S Ohta

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. doi request reprint Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Nippon Medical School, Kawasaki City, Japan
    Biochim Biophys Acta 1820:586-94. 2012
  2. ncbi request reprint Contribution of somatic mutations in the mitochondrial genome to the development of cancer and tolerance against anticancer drugs
    S Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kosugi cho, Nakahara ku, Kawasaki City, Kanagawa Pref, Japan
    Oncogene 25:4768-76. 2006
  3. ncbi request reprint Mitochondrial ALDH2 deficiency as an oxidative stress
    Shigeo Ohta
    Institute of Development and Aging Sciences, Nippon Medical School, Kosugi, Kawasaki, Kanagawa, 211 8533 Japan
    Ann N Y Acad Sci 1011:36-44. 2004
  4. ncbi request reprint A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki City, Nakagawa pref, 211 8533 Japan
    Curr Med Chem 10:2485-94. 2003
  5. ncbi request reprint Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki City, Kanagawa Pref, 211 8533 Japan
    J Alzheimers Dis 9:155-66. 2006
  6. ncbi request reprint [Transfection of mitochondrial genes converted to universal codons into the nucleus]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 50:1901-3. 2005
  7. ncbi request reprint [Prospect for the technology manipulating mtDNA]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 50:1899-900. 2005
  8. ncbi request reprint [Mitochondrial tRNA diseases: defect of modification in anticodon in mutant tRNA molecules]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 48:493-500. 2003
  9. pmc Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Japan
    Curr Pharm Des 17:2241-52. 2011
  10. ncbi request reprint [Involvement of somatic mutations in mtDNA with aging, cancer and apoptosis]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 50:1765-9. 2005

Collaborators

Detail Information

Publications73

  1. doi request reprint Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Nippon Medical School, Kawasaki City, Japan
    Biochim Biophys Acta 1820:586-94. 2012
    ..We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [Ohsawa et al., Nat. Med. 13 (2007) 688-694]...
  2. ncbi request reprint Contribution of somatic mutations in the mitochondrial genome to the development of cancer and tolerance against anticancer drugs
    S Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kosugi cho, Nakahara ku, Kawasaki City, Kanagawa Pref, Japan
    Oncogene 25:4768-76. 2006
    ..Finally, we discuss the role of mutant mtDNA in conferring tolerance against anticancer drugs...
  3. ncbi request reprint Mitochondrial ALDH2 deficiency as an oxidative stress
    Shigeo Ohta
    Institute of Development and Aging Sciences, Nippon Medical School, Kosugi, Kawasaki, Kanagawa, 211 8533 Japan
    Ann N Y Acad Sci 1011:36-44. 2004
    ..Mitochondrial ALDH2 functions as a protector against oxidative stress...
  4. ncbi request reprint A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki City, Nakagawa pref, 211 8533 Japan
    Curr Med Chem 10:2485-94. 2003
    ..The mitochondrion plays a significant role in necrosis and is a center for apoptosis, determining its initiation, regulation and execution. Thus, the mitochondrion is widely involved in cell proliferation, cell death and disease...
  5. ncbi request reprint Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki City, Kanagawa Pref, 211 8533 Japan
    J Alzheimers Dis 9:155-66. 2006
    ....
  6. ncbi request reprint [Transfection of mitochondrial genes converted to universal codons into the nucleus]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 50:1901-3. 2005
  7. ncbi request reprint [Prospect for the technology manipulating mtDNA]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 50:1899-900. 2005
  8. ncbi request reprint [Mitochondrial tRNA diseases: defect of modification in anticodon in mutant tRNA molecules]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 48:493-500. 2003
  9. pmc Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Japan
    Curr Pharm Des 17:2241-52. 2011
    ..H(2) regulates various gene expressions and protein-phosphorylations, though the molecular mechanisms underlying the marked effects of very small amounts of H(2) remain elusive...
  10. ncbi request reprint [Involvement of somatic mutations in mtDNA with aging, cancer and apoptosis]
    Shigeo Ohta
    Tanpakushitsu Kakusan Koso 50:1765-9. 2005
  11. pmc Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide
    Teruyasu Hanaoka
    Department of Orthopedic Surgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyou ku, Tokyo, 113 8602, Japan
    Med Gas Res 1:18. 2011
    ..abstract:..
  12. pmc The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi machi, Nakahara ku, Kawasaki City, Kanagawa 211 8533, Japan
    Med Gas Res 1:10. 2011
    ..Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects...
  13. ncbi request reprint Inhibitory effects of suplatast tosilate on the differentiation and function of monocyte-derived dendritic cells from patients with asthma
    A Tanaka
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Allergy 37:1083-9. 2007
    ..Dendritic cells (DCs) are antigen-presenting cells that efficiently activate T cells...
  14. ncbi request reprint Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma
    S Ohta
    Department of Internal Medicine, Division of Allergy and Respiratory Medicine, School of Medicine, Showa University, Tokyo, Japan
    Clin Exp Allergy 40:1266-75. 2010
    ..Tiotropium bromide, a long acting muscarinic receptor inhibitor, is a potent agent for patients with bronchial asthma as well as chronic obstructive pulmonary disease...
  15. ncbi request reprint Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, 1 396 Kosugi cho, Nahakara ku, Kawasaki 211 8533, Japan
    J Neurochem 84:1110-7. 2003
    ..Thus, these findings suggest that mitochondrial ALDH2 functions as a protector against oxidative stress...
  16. doi request reprint Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress
    Alexander M Wolf
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, Nakahara ku, Kawasaki, Kanagawa, Japan
    J Nutr Biochem 21:381-9. 2010
    ..Taken together, these results suggest that AX is effective in improving mitochondrial function through retaining mitochondria in the reduced state...
  17. ncbi request reprint [Molecular mechanism of apoptosis]
    S Ohta
    Department of Biochemistry and Cell Biology, Nippon Medical School, Kanagawa
    No To Hattatsu 31:122-8. 1999
    ..The resulting activated caspase-9 cleaves pro-caspase-3 into an activated form, which is responsible for the later process of apoptosis...
  18. ncbi request reprint Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae
    Y Suzuki
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Neurology 63:1711-3. 2004
    ..Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele...
  19. doi request reprint Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice
    Sanae Nakajima
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Kanagawa 211 8533, Japan
    Behav Brain Res 211:178-84. 2010
    ..This exercise-induced improvement was attributed to exercise-induced enhancement of IGF-1 protein and GST activity in the brain...
  20. ncbi request reprint MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction
    Naomi Nakashima-Kamimura
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Kawasaki, Kanagawa 211 8533, Japan
    J Cell Sci 118:5357-67. 2005
    ..Thus, MIDAS is involved in the regulation of mitochondrial lipids, leading to increases of total mitochondrial mass in response to mitochondrial dysfunction...
  21. ncbi request reprint [Gene therapy and protein therapy for mitochondrial diseases]
    Sadamitsu Asoh
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School
    Nihon Rinsho 60:674-8. 2002
  22. ncbi request reprint PTD-mediated delivery of anti-cell death proteins/peptides and therapeutic enzymes
    Sadamitsu Asoh
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396, Kosugi cho, Nakahara ku, Kawasaki City, Kanagawa 211 8533, Japan
    Adv Drug Deliv Rev 60:499-516. 2008
    ....
  23. ncbi request reprint Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of mice [correction of rats] exposed to stress by induction of heat shock protein 70
    Toshio Mikami
    Department of Health and Sports Science, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    J Appl Physiol (1985) 96:1776-81. 2004
    ..These results suggest that exercise training enhanced the resting level of liver HSP70 and hepatic protection against various stresses, at least partly attributing to the suppression of caspase-3 activity by the increase in HSP70...
  24. ncbi request reprint Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus
    Yoshihiko Suzuki
    Saiseikai Central Hospital, 1 4 17 Mita, Minato ku, Tokyo, Japan
    Diabetes Res Clin Pract 60:139-41. 2003
  25. ncbi request reprint Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 211 8533, Japan
    J Neurosci 28:6239-49. 2008
    ....
  26. ncbi request reprint [The origin of mitochondria]
    Shigeo Ohta
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School
    Nihon Rinsho 60:799-804. 2002
  27. pmc Characterisation of a vindesine-resistant human small-cell lung cancer cell line
    S Ohta
    Pharmacology Division of National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 68:74-9. 1993
    ..In H69/VDS cells, however, verapamil increased the amount of total tubulin to the level of parental cells, but decreased the amount of polymerised tubulin. Modulation of tubulin may play a role in the resistance to vindesine...
  28. ncbi request reprint Defect in modification at the anticodon wobble nucleotide of mitochondrial tRNA(Lys) with the MERRF encephalomyopathy pathogenic mutation
    T Yasukawa
    Department of Chemistry, Graduate School of Engineering, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    FEBS Lett 467:175-8. 2000
    ..We therefore suggest the defect in the anticodon is responsible, through the translational process, for the pathogenesis of mitochondrial diseases...
  29. pmc Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain
    Takashi Kanamori
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 8533, Japan
    EMBO J 22:2913-23. 2003
    ..Thus, the DLST gene is bifunctional and MIRTD transcribed from the gene contributes to the biogenesis of the mitochondrial respiratory complexes...
  30. doi request reprint Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice
    Kazufumi Nagata
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Nakahara ku, Kawasaki, Japan
    Neuropsychopharmacology 34:501-8. 2009
    ..Hydrogen water may be applicable for preventive use in cognitive or other neuronal disorders...
  31. ncbi request reprint Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese
    Yoshihiko Suzuki
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa 211 8533, Japan
    J Hum Genet 51:31-7. 2006
    ....
  32. ncbi request reprint Various morphologies of mitochondria
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    J Nippon Med Sch 72:136. 2005
  33. doi request reprint Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity
    A Kashio
    Faculty of Medicine, Department of Otolaryngology and Head and Neck Surgery, The University of Tokyo, Tokyo, Japan
    Gene Ther 19:1141-9. 2012
    ..These findings indicate that TAT-FNK topically applied on the RWM can enter the cochlea by diffusion and effectively prevent AG-induced apoptosis of cochlear HCs by suppressing the mitochondrial caspase-9 pathway...
  34. ncbi request reprint Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester
    N Mito
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Eur J Clin Nutr 61:83-90. 2007
    ..To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy...
  35. ncbi request reprint Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients with allergic asthma
    K T R Samson
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Allergy 36:475-82. 2006
    ..Statins have anti-inflammatory effects on immune cells...
  36. ncbi request reprint Zonal necrosis prevented by transduction of the artificial anti-death FNK protein
    S Asoh
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki City, Kanagawa, Japan
    Cell Death Differ 12:384-94. 2005
    ..These results suggest that PTD-FNK has great potential for clinical applications to prevent cell death, whether from apoptosis or necrosis, and organ failure...
  37. ncbi request reprint Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki 211 8533, Japan
    J Hum Genet 48:404-9. 2003
    ..Thus, these findings suggest that ALDH2 functions as a protector against oxidative stress and the decrease in protection may influence the onset of AD, hypertension, and myocardial infarction...
  38. ncbi request reprint Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde
    Yayoi Murakami
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki City, Kanagawa pref 211 8533, Japan
    Neurobiol Aging 30:325-9. 2009
    ..These results propose an additional role of ABAD in neural cell death in AD: ABAD detoxifies aldehydes, such as 4-HNE derived from lipid peroxides in healthy brains, and inhibited by A beta in the development of AD...
  39. doi request reprint Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury
    Hideaki Oharazawa
    Department of Ophthalmology, Musashikosugi Hospital, Nippon Medical School, Kanagawa, Japan
    Invest Ophthalmol Vis Sci 51:487-92. 2010
    ..This study was conducted to explore the neuroprotective effect of H(2)-loaded eye drops on retinal I/R injury...
  40. ncbi request reprint Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress
    Kei ichi Fukuda
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa 211 8533, Japan
    Biochem Biophys Res Commun 361:670-4. 2007
    ..In contrast, helium gas showed no protective effect, suggesting that the protective effect by hydrogen gas is specific. Thus, we propose that inhalation of hydrogen gas is a widely applicable method to reduce oxidative stress...
  41. ncbi request reprint Green fluorescent protein causes mitochondria to aggregate in the presence of the Bcl-2 family proteins
    Toshiyuki Aokage
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, 211 8533, Kawasaki, Japan
    Biochem Biophys Res Commun 314:711-6. 2004
    ..GFP but not EGFP seemed to promote cell death induced by pro-apoptotic Bax. Thus, GFP specifically promotes the aggregation of mitochondria when co-expressed with a member of the Bcl-2 family in association with apoptosis...
  42. doi request reprint Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 8533, Japan
    Biochem Biophys Res Commun 377:1195-8. 2008
    ..The oxidative stress level of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H(2)-dissolved water has the potential to prevent arteriosclerosis...
  43. doi request reprint Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs
    Satoshi Mizutani
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate of School of Medicine, Nippon Medical School, Kawasaki, Japan
    Cancer Sci 100:1680-7. 2009
    ..Thus, we propose that mutations in the mitochondrial genome are potential targets for prognosis in the administration of anticancer drugs to cancer patients...
  44. ncbi request reprint Imaging mitochondrial redox environment and oxidative stress using a redox-sensitive fluorescent protein
    Alexander M Wolf
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Japan
    J Nippon Med Sch 75:66-7. 2008
    ..The fluorescence ratio indicates reduction/oxidation, i.e., the redox potential at specific cellular locations...
  45. ncbi request reprint [Assay of biochemical activity (respiratory complex activity, pyruvate dehydrogenase complex activity etc)for diagnosis of mitochondrial diseases]
    Takashi Kanamori
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School
    Nihon Rinsho 60:256-60. 2002
  46. ncbi request reprint [Protein transduction and protection of cells against apoptosis]
    Sadamitsu Asoh
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kanagawa, Japan
    Seikagaku 76:654-8. 2004
  47. ncbi request reprint Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
    Ikuroh Ohsawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki City 211 8533, Japan
    Nat Med 13:688-94. 2007
    ..Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage...
  48. ncbi request reprint The anti-cell death FNK protein protects cells from death induced by freezing and thawing
    Kentaro Sudo
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa 211 8533, Japan
    Biochem Biophys Res Commun 330:850-6. 2005
    ..Thus, PTD-FNK prevented cell death induced by freezing and thawing, suggesting that it provides for the successful cryopreservation of biological materials...
  49. ncbi request reprint Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture
    Daiya Ozaki
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa 211 8533, Japan
    Biochem Biophys Res Commun 313:522-7. 2004
    ..Thus, the PTD peptide has the ability to deliver passenger proteins into chondrocytes by penetrating the extracellular matrix of cartilage...
  50. pmc Transduction of anti-cell death protein FNK suppresses graft degeneration after autologous cylindrical osteochondral transplantation
    Noriki Nakachi
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki City, Kanagawa pref 211 8533, Japan
    J Histochem Cytochem 57:197-206. 2009
    ....
  51. ncbi request reprint Aggregation of mitochondria
    Toshiyuki Aokage
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
    J Nippon Med Sch 72:72-3. 2005
  52. doi request reprint Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice
    Naomi Nakashima-Kamimura
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Cancer Chemother Pharmacol 64:753-61. 2009
    ..We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by reducing oxidative stress...
  53. ncbi request reprint Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion
    Masayuki Arakawa
    Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki shi, Kanagawa, 211 8533, Japan
    Life Sci 80:2076-84. 2007
    ..These findings suggest that PTD-FNK reduces the volume of myocardial infarction with corresponding functional recovery, at least in part, through the suppression of myocardial apoptosis following ischemia/reperfusion...
  54. ncbi request reprint Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory
    Sanae Nakajima
    Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Kanagawa 211 8533, Japan
    Behav Brain Res 200:15-21. 2009
    ..These finding suggests that GliSODin prevents stress-induced impairment of cognitive function and maintains neurogenesis in the hippocampus through antioxidant activity...
  55. doi request reprint Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata cho, Okayama, Japan
    J Neurosci Res 86:3028-37. 2008
    ..Our results indicate that intrathecal protein therapy using a TAT-fused protein is an effective clinical tool for the treatment of ALS...
  56. ncbi request reprint Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis
    Yujiro Shidara
    Department of Pathology, Tokyo Women s Medical University, School of Medicine, Tokyo, Japan
    Cancer Res 65:1655-63. 2005
    ..Because apoptosis occurred less frequently in the mutant versus wild-type cybrids in cultures and tumors, the pathogenic mtDNA mutations seem to promote tumors by preventing apoptosis...
  57. ncbi request reprint Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Alcohol Alcohol 39:25-8. 2004
    ..The aims of the present study were to determine the prevalence of the -81A/G and -128G/T polymorphism of the CCK-AR gene between alcoholics and normal control subjects and the occurrences of the polymorphisms in subtypes of alcoholics...
  58. ncbi request reprint Mitochondrial tRNA(Leu(UUR)) mutation at position 3243 and symptomatic polyneuropathy in type 2 diabetes
    Yoshihiko Suzuki
    Diabetes Care 26:1315-6. 2003
  59. ncbi request reprint Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Pancreas 30:95-8. 2005
    ..Possible associations between pancreatic cancer and ALDH2 gene polymorphism, in conjunction with smoking and/or drinking habits, were examined in a Japanese population...
  60. ncbi request reprint [Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations]
    Takehiro Yasukawa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
    Nihon Rinsho 60:197-201. 2002
  61. ncbi request reprint ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes
    Yoshihiko Suzuki
    Saiseikai Central Hospital, Tokyo, Japan
    Alcohol Clin Exp Res 28:111S-116S. 2004
    ....
  62. ncbi request reprint Multiple cranial mononeuropathies with acetylcholine receptor antibody in mitochondrial diabetes
    Yoshihiko Suzuki
    Diabetes Care 26:1318. 2003
  63. ncbi request reprint Influence of alcohol intake and aldehyde dehydrogenase 2 phenotype on peripheral neuropathy of diabetes
    Yoshihiko Suzuki
    Diabetes Care 26:249. 2003
  64. ncbi request reprint Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, and Institute of Applied Biochemistry, Mitake, Gifu 505 0116, Japan
    J Mol Med (Berl) 80:452-60. 2002
    ..These results suggest that the estrogen receptor alpha gene is a susceptibility locus for bone mass, especially for the femoral neck, in elderly Japanese women...
  65. pmc Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease
    Yohei Kirino
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Proc Natl Acad Sci U S A 101:15070-5. 2004
    ..We thus concluded that the UUG codon-specific translational defect of the mutant mt tRNAs(Leu(UUR)) is the primary cause of MELAS at the molecular level. This result could explain the complex I deficiency observed clinically in MELAS...
  66. pmc FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets
    Naonobu Nishino
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 118:2808-21. 2008
    ..In addition, we found that the nature of lipid accumulation in WAT appears to be associated with maintenance of energy balance and insulin sensitivity...
  67. ncbi request reprint Multiple tumors in mitochondrial diabetes associated with tRNALeu(UUR) mutation at position 3264
    Yoshihiko Suzuki
    Diabetes Care 26:1942-3. 2003
  68. ncbi request reprint Hepatic failure and enhanced oxidative stress in mitochondrial diabetes
    Yutaka Takahashi
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Endocr J 55:509-14. 2008
    ..The presence of steatosis and enhanced oxidative stress in the liver suggested that hepatic failure was associated with mitochondrial dysfunction...
  69. ncbi request reprint A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo
    Akinori Kashio
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan
    J Neurosci Res 85:1403-12. 2007
    ..These findings indicate that systemically administered TAT-FNK was successfully delivered to the guinea pig cochlea and effectively prevented apoptotic cell death of the cochlear HCs induced by KM and EA...
  70. ncbi request reprint Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2
    Yayoi Murakami
    Department of Biochemistry, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Tokyo 105 8512, Japan
    J Biochem 141:401-10. 2007
    ..Thus, our results suggest that protective effects of Bcl-x(L) and Bcl-2 against brefeldin A-induced cell death appear to be dependent on the regulation of JNK activation...
  71. ncbi request reprint Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients
    Takashi Nomiyama
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1011:193-204. 2004
    ..In conclusion, diabetes accelerates the accumulation of the somatic A3243G mutation in mitochondrial DNA, and this somatic mutation may be a marker for the duration of diabetes and atherosclerosis...
  72. pmc Mitochondrial genome variation in eastern Asia and the peopling of Japan
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Genome Res 14:1832-50. 2004
    ..All the theories that have been proposed up to now to explain the peopling of Japan seem insufficient to accommodate fully this complex picture...
  73. ncbi request reprint Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases
    Takehiro Yasukawa
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Japan
    FEBS Lett 579:2948-52. 2005
    ..These findings demonstrate the generality of the wobble modification deficiency in mutant tRNAs in MELAS and MERRF...