Kimihiro Ohkubo

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. ncbi request reprint [Development of patient satisfaction questionnaire in allergic rhinitis]
    Minoru Okuda
    Japan Allergy Asthma Clinic
    Arerugi 53:1195-202. 2004
  2. ncbi request reprint [Significance and methods of allergen immunotherapy for pollinosis]
    Kimihiro Ohkubo
    Department of Otorhynolaryngology, Nippon Medical School
    Arerugi 57:73-8. 2008
  3. ncbi request reprint Mechanisms of IL-6, IL-8, and GM-CSF release in nasal secretions of allergic patients after nasal challenge
    K Ohkubo
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Rhinology 36:156-61. 1998
  4. ncbi request reprint Therapeutic effect of montelukast, a cysteinyl leukotriene receptor 1 antagonist, on Japanese patients with seasonal allergic rhinitis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School Hospital, Tokyo
    Allergol Int 57:247-55. 2008
  5. ncbi request reprint A randomized double-blind comparative study of sublingual immunotherapy for cedar pollinosis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 57:265-75. 2008
  6. ncbi request reprint Anti-IgE antibody therapy for Japanese cedar pollinosis: omalizumab update
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 57:205-9. 2008
  7. doi request reprint A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School Hospital, Tokyo, Japan
    Allergol Int 57:383-90. 2008
  8. ncbi request reprint Dose-ranging study of fluticasone furoate nasal spray for Japanese patients with perennial allergic rhinitis*
    K Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Curr Med Res Opin 24:3393-403. 2008
  9. doi request reprint Comparison of fluticasone furoate and fluticasone propionate for the treatment of Japanese cedar pollinosis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, 1 1 5 Sendagi Bunko yu, Tokyo 113 8603, Japan
    Allergy Asthma Proc 30:84-94. 2009
  10. doi request reprint Sublingual immunotherapy for Japanese cedar pollinosis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 58:149-54. 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint [Development of patient satisfaction questionnaire in allergic rhinitis]
    Minoru Okuda
    Japan Allergy Asthma Clinic
    Arerugi 53:1195-202. 2004
    ..Thus, it was verified that our newly developed questionnaire is a useful and scientific tool for examination of patient satisfaction with medical care in allergic rhinitis...
  2. ncbi request reprint [Significance and methods of allergen immunotherapy for pollinosis]
    Kimihiro Ohkubo
    Department of Otorhynolaryngology, Nippon Medical School
    Arerugi 57:73-8. 2008
  3. ncbi request reprint Mechanisms of IL-6, IL-8, and GM-CSF release in nasal secretions of allergic patients after nasal challenge
    K Ohkubo
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Rhinology 36:156-61. 1998
    ..These results suggest that the levels, sources, and mechanisms of release of IL-6, IL-8, and GM-CSF in the nasal secretion of patients with HDMAR do vary, but are important in the manifestation of the allergic reaction...
  4. ncbi request reprint Therapeutic effect of montelukast, a cysteinyl leukotriene receptor 1 antagonist, on Japanese patients with seasonal allergic rhinitis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School Hospital, Tokyo
    Allergol Int 57:247-55. 2008
    ..These results indicate that leukotrienes play an important role in the pathogenesis of allergic rhinitis...
  5. ncbi request reprint A randomized double-blind comparative study of sublingual immunotherapy for cedar pollinosis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 57:265-75. 2008
    ..We investigated the safety and efficacy of SLIT in the treatment of cedar pollinosis patients compared to placebo...
  6. ncbi request reprint Anti-IgE antibody therapy for Japanese cedar pollinosis: omalizumab update
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 57:205-9. 2008
    ..And the methods of increasing effects by combining omalizumab with antibody-specific immunotherapy are being considered. These strategy is more effective than immune-therapy alone...
  7. doi request reprint A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School Hospital, Tokyo, Japan
    Allergol Int 57:383-90. 2008
    ....
  8. ncbi request reprint Dose-ranging study of fluticasone furoate nasal spray for Japanese patients with perennial allergic rhinitis*
    K Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Curr Med Res Opin 24:3393-403. 2008
    ....
  9. doi request reprint Comparison of fluticasone furoate and fluticasone propionate for the treatment of Japanese cedar pollinosis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, 1 1 5 Sendagi Bunko yu, Tokyo 113 8603, Japan
    Allergy Asthma Proc 30:84-94. 2009
    ..FFNS was well tolerated. Treatment with once-daily FFNS was effective and noninferior to twice-daily FPNS in reducing nasal symptoms. Faster onset of action for FFNS was observed...
  10. doi request reprint Sublingual immunotherapy for Japanese cedar pollinosis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 58:149-54. 2009
    ..Moreover, the development of a special SLIT and the import of an overseas product are needed in Japan...
  11. doi request reprint Levocabastine nasal spray significantly improves perennial allergic rhinitis: a single-blind placebo-controlled study
    Kimihiro Okubo
    Department of Otolaryngology, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 37:436-42. 2010
    ..The efficacy of levocabastine nasal spray for relieving the symptoms of perennial allergic rhinitis was compared with placebo in a single-blind study...
  12. ncbi request reprint Olopatadine hydrochloride in children: efficacy and safety for perennial allergic rhinitis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Curr Med Res Opin 26:1657-65. 2010
    ....
  13. ncbi request reprint Omalizumab is effective and safe in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitis
    Kimihiro Okubo
    The Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 55:379-86. 2006
    ..We investigated the safety and efficacy of omalizumab in the treatment of patients with Japanese cedar pollen-induced SAR compared to placebo...
  14. ncbi request reprint Inhibition of the antigen provoked nasal reaction by second-generation antihistamines in patients with Japanese cedar pollinosis
    Kimihiro Okubo
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Allergol Int 55:261-9. 2006
    ..The purpose of this study was to compare the protective efficacy of epinastine hydrochloride or fexofenadine hydrochloride using a nasal provocation test with Japanese cedar pollen allergen...
  15. ncbi request reprint Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season
    Kimihiro Okubo
    Nippon Medical School, Tokyo, Japan
    Int Arch Allergy Immunol 136:148-54. 2005
    ....
  16. ncbi request reprint Clinical impact of a combined therapy of peritoneal dialysis and hemodialysis
    N Matsuo
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Nephrol 74:209-16. 2010
    ..The aim of this study was to evaluate the clinical efficacy of this combined therapy...
  17. ncbi request reprint [Is the frequency of pre-seasonal manifestation in patients with Japanese cedar pollinosis so high?]
    Minoru Okuda
    Japan Allergy and Asthma Clinic
    Arerugi 54:636-40. 2005
    ..Since this is not objectively evidenced, we aimed to clarify whether or not it is true...
  18. ncbi request reprint [Nasal symptoms in persons with normal nose]
    Minoru Okuda
    Japan Allergy and Asthma Clinic, Nippon Medical School
    Arerugi 54:551-4. 2005
    ..It is necessary to define what is the symptom of normal nose in order to make a proper diagnosis of rhinitis, grading of severity of nasal symptom in rhinitis and criteria of normalization after the treatment of rhinitis...
  19. ncbi request reprint [Natural airborne pollen contamination of clothes and facial skin]
    Minoru Okuda
    Japan Allergy and Asthma Clinic, Nippon Medical School
    Arerugi 54:555-8. 2005
    ..To clarify natural airborne Japanese cedar pollen contamination of clothes (cotton made T shirt and cap) and face skin for preventive strategy against pollinosis...
  20. ncbi request reprint [Are otolaryngologists specialist for pollinosis?]
    Minoru Okuda
    Japan Allergy Asthma Clinic
    Arerugi 53:1144-51. 2004
    ..In conclusion, patients prefer agreeable and convenient treatment. If ENT doctors still want to be specialist for pollinosis, they should take care patients well and develop their own specific treatment methodology to cure this disease...
  21. ncbi request reprint [Treatment of Japanese cedar pollinosis and its impact on patient satisfaction]
    Minoru Okuda
    Japan Allergy Asthma Clinic
    Arerugi 53:596-600. 2004
    ..Immunotherapy was also used in 90 patients treated. As a result, 97% of patients was satisfied in this treatment and immunotherapy contributed to reduction in the amount of drug and high treatment outcome...
  22. ncbi request reprint [Clinical validity of our new patient satisfaction questionnaire for allergic rhinitis]
    Minoru Okuda
    Japan Allergy and Asthma Clinic, Nippon Medical School
    Arerugi 54:12-7. 2005
    ..A persistent contact with patients in immunotherapy plays an important role in establishing good doctor-patient relation and treatment outcome, resulting in increased patient satisfaction...