Affiliation: Nippon Medical School
Ishizuya Oka A, Hasebe T, Shi Y. Apoptosis in amphibian organs during metamorphosis. Apoptosis. 2010;15:350-64 pubmed publisher
..Here, we propose that multiple intra- and extracellular apoptotic pathways are coordinately controlled by TH to ensure massive but well-organized apoptosis, which is essential for the proper progression of amphibian metamorphosis. ..
Fujimoto K, Hasebe T, Kajita M, Ishizuya Oka A. Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis. Dev Genes Evol. 2018;228:267-273 pubmed publisher
..These findings suggest that HA newly synthesized by HAS2 and/or HAS3 is required for intestinal stem cell development through a positive feedback loop and is involved in the formation of the stem cell niche during metamorphosis. ..
Ishizuya Oka A, Hasebe T, Buchholz D, Kajita M, Fu L, Shi Y. Origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis. FASEB J. 2009;23:2568-75 pubmed publisher
..Our results provide direct evidence that stem cells that generate the adult intestinal epithelium originate from the larval epithelium, through thyroid hormone-induced dedifferentiation. ..
Hasebe T, Fujimoto K, Kajita M, Ishizuya Oka A. Thyroid hormone activates Wnt/?-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis. Cell Tissue Res. 2016;365:309-18 pubmed publisher
..Thus, TH-up-regulated SFRP2 in the postembryonic intestine promotes adult stem cell development, possibly by acting as an agonist of both canonical and non-canonical Wnt signaling. ..
Ishizuya Oka A, Hasebe T, Shimizu K, Suzuki K, Ueda S. Shh/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling. Dev Dyn. 2006;235:3240-9 pubmed
..These results strongly suggest that the Shh/BMP-4 signaling pathway plays key roles in the amphibian intestinal remodeling through epithelial-connective tissue interactions. ..
Ishizuya Oka A. How thyroid hormone regulates transformation of larval epithelial cells into adult stem cells in the amphibian intestine. Mol Cell Endocrinol. 2017;459:98-103 pubmed publisher
..The present review focuses on such recent findings and discusses the evolutionally conserved roles of TH in development or maintenance of the stem cells which are common to the terrestrial vertebrate intestines. ..
Ishizuya Oka A. Organ Culture of the Xenopus Tadpole Intestine. Cold Spring Harb Protoc. 2017;2017:pdb.prot097683 pubmed publisher
..Such tissue recombination experiments will help to reveal the important role of nonepithelial tissues in larval epithelial apoptosis and/or adult stem cell development in the X. laevis intestine. ..