Research Topics
Species | Qing LiSummaryAffiliation: Nippon Medical School Country: Japan Publications
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Publications
Effect of forest bathing trips on human immune functionQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
Environ Health Prev Med 15:9-17. 2010..These findings indicate that forest bathing trips resulted in an increase in NK activity, which was mediated by increases in the number of NK cells and the levels of intracellular granulysin, perforin, and granzymes A/B...
Mechanism of ziram-induced apoptosis in human natural killer cellsQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Int J Immunopathol Pharmacol 25:883-91. 2012..These findings indicate that ziram can induce apoptosis in human NK cells, and the apoptosis is at least mediated by both the caspase-cascade and the mitochondria/cytochrome-c pathways...
Mechanism of ziram-induced apoptosis in human T lymphocytesQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Arch Toxicol 86:615-23. 2012..These findings indicate that ziram can induce apoptosis in human T cells, and the apoptosis is mediated by both the caspase-cascade and the mitochondria/cytochrome-c pathways...- Effect of ziram on natural killer, lymphokine-activated killer, and cytotoxic T lymphocyte activityQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Arch Toxicol 86:475-81. 2012..Taken together, these findings suggest the ziram-induced inhibition of NK, LAK, and CTL activities to be at least partially mediated by decreases in the intracellular levels of Gr3/K, granulysin, perforin, GrA, and GrB... - Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in miceQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo
Int J Immunopathol Pharmacol 24:837-47. 2011..However, ETBE exposure did not affect the numbers of splenic NK cells, B cells, or macrophages or the total number of splenocytes. The above findings indicate that ETBE selectively affects the number of splenic T cells in mice... - A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjectsQing Li
Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
J Biol Regul Homeost Agents 24:157-65. 2010..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity... - Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell lineQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Toxicology 213:107-16. 2005..We also found that DDVP have a modest, but a significant inhibitory effect on the transcription of mRNA of perforin, granzyme A and granulysin... - Effect of electric foot shock and psychological stress on activities of murine splenic natural killer and lymphokine-activated killer cells, cytotoxic T lymphocytes, natural killer receptors and mRNA transcripts for granzymes and perforinQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
Stress 8:107-16. 2005..On the other hand, the foot-shock stress increased granzyme B. The above findings suggest that stress induced inhibition of NK, LAK and CTL activities partially via affecting NK receptors, granzymes and perforin... - Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) miceQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Toxicology 204:41-50. 2004..Taken together, these findings indicate that the DDVP-induced inhibition of NK, LAK and CTL activities in PKO mice is mediated by the impairment of the FasL/Fas pathway... - Phytoncides (wood essential oils) induce human natural killer cell activityQing Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Immunopharmacol Immunotoxicol 28:319-33. 2006..Taken together, these data indicate that phytoncides significantly enhance human NK activity and this effect is at least partially mediated by induction of intracellular perforin, granzyme A, and granulysin... - The mechanism of organophosphorus pesticide-induced inhibition of cytolytic activity of killer cellsQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Cell Mol Immunol 3:171-8. 2006.... - Healthy lifestyles are associated with higher levels of perforin, granulysin and granzymes A/B-expressing cells in peripheral blood lymphocytesQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Prev Med 44:117-23. 2007..In order to explore the underlying mechanism, we investigated the effect of lifestyle on intracellular perforin, granulysin, and granzymes A/B in peripheral blood lymphocytes (PBL)... - A forest bathing trip increases human natural killer activity and expression of anti-cancer proteins in female subjectsQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
J Biol Regul Homeost Agents 22:45-55. 2008..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity... - Effect of phytoncide from trees on human natural killer cell functionQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Int J Immunopathol Pharmacol 22:951-9. 2009..Phytoncides, such as alpha-pinene and beta-pinene, were detected in the hotel room air. These findings indicate that phytoncide exposure and decreased stress hormone levels may partially contribute to increased NK activity... - New mechanism of organophosphorus pesticide-induced immunotoxicityQing Li
Department of Environmental Medicine, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
J Nippon Med Sch 74:92-105. 2007..3) OPs induce apoptosis of immune cells... - Forest bathing enhances human natural killer activity and expression of anti-cancer proteinsQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo
Int J Immunopathol Pharmacol 20:3-8. 2007.... - DDVP markedly decreases the expression of granzyme B and granzyme 3/K in human NK cellsQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Toxicology 243:294-302. 2008..Taken together, DDVP significantly inhibits NK activity and reduces the intracellular GrB and Gr3/K levels in NK cells... - Chlorpyrifos induces apoptosis in human T cellsQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, 113 8602 Tokyo, Japan
Toxicology 255:53-7. 2009..These findings indicate that chlorpyrifos can induce apoptosis in human Jurkat T cell cells, and this effect is partially mediated by the activation of intracellular caspase-3... - Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteinsQ Li
Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Int J Immunopathol Pharmacol 21:117-27. 2008..Phytoncides released from trees and decreased stress hormone may partially contribute to the increased NK activity... - Elevated frequency of sister chromatid exchanges of lymphocytes in sarin-exposed victims of the Tokyo sarin disaster 3 years after the eventQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Toxicology 201:209-17. 2004..On the other hand, there was no significant difference in natural killer activity between the exposed and the controls... - Ziram induces apoptosis and necrosis in human immune cellsQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Arch Toxicol 85:355-61. 2011..These findings indicate that ziram can induce apoptosis/necrosis in U937 cells, and this effect is partially mediated by activation of intracellular caspase-3 and mitochondrial cytochrome c release... - Acute effects of walking in forest environments on cardiovascular and metabolic parametersQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
Eur J Appl Physiol 111:2845-53. 2011.... - [Effect of forest therapy on the human psycho-neuro-endocrino-immune network]Qing Li
Department of Hygiene and Public Health, Nippon Medical School, Japan
Nihon Eiseigaku Zasshi 66:645-50. 2011..Taken together, forest therapy brings various effects on human health via the psycho-neuro-endocrino-immune network... - Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar ratsQing Li
Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Hum Exp Toxicol 30:665-74. 2011..However, FNT and MNP exposures did not affect splenic NK cells, B cells, macrophages, and granulocytes. The above findings indicate that FNT and MNP may selectively affect splenic T cells in rats... - Effect of forest environments on human natural killer (NK) activityQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Int J Immunopathol Pharmacol 24:39S-44S. 2011.... - Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphokine-activated killer: a proposed inhibiting mechanism via granzyme inhibitionQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Toxicology 172:181-90. 2002..We also found that DDVP significantly inhibited granzyme activity in a dose-dependent manner. These findings indicate that OPs significantly decrease NK, LAK and CTL activities in vitro via granzyme inhibition... - Organophosphorus pesticides induce apoptosis in human NK cellsQing Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Tokyo, Japan
Toxicology 239:89-95. 2007..Taken together, these findings suggest that OP-induced inhibition of NK activity may be at least partially mediated by OP-induced apoptosis in NK... - Chlorpyrifos induces apoptosis in human monocyte cell line U937Ari Nakadai
Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Toxicology 224:202-9. 2006..These findings indicate that chlorpyrifos can induce apoptosis in U937 cells, and this effect is partially mediated by activation of intracellular caspase-3... - Increase in the prevalence of metabolic syndrome among workers according to ageTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Aging Male 13:184-7. 2010..Statistical information regarding the prevalence of metabolic syndrome among a wide age range of workers is insufficient... - Relationship among lifestyles, aging and psychological wellbeing using the General Health Questionnaire 12-items in Japanese working menTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Aging Male 14:115-8. 2011..CONCLUSION. Although cause-effect relationship cannot make clear, some of desirable health practices and aging were closely related to psychological wellbeing judged by GHQ12... - Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificityYukiyo Hirata
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Arch Biochem Biophys 446:35-43. 2006.... - A cross-sectional study on the shift work and metabolic syndrome in Japanese male workersTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
Aging Male 13:174-8. 2010..To clarify the association between the type of shift work and the risk of MetS, a cross-sectional field survey was conducted after adjusting for age and lifestyle factors... - Patterns in self-rated health according to age and sex in a Japanese national survey, 1989-2004Tomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Gend Med 6:329-34. 2009..Perceived good health or good self-rated health is considered to be a predictor of longer survival and maintenance of good quality of life, which is a public health goal... - Relationship between two indicators of coronary risk estimated by the Framingham Risk Score and the number of metabolic syndrome components in Japanese male manufacturing workersTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, Tokyo 113 8602, Japan
Metab Syndr Relat Disord 7:435-40. 2009..Components of the metabolic syndrome and several lifestyle factors have also been evaluated to estimate the risk of CHD... - Insomnia as a sequela of sarin toxicity several years after exposure in Tokyo subway trainsTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Percept Mot Skills 100:1121-6. 2005..Although posttraumatic stress disorder is assumed to be a psychological effect of exposure to a toxic substance, a cause-and-effect relationship has not been established... - Serum insulin is significantly related to components of the metabolic syndrome in Japanese working menTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
J Clin Hypertens (Greenwich) 12:309-14. 2010..09, 0.13, -0.16, and -0.11, respectively. A statistically significant relationship existed between the components of MS, especially abdominal obesity, and the serum insulin levels... - Depressive state and subsequent weight gain in workers: A 4-year follow-up studyTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, Japan
Work 38:123-7. 2011..However, to precisely understand the nature of this relationship, the data should be controlled for other factors that can also be associated with weight gain... - Optimal cut-off levels of body mass index and waist circumference in relation to each component of metabolic syndrome (MetS) and the number of MetS componentTomoyuki Kawada
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8602, Japan
Diabetes Metab Syndr 5:25-8. 2011..There is an ethnic difference of obesity index to diagnose metabolic syndrome. The authors explored the optimal cut-off levels for body mass index (BMI) and waist circumference (WC) in relation to each component of metabolic syndrome... - New mechanism of organophosphorus pesticide-induced immunotoxicityQing Li
Department of Hygiene and Public Health, Nippon Medical School
J Nippon Med Sch 74:70-3. 2007 - A point mutation in a silencer module reduces the promoter activity for the human mercaptopyruvate sulfurtransferaseNoriyuki Nagahara
Department of Environmental Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Biochim Biophys Acta 1680:176-84. 2004..A replacement of -391G to C lost the silencer function; on the other hand, a replacement of -394G to T or C, -393C to T or -392T to G markedly reduced the promoter activity... - Sister chromatid exchanges of human peripheral blood lymphocytes induced by N,N-diethylaniline in vitroQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Mutat Res 395:151-7. 1997..ANOVA analyses indicated that there is a dose-response relationship between doses of N,N-diethylaniline and the frequency of SCEs, especially in the presence of S-9 mix. The results suggested that N,N-diethylaniline has genotoxicity... - Elevated frequency of sister chromatid exchanges in lymphocytes of victims of the Tokyo sarin disaster and in experiments exposing lymphocytes to by-products of sarin synthesisQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Toxicol Lett 98:95-103. 1998..Thus, the in vitro SCE-inducing effect of DIMP, DEMP and EIMP was examined using human lymphocytes and we obtained positive results... - Acute immunotoxicity of p-chloronitrobenzene in mice: II. Effect of p-chloronitrobenzene on the immunophenotype of murine splenocytes determined by flow cytometryQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Toxicology 137:35-45. 1999..p. injection of p-CNB. The above findings indicate that p-CNB has an immunotoxic effect on mice... - Acute and subchronic immunotoxicity of p-chloronitrobenzene in mice. I. Effect on natural killer, cytotoxic T-lymphocyte activities and mitogen-stimulated lymphocyte proliferationQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Toxicology 127:223-32. 1998..Body weight in subchronically exposed mice was significantly lower than the control from day 19. The above evidence indicated that p-CNB has an inherent immunotoxic effect on mice... - The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activityQ Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
Toxicology 146:209-20. 2000..The effect of DIMP and DEMP on the splenic NK activity of mice was stronger than on the splenic CTL activity, and the human lymphocytes is more sensitive to DIMP and DEMP than the splenocytes of mice... - Immunotoxicity of N,N-diethylaniline in mice: effect on natural killer activity, cytotoxic T lymphocyte activity, lymphocyte proliferation response and cellular components of the spleenQ Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8602, Tokyo, Japan
Toxicology 150:179-89. 2000..The above findings indicated that N,N-diethylaniline selectively inhibited splenic NK and CTL activity and this inhibition was due to decreased NK and CTL functions, but not due to changes in the numbers of splenic NK and T cells... - Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?Noriyuki Nagahara
Department of Environmental Medicine, Nippon Medical School, Tokyo, Japan
Curr Drug Targets Immune Endocr Metabol Disord 3:198-204. 2003.... - New aspects in pathogenesis of konzo: neural cell damage directly caused by linamarin contained in cassava (Manihot esculenta Crantz)V G Sreeja
Department of Environmental Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Br J Nutr 90:467-72. 2003..0088). Furthermore, glucose also prevented cell death. These present results strongly suggest that linamarin competes with cytochalasin B and glucose for binding to a glucose transporter and enters into cells via glucose transporter... - Facilitation of hematopoietic recovery by bone grafts with intra-bone marrow-bone marrow transplantationChangye Song
First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, Japan
Immunobiology 213:455-68. 2008..Moreover, the analyses of thymic sections using confocal microscopy revealed that donor BM stromal cells had migrated into the thymus. Thus, the co-administration of donor bones has great advantages for allogeneic BMT in adult mice... - RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine modelAlexey Aleshin
Department of Surgery, Columbia University, New York, NY 10032, USA
Am J Physiol Heart Circ Physiol 294:H1823-32. 2008.... - Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's diseaseNaoki Masuda
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 N Wolfe Street, Baltimore, MD 21287, USA
Neurobiol Dis 30:293-302. 2008..These results suggest that tiagabine may have beneficial effects in the treatment of HD. Because tiagabine is an FDA-approved drug, it may be a promising candidate for future clinical trials for the treatment of HD... - T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjögren's syndromeXiaomei Li
Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, Anhui Province, China
J Rheumatol 34:2438-45. 2007..To investigate the abnormalities of T regulatory cells (Treg) in salivary glands and peripheral blood in patients with primary Sjögren's syndrome (pSS)... - Intracellular mediators of granulysin-induced cell deathSatoshi Okada
Division of Immunology and Transplantation Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
J Immunol 171:2556-62. 2003..Finally, an increase in intracellular glutathione protects target cells from granulysin-induced lysis, indicating the importance of the redox state in granulysin-mediated cell death... - Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activatorAnmei Deng
Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 174:5243-8. 2005.... - Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysinQing Li
Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
Antimicrob Agents Chemother 49:388-97. 2005..The finding that some derivatives of granulysin are hemolytic may have important implications for the design of granulysin-based antimicrobial therapeutics... - Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterizationThomas Marti
Celiac Sprue Research Foundation, 3181 Porter Dr, Palo Alto, CA 94304, USA
J Pharmacol Exp Ther 312:19-26. 2005.... - Analysis of tolerance induction using triple chimeric mice: major histocompatibility complex-disparate thymus, hemopoietic cells, and microenvironmentWenhao Cui
Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
Transplantation 85:1151-8. 2008..We have previously shown that fetal thymus transplantation (TT) with BMT is effective for elderly recipients in mice... - Simultaneous determination of 13 bioactive compounds in Herba Artemisiae Scopariae (Yin Chen) from different harvest seasons by HPLC-DADXiao jie Tan
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, PR China
J Pharm Biomed Anal 47:847-53. 2008..The samples analyzed contained a much lower level of the amount of other flavonoids and coumarins as rutin, hyperoside, isoquercitrin and scoparone... - PPF1 may suppress plant senescence via activating TFL1 in transgenic Arabidopsis plantsDa yong Wang
Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009, China
J Integr Plant Biol 50:475-83. 2008..The activation of TFL1 expression by PPF1 defines an important pathway possibly essential for the negative regulation of plant senescence in transgenic Arabidopsis... - Successful acceptance of adult liver allografts by intra-bone marrow-bone marrow transplantationSatoshi Okazaki
1st Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
Stem Cells Dev 17:629-39. 2008..These results demonstrate that the acceptance of allogeneic liver can be achieved by cografting donor BMCs via the IBM route... - Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunityDaniel F Hoft
Division of Infectious Diseases and Immunology and Vaccine and Treatment Evaluation Unit, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
J Infect Dis 186:1448-57. 2002..Despite previous evidence that type 1 immune responses are essential for TB immunity, interferon-gamma production did not correlate with mycobacterial inhibition. These results have important implications for TB vaccine development... - Over expression of transforming growth factor-alpha and epidermal growth factor receptor in human hepatic cirrhosis tissuesQing Qiao
Department of General Surgery, Xijing Hospital Fourth Military Medical University, Xi an, China
Hepatogastroenterology 55:169-72. 2008..The purpose of this study was to investigate the expression of transforming growth factor-alpha and epidermal growth factor receptor in human hepatic cirrhosis tissues... - Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease miceXiang Ying Kong
Department of Pharmacology, School of Basic Medicine, Peking Union Medical College and Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing, 100005 China
Brain Res 1205:108-15. 2008..The results suggested that transplanted HACs could survive and promote the endogenous neurogenesis of mice, which maybe related to the increased level of neurotrophins of the striatum... - A novel apoptosis pathway activated by the carboxyl terminus of p21Chen Dong
Division of Immunology and Transplantation Biology, Department of Pediatrics, CCSR 2105, 300 Pasteur Dr, Stanford University, Stanford, CA 94305-5164, USA
Blood 105:1187-94. 2005..Targeting the p21 peptide to specific cell populations may allow development of novel therapies to eliminate aberrant cells in human diseases... - A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathwayQing Li
Clinical Immunology Unit and Sir Y K Pao Centre for Cancer, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong Special Administrative Region, China
J Biol Chem 279:52106-16. 2004..We propose that BRE inhibits, by ubiquitination-like activity, components in or proximal to the death-inducing signaling complexes that are necessary for activation of the mitochondria... - Induction of tolerance in quadruple chimeric miceTian-Xue Fan
Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan
Stem Cells 22:683-95. 2004.... - Effects of 17beta-estradiol on in vitro maturation of pig oocytes in protein-free mediumQing Li
The Graduate School of Natural Science and Technology, Okayama University, Japan
J Reprod Dev 50:305-13. 2004..This E(2) inhibition may occur indirectly via the cumulus cells and inhibition of P(4) synthesis... - Mechanism of action of NB2001 and NB2030, novel antibacterial agents activated by beta-lactamasesGeoffrey W Stone
NewBiotics, Inc, San Diego, California 92121, USA
Antimicrob Agents Chemother 48:477-83. 2004..aureus and E. coli. Taken together, the results suggest that NB2001 and NB2030 act primarily as triclosan prodrugs in S. aureus and E. coli... - [Chewing gum and caries]Qing Li
Shanghai Kou Qiang Yi Xue 12:208-11. 2003 - Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skinQing Li
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
J Pathol 201:296-302. 2003..Furthermore, it is possible that antibodies against CD146 may be useful for separating haemangioma-derived endothelial cells from normal endothelial cells and pericytes... - N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferationYanchun Deng
Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
Int J Cancer 106:342-7. 2003..Our findings provide the first evidence to suggest that hNDRG2 may play a role in glioblastoma carcinogenesis... - Racial differences in thoracic aorta atherosclerosis among ischemic stroke patientsVishal Gupta
Heart Station/Echocardiography Laboratories, University of Alabama, Birmingham 35249, USA
Stroke 34:408-12. 2003..This difference cannot be explained by the existing risk factors in ischemic stroke patients... - Enhanced immunogenicity of pneumococcal surface adhesin A by genetic fusion to cytokines and evaluation of protective immunity in miceDennis O Gor
Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4943, USA
Infect Immun 70:5589-95. 2002..The modest levels of protection seen in mice immunized with PsaA and its more immunogenic derivatives may be explained in part by the relative inaccessibility of antibody to PsaA on the surface of encapsulated S. pneumoniae... - Bactericidal activity in whole blood as a potential surrogate marker of immunity after vaccination against tuberculosisSeon-Hee Cheon
Case Western Reserve University, Cleveland, Ohio, USA
Clin Diagn Lab Immunol 9:901-7. 2002..These experiments indicate that whole blood culture may be used to measure immunity to M. tuberculosis and that further studies of repeated BCG vaccination are warranted... - A new assay method for late CFU-S formation and long-term reconstituting activity using a small number of pluripotent hemopoietic stem cellsGuoxiang Yang
First Department of Pathology, Transplantation Center, and Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
Stem Cells 20:241-8. 2002..Moreover, donor-derived multilineage cells were detected in all the hematolymphoid organs of the recipient mice. This new assay method using a small number of cells would be of great advantage for clarifying which cells are truly P-HSCs... - Activity and stability of laccase in conjugation with chitosanGary Delanoy
Department of Molecular Bioscience and Bioengineering, Honolulu, HI 96822, USA
Int J Biol Macromol 35:89-95. 2005..Compared to free laccase, the conjugated laccase had a similar affinity (Km), but reduced turnover (kcat) that was adversely affected with increase of molecular mass of chitosan... - Analyses of very early hemopoietic regeneration after bone marrow transplantation: comparison of intravenous and intrabone marrow routesQing Li
First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
Stem Cells 25:1186-94. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Prevalence of plasmid-mediated AmpC beta-lactamases in a Chinese university hospital from 2003 to 2005: first report of CMY-2-Type AmpC beta-lactamase resistance in ChinaYi Li
Department of Clinical Laboratory Medicine, Sixth Affiliate Hospital of Shanghai Jiao Tong University, 600 Yi Shan Rd, Shanghai 200233, People s Republic of China
J Clin Microbiol 46:1317-21. 2008..pneumoniae was the most prevalent bacterium harboring a PABL. To the best of our knowledge, this is the first report of CMY-2-type AmpC beta-lactamases in the Chinese mainland... - Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogramJonathan E McDunn
Center for Critical Illness and Health Engineering, Department of Surgery, Washington University in St Louis, St Louis, Missouri, USA
PLoS ONE 3:e1564. 2008..We hypothesized that circulating leukocyte transcriptional profiles can be used to monitor the host response to and recovery from infection complicating critical illness... - Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprueGail G Pyle
Celiac Sprue Research Foundation, Palo Alto, California 94304-1193, USA
Clin Gastroenterol Hepatol 3:687-94. 2005..Pretreatment of gluten with PEP avoided the development of fat or carbohydrate malabsorption in the majority of those patients who developed fat or carbohydrate malabsorption after a 2-week gluten challenge... - Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in miceJohn Bylander
Deparment of Biochemistry and Molecular Biology, Penn State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
Am J Physiol Renal Physiol 294:F480-90. 2008..These studies indicate that meprin-beta is important in the pathogenesis of renal injury following I/R and that the redistribution of active meprin-alpha/beta is a major contributor to renal injury and subsequent inflammation... - The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse modelQi Peng
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Exp Neurol 210:154-63. 2008..Our findings suggest that a clinical trial of SSRI treatment in order to retard disease progression in human HD may be warranted... - Prevention of osteoporosis and hypogonadism by allogeneic ovarian transplantation in conjunction with intra-bone marrow-bone marrow transplantationWei Feng
First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
Transplantation 84:1459-66. 2007..We investigated the effects of ovarian allograft in conjunction with intra-bone marrow-bone marrow transplantation (IBM-BMT) on estrogen deficiency in mice... - Protective effects of phytoestrogen alpha-zearalanol on beta amyloid25-35 induced oxidative damage in cultured rat hippocampal neuronsYi Long Dong
Department of Pharmacology, Institute of Basic Science, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, China
Endocrine 32:206-11. 2007..These data suggested that the phytoestrogen alpha-ZAL, like estrogen, may effectively antagonize A beta 25-35-induced cell toxicity, which might be beneficial for neurons... - Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley ratsShuang Wang
Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 China
Neurobiol Dis 29:52-8. 2008..Our study suggests that LFS of targets outside the limbic system, such as the FN, may have a significant anti-epileptogenic action, and the effects of LFS depend on the frequency and timing of stimulation... - [Expression of CD4+ CD25+ regulatory T cells in peripheral blood and salivary gland of patients with primary Sjögren's syndrome]Xiao Mei Li
Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei 230001, China
Zhonghua Yi Xue Za Zhi 87:1034-6. 2007..To investigate the expression of CD(4)(+) CD(25)(+) regulatory T cells (Tregs) in the peripheral blood and salivary gland of patients with primary Sjögren's syndrome (pSS)... - Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidationJohn Zhong Li
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Diabetes 56:2523-32. 2007..Cideb, another member of Cide family protein, is highly expressed in the liver. We would like to understand the physiological role of Cideb in the regulation of energy expenditure and lipid metabolism... - The characteristics of hematopoietic stem cells from autoimmune-prone mice and the role of neural cell adhesion molecules in abnormal proliferation of these cells in MRL/lpr miceXiaoli Wang
First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
Haematologica 92:300-7. 2007..1 In order to understand how autoimmune diseases develop, we investigated the distinct qualitative differences between hematopoietic stem cells (HSC) from normal and autoimmune-prone mice... - The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantlyChengjin Zhang
Laboratory of Developmental Signalling and Patterning, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore
Dev Biol 305:14-27. 2007..It was also shown that Notch signaling negatively regulates mib expression in a Su(H)-dependent manner, forming a negative feedback loop in modulating Notch activation... - NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strainsQing Li
NewBiotics, Inc, San Diego, California 92121, USA
Antimicrob Agents Chemother 46:1262-8. 2002..The results indicate that NB2001 is a potent, broad-spectrum antibacterial agent and demonstrate the potential of ECTA in overcoming beta-lactamase-mediated resistance...