Qing Li

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. pmc Effect of forest bathing trips on human immune function
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    Environ Health Prev Med 15:9-17. 2010
  2. ncbi request reprint Mechanism of ziram-induced apoptosis in human natural killer cells
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Int J Immunopathol Pharmacol 25:883-91. 2012
  3. doi request reprint Mechanism of ziram-induced apoptosis in human T lymphocytes
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Toxicol 86:615-23. 2012
  4. doi request reprint Effect of ziram on natural killer, lymphokine-activated killer, and cytotoxic T lymphocyte activity
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Toxicol 86:475-81. 2012
  5. ncbi request reprint Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo
    Int J Immunopathol Pharmacol 24:837-47. 2011
  6. ncbi request reprint A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjects
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    J Biol Regul Homeost Agents 24:157-65. 2010
  7. ncbi request reprint Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 213:107-16. 2005
  8. ncbi request reprint Effect of electric foot shock and psychological stress on activities of murine splenic natural killer and lymphokine-activated killer cells, cytotoxic T lymphocytes, natural killer receptors and mRNA transcripts for granzymes and perforin
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    Stress 8:107-16. 2005
  9. ncbi request reprint Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 204:41-50. 2004
  10. ncbi request reprint Phytoncides (wood essential oils) induce human natural killer cell activity
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Immunopharmacol Immunotoxicol 28:319-33. 2006

Collaborators

Detail Information

Publications90

  1. pmc Effect of forest bathing trips on human immune function
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    Environ Health Prev Med 15:9-17. 2010
    ..These findings indicate that forest bathing trips resulted in an increase in NK activity, which was mediated by increases in the number of NK cells and the levels of intracellular granulysin, perforin, and granzymes A/B...
  2. ncbi request reprint Mechanism of ziram-induced apoptosis in human natural killer cells
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Int J Immunopathol Pharmacol 25:883-91. 2012
    ..These findings indicate that ziram can induce apoptosis in human NK cells, and the apoptosis is at least mediated by both the caspase-cascade and the mitochondria/cytochrome-c pathways...
  3. doi request reprint Mechanism of ziram-induced apoptosis in human T lymphocytes
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Toxicol 86:615-23. 2012
    ..These findings indicate that ziram can induce apoptosis in human T cells, and the apoptosis is mediated by both the caspase-cascade and the mitochondria/cytochrome-c pathways...
  4. doi request reprint Effect of ziram on natural killer, lymphokine-activated killer, and cytotoxic T lymphocyte activity
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Toxicol 86:475-81. 2012
    ..Taken together, these findings suggest the ziram-induced inhibition of NK, LAK, and CTL activities to be at least partially mediated by decreases in the intracellular levels of Gr3/K, granulysin, perforin, GrA, and GrB...
  5. ncbi request reprint Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo
    Int J Immunopathol Pharmacol 24:837-47. 2011
    ..However, ETBE exposure did not affect the numbers of splenic NK cells, B cells, or macrophages or the total number of splenocytes. The above findings indicate that ETBE selectively affects the number of splenic T cells in mice...
  6. ncbi request reprint A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjects
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    J Biol Regul Homeost Agents 24:157-65. 2010
    ..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity...
  7. ncbi request reprint Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 213:107-16. 2005
    ..We also found that DDVP have a modest, but a significant inhibitory effect on the transcription of mRNA of perforin, granzyme A and granulysin...
  8. ncbi request reprint Effect of electric foot shock and psychological stress on activities of murine splenic natural killer and lymphokine-activated killer cells, cytotoxic T lymphocytes, natural killer receptors and mRNA transcripts for granzymes and perforin
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    Stress 8:107-16. 2005
    ..On the other hand, the foot-shock stress increased granzyme B. The above findings suggest that stress induced inhibition of NK, LAK and CTL activities partially via affecting NK receptors, granzymes and perforin...
  9. ncbi request reprint Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 204:41-50. 2004
    ..Taken together, these findings indicate that the DDVP-induced inhibition of NK, LAK and CTL activities in PKO mice is mediated by the impairment of the FasL/Fas pathway...
  10. ncbi request reprint Phytoncides (wood essential oils) induce human natural killer cell activity
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Immunopharmacol Immunotoxicol 28:319-33. 2006
    ..Taken together, these data indicate that phytoncides significantly enhance human NK activity and this effect is at least partially mediated by induction of intracellular perforin, granzyme A, and granulysin...
  11. ncbi request reprint The mechanism of organophosphorus pesticide-induced inhibition of cytolytic activity of killer cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Cell Mol Immunol 3:171-8. 2006
    ....
  12. ncbi request reprint Healthy lifestyles are associated with higher levels of perforin, granulysin and granzymes A/B-expressing cells in peripheral blood lymphocytes
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Prev Med 44:117-23. 2007
    ..In order to explore the underlying mechanism, we investigated the effect of lifestyle on intracellular perforin, granulysin, and granzymes A/B in peripheral blood lymphocytes (PBL)...
  13. ncbi request reprint A forest bathing trip increases human natural killer activity and expression of anti-cancer proteins in female subjects
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Biol Regul Homeost Agents 22:45-55. 2008
    ..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity...
  14. ncbi request reprint Effect of phytoncide from trees on human natural killer cell function
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Int J Immunopathol Pharmacol 22:951-9. 2009
    ..Phytoncides, such as alpha-pinene and beta-pinene, were detected in the hotel room air. These findings indicate that phytoncide exposure and decreased stress hormone levels may partially contribute to increased NK activity...
  15. ncbi request reprint New mechanism of organophosphorus pesticide-induced immunotoxicity
    Qing Li
    Department of Environmental Medicine, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Nippon Med Sch 74:92-105. 2007
    ..3) OPs induce apoptosis of immune cells...
  16. ncbi request reprint Forest bathing enhances human natural killer activity and expression of anti-cancer proteins
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo
    Int J Immunopathol Pharmacol 20:3-8. 2007
    ....
  17. ncbi request reprint DDVP markedly decreases the expression of granzyme B and granzyme 3/K in human NK cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 243:294-302. 2008
    ..Taken together, DDVP significantly inhibits NK activity and reduces the intracellular GrB and Gr3/K levels in NK cells...
  18. doi request reprint Chlorpyrifos induces apoptosis in human T cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, 113 8602 Tokyo, Japan
    Toxicology 255:53-7. 2009
    ..These findings indicate that chlorpyrifos can induce apoptosis in human Jurkat T cell cells, and this effect is partially mediated by the activation of intracellular caspase-3...
  19. ncbi request reprint Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Int J Immunopathol Pharmacol 21:117-27. 2008
    ..Phytoncides released from trees and decreased stress hormone may partially contribute to the increased NK activity...
  20. ncbi request reprint Elevated frequency of sister chromatid exchanges of lymphocytes in sarin-exposed victims of the Tokyo sarin disaster 3 years after the event
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 201:209-17. 2004
    ..On the other hand, there was no significant difference in natural killer activity between the exposed and the controls...
  21. doi request reprint Ziram induces apoptosis and necrosis in human immune cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Toxicol 85:355-61. 2011
    ..These findings indicate that ziram can induce apoptosis/necrosis in U937 cells, and this effect is partially mediated by activation of intracellular caspase-3 and mitochondrial cytochrome c release...
  22. doi request reprint Acute effects of walking in forest environments on cardiovascular and metabolic parameters
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    Eur J Appl Physiol 111:2845-53. 2011
    ....
  23. doi request reprint Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar rats
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Hum Exp Toxicol 30:665-74. 2011
    ..However, FNT and MNP exposures did not affect splenic NK cells, B cells, macrophages, and granulocytes. The above findings indicate that FNT and MNP may selectively affect splenic T cells in rats...
  24. ncbi request reprint [Effect of forest therapy on the human psycho-neuro-endocrino-immune network]
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Japan
    Nihon Eiseigaku Zasshi 66:645-50. 2011
    ..Taken together, forest therapy brings various effects on human health via the psycho-neuro-endocrino-immune network...
  25. ncbi request reprint Organophosphorus pesticides induce apoptosis in human NK cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Tokyo, Japan
    Toxicology 239:89-95. 2007
    ..Taken together, these findings suggest that OP-induced inhibition of NK activity may be at least partially mediated by OP-induced apoptosis in NK...
  26. ncbi request reprint Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphokine-activated killer: a proposed inhibiting mechanism via granzyme inhibition
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 172:181-90. 2002
    ..We also found that DDVP significantly inhibited granzyme activity in a dose-dependent manner. These findings indicate that OPs significantly decrease NK, LAK and CTL activities in vitro via granzyme inhibition...
  27. ncbi request reprint Effect of forest environments on human natural killer (NK) activity
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Int J Immunopathol Pharmacol 24:39S-44S. 2011
    ....
  28. ncbi request reprint Chlorpyrifos induces apoptosis in human monocyte cell line U937
    Ari Nakadai
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 224:202-9. 2006
    ..These findings indicate that chlorpyrifos can induce apoptosis in U937 cells, and this effect is partially mediated by activation of intracellular caspase-3...
  29. doi request reprint Increase in the prevalence of metabolic syndrome among workers according to age
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Aging Male 13:184-7. 2010
    ..Statistical information regarding the prevalence of metabolic syndrome among a wide age range of workers is insufficient...
  30. doi request reprint Relationship among lifestyles, aging and psychological wellbeing using the General Health Questionnaire 12-items in Japanese working men
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Aging Male 14:115-8. 2011
    ..CONCLUSION. Although cause-effect relationship cannot make clear, some of desirable health practices and aging were closely related to psychological wellbeing judged by GHQ12...
  31. ncbi request reprint Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificity
    Yukiyo Hirata
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Biochem Biophys 446:35-43. 2006
    ....
  32. doi request reprint A cross-sectional study on the shift work and metabolic syndrome in Japanese male workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Aging Male 13:174-8. 2010
    ..To clarify the association between the type of shift work and the risk of MetS, a cross-sectional field survey was conducted after adjusting for age and lifestyle factors...
  33. ncbi request reprint Insomnia as a sequela of sarin toxicity several years after exposure in Tokyo subway trains
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Percept Mot Skills 100:1121-6. 2005
    ..Although posttraumatic stress disorder is assumed to be a psychological effect of exposure to a toxic substance, a cause-and-effect relationship has not been established...
  34. doi request reprint Patterns in self-rated health according to age and sex in a Japanese national survey, 1989-2004
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Gend Med 6:329-34. 2009
    ..Perceived good health or good self-rated health is considered to be a predictor of longer survival and maintenance of good quality of life, which is a public health goal...
  35. doi request reprint Relationship between two indicators of coronary risk estimated by the Framingham Risk Score and the number of metabolic syndrome components in Japanese male manufacturing workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo 113 8602, Japan
    Metab Syndr Relat Disord 7:435-40. 2009
    ..Components of the metabolic syndrome and several lifestyle factors have also been evaluated to estimate the risk of CHD...
  36. doi request reprint Serum insulin is significantly related to components of the metabolic syndrome in Japanese working men
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Clin Hypertens (Greenwich) 12:309-14. 2010
    ..09, 0.13, -0.16, and -0.11, respectively. A statistically significant relationship existed between the components of MS, especially abdominal obesity, and the serum insulin levels...
  37. doi request reprint Optimal cut-off levels of body mass index and waist circumference in relation to each component of metabolic syndrome (MetS) and the number of MetS component
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8602, Japan
    Diabetes Metab Syndr 5:25-8. 2011
    ..There is an ethnic difference of obesity index to diagnose metabolic syndrome. The authors explored the optimal cut-off levels for body mass index (BMI) and waist circumference (WC) in relation to each component of metabolic syndrome...
  38. doi request reprint Depressive state and subsequent weight gain in workers: A 4-year follow-up study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Japan
    Work 38:123-7. 2011
    ..However, to precisely understand the nature of this relationship, the data should be controlled for other factors that can also be associated with weight gain...
  39. ncbi request reprint New mechanism of organophosphorus pesticide-induced immunotoxicity
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School
    J Nippon Med Sch 74:70-3. 2007
  40. ncbi request reprint A point mutation in a silencer module reduces the promoter activity for the human mercaptopyruvate sulfurtransferase
    Noriyuki Nagahara
    Department of Environmental Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Biochim Biophys Acta 1680:176-84. 2004
    ..A replacement of -391G to C lost the silencer function; on the other hand, a replacement of -394G to T or C, -393C to T or -392T to G markedly reduced the promoter activity...
  41. ncbi request reprint Sister chromatid exchanges of human peripheral blood lymphocytes induced by N,N-diethylaniline in vitro
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Mutat Res 395:151-7. 1997
    ..ANOVA analyses indicated that there is a dose-response relationship between doses of N,N-diethylaniline and the frequency of SCEs, especially in the presence of S-9 mix. The results suggested that N,N-diethylaniline has genotoxicity...
  42. ncbi request reprint Elevated frequency of sister chromatid exchanges in lymphocytes of victims of the Tokyo sarin disaster and in experiments exposing lymphocytes to by-products of sarin synthesis
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Toxicol Lett 98:95-103. 1998
    ..Thus, the in vitro SCE-inducing effect of DIMP, DEMP and EIMP was examined using human lymphocytes and we obtained positive results...
  43. ncbi request reprint Acute immunotoxicity of p-chloronitrobenzene in mice: II. Effect of p-chloronitrobenzene on the immunophenotype of murine splenocytes determined by flow cytometry
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Toxicology 137:35-45. 1999
    ..p. injection of p-CNB. The above findings indicate that p-CNB has an immunotoxic effect on mice...
  44. ncbi request reprint Acute and subchronic immunotoxicity of p-chloronitrobenzene in mice. I. Effect on natural killer, cytotoxic T-lymphocyte activities and mitogen-stimulated lymphocyte proliferation
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Toxicology 127:223-32. 1998
    ..Body weight in subchronically exposed mice was significantly lower than the control from day 19. The above evidence indicated that p-CNB has an inherent immunotoxic effect on mice...
  45. ncbi request reprint The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activity
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Toxicology 146:209-20. 2000
    ..The effect of DIMP and DEMP on the splenic NK activity of mice was stronger than on the splenic CTL activity, and the human lymphocytes is more sensitive to DIMP and DEMP than the splenocytes of mice...
  46. ncbi request reprint Immunotoxicity of N,N-diethylaniline in mice: effect on natural killer activity, cytotoxic T lymphocyte activity, lymphocyte proliferation response and cellular components of the spleen
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8602, Tokyo, Japan
    Toxicology 150:179-89. 2000
    ..The above findings indicated that N,N-diethylaniline selectively inhibited splenic NK and CTL activity and this inhibition was due to decreased NK and CTL functions, but not due to changes in the numbers of splenic NK and T cells...
  47. ncbi request reprint Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?
    Noriyuki Nagahara
    Department of Environmental Medicine, Nippon Medical School, Tokyo, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 3:198-204. 2003
    ....
  48. ncbi request reprint New aspects in pathogenesis of konzo: neural cell damage directly caused by linamarin contained in cassava (Manihot esculenta Crantz)
    V G Sreeja
    Department of Environmental Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Br J Nutr 90:467-72. 2003
    ..0088). Furthermore, glucose also prevented cell death. These present results strongly suggest that linamarin competes with cytochalasin B and glucose for binding to a glucose transporter and enters into cells via glucose transporter...
  49. doi request reprint Facilitation of hematopoietic recovery by bone grafts with intra-bone marrow-bone marrow transplantation
    Changye Song
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, Japan
    Immunobiology 213:455-68. 2008
    ..Moreover, the analyses of thymic sections using confocal microscopy revealed that donor BM stromal cells had migrated into the thymus. Thus, the co-administration of donor bones has great advantages for allogeneic BMT in adult mice...
  50. doi request reprint RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model
    Alexey Aleshin
    Department of Surgery, Columbia University, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 294:H1823-32. 2008
    ....
  51. pmc Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease
    Naoki Masuda
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:293-302. 2008
    ..These results suggest that tiagabine may have beneficial effects in the treatment of HD. Because tiagabine is an FDA-approved drug, it may be a promising candidate for future clinical trials for the treatment of HD...
  52. ncbi request reprint Intracellular mediators of granulysin-induced cell death
    Satoshi Okada
    Division of Immunology and Transplantation Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Immunol 171:2556-62. 2003
    ..Finally, an increase in intracellular glutathione protects target cells from granulysin-induced lysis, indicating the importance of the redox state in granulysin-mediated cell death...
  53. ncbi request reprint Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization
    Thomas Marti
    Celiac Sprue Research Foundation, 3181 Porter Dr, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 312:19-26. 2005
    ....
  54. ncbi request reprint Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator
    Anmei Deng
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 174:5243-8. 2005
    ....
  55. pmc Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin
    Qing Li
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Antimicrob Agents Chemother 49:388-97. 2005
    ..The finding that some derivatives of granulysin are hemolytic may have important implications for the design of granulysin-based antimicrobial therapeutics...
  56. ncbi request reprint T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjögren's syndrome
    Xiaomei Li
    Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, Anhui Province, China
    J Rheumatol 34:2438-45. 2007
    ..To investigate the abnormalities of T regulatory cells (Treg) in salivary glands and peripheral blood in patients with primary Sjögren's syndrome (pSS)...
  57. doi request reprint Analysis of tolerance induction using triple chimeric mice: major histocompatibility complex-disparate thymus, hemopoietic cells, and microenvironment
    Wenhao Cui
    Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Transplantation 85:1151-8. 2008
    ..We have previously shown that fetal thymus transplantation (TT) with BMT is effective for elderly recipients in mice...
  58. doi request reprint Simultaneous determination of 13 bioactive compounds in Herba Artemisiae Scopariae (Yin Chen) from different harvest seasons by HPLC-DAD
    Xiao jie Tan
    School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, PR China
    J Pharm Biomed Anal 47:847-53. 2008
    ..The samples analyzed contained a much lower level of the amount of other flavonoids and coumarins as rutin, hyperoside, isoquercitrin and scoparone...
  59. doi request reprint PPF1 may suppress plant senescence via activating TFL1 in transgenic Arabidopsis plants
    Da yong Wang
    Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009, China
    J Integr Plant Biol 50:475-83. 2008
    ..The activation of TFL1 expression by PPF1 defines an important pathway possibly essential for the negative regulation of plant senescence in transgenic Arabidopsis...
  60. doi request reprint Successful acceptance of adult liver allografts by intra-bone marrow-bone marrow transplantation
    Satoshi Okazaki
    1st Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells Dev 17:629-39. 2008
    ..These results demonstrate that the acceptance of allogeneic liver can be achieved by cografting donor BMCs via the IBM route...
  61. ncbi request reprint Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity
    Daniel F Hoft
    Division of Infectious Diseases and Immunology and Vaccine and Treatment Evaluation Unit, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    J Infect Dis 186:1448-57. 2002
    ..Despite previous evidence that type 1 immune responses are essential for TB immunity, interferon-gamma production did not correlate with mycobacterial inhibition. These results have important implications for TB vaccine development...
  62. ncbi request reprint Over expression of transforming growth factor-alpha and epidermal growth factor receptor in human hepatic cirrhosis tissues
    Qing Qiao
    Department of General Surgery, Xijing Hospital Fourth Military Medical University, Xi an, China
    Hepatogastroenterology 55:169-72. 2008
    ..The purpose of this study was to investigate the expression of transforming growth factor-alpha and epidermal growth factor receptor in human hepatic cirrhosis tissues...
  63. doi request reprint Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease mice
    Xiang Ying Kong
    Department of Pharmacology, School of Basic Medicine, Peking Union Medical College and Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing, 100005 China
    Brain Res 1205:108-15. 2008
    ..The results suggested that transplanted HACs could survive and promote the endogenous neurogenesis of mice, which maybe related to the increased level of neurotrophins of the striatum...
  64. ncbi request reprint A novel apoptosis pathway activated by the carboxyl terminus of p21
    Chen Dong
    Division of Immunology and Transplantation Biology, Department of Pediatrics, CCSR 2105, 300 Pasteur Dr, Stanford University, Stanford, CA 94305 5164, USA
    Blood 105:1187-94. 2005
    ..Targeting the p21 peptide to specific cell populations may allow development of novel therapies to eliminate aberrant cells in human diseases...
  65. ncbi request reprint A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway
    Qing Li
    Clinical Immunology Unit and Sir Y K Pao Centre for Cancer, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong Special Administrative Region, China
    J Biol Chem 279:52106-16. 2004
    ..We propose that BRE inhibits, by ubiquitination-like activity, components in or proximal to the death-inducing signaling complexes that are necessary for activation of the mitochondria...
  66. ncbi request reprint Induction of tolerance in quadruple chimeric mice
    Tian xue Fan
    Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Stem Cells 22:683-95. 2004
    ....
  67. ncbi request reprint Effects of 17beta-estradiol on in vitro maturation of pig oocytes in protein-free medium
    Qing Li
    The Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 50:305-13. 2004
    ..This E(2) inhibition may occur indirectly via the cumulus cells and inhibition of P(4) synthesis...
  68. pmc Mechanism of action of NB2001 and NB2030, novel antibacterial agents activated by beta-lactamases
    Geoffrey W Stone
    NewBiotics, Inc, San Diego, California 92121, USA
    Antimicrob Agents Chemother 48:477-83. 2004
    ..aureus and E. coli. Taken together, the results suggest that NB2001 and NB2030 act primarily as triclosan prodrugs in S. aureus and E. coli...
  69. ncbi request reprint [Chewing gum and caries]
    Qing Li
    Shanghai Kou Qiang Yi Xue 12:208-11. 2003
  70. ncbi request reprint Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin
    Qing Li
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Pathol 201:296-302. 2003
    ..Furthermore, it is possible that antibodies against CD146 may be useful for separating haemangioma-derived endothelial cells from normal endothelial cells and pericytes...
  71. ncbi request reprint N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation
    Yanchun Deng
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Int J Cancer 106:342-7. 2003
    ..Our findings provide the first evidence to suggest that hNDRG2 may play a role in glioblastoma carcinogenesis...
  72. ncbi request reprint Racial differences in thoracic aorta atherosclerosis among ischemic stroke patients
    Vishal Gupta
    Heart Station Echocardiography Laboratories, University of Alabama, Birmingham 35249, USA
    Stroke 34:408-12. 2003
    ....
  73. pmc Enhanced immunogenicity of pneumococcal surface adhesin A by genetic fusion to cytokines and evaluation of protective immunity in mice
    Dennis O Gor
    Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4943, USA
    Infect Immun 70:5589-95. 2002
    ..The modest levels of protection seen in mice immunized with PsaA and its more immunogenic derivatives may be explained in part by the relative inaccessibility of antibody to PsaA on the surface of encapsulated S. pneumoniae...
  74. pmc Bactericidal activity in whole blood as a potential surrogate marker of immunity after vaccination against tuberculosis
    Seon Hee Cheon
    Case Western Reserve University, Cleveland, Ohio, USA
    Clin Diagn Lab Immunol 9:901-7. 2002
    ..These experiments indicate that whole blood culture may be used to measure immunity to M. tuberculosis and that further studies of repeated BCG vaccination are warranted...
  75. ncbi request reprint A new assay method for late CFU-S formation and long-term reconstituting activity using a small number of pluripotent hemopoietic stem cells
    Guoxiang Yang
    First Department of Pathology, Transplantation Center, and Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells 20:241-8. 2002
    ..Moreover, donor-derived multilineage cells were detected in all the hematolymphoid organs of the recipient mice. This new assay method using a small number of cells would be of great advantage for clarifying which cells are truly P-HSCs...
  76. ncbi request reprint Activity and stability of laccase in conjugation with chitosan
    Gary Delanoy
    Department of Molecular Bioscience and Bioengineering, Honolulu, HI 96822, USA
    Int J Biol Macromol 35:89-95. 2005
    ..Compared to free laccase, the conjugated laccase had a similar affinity (Km), but reduced turnover (kcat) that was adversely affected with increase of molecular mass of chitosan...
  77. ncbi request reprint Analyses of very early hemopoietic regeneration after bone marrow transplantation: comparison of intravenous and intrabone marrow routes
    Qing Li
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 25:1186-94. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  78. pmc Prevalence of plasmid-mediated AmpC beta-lactamases in a Chinese university hospital from 2003 to 2005: first report of CMY-2-Type AmpC beta-lactamase resistance in China
    Yi Li
    Department of Clinical Laboratory Medicine, Sixth Affiliate Hospital of Shanghai Jiao Tong University, 600 Yi Shan Rd, Shanghai 200233, People s Republic of China
    J Clin Microbiol 46:1317-21. 2008
    ..pneumoniae was the most prevalent bacterium harboring a PABL. To the best of our knowledge, this is the first report of CMY-2-type AmpC beta-lactamases in the Chinese mainland...
  79. pmc Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram
    Jonathan E McDunn
    Center for Critical Illness and Health Engineering, Department of Surgery, Washington University in St Louis, St Louis, Missouri, USA
    PLoS ONE 3:e1564. 2008
    ..We hypothesized that circulating leukocyte transcriptional profiles can be used to monitor the host response to and recovery from infection complicating critical illness...
  80. ncbi request reprint Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue
    Gail G Pyle
    Celiac Sprue Research Foundation, Palo Alto, California 94304 1193, USA
    Clin Gastroenterol Hepatol 3:687-94. 2005
    ..We sought to determine whether prolyl endopeptidase (PEP) treatment of food gluten would obviate the intestinal dysfunction produced by small amounts of dietary gluten supplement in patients with celiac sprue...
  81. doi request reprint Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
    John Bylander
    Deparment of Biochemistry and Molecular Biology, Penn State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F480-90. 2008
    ..These studies indicate that meprin-beta is important in the pathogenesis of renal injury following I/R and that the redistribution of active meprin-alpha/beta is a major contributor to renal injury and subsequent inflammation...
  82. pmc The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
    Qi Peng
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Exp Neurol 210:154-63. 2008
    ..Our findings suggest that a clinical trial of SSRI treatment in order to retard disease progression in human HD may be warranted...
  83. ncbi request reprint Prevention of osteoporosis and hypogonadism by allogeneic ovarian transplantation in conjunction with intra-bone marrow-bone marrow transplantation
    Wei Feng
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Transplantation 84:1459-66. 2007
    ..We investigated the effects of ovarian allograft in conjunction with intra-bone marrow-bone marrow transplantation (IBM-BMT) on estrogen deficiency in mice...
  84. ncbi request reprint Protective effects of phytoestrogen alpha-zearalanol on beta amyloid25-35 induced oxidative damage in cultured rat hippocampal neurons
    Yi Long Dong
    Department of Pharmacology, Institute of Basic Science, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, China
    Endocrine 32:206-11. 2007
    ..These data suggested that the phytoestrogen alpha-ZAL, like estrogen, may effectively antagonize A beta 25-35-induced cell toxicity, which might be beneficial for neurons...
  85. ncbi request reprint Low-frequency stimulation of cerebellar fastigial nucleus inhibits amygdaloid kindling acquisition in Sprague-Dawley rats
    Shuang Wang
    Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058 China
    Neurobiol Dis 29:52-8. 2008
    ..Our study suggests that LFS of targets outside the limbic system, such as the FN, may have a significant anti-epileptogenic action, and the effects of LFS depend on the frequency and timing of stimulation...
  86. ncbi request reprint [Expression of CD4+ CD25+ regulatory T cells in peripheral blood and salivary gland of patients with primary Sjögren's syndrome]
    Xiao Mei Li
    Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei 230001, China
    Zhonghua Yi Xue Za Zhi 87:1034-6. 2007
    ..To investigate the expression of CD(4)(+) CD(25)(+) regulatory T cells (Tregs) in the peripheral blood and salivary gland of patients with primary Sjögren's syndrome (pSS)...
  87. ncbi request reprint Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation
    John Zhong Li
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Diabetes 56:2523-32. 2007
    ..Cideb, another member of Cide family protein, is highly expressed in the liver. We would like to understand the physiological role of Cideb in the regulation of energy expenditure and lipid metabolism...
  88. ncbi request reprint The characteristics of hematopoietic stem cells from autoimmune-prone mice and the role of neural cell adhesion molecules in abnormal proliferation of these cells in MRL/lpr mice
    Xiaoli Wang
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Haematologica 92:300-7. 2007
    ..1 In order to understand how autoimmune diseases develop, we investigated the distinct qualitative differences between hematopoietic stem cells (HSC) from normal and autoimmune-prone mice...
  89. ncbi request reprint The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly
    Chengjin Zhang
    Laboratory of Developmental Signalling and Patterning, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore
    Dev Biol 305:14-27. 2007
    ..It was also shown that Notch signaling negatively regulates mib expression in a Su(H)-dependent manner, forming a negative feedback loop in modulating Notch activation...
  90. pmc NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strains
    Qing Li
    NewBiotics, Inc, San Diego, California 92121, USA
    Antimicrob Agents Chemother 46:1262-8. 2002
    ..The results indicate that NB2001 is a potent, broad-spectrum antibacterial agent and demonstrate the potential of ECTA in overcoming beta-lactamase-mediated resistance...