Kiyoyuki Ogata

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. doi request reprint Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Leuk Res 36:1229-36. 2012
  2. ncbi request reprint Thrombopoietin and myelodysplastic syndromes
    K Ogata
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Int J Hematol 72:173-7. 2000
  3. pmc Diagnostic utility of flow cytometry in low-grade myelodysplastic syndromes: a prospective validation study
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Haematologica 94:1066-74. 2009
  4. doi request reprint Diagnostic flow cytometry for low-grade myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Hematol Oncol 26:193-8. 2008
  5. ncbi request reprint Myelodysplastic syndromes: recent progress in diagnosis and understanding of their pathophysiology
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 73:300-7. 2006
  6. ncbi request reprint Diagnostic application of flow cytometric characteristics of CD34+ cells in low-grade myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8603, Japan
    Blood 108:1037-44. 2006
  7. ncbi request reprint Clinical implications of blast immunophenotypes in myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Leuk Lymphoma 46:1269-74. 2005
  8. ncbi request reprint Identification and hematopoietic potential of CD45- clonal cells with very immature phenotype (CD45-CD34-CD38-Lin-) in patients with myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Stem Cells 23:619-30. 2005
  9. ncbi request reprint Association between phenotypic features of blasts and the blast percentage in bone marrow of patients with myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Leuk Res 28:1171-5. 2004
  10. ncbi request reprint [Myelodysplastic syndromes (preleukemic states)]
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School
    J Nippon Med Sch 70:2-3. 2003

Collaborators

Detail Information

Publications39

  1. doi request reprint Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Leuk Res 36:1229-36. 2012
    ..Logistic regression analyses showed that, in addition to myeloblast percentages, the expression of CD7 and B7-H1 on myeloblasts was independently associated with AL-MDS patients...
  2. ncbi request reprint Thrombopoietin and myelodysplastic syndromes
    K Ogata
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Int J Hematol 72:173-7. 2000
    ..These findings may be of use when designing a clinical trial of TPO for MDS...
  3. pmc Diagnostic utility of flow cytometry in low-grade myelodysplastic syndromes: a prospective validation study
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Haematologica 94:1066-74. 2009
    ..The diagnosis of myelodysplastic syndromes is not always straightforward when patients lack specific diagnostic markers, such as blast excess, karyotype abnormality, and ringed sideroblasts...
  4. doi request reprint Diagnostic flow cytometry for low-grade myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Hematol Oncol 26:193-8. 2008
    ..CD34+ cell-related parameters that are applicable for diagnosing low-grade MDS in many laboratories are introduced here...
  5. ncbi request reprint Myelodysplastic syndromes: recent progress in diagnosis and understanding of their pathophysiology
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 73:300-7. 2006
    ..This review touches on some recent developments in the diagnosis and pathophysiology of MDS...
  6. ncbi request reprint Diagnostic application of flow cytometric characteristics of CD34+ cells in low-grade myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8603, Japan
    Blood 108:1037-44. 2006
    ..Among LGw/oRS patients with chromosomal aberrations, patients with trisomy 8 or del20(q) had low FCM scores (P = .002). As a result, most LGw/oRS patients were identified based on high FCM score, chromosomal aberration, or both...
  7. ncbi request reprint Clinical implications of blast immunophenotypes in myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Leuk Lymphoma 46:1269-74. 2005
    ..Further studies of blast immunophenotypes will deepen our understanding of MDS and hopefully improve the clinical approach to these intractable disorders...
  8. ncbi request reprint Identification and hematopoietic potential of CD45- clonal cells with very immature phenotype (CD45-CD34-CD38-Lin-) in patients with myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Stem Cells 23:619-30. 2005
    ..This newly identified cell population represents the most immature immunophenotype so far identified in the hematopoietic lineage and is involved in the malignant clone in MDS...
  9. ncbi request reprint Association between phenotypic features of blasts and the blast percentage in bone marrow of patients with myelodysplastic syndromes
    Kiyoyuki Ogata
    Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Leuk Res 28:1171-5. 2004
    ..The BM blast percentages where the blast immunophenotype changed were 5, 10, 20 and 25%. Blast immunophenotypes have the potential to provide a biological basis for and refine the present MDS classifications...
  10. ncbi request reprint [Myelodysplastic syndromes (preleukemic states)]
    Kiyoyuki Ogata
    Division of Hematology, Department of Medicine, Nippon Medical School
    J Nippon Med Sch 70:2-3. 2003
  11. ncbi request reprint Reappraisal of the clinical significance of CD7 expression in association with cytogenetics in de novo acute myeloid leukaemia
    K Ogata
    Division of Haematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Br J Haematol 115:612-5. 2001
    ..0001). CD7-positivity adversely affected the survival only in the cases with unfavourable cytogenetics (P < 0.03). We recommend that CD7 expression in AML be interpreted in association with the cytogenetics...
  12. pmc Association between natural killer cell activity and infection in immunologically normal elderly people
    K Ogata
    Division of Haematology, Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Clin Exp Immunol 124:392-7. 2001
    ..Our data indicate that low NK cell activity is associated with development of infections and death due to infection in immunologically normal elderly subjects with an impaired PS...
  13. ncbi request reprint Clinical significance of phenotypic features of blasts in patients with myelodysplastic syndrome
    Kiyoyuki Ogata
    Division of Hematology, Nippon Medical School, Kyoto, Japan
    Blood 100:3887-96. 2002
    ..Further, CD7 positivity of EBCs was an independent variable for a poor prognosis in MDS. These data represent new, valuable information regarding MDS...
  14. ncbi request reprint A simple centrifugation method for harvesting myeloblasts
    K Ogata
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Int J Hematol 74:272-6. 2001
    ..0% before separation, 56.6% +/- 28.3% after separation) (n = 22). The enriched blasts were suitable for various analyses, eg, flow cytometry, immunocytochemistry, cytochemistry, fluorescence in situ hybridization, and gene analysis...
  15. pmc Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes
    Asaka Kondo
    Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Blood 116:1124-31. 2010
    ..B7-H1(+) MDS blasts have an intrinsic proliferative advantage and induce T-cell suppression, which may be associated with disease progression in MDS...
  16. ncbi request reprint Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia
    Hideto Tamura
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Clin Cancer Res 11:5708-17. 2005
    ..The aim of this study was to examine whether leukemic cells of acute myeloid leukemia express functional B7 family molecules and, if so, whether such expression has any clinical significance...
  17. doi request reprint Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage
    Taishi Yamashita
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Clin Cancer Res 15:770-7. 2009
    ..The aim of this study was to investigate whether functional B7.2 and B7-H2 molecules are expressed on myeloma cells and, if so, whether they are associated with pathophysiology in myeloma...
  18. doi request reprint Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes
    Hideto Tamura
    Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Leuk Res 34:986-90. 2010
    ..Moreover, high values of anti-WT1 antibody were an independent predictor of longer survival. These data may justify therapeutic strategies targeting WT1 molecules in MDS...
  19. doi request reprint Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes
    Chikako Satoh
    Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Leuk Res 33:326-31. 2009
    ..These findings might underlie the clinical aggressiveness in CD7+ MDS...
  20. ncbi request reprint Flow cytometric parameters with little interexaminer variability for diagnosing low-grade myelodysplastic syndromes
    Chikako Satoh
    Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Leuk Res 32:699-707. 2008
    ..These parameters can be analyzed from one test tube for three-color FCM, and their analysis in combination can diagnose a certain percentage of low-grade MDS patients...
  21. ncbi request reprint Increased apoptosis of circulating T cells in myelodysplastic syndromes
    Yumiko Shioi
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Leuk Res 31:1641-8. 2007
    ..Mechanisms other than the Fas-Fas ligand pathway may induce T cell apoptosis in MDS...
  22. ncbi request reprint Characterization of blasts in clinical samples containing few blasts
    Hideya Hyodo
    Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Int J Hematol 77:376-82. 2003
    ..The revealed blast characteristics were valuable for choosing appropriate therapy for the patients...
  23. ncbi request reprint [Double balloon endoscopy as a useful tool for the diagnosis and treatment of four cases of primary small intestinal lymphoma]
    Hideto Tamura
    Division of Hematology, Department of Medicine, Nippon Medical School
    Rinsho Ketsueki 48:510-3. 2007
    ..We conclude that DBE is useful in the management of PSIL. More PSIL cases must be analyzed to establish the optimal management of patients with this form of lymphoma...
  24. ncbi request reprint Pure white cell aplasia: report of the first case associated with primary biliary cirrhosis
    Hideto Tamura
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Int J Hematol 85:97-100. 2007
    ..She died of infection, and the autopsy confirmed the diagnosis of PBC. In vitro investigations showed that factors inhibitory to normal CD34 cell-derived granulopoiesis were present in the patient's serum...
  25. doi request reprint Disease progression mechanism in myelodysplastic syndromes: insight into the role of the microenvironment
    Mariko Ishibashi
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Leuk Res 35:1449-52. 2011
    ..This causes B7-H1 molecule expression on MDS blasts, which generates a bifunctional signal inducing T-cell apoptosis and enhancing blast proliferation. The latter may provide more opportunity for developing secondary genetic changes...
  26. ncbi request reprint Hypothesis: myeloid-restricted hematopoietic stem cells with self-renewal capacity may be the transformation site in acute myeloid leukemia
    Chikako Satoh
    Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Leuk Res 30:491-5. 2006
    ..Based on these findings and re-evaluating the published data on AML stem cells, we hypothesize that MyHSCs may be the transformation site in AML. If so, therapy targeting leukemic MyHSCs but sparing PHSCs is worth investigating...
  27. ncbi request reprint Immunology of B7-H1 and its roles in human diseases
    Hideto Tamura
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Int J Hematol 78:321-8. 2003
    ..Precise manipulation of B7-H1 and its receptors may provide unique opportunities for designing new disease treatments...
  28. doi request reprint Prognosis of acute myeloid leukemia transformed from myelodysplastic syndromes: a multicenter retrospective study
    Namiko Okuyama
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Leuk Res 37:862-7. 2013
    ..In older patients treated with DMT (≥60 years, N=69), the therapy type did not affect survival, and performance status and MDS-specific comorbidity index were independent prognostic factors. ..
  29. ncbi request reprint [Usefulness of a novel Blastretriever for harvesting blasts]
    K Ogata
    Third Department of Internal Medicine, Nippon Medical School
    Nippon Rinsho 59:2353-7. 2001
    ..This new reagent should provide valuable information for the management and pathophysiology of hematologic malignancies...
  30. doi request reprint Nationwide public-access defibrillation in Japan
    Tetsuhisa Kitamura
    Kyoto University Health Service, Kyoto, Japan
    N Engl J Med 362:994-1004. 2010
    ..It is unclear whether dissemination of automated external defibrillators (AEDs) in public places can improve the rate of survival among patients who have had an out-of-hospital cardiac arrest...
  31. ncbi request reprint Phenotype and functional identity of GM-CSF-independent dendritic cells generated by long-term propagation of DC progenitor cells in bone marrow cells and skin Langerhans cells
    H Katayama
    Department of Research Surgery, National Research Center for Child Health and Development, Tokyo, Japan
    Transplant Proc 37:17-9. 2005
    ..A large population of DC generated by Flt3L/IL-6 from GM-CSF receptor-deficient mice by do not express NK1.1 (NKR-P1B and NKR-P1C). The profiles for BMC-derived DC were the same as for skin Langerhans cells...
  32. ncbi request reprint CD20-positive T cell leukemia/lymphoma: case report and review of the literature
    N Yokose
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Ann Hematol 80:372-5. 2001
    ..Hepatomegaly and/or splenomegaly were common features. Further cases must be evaluated to understand the clinical significance of the CD20 expression on the surface of T cell malignancies...
  33. ncbi request reprint Flow cytometry in myelodysplastic syndromes: report from a working conference
    Michael R Loken
    HematoLogics, Inc, Seattle, USA
    Leuk Res 32:5-17. 2008
    ..Clearly defined aberrancies on myeloid immature and maturing cells are now identified with possible impact on diagnosis, classification and prognostication in the near feature...
  34. ncbi request reprint CD5-positive diffuse large B-cell lymphoma with an unusual phenotype: Cytoplasmic CD20 (+), surface CD20 (-)
    Norio Yokose
    Leuk Lymphoma 47:1415-7. 2006
  35. ncbi request reprint Selective expansion of perforin-positive CD8+ T cells by immature dendritic cells infected with live Bacillus Calmette-Guérin mycobacteria
    Yasuko Tsunetsugu-Yokota
    Department of Immunology, National Institute of Infectious Diseases, 1 23 1 Toyama cho, Shinjuku ku, Tokyo 162 8640, Japan
    J Leukoc Biol 72:115-24. 2002
    ....
  36. ncbi request reprint Blastic natural killer cell lymphoma/leukemia (CD56-positive blastic tumor): prognostication and categorization according to anatomic sites of involvement
    Ritsuro Suzuki
    Division of Molecular Medicine, Aichi Cancer Center, Nagoya, Japan
    Cancer 104:1022-31. 2005
    ..Blastic natural killer (NK) cell lymphoma/leukemia (BNKL) is an immature CD56-positive neoplasm, which was recognized recently and characterized by systemic proliferation of tumor cells including skin, lymph node, and bone marrow...
  37. ncbi request reprint Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies
    Olga A Elisseeva
    Department of Radiation Biology, Osaka University Medical School, Japan
    Blood 99:3272-9. 2002
    ..Our findings may provide new insight into the rationale for elicitation of cytotoxic T-cell responses against the WT1 protein in cancer immunotherapy using the WT1 vaccine...
  38. ncbi request reprint On flow cytometry in myelodysplastic syndromes, with caveats
    Denise A Wells
    Leuk Res 32:209-10. 2008
  39. ncbi request reprint Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference
    Peter Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Leuk Res 31:727-36. 2007
    ..Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials...