Affiliation: Nippon Medical School
- Hasebe T, Fujimoto K, Kajita M, Ishizuya Oka A. Thyroid hormone activates Wnt/?-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis. Cell Tissue Res. 2016;365:309-18 pubmed publisher..Thus, TH-up-regulated SFRP2 in the postembryonic intestine promotes adult stem cell development, possibly by acting as an agonist of both canonical and non-canonical Wnt signaling. ..
- Ishizuya Oka A, Hasebe T, Shimizu K, Suzuki K, Ueda S. Shh/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling. Dev Dyn. 2006;235:3240-9 pubmed..These results strongly suggest that the Shh/BMP-4 signaling pathway plays key roles in the amphibian intestinal remodeling through epithelial-connective tissue interactions. ..
- Ishizuya Oka A. How thyroid hormone regulates transformation of larval epithelial cells into adult stem cells in the amphibian intestine. Mol Cell Endocrinol. 2017;: pubmed publisher..The present review focuses on such recent findings and discusses the evolutionally conserved roles of TH in development or maintenance of the stem cells which are common to the terrestrial vertebrate intestines. ..
- Ishizuya Oka A. Organ Culture of the Xenopus Tadpole Intestine. Cold Spring Harb Protoc. 2017;2017:pdb.prot097683 pubmed publisher..Such tissue recombination experiments will help to reveal the important role of nonepithelial tissues in larval epithelial apoptosis and/or adult stem cell development in the X. laevis intestine. ..