Tomoyuki Kawada

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. ncbi request reprint Comparison of daily life habits and health examination data between smokers and ex-smokers suggests that ex-smokers acquire several healthy-lifestyle practices
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Med Res 35:329-33. 2004
  2. ncbi request reprint Chlorpyrifos induces apoptosis in human monocyte cell line U937
    Ari Nakadai
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 224:202-9. 2006
  3. pmc Feeling refreshed by sleep can predict psychological wellbeing assessed using the general health questionnaire in male workers: a 3-year follow-up study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Psychiatry Investig 9:418-21. 2012
  4. pmc Factor structure of indices of the second derivative of the finger photoplethysmogram with metabolic components and other cardiovascular risk indicators
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Diabetes Metab J 37:40-5. 2013
  5. doi request reprint Insulin resistance, as expressed by HOMA-R, is strongly determined by waist circumference or body mass index among Japanese working men
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Electronic
    Obes Res Clin Pract 4:e1-e82. 2010
  6. doi request reprint Association of smoking status, insulin resistance, body mass index, and metabolic syndrome in workers: A 1-year follow-up study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Electronic
    Obes Res Clin Pract 4:e163-246. 2010
  7. doi request reprint Effect of shift work on the development of metabolic syndrome after 3 years in Japanese male workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Arch Environ Occup Health 69:55-61. 2014
  8. doi request reprint Relationship between several markers and presence of metabolic syndrome or components of the metabolic syndrome in Japanese workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Occup Environ Med 54:984-8. 2012
  9. ncbi request reprint Optimal cut-off levels of body mass index and waist circumference in relation to each component of metabolic syndrome (MetS) and the number of MetS component
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8602, Japan
    Diabetes Metab Syndr 5:25-8. 2011
  10. ncbi request reprint Agreement in regard to total sleep time during a nap obtained via a sleep polygraph and accelerometer: a comparison of different sensitivity thresholds of the accelerometer
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Int J Behav Med 19:398-401. 2012

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Comparison of daily life habits and health examination data between smokers and ex-smokers suggests that ex-smokers acquire several healthy-lifestyle practices
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Med Res 35:329-33. 2004
    ..The association between smoking and health status including healthful life habits was evaluated in subjects living in a rural Japanese area...
  2. ncbi request reprint Chlorpyrifos induces apoptosis in human monocyte cell line U937
    Ari Nakadai
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 224:202-9. 2006
    ..These findings indicate that chlorpyrifos can induce apoptosis in U937 cells, and this effect is partially mediated by activation of intracellular caspase-3...
  3. pmc Feeling refreshed by sleep can predict psychological wellbeing assessed using the general health questionnaire in male workers: a 3-year follow-up study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Psychiatry Investig 9:418-21. 2012
    ..559 (0.415-0.753). None of the other factors showed any statistically significant association. Feeling refreshed by sleep was identified as a predictor of maintained psychological wellbeing in this 3-year follow-up study...
  4. pmc Factor structure of indices of the second derivative of the finger photoplethysmogram with metabolic components and other cardiovascular risk indicators
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Diabetes Metab J 37:40-5. 2013
    ....
  5. doi request reprint Insulin resistance, as expressed by HOMA-R, is strongly determined by waist circumference or body mass index among Japanese working men
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Electronic
    Obes Res Clin Pract 4:e1-e82. 2010
    ..Conclusions: A close relation exists between obesity-related indices (waist circumference and body mass index) and insulin resistance, independent of age and other vascular risk factors in Japanese working men. ..
  6. doi request reprint Association of smoking status, insulin resistance, body mass index, and metabolic syndrome in workers: A 1-year follow-up study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Electronic
    Obes Res Clin Pract 4:e163-246. 2010
    ..In contrast, smoking cessation within 1 year and work history did not contribute to metabolic syndrome. ..
  7. doi request reprint Effect of shift work on the development of metabolic syndrome after 3 years in Japanese male workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Arch Environ Occup Health 69:55-61. 2014
    ..88 (1.29, 2.74) and 0.87 (0.39, 1.97), respectively. The results of the analyses suggested that 2-shift work was a risk factor for the development of metabolic syndrome...
  8. doi request reprint Relationship between several markers and presence of metabolic syndrome or components of the metabolic syndrome in Japanese workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Occup Environ Med 54:984-8. 2012
    ..The reported associations between metabolic syndrome (MetS) and systemic vascular inflammation/insulin resistance prompted the author to determine the predictive ability of markers for MetS in the occupational field...
  9. ncbi request reprint Optimal cut-off levels of body mass index and waist circumference in relation to each component of metabolic syndrome (MetS) and the number of MetS component
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8602, Japan
    Diabetes Metab Syndr 5:25-8. 2011
    ..There is an ethnic difference of obesity index to diagnose metabolic syndrome. The authors explored the optimal cut-off levels for body mass index (BMI) and waist circumference (WC) in relation to each component of metabolic syndrome...
  10. ncbi request reprint Agreement in regard to total sleep time during a nap obtained via a sleep polygraph and accelerometer: a comparison of different sensitivity thresholds of the accelerometer
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Int J Behav Med 19:398-401. 2012
    ..Appropriate sensitivity threshold of accelerometer to measure total sleep time during nap is not established...
  11. doi request reprint 100-point scale evaluating job satisfaction and the results of the 12-item General Health Questionnaire in occupational workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Work 42:415-8. 2012
    ..Job satisfaction is an important factor in the occupational lives of workers. In this study, the relationship between one-dimensional scale of job satisfaction and psychological wellbeing was evaluated...
  12. doi request reprint Aging, components of metabolic syndrome and serum C-reactive protein showed significant relationship with carotid atherosclerosis
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Aging Male 15:42-7. 2012
    ..Prediction of carotid atherosclerosis by components of MetS, serum C-reactive protein, aging and related factors was conducted for Japanese inhabitants...
  13. ncbi request reprint Results of a 100-point scale for evaluating job satisfaction and the Occupational Depression Scale questionnaire survey in workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Occup Environ Med 54:420-3. 2012
    ..To evaluate the relationship between the score of job satisfaction and depression...
  14. doi request reprint Predictors of the development of metabolic syndrome in male workers: a 3-year follow-up study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Occup Environ Med 54:292-5. 2012
    ..Risk assessment for the development of metabolic syndrome (MetS) is an important strategy for prevention...
  15. doi request reprint Predictive ability of serum high-molecular-weight adiponectin in combination with serum insulin and serum C-reactive protein for the presence of metabolic syndrome
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Ann Hum Biol 39:108-12. 2012
    ..Metabolic syndrome (MetS) is an insulin-resistance syndrome deeply associated with obesity. The association between MetS and several clinical factors, including serum levels of adiponectin, C-reactive protein and insulin, was examined...
  16. pmc EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts
    Ying Ji Li
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Respir Res 7:16. 2006
    ..We investigated the anti-inflammatory and antifibrotic effects of EM703 in an experimental model of bleomycin-induced lung injury and subsequent fibrosis in mice...
  17. doi request reprint Anthropometric obesity indices and metabolic syndrome in Japanese working men
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Japan
    Work 34:89-94. 2009
    ..In this study, the usefulness of waist circumference (WC) and body mass index (BMI) determination as predictors of metabolic syndrome (MetS) was evaluated in Japanese working men...
  18. doi request reprint Lifestyle determinants of depressive feeling and a feeling of unhappiness among workers: a study in Japan
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Work 33:255-60. 2009
    ..Lifestyle determinants of depressive state and a feeling of unhappiness in daily life were evaluated among the workers in Japan by adjusting obesity and age...
  19. ncbi request reprint Prostate-specific antigen screening of workers under the age of 40 in Japan
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo 113 8602, Japan
    Cancer Epidemiol 33:309-10. 2009
    ..To understand the prevalence of PSA testing in young men, the authors examined the age distribution of workers who underwent the PSA test...
  20. doi request reprint Patterns in self-rated health according to age and sex in a Japanese national survey, 1989-2004
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Gend Med 6:329-34. 2009
    ..Perceived good health or good self-rated health is considered to be a predictor of longer survival and maintenance of good quality of life, which is a public health goal...
  21. doi request reprint Relationship between two indicators of coronary risk estimated by the Framingham Risk Score and the number of metabolic syndrome components in Japanese male manufacturing workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo 113 8602, Japan
    Metab Syndr Relat Disord 7:435-40. 2009
    ..Components of the metabolic syndrome and several lifestyle factors have also been evaluated to estimate the risk of CHD...
  22. ncbi request reprint Physical symptoms and psychological health status by the type of job
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Work 31:397-403. 2008
    ..The purpose of this study is to determine the relationship between job content and subjective health status...
  23. ncbi request reprint Activity and sleeping time monitored by an accelerometer in rotating shift workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Work 30:157-60. 2008
    ..The relationship between total sleep time and activity levels during work before or after sleep in two rotating work shifts was compared...
  24. ncbi request reprint Components of the metabolic syndrome and lifestyle factors in Japanese male workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Metab Syndr Relat Disord 6:263-6. 2008
    ..44, 0.59), 0.40 (0.35, 0.46), and 0.55 (0.45, 0.66), respectively. In contrast, eating breakfast everyday, not snacking frequently, and sleeping 6 hours or more did not relate to the occurrence of any components of the metabolic syndrome...
  25. doi request reprint Agreement rates for sleep/wake judgments obtained via accelerometer and sleep diary: a comparison
    Tomoyuki Kawada
    Nippon Medical School, Tokyo, Japan
    Behav Res Methods 40:1026-9. 2008
    ..In contrast, nocturnal sleep diary data might be supplemented by the use of an accelerometer as long as participants do not have insomnia...
  26. ncbi request reprint Effects of exercise and serum uric acid on the metabolic syndrome for Japanese workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Metab Syndr Relat Disord 6:137-41. 2008
    ..The effects of exercise and serum uric acid on the metabolic syndrome (MetS) were evaluated...
  27. ncbi request reprint Preliminary report: homeostasis model assessment of insulin resistance, an indicator of insulin resistance, is strongly related to serum insulin: practical data presentation and the mathematical basis
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Metabolism 59:1044-6. 2010
    ..Although HOMA-R is a popular indicator of insulin resistance, we recommend that HOMA-R could be substituted simply by serum insulin. This may be valid in the general population with no remakable medical condition...
  28. ncbi request reprint A cross-sectional study on the shift work and metabolic syndrome in Japanese male workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Aging Male 13:174-8. 2010
    ..To clarify the association between the type of shift work and the risk of MetS, a cross-sectional field survey was conducted after adjusting for age and lifestyle factors...
  29. ncbi request reprint Noise and health--sleep disturbance in adults
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Japan
    J Occup Health 53:413-6. 2011
    ..Factors modifying the effect of environmental noise on sleep include sex, age, susceptibility, personality and the health status, including past and present history of disease...
  30. ncbi request reprint Prevalence of the metabolic syndrome and its relationship with diabetes mellitus by aging
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Aging Male 14:203-6. 2011
    ..The authors estimated the risk of development of DM by the presence/absence of MetS and age groups...
  31. doi request reprint Depressive feelings, feelings of unhappiness, and subsequent psychological wellbeing among workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Work 39:315-9. 2011
    ..A depressive state and feelings of unhappiness in daily life are regarded as indispensable factors for the diagnosis of major depression. These factors are also speculated to contribute to subsequent psychological wellbeing...
  32. doi request reprint Depressive state and subsequent weight gain in workers: A 4-year follow-up study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Japan
    Work 38:123-7. 2011
    ..However, to precisely understand the nature of this relationship, the data should be controlled for other factors that can also be associated with weight gain...
  33. doi request reprint Relationship among workload, health complaints, and depressive state of workers as revealed using a questionnaire survey
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Japan
    Work 37:333-9. 2010
    ..Identifying the relationship between workload content and health complaints would likely aid the establishment of preventative health care strategies...
  34. doi request reprint The alcohol use disorders identification test: reliability study of the Japanese version
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Alcohol 45:205-7. 2011
    ..0% (9/113). Thus, the Japanese version of AUDIT showed satisfactory internal reliability. AUDIT is easy to use and is useful for the detection of alcohol-related problems in occupational workers...
  35. doi request reprint Serum insulin is significantly related to components of the metabolic syndrome in Japanese working men
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Clin Hypertens (Greenwich) 12:309-14. 2010
    ..09, 0.13, -0.16, and -0.11, respectively. A statistically significant relationship existed between the components of MS, especially abdominal obesity, and the serum insulin levels...
  36. doi request reprint Significance of the 100-point scale to evaluate perceived tobacco dependence
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Work 35:183-9. 2010
    ....
  37. ncbi request reprint Increase in the prevalence of metabolic syndrome among workers according to age
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Aging Male 13:184-7. 2010
    ..Statistical information regarding the prevalence of metabolic syndrome among a wide age range of workers is insufficient...
  38. doi request reprint Monitoring of the sleep patterns of shift workers in the automotive industry
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Work 38:163-7. 2011
    ..The objective of this study is to compare sleep period among workers engaging in each of the three-shift work...
  39. ncbi request reprint Serum uric acid is significantly related to the components of the metabolic syndrome in Japanese workingmen
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Cardiometab Syndr 2:158-62. 2007
    ..76 (CI, 1.21-2.55), 1.72 (CI, 1.21-2.45), 1.42 (CI, 1.01-2.00), and 1.87 (CI, 1.30-2.69), respectively. Most of the components of MS were significant determinants of SUA...
  40. ncbi request reprint Insomnia as a sequela of sarin toxicity several years after exposure in Tokyo subway trains
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Percept Mot Skills 100:1121-6. 2005
    ..Although posttraumatic stress disorder is assumed to be a psychological effect of exposure to a toxic substance, a cause-and-effect relationship has not been established...
  41. ncbi request reprint Actigraphic predictors of the depressive state in students with no psychiatric disorders
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Affect Disord 98:117-20. 2007
    ..In this study, we examined whether the depressive state would be correlated with the actigraphic-derived daytime activity levels (DAL) and total sleep time (TST) in students with no psychiatric disorders...
  42. ncbi request reprint The effect of noise on the health of children
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Nippon Med Sch 71:5-10. 2004
    ..Researches and studies effective enough to influence policy decisions must be continually conducted in the future, with appropriate control for related factors...
  43. ncbi request reprint Smoking-induced leukocytosis can persist after cessation of smoking
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Arch Med Res 35:246-50. 2004
    ..Associations between smoking and leukocytosis or elevated hemoglobin concentrations in the blood need to be validated using multivariate analysis...
  44. ncbi request reprint Risk factors and prevalence of asthma or atopic dermatitis in young children by a questionnaire survey
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School
    J Nippon Med Sch 71:167-71. 2004
    ..There was an increase in the prevalence of atopic disorders in groups living at a higher altitude was observed in this area...
  45. ncbi request reprint Factors associated with perceived health of very old inhabitants of Japan
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Gerontology 52:258-63. 2006
    ..Perceived health or self-rated subjective health of the oldest inhabitants of Japan was studied to identify its associated impact on their lives...
  46. ncbi request reprint Health practices and survival among middle-aged residents of Japan: a ten-year follow-up cohort study of 9 towns in Gunma
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 71:242-51. 2004
    ..In addition, there was a sex difference in lifestyle-related factors such as exercise, and health examination data such as proteinuria contributing to mortality in middle-aged general inhabitants in rural towns in Japan...
  47. ncbi request reprint Relations of body mass index and coronary risk as estimated by the Framingham Risk Score
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Percept Mot Skills 102:254-8. 2006
    ..271 in men (p < .001) and .211 in women (p < .001), respectively. The significant association of body mass index with coronary heart disease risk, as estimated by the Framingham Risk Score, confirmed prior work...
  48. ncbi request reprint Workload and health complaints in overtime workers: a survey
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Arch Med Res 36:594-7. 2005
    ..Evaluation for the relationship between workload and complaints were urgently required...
  49. ncbi request reprint Validation study on self-reported height, weight, and blood pressure
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Percept Mot Skills 101:187-91. 2005
    ..73, .67, .97, .97, and .94, respectively. Self-reported values for height, weight, and Body Mass Index appear to be valid over years or so...
  50. ncbi request reprint Difference of body mass index stratified by the period of smoking cessation from a cross-sectional study
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Med Res 35:181-4. 2004
    ..Smoking cessation is associated with subsequent obesity. This study was designed to clarify the duration of weight gain lasted after cessation of smoking...
  51. ncbi request reprint The metabolic syndrome: prevalence and associated lifestyles in Japanese workingmen
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Cardiometab Syndr 1:313-7. 2006
    ..381 (1.088-1.752) (P=.008) and 1.812 (1.365-2.407) (P<.001), respectively. In contrast, no preventive effect of alcohol on the occurrence of the metabolic syndrome was noted...
  52. ncbi request reprint Association between components of the metabolic syndrome and serum levels of C-reactive protein in Japanese workingmen
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Cardiometab Syndr 1:168-72. 2006
    ..The odds ratios were 2.5 (group A) and 4.0 (group B), when 3 mg/L was adopted as the cutoff value of C-reactive protein...
  53. ncbi request reprint Body mass index of 23 or more is a risk factor for hypertension and hyperlipidemia in Japanese workers
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Percept Mot Skills 104:733-8. 2007
    ..Health education of weight control of borderline obesity of workers is important for the primary prevention of hypertension and hyperlipidemia in Japan...
  54. ncbi request reprint Self-rated health and life prognosis
    Tomoyuki Kawada
    Department of Public Health, Gunma University School of Medicine, Maebashi, Japan
    Arch Med Res 34:343-7. 2003
    ..An overview on this field of research was necessary to know the range of risk ratio (RR) of poor self-rated health...
  55. ncbi request reprint Population study on the prevalence of insomnia and insomnia-related factors among Japanese women
    Tomoyuki Kawada
    Department of Public Health, Gunma University School of Medicine, Showa 3, Maebashi 371 8511, Japan
    Sleep Med 4:563-7. 2003
    ..To identify the effect of certain factors on insomnia in the general population...
  56. doi request reprint Relationship between job stress, occupational position and job satisfaction using a brief job stress questionnaire (BJSQ)
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Work 40:393-9. 2011
    ..This study focused on the relationship between job satisfaction and three sub-scales of a brief job stress questionnaire (BJSQ) related to workload...
  57. ncbi request reprint Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Clin Immunol 128:366-73. 2008
    ..These results strongly suggest that DEP-induced oxidative stress and host antioxidant responses play some role in the development of DEP-induced airway inflammation...
  58. doi request reprint The effects of oxidative stress induced by prolonged low-dose diesel exhaust particle exposure on the generation of allergic airway inflammation differ between BALB/c and C57BL/6 mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Immunopharmacol Immunotoxicol 31:230-7. 2009
    ..Our results contribute more information to the search for genetic susceptibility factors in the response to DEP, and may thus assist in the discovery of new biomarkers for DEP-related disease...
  59. doi request reprint Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Clin Immunol 137:234-41. 2010
    ....
  60. ncbi request reprint Healthy lifestyles are associated with higher levels of perforin, granulysin and granzymes A/B-expressing cells in peripheral blood lymphocytes
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Prev Med 44:117-23. 2007
    ..In order to explore the underlying mechanism, we investigated the effect of lifestyle on intracellular perforin, granulysin, and granzymes A/B in peripheral blood lymphocytes (PBL)...
  61. doi request reprint EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: importance in IL-8 transcription
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo 113 8602, Japan
    Pulm Pharmacol Ther 26:318-24. 2013
    ..EM and EM703 might contribute to chemical prevention of the risk of pulmonary diseases induced by oxidative stress from environmental pollutant, such as DEP...
  62. ncbi request reprint Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 34:125-39. 2008
    ....
  63. doi request reprint Independent determinants of second derivative of the finger photoplethysmogram among various cardiovascular risk factors in middle-aged men
    Toshiaki Otsuka
    Environmental Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Hypertens Res 30:1211-8. 2007
    ..In conclusion, the SDPTG indices reflect arterial properties affected by several cardiovascular risk factors in middle-aged Japanese men. The association between inflammation and the SDPTG should be evaluated in further studies...
  64. doi request reprint Relationship among lifestyles, aging and psychological wellbeing using the General Health Questionnaire 12-items in Japanese working men
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Aging Male 14:115-8. 2011
    ..CONCLUSION. Although cause-effect relationship cannot make clear, some of desirable health practices and aging were closely related to psychological wellbeing judged by GHQ12...
  65. doi request reprint Relationship between job strain and radial arterial wave reflection in middle-aged male workers
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Prev Med 49:260-4. 2009
    ..This study examined the relationship between job stain and radial arterial wave reflection as expressed by the augmentation index (AI), a marker of cardiovascular risk, in middle-aged male workers...
  66. ncbi request reprint [Incidence of metabolic syndrome and associated lifestyle factors in a worksite male population]
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Sangyo Eiseigaku Zasshi 53:78-86. 2011
    ..The prevention of metabolic syndrome (MetS) is one of the main targets of health promotion activities in the workplace. The present study aimed to clarify the incidence of MetS and associated lifestyle factors in a worksite male population...
  67. ncbi request reprint High-sensitivity C-reactive protein is associated with the risk of coronary heart disease as estimated by the Framingham Risk Score in middle-aged Japanese men
    Toshiaki Otsuka
    Environmental Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Int J Cardiol 129:245-50. 2008
    ..High-sensitivity C-reactive protein (hsCRP) has emerged as an independent predictor of coronary heart disease (CHD) in Western countries. However, it is still uncertain regarding whether hsCRP is associated with the risk of CHD in Japan...
  68. ncbi request reprint Radial arterial wave reflection is associated with the MEGA risk prediction score, an indicator of coronary heart disease risk, in middle-aged men with mild to moderate hypercholesterolemia
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    J Atheroscler Thromb 17:688-94. 2010
    ....
  69. doi request reprint Acute effects of walking in forest environments on cardiovascular and metabolic parameters
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    Eur J Appl Physiol 111:2845-53. 2011
    ....
  70. ncbi request reprint Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificity
    Yukiyo Hirata
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Biochem Biophys 446:35-43. 2006
    ....
  71. doi request reprint Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar rats
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Hum Exp Toxicol 30:665-74. 2011
    ..However, FNT and MNP exposures did not affect splenic NK cells, B cells, macrophages, and granulocytes. The above findings indicate that FNT and MNP may selectively affect splenic T cells in rats...
  72. ncbi request reprint Effect of electric foot shock and psychological stress on activities of murine splenic natural killer and lymphokine-activated killer cells, cytotoxic T lymphocytes, natural killer receptors and mRNA transcripts for granzymes and perforin
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    Stress 8:107-16. 2005
    ..On the other hand, the foot-shock stress increased granzyme B. The above findings suggest that stress induced inhibition of NK, LAK and CTL activities partially via affecting NK receptors, granzymes and perforin...
  73. doi request reprint Mechanism of ziram-induced apoptosis in human T lymphocytes
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Toxicol 86:615-23. 2012
    ..These findings indicate that ziram can induce apoptosis in human T cells, and the apoptosis is mediated by both the caspase-cascade and the mitochondria/cytochrome-c pathways...
  74. doi request reprint Chlorpyrifos induces apoptosis in human T cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, 113 8602 Tokyo, Japan
    Toxicology 255:53-7. 2009
    ..These findings indicate that chlorpyrifos can induce apoptosis in human Jurkat T cell cells, and this effect is partially mediated by the activation of intracellular caspase-3...
  75. ncbi request reprint Role of oxidative stresses induced by diesel exhaust particles in airway inflammation, allergy and asthma: their potential as a target of chemoprevention
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Inflamm Allergy Drug Targets 9:300-5. 2010
    ..Therefore, chemoprevention against DEPs health effects in susceptible individuals may become a choice for future environmental protection policy...
  76. ncbi request reprint Ankle-brachial blood pressure index predicts all-cause and cardiovascular mortality in hemodialysis patients
    Kumeo Ono
    Kan etsu Chuo Hospital, Maebashi, Gunma, Japan
    J Am Soc Nephrol 14:1591-8. 2003
    ..04 [1.14 to 8.12] for all-cause and cardiovascular mortality, respectively). Thus, the present findings validate ABPI as a powerful and independent predictor for all-cause and cardiovascular mortality among hemodialysis patients...
  77. ncbi request reprint Phytoncides (wood essential oils) induce human natural killer cell activity
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Immunopharmacol Immunotoxicol 28:319-33. 2006
    ..Taken together, these data indicate that phytoncides significantly enhance human NK activity and this effect is at least partially mediated by induction of intracellular perforin, granzyme A, and granulysin...
  78. doi request reprint Ziram induces apoptosis and necrosis in human immune cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Arch Toxicol 85:355-61. 2011
    ..These findings indicate that ziram can induce apoptosis/necrosis in U937 cells, and this effect is partially mediated by activation of intracellular caspase-3 and mitochondrial cytochrome c release...
  79. ncbi request reprint Organophosphorus pesticides induce apoptosis in human NK cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Tokyo, Japan
    Toxicology 239:89-95. 2007
    ..Taken together, these findings suggest that OP-induced inhibition of NK activity may be at least partially mediated by OP-induced apoptosis in NK...
  80. doi request reprint Association between high-sensitivity cardiac troponin T levels and the predicted cardiovascular risk in middle-aged men without overt cardiovascular disease
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Am Heart J 159:972-8. 2010
    ..However, it remains unclear whether a slight elevation of hsTnT is associated with an increased cardiovascular risk in subjects without overt cardiovascular disease (CVD)...
  81. ncbi request reprint Relation of smoking status to serum levels of N-terminal pro-brain natriuretic peptide in middle-aged men without overt cardiovascular disease
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Am J Cardiol 106:1456-60. 2010
    ..15, p = 0.034) in former smokers. In conclusion, these results suggest that cigarette smoking increases cardiac overload, whereas smoking cessation ameliorates these conditions...
  82. ncbi request reprint Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 213:107-16. 2005
    ..We also found that DDVP have a modest, but a significant inhibitory effect on the transcription of mRNA of perforin, granzyme A and granulysin...
  83. ncbi request reprint The mechanism of organophosphorus pesticide-induced inhibition of cytolytic activity of killer cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Cell Mol Immunol 3:171-8. 2006
    ....
  84. ncbi request reprint [Evaluation of new saliva collection device for determination of salivary cotinine, cortisol, dehydroepiandrosterone and testosterone concentrations]
    Masao Katsumata
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyou ku, Tokyo, Japan
    Nihon Eiseigaku Zasshi 64:811-6. 2009
    ..This study was conducted to examine the effectiveness of a new salivary collection device (psi10 mm x 25 mm) made of polypropylene and polyethylene polymers (Salisoft((R)))...
  85. ncbi request reprint Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 204:41-50. 2004
    ..Taken together, these findings indicate that the DDVP-induced inhibition of NK, LAK and CTL activities in PKO mice is mediated by the impairment of the FasL/Fas pathway...
  86. doi request reprint Obesity as an independent influential factor for reduced radial arterial wave reflection in a middle-aged Japanese male population
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Hypertens Res 32:387-91. 2009
    ..In conclusion, although it does not have a major impact, obesity, including abdominal obesity, may be an influential factor for reduced radial AI, independently of well-known confounders, in middle-aged Japanese men...
  87. ncbi request reprint [Health management trial using a portable transtelephonic electrocardiograph in company workers with palpitation]
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo, Japan
    Sangyo Eiseigaku Zasshi 50:1-3. 2008
  88. ncbi request reprint DDVP markedly decreases the expression of granzyme B and granzyme 3/K in human NK cells
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 243:294-302. 2008
    ..Taken together, DDVP significantly inhibits NK activity and reduces the intracellular GrB and Gr3/K levels in NK cells...
  89. ncbi request reprint [The trial of simple gas analysis of tobacco smoke that can be used for medical education]
    Masao Katsumata
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Nihon Eiseigaku Zasshi 60:355-61. 2005
    ..The purpose of this study was to check a simple sampling and easy gas analysis of tobacco smoke for effective tobacco intervention in medical education...
  90. ncbi request reprint Utility of second derivative of the finger photoplethysmogram for the estimation of the risk of coronary heart disease in the general population
    Toshiaki Otsuka
    Environmental Medicine, Graduate School of Medicine, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    Circ J 70:304-10. 2006
    ....
  91. ncbi request reprint A monoclonal antibody to hippuric acid: an improved enzyme-linked immunosorbent assay for biological monitoring of toluene exposure
    Hirofumi Inagaki
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Immunoassay Immunochem 27:213-23. 2006
    ..The detection limit of HA by the ELISA was approximately 1 microg/mL. The urinary HA concentration determined by the ELISA system correlated well with that obtained by high performance liquid chromatography...
  92. ncbi request reprint Elevated frequency of sister chromatid exchanges of lymphocytes in sarin-exposed victims of the Tokyo sarin disaster 3 years after the event
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Toxicology 201:209-17. 2004
    ..On the other hand, there was no significant difference in natural killer activity between the exposed and the controls...
  93. ncbi request reprint Recombinant human progranzyme 3 expressed in Escherichia coli for analysis of its activation mechanism
    Yukiyo Hirata
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo 113 8602, Japan
    Microbiol Immunol 54:98-104. 2010
    ..The recombinant pro-Gr3 would be a valuable tool for analyzing the activation mechanism and exploring other activating enzymes besides cathepsin C...
  94. ncbi request reprint Factors affecting bone mineral density in the general adult female population in Japan
    Tomoyuki Kawada
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Percept Mot Skills 97:723-30. 2003
    ....
  95. ncbi request reprint Information on cholesterol program
    Tomoyuki Kawada
    Department of Public Health, Gunma University School of Medicine, Maebashi, Japan
    Percept Mot Skills 94:670. 2002
    ..Factors in low cholesterol values among elderly require very careful monitoring and attention during treatment...
  96. pmc Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin
    Qing Li
    Division of Immunology and Transplantation Biology, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Antimicrob Agents Chemother 49:388-97. 2005
    ..The finding that some derivatives of granulysin are hemolytic may have important implications for the design of granulysin-based antimicrobial therapeutics...