Naoki Inoue

Summary

Affiliation: Nippon Shinyaku Co
Country: Japan

Publications

  1. ncbi request reprint Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain
    Naoki Inoue
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kisshoin, Kyoto, Japan
    J Pharmacol Sci 109:600-5. 2009
  2. doi request reprint Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation
    Naoki Inoue
    Exploratory Department, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan
    Pharmacology 90:47-54. 2012
  3. ncbi request reprint Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis
    Naoki Inoue
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Japan
    J Pharmacol Sci 112:73-82. 2010
  4. ncbi request reprint The enantiomers of etodolac, a racemic anti-inflammatory agent, play different roles in efficacy and gastrointestinal safety
    Naoki Inoue
    Pharmacology Department, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Biol Pharm Bull 34:655-9. 2011
  5. doi request reprint Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia
    Sunao Ito
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14, Nishinosho monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    J Pharmacol Exp Ther 342:53-60. 2012
  6. doi request reprint Blockade of voltage-gated calcium channel Ca(v)1.2 and α1-adrenoceptors increases vertebral artery blood flow induced by the antivertigo agent difenidol
    Kohji Murakami
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14, Kisshoin, Kyoto 601 8550, Japan
    Eur J Pharmacol 689:165-71. 2012
  7. ncbi request reprint Relevance of anti-reactive oxygen species activity to anti-inflammatory activity of components of eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia
    Michiko Oka
    Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Phytomedicine 14:465-72. 2007
  8. doi request reprint Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors
    Kohei Kagayama
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Bioorg Med Chem 17:6959-70. 2009
  9. ncbi request reprint Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats
    Masaki Tachibana
    Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan
    Pharmacology 68:96-104. 2003

Collaborators

  • Takashi Kyoi
  • Michiko Oka
  • Akio Nakamura
  • Xin Zhang
  • Seigo Nagata
  • Junichi Yano
  • Koyuki Tajima
  • Sunao Ito
  • Kohji Murakami
  • Asami Hashino
  • Kohei Kagayama
  • Masaki Tachibana
  • Chiaki Fuchikami
  • Hisashi Fukui
  • Kumiko Noda
  • Yasuhiro Yamashita
  • Yosuke Takahashi
  • Masaki Nogawa
  • Takahiro Sasagawa
  • Kouji Banno
  • Makoto Ueda
  • Takashi Kotera
  • Kiyoto Kageyama
  • Jiro Shikaura
  • Fumitaka Katoh
  • Tomoko Niwa
  • Tatsuya Morimoto
  • Masami Matsui
  • Yojiro Ukai
  • Eri Yoshida

Detail Information

Publications9

  1. ncbi request reprint Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain
    Naoki Inoue
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kisshoin, Kyoto, Japan
    J Pharmacol Sci 109:600-5. 2009
    ....
  2. doi request reprint Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation
    Naoki Inoue
    Exploratory Department, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan
    Pharmacology 90:47-54. 2012
    ..Here, we investigate the role of TRPA1 in the mechanism of the antinociceptive action of etodolac in vitro and in vivo...
  3. ncbi request reprint Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis
    Naoki Inoue
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Japan
    J Pharmacol Sci 112:73-82. 2010
    ..NS-126 is a long-acting intranasal corticosteroid and a promising therapeutic agent for allergic rhinitis...
  4. ncbi request reprint The enantiomers of etodolac, a racemic anti-inflammatory agent, play different roles in efficacy and gastrointestinal safety
    Naoki Inoue
    Pharmacology Department, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Biol Pharm Bull 34:655-9. 2011
    ..Our results show that each enantiomer plays a different role in the efficacy and gastrointestinal safety of etodolac...
  5. doi request reprint Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia
    Sunao Ito
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14, Nishinosho monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    J Pharmacol Exp Ther 342:53-60. 2012
    ..Our findings suggest that etodolac attenuates paclitaxel-induced peripheral neuropathy by a COX-independent pathway and that it might be useful for the treatment of paclitaxel-induced peripheral neuropathy...
  6. doi request reprint Blockade of voltage-gated calcium channel Ca(v)1.2 and α1-adrenoceptors increases vertebral artery blood flow induced by the antivertigo agent difenidol
    Kohji Murakami
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14, Kisshoin, Kyoto 601 8550, Japan
    Eur J Pharmacol 689:165-71. 2012
    ..These findings suggest that the difenidol-induced increase in vertebral arterial blood flow may be due to vascular relaxation mediated by mixed blocking actions at α(1)-adrenoceptors and voltage-gated calcium channel Ca(v)1.2...
  7. ncbi request reprint Relevance of anti-reactive oxygen species activity to anti-inflammatory activity of components of eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia
    Michiko Oka
    Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Phytomedicine 14:465-72. 2007
    ..These findings suggest that the suppression of ROS by EVI-1, EVI-2 and EVI-4 may partly contribute to the anti-inflammatory action of eviprostat, and this action may be implicated in its therapeutic effect on BPH...
  8. doi request reprint Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors
    Kohei Kagayama
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Bioorg Med Chem 17:6959-70. 2009
    ..The most potent of these, when topically administered, were effective in a mouse model of dermatitis...
  9. ncbi request reprint Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats
    Masaki Tachibana
    Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan
    Pharmacology 68:96-104. 2003
    ....