infusion were assessed in patients with postherpetic neuralgia (PHN)...
  74. ncbi request reprint Landiolol attenuates acute hemodynamic responses but does not reduce seizure duration during maintenance electroconvulsive therapy
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Psychiatry Clin Neurosci 58:630-5. 2004
    ..Landiolol did not affect seizure duration, recovery from anesthesia, or cognitive function before or after ECT. These results suggest that landiolol can be used effectively and safely during mECT...
  75. ncbi request reprint Successful thoracoscopic sympathectomy for primary erythromelalgia in the upper extremities
    Yuki Nakajima
    Department of Surgery II, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Jpn J Thorac Cardiovasc Surg 52:524-6. 2004
    ..We report two cases including a 57-year-old woman and a 64-year-old woman, showing the successful clinical outcome by bilateral thoracoscopic sympathectomy...
  76. ncbi request reprint A prostaglandin E2 receptor subtype EP4 agonist attenuates cardiovascular depression in endotoxin shock by inhibiting inflammatory cytokines and nitric oxide production
    Atsuhiro Sakamoto
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Shock 22:76-81. 2004
    ..Anti-inflammatory effects thus would be involved in protection by EP4 agonist against cardiovascular depression in endotoxin shock...
  77. ncbi request reprint Nicorandil decreases cardiac events during and after noncardiac surgery
    Satoshi Kashimoto
    Department of Anesthesiology, Faculty of Medicine, University of Yamanashi, Tamaho, Yamanashi 409 3898, and Department of Anesthesia, Cancer Institute Hospital, Tokyo, Japan
    J Clin Anesth 19:44-8. 2007
    ..To assess whether nicorandil reduces the likelihood of cardiac events during and after intermediate risk surgery...
  78. ncbi request reprint Are the incidences of cardiac events during noncardiac surgery in Japan the same as in the United States and Europe?
    Makoto Seki
    Department of Anesthesiology, Cancer Institute Hospital, Tosima Ku, Kamiikebukuro, 1 37 1, Tokyo, Japan
    Anesth Analg 100:1236-40, table of contents. 2005
    ..884, coronary risk index grade; odds ratio = 2.884, and a history of intervention; odds ratio = 4.774)...
  79. ncbi request reprint Effect of landiolol on nonsustained ventricular tachycardia during electroconvulsive therapy
    Chol Kim
    Anesth Analg 101:1247. 2005
  80. ncbi request reprint [Application of new vascular regenerative therapy using autologous bone marrow cells for intractable cardiovascular diseases]
    Masaaki Miyamoto
    Masui 52:S67-75. 2003
  81. ncbi request reprint Successful management of tachycardiac atrial fibrillation in a septic patient with landiolol
    Yuko Yoshida
    Anesth Analg 100:294. 2005
  82. ncbi request reprint Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation
    Shingi Akada
    Department of Anesthesiology and Intensive Care Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Respir Physiol Neurobiol 160:284-8. 2008
    ....
  83. ncbi request reprint Electroconvulsive therapy with thiamylal or propofol during pregnancy
    Kanako Iwasaki
    Can J Anaesth 49:324-5. 2002
  84. ncbi request reprint Predicting difficult intubation in apparently normal patients: a meta-analysis of bedside screening test performance
    Toshiya Shiga
    Department of Anesthesia, Nippon Medical School Chiba Hokusoh Hospital, Kamagari, Chiba, Japan
    Anesthesiology 103:429-37. 2005
    ..Combinations of tests add some incremental diagnostic value in comparison to the value of each test alone. The clinical value of bedside screening tests for predicting difficult intubation remains limited...