Akihito Nakai

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. ncbi request reprint Developmental changes in tolerance to transient intrauterine ischemia in rat cerebral mitochondria
    A Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Am J Obstet Gynecol 184:731-5. 2001
  2. ncbi request reprint Windows of therapeutic opportunity on fetal growth retardation induced by transient intrauterine ischemia in rats
    Akihito Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, Tama shi, Tokyo, Japan
    J Nippon Med Sch 69:534-41. 2002
  3. ncbi request reprint Assessment of endometrial perfusion with Doppler ultrasound in spontaneous and stimulated menstrual cycles
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Japan
    J Nippon Med Sch 69:328-32. 2002
  4. ncbi request reprint Short therapeutic window for nifedipine in transient intrauterine ischemia in fetal rat brain
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Brain Res 943:30-7. 2002
  5. ncbi request reprint Reproducibility of pulsed Doppler measurements of the maternal renal circulation in normal pregnancies and those with pregnancy-induced hypertension
    A Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Ultrasound Obstet Gynecol 19:598-604. 2002
  6. ncbi request reprint Effect of dexamethasone on mitochondrial maturation in the fetal rat brain
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Am J Obstet Gynecol 186:574-8. 2002
  7. ncbi request reprint Increased level of granulocyte elastase in cervical secretion is an independent predictive factor for preterm delivery
    Akihito Nakai
    Tama Nagayama Hospital, Department of Obstetrics and Gynecology, Nippon Medical School, 1 7 1 Nagayama, Tama City, Tokyo, Japan
    Gynecol Obstet Invest 60:87-91. 2005
  8. ncbi request reprint Incidence and risk factors for severe perineal laceration after vaginal delivery in Japanese patients
    Akihito Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama, Hospital, Nippon Medical School, 1 7 1 Nagayama Tama City, Tokyo 206 8512, Japan
    Arch Gynecol Obstet 274:222-6. 2006
  9. ncbi request reprint Incidence and risk factors for inpatient falls in an academic acute-care hospital
    Akihito Nakai
    Department of Injury Prevention and Quality Management, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 73:265-70. 2006
  10. ncbi request reprint Maternal treatment with alpha-phenyl-N-tert-butylnitrone attenuates secondary mitochondrial dysfunction after transient intrauterine asphyxia in the fetal rat brain
    Yoshinari Taniuchi
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Gynecol Obstet Invest 55:145-50. 2003

Detail Information

Publications47

  1. ncbi request reprint Developmental changes in tolerance to transient intrauterine ischemia in rat cerebral mitochondria
    A Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Am J Obstet Gynecol 184:731-5. 2001
    ....
  2. ncbi request reprint Windows of therapeutic opportunity on fetal growth retardation induced by transient intrauterine ischemia in rats
    Akihito Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, Tama shi, Tokyo, Japan
    J Nippon Med Sch 69:534-41. 2002
    ..To assess the windows of therapeutic opportunity for drugs with various chemical actions on fetal growth retardation induced by transient intrauterine ischemia in rats...
  3. ncbi request reprint Assessment of endometrial perfusion with Doppler ultrasound in spontaneous and stimulated menstrual cycles
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Japan
    J Nippon Med Sch 69:328-32. 2002
    ..Endometrial perfusions were measured by Doppler ultrasound to evaluate the influence of spontaneous menstrual cycles and to study the effect of clomiphene citrate...
  4. ncbi request reprint Short therapeutic window for nifedipine in transient intrauterine ischemia in fetal rat brain
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Brain Res 943:30-7. 2002
    ..Despite the short therapeutic window, the treatment of nifedipine attenuates the secondary deterioration of cerebral mitochondrial function after transient intrauterine ischemia in fetal rats when given just prior to ischemia...
  5. ncbi request reprint Reproducibility of pulsed Doppler measurements of the maternal renal circulation in normal pregnancies and those with pregnancy-induced hypertension
    A Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Ultrasound Obstet Gynecol 19:598-604. 2002
    ..To assess the inter- and intraobserver reproducibilities of pulsed Doppler measurements of the maternal renal circulation in normal pregnancies and those affected by pregnancy-induced hypertension...
  6. ncbi request reprint Effect of dexamethasone on mitochondrial maturation in the fetal rat brain
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Am J Obstet Gynecol 186:574-8. 2002
    ..The objective of the present study was to explore whether prenatal dexamethasone treatment influences mitochondrial maturation in the fetal rat brain...
  7. ncbi request reprint Increased level of granulocyte elastase in cervical secretion is an independent predictive factor for preterm delivery
    Akihito Nakai
    Tama Nagayama Hospital, Department of Obstetrics and Gynecology, Nippon Medical School, 1 7 1 Nagayama, Tama City, Tokyo, Japan
    Gynecol Obstet Invest 60:87-91. 2005
    ..The objective of this study was to explore whether increased levels of granulocyte elastase in cervical secretion is an independent predictive factor for preterm delivery before 34 weeks of gestation in the patient with preterm labor...
  8. ncbi request reprint Incidence and risk factors for severe perineal laceration after vaginal delivery in Japanese patients
    Akihito Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama, Hospital, Nippon Medical School, 1 7 1 Nagayama Tama City, Tokyo 206 8512, Japan
    Arch Gynecol Obstet 274:222-6. 2006
    ..The aim of this study was to assess the frequency of severe perineal lacerations defined as either third- or fourth-degree lacerations during normal spontaneous vaginal delivery and to evaluate potential risk factors in Japanese patients...
  9. ncbi request reprint Incidence and risk factors for inpatient falls in an academic acute-care hospital
    Akihito Nakai
    Department of Injury Prevention and Quality Management, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 73:265-70. 2006
    ..The aims of this study were to assess the frequency of inpatient falls and to evaluate potential risk factors in an academic hospital...
  10. ncbi request reprint Maternal treatment with alpha-phenyl-N-tert-butylnitrone attenuates secondary mitochondrial dysfunction after transient intrauterine asphyxia in the fetal rat brain
    Yoshinari Taniuchi
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Gynecol Obstet Invest 55:145-50. 2003
    ....
  11. pmc Type and location of placenta previa affect preterm delivery risk related to antepartum hemorrhage
    Atsuko Sekiguchi
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Int J Med Sci 10:1683-8. 2013
    ..To evaluate whether type and location of placenta previa affect risk of antepartum hemorrhage-related preterm delivery...
  12. ncbi request reprint Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain
    Akishige Yokota
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 72:127-30. 2005
    ..The deterioration was not prevented by a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), given immediately after recirculation...
  13. ncbi request reprint Vitamins ameliorate secondary mitochondrial failure in neonatal rat brain
    Akihito Nakai
    Tama Nagayama Hospital, Department of Obstetrics and Gynecology, Nippon Medical School, 1 7 1 Nagayama, Tama City, Tokyo, 206 8512, Japan
    Pediatr Neurol 27:30-5. 2002
    ....
  14. ncbi request reprint Role of mitochondrial permeability transition in fetal brain damage in rats
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Pediatr Neurol 30:247-53. 2004
    ..The results suggest that mitochondria and mitochondrial permeability transition may be involved in the development of ischemic brain damage in the immature rat...
  15. ncbi request reprint Factors influencing the accuracy of digital examination for determining fetal head position during the first stage of labor
    Ikuno Kawabata
    Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:290-5. 2010
    ..The objective of this study was to explore factors influencing the accuracy of transvaginal digital examination for determining fetal head position during the first stage of labor...
  16. ncbi request reprint Is a red umbilical cord a sign of umbilical venous congestion?: a case report
    Hidehiko Miyake
    Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 78:42-5. 2011
    ..Moreover, we considered that the umbilical venous congestion was due to increased resistance in the fetal intra-abdominal umbilical vein, which was associated with the non-reassuring fetal status...
  17. ncbi request reprint Risk factors for peripartum blood transfusion in women with placenta previa: a retrospective analysis
    Atsuko Oya
    Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School Tama Nagayama Hospital, Nagayama, Tama, Tokyo, Japan
    J Nippon Med Sch 75:146-51. 2008
    ..The incidence of placenta previa has been increasing. It is of a great importance to determine the clinical risk factors for peripartum blood transfusion in women with placenta previa in an effort to anticipate cases of severe hemorrhage...
  18. ncbi request reprint The influence of assisted reproductive technology on women with pregnancy-induced hypertension: a retrospective study at a Japanese Regional Perinatal Center
    Hidehiko Miyake
    Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:312-7. 2010
    ..To evaluate clinical features of assisted reproductive technology (ART) patients with pregnancy-induced hypertension (PIH) compared to spontaneously conceived PIH patients...
  19. ncbi request reprint Short-term effects of different thermal conditions during uteroplacental ischaemia on fetal growth of Sprague-Dawley rats
    Asakura Hirobumi
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Reprod Fertil Dev 14:355-61. 2002
    ..It was concluded that both mild hyperthermia and normothermia during ischaemia retard the growth of late-gestation rat pups, in contrast to the sparing effect of mild hypothermia...
  20. doi request reprint Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used
    Masako Hayashi
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Fertil Steril 98:922-8. 2012
    ..To compare obstetric and perinatal outcomes of singleton pregnancies conceived with different types of assisted reproductive technology (ART) procedures with those of naturally conceived pregnancies...
  21. doi request reprint Umbilical cord ulceration after prenatal diagnosis of duodenal atresia with interstitial deletion of chromosome 13q: a case report
    Hidehiko Miyake
    Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Tokyo, Japan
    Fetal Diagn Ther 24:115-8. 2008
    ..Just before the cesarean section, ultrasonography showed a 'double bubble' sign and a linear shadow, suggesting fibrin in the amniotic cavity. This finding may help in the diagnosis of bleeding from the cord...
  22. ncbi request reprint Recovery from peripartum cardiomyopathy in a Japanese woman after administration of bromocriptine as a new treatment option
    Takashi Abe
    Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    J Nippon Med Sch 77:226-30. 2010
    ..Following treatment, the serum prolactin levels dropped swiftly. Concurrently, LV function improved, and heart failure symptoms decreased, accompanied by a decrease in the BNP level...
  23. ncbi request reprint Prediction of HELLP syndrome with assessment of maternal dual hepatic blood supply by using Doppler ultrasound
    Ikuno Kawabata
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, 1 7 1 Nagayama, Tama City, Tokyo 206 8512, Japan
    Arch Gynecol Obstet 274:303-9. 2006
    ..Our objective was to assess whether the evaluation of maternal hepatic blood supply is instructive to the prediction of onset of HELLP syndrome...
  24. ncbi request reprint Changes in plasma endothelin-1 after elective cesarean section in women with preeclampsia and the relationship to thrombocytopenia
    Hirobumi Asakura
    Department of Obstetrics and Gynecology, Nippon Medical School Second Hospital, Kawasaki City, Kanagawa, Japan
    J Nippon Med Sch 70:480-9. 2003
    ..The aim of this study was to clarify the time course of plasma endothelin-1 levels and platelet counts after elective cesarean section in women with preeclampsia, and to investigate the relationship between them postoperatively...
  25. ncbi request reprint Continuous observation of nitric oxide production in the fetal rat brain during uteroplacental ischemia
    H Asakura
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Fetal Diagn Ther 14:354-9. 1999
    ..To demonstrate real-time changes in nitric oxide (NO) production within fetal rat brain during uteroplacental ischemia and subsequent reperfusion...
  26. ncbi request reprint Prediction of uterine dehiscence by measuring lower uterine segment thickness prior to the onset of labor: evaluation by transvaginal ultrasonography
    H Asakura
    Department of Obstetrics and Gynecology, Nippon Medical School, Sedagi, Tokyo, Japan asakura
    J Nippon Med Sch 67:352-6. 2000
    ..Lower uterine segment thickness was measured by transvaginal ultrasound examination and its correlations with the occurrence of uterine dehiscence and rupture was examined...
  27. ncbi request reprint Influence of mild hypothermia on delayed mitochondrial dysfunction after transient intrauterine ischemia in the immature rat brain
    A Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, 1 7 1 Nagayama, Tama City, 206 8512, Tokyo, Japan
    Brain Res Dev Brain Res 128:1-7. 2001
    ....
  28. ncbi request reprint Doppler velocimetry of maternal renal circulation in pregnancy-induced hypertension
    H Miyake
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama-shi, Tokyo 206-8512, Japan
    J Clin Ultrasound 29:449-55. 2001
    ....
  29. ncbi request reprint Changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery
    A Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 67:434-9. 2000
    ..Our goal was to characterize the changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery...
  30. ncbi request reprint Assessment of the hepatic arterial and portal venous blood flows during pregnancy with Doppler ultrasonography
    A Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    Arch Gynecol Obstet 266:25-9. 2002
    ..The aim of this study was to evaluate whether the dual hepatic blood supply is altered in healthy pregnant women compared with that in nonpregnant women...
  31. ncbi request reprint Pulsed Doppler US findings of renal interlobar arteries in pregnancy-induced hypertension
    A Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    Radiology 213:423-8. 1999
    ..To evaluate whether Doppler ultrasonographic (US) velocimetry in renal interlobar arteries is altered in women with pregnancy-induced hypertension (PIH) compared with that in healthy pregnant and nonpregnant women...
  32. ncbi request reprint Developmental changes in mitochondrial activity and energy metabolism in fetal and neonatal rat brain
    A Nakai
    Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, 1 7 1 Nagayama, Tama shi, 206 8512, Tokyo, Japan
    Brain Res Dev Brain Res 121:67-72. 2000
    ..Acceleration in mitochondrial respiration occurs immediately after birth in order to maintain high-energy phosphate levels, and this may be crucial for the successful outcome of the newborn...
  33. ncbi request reprint Fetal heart rate classification proposed by the perinatology committee of the Japan Society of Obstetrics and Gynecology: reproducibility and clinical usefulness
    Masako Hayashi
    Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 79:60-8. 2012
    ..This study aimed to assess the reproducibility and clinical usefulness of this classification...
  34. ncbi request reprint Accuracy and reproducibility of ultrasound measurements in obstetric management
    Akihito Nakai
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    Gynecol Obstet Invest 54:31-6. 2002
    ..The aim of this study was to assess the potential of ultrasonography as a routine diagnostic tool in obstetric management...
  35. ncbi request reprint Effect of first-trimester ultrasound examination for chromosomal aberrations in women undergoing amniocentesis
    Hidehiko Miyake
    Department of Female Reproductive and Developmental Medicine, Nippon Medical School Graduate School of Medicine, Tokyo, Japan
    J Nippon Med Sch 73:271-6. 2006
    ..The purpose of this study was to assess the effect of first-trimester ultrasound examination for chromosomal aberrations in women who underwent amniocentesis...
  36. ncbi request reprint Fetal heart rate monitoring as a predictor of histopathologic chorioamnionitis in the third trimester
    Hidehiko Miyake
    Department of Female Reproductive and Developmental Medicine, Nippon Medical School, Graduate School of Medicine, Japan
    J Nippon Med Sch 75:106-10. 2008
    ..The present study suggests that FHR monitoring is not a reliable means of diagnosing histopathological CAM, because the FHR pattern was normal in most cases of histopathological CAM...
  37. ncbi request reprint Correlations between interscapular deep temperature and plasma free fatty acid levels in pregnant women with hyperemesis gravidarum
    Hirobumi Asakura
    Department of Obstetrics and Gynecology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan 113 8602
    Arch Gynecol Obstet 268:35-40. 2003
    ..3 kg since becoming pregnant and 20 pregnant controls who did not experience hyperemesis gravidarum and were matched for weeks of gestation and pre-conception weight and height...
  38. ncbi request reprint Clinical relevance of grade III placenta in assessment of low level of plasma antithrombin III activity in pregnant women at term
    Hirobumi Asakura
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 69:415-21. 2002
    ..In this report, the clinical relevance of grade III placenta in the assessment of low plasma ATIII was compared with other factors that raise the risk of blood hypercoagulability...
  39. doi request reprint Clinical efficacy of Kampo medicine (Japanese traditional herbal medicine) in the treatment of primary dysmenorrhea
    Atsuko Oya
    Department of Obstetrics and Gynecology, Nippon Medical School, Kitasato University, YAMA, Tokyo, Japan
    J Obstet Gynaecol Res 34:898-908. 2008
    ..We intended to evaluate the clinical efficacy of Kampo medicine, a Japanese traditional herbal medicine, for primary dysmenorrhea which was prescribed according to the Kampo diagnosis, with classification of its severity...
  40. ncbi request reprint Prognostic significance of Ki-67 antigen immunostaining (MIB-1 monoclonal antibody) in ovarian cancer
    Shunji Mita
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo 206 8512, Japan
    J Nippon Med Sch 71:384-91. 2004
    ..To assess the potential usefulness of Ki-67 antigen expression as a predictor of outcome in ovarian cancer through the analysis of MIB-1 monoclonal antibody reactivity...
  41. ncbi request reprint Deciduoid mesothelioma in the pelvic cavity
    Shotaro Maeda
    Department of Pathology, Nippon Medical School, Tama Nagayama Hospital, Tokyo, Japan
    Pathol Int 54:67-72. 2004
    ..Consequently, this case was diagnosed as deciduoid mesothelioma and 2 years and 4 months after operation, the patient's clinical course has been good. This case is considered to be the first reported in Japan...
  42. ncbi request reprint Effect of regular maternal exercise on lipid peroxidation levels and antioxidant enzymatic activities before and after delivery
    Hitoshi Kobe
    Department of Obstetrics and Gynecology, Nippon Medical School, Tama shi, Tokyo, Japan
    J Nippon Med Sch 69:542-8. 2002
    ....
  43. doi request reprint Current status of HTLV-1 carrier in Japanese pregnant women
    Shunji Suzuki
    Department of Obstetrics and Gynecology, Japan Association of Obstetricians and Gynecologists, Tokyo, Japan
    J Matern Fetal Neonatal Med 27:312-3. 2014
    ..3% of them responded. Considering the response rate and the rate of implementation of confirmation tests, the number of HTLV-1 carrier in Japanese pregnant women was estimated to be 1620 (0.16%) per year...
  44. doi request reprint Outcomes of infants exposed to oseltamivir or zanamivir in utero during pandemic (H1N1) 2009
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Obstet Gynecol 209:130.e1-9. 2013
    ..To assess adverse fetal outcomes and short-term prognoses of infants exposed to oseltamivir or zanamivir in utero during pandemic (H1N1) 2009 in Japan...
  45. doi request reprint Relevance of declines in serum human chorionic gonadotropin levels to the management of persistent ectopic pregnancy
    Takashi Abe
    Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
    J Obstet Gynaecol Res 35:961-6. 2009
    ..To evaluate postoperative declines in serum human chorionic gonadotropin (hCG) levels (percentages of preoperative hCG levels) to rule out persistent ectopic pregnancy (PEP)...
  46. ncbi request reprint Role of mitochondrial permeability transition in the immature brain following intrauterine ischemia
    Akihito Nakai
    Department of Female Reproductive and Developmental Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 74:190-201. 2007
    ..The results suggest that mitochondria and MPT may be involved in the development of ischemic brain damage in the immature rat...
  47. ncbi request reprint A Ca(2+) channel blocker-like effect of dehydrocurdione on rodent intestinal and vascular smooth muscle
    K Irie
    Department of Pharmacology, Tokyo Women s Medical University, School of Medicine, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Eur J Pharmacol 403:235-42. 2000
    ..These results suggest that the inhibitory effects of dehydrocurdione on intestinal and vascular smooth muscle are mediated by blockade of Ca(2+) entry from the extracellular space...