Akihiko Gemma

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. ncbi request reprint Drug-induced interstitial lung diseases associated with molecular-targeted anticancer agents
    Akihiko Gemma
    Division of Pulmonary Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 76:4-8. 2009
  2. ncbi request reprint Phase I/II study of paclitaxel + carboplatin for refractory or recurrent non-small cell lung cancer
    Akihiko Gemma
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Tokyo, Japan
    Anticancer Res 26:3083-7. 2006
  3. pmc Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database
    Akihiko Gemma
    The Fourth Department of Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    BMC Cancer 6:174. 2006
  4. doi request reprint Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression
    Rintaro Noro
    Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Cancer Sci 101:1424-30. 2010
  5. doi request reprint Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model
    Akihiko Miyanaga
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Mol Cancer Ther 7:1923-30. 2008
  6. ncbi request reprint Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer
    Tetsuya Okano
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Oncol Rep 15:545-9. 2006
  7. pmc Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation
    Rintaro Noro
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    BMC Cancer 6:277. 2006
  8. ncbi request reprint Gemcitabine resistance in a highly metastatic subpopulation of a pulmonary adenocarcinoma cell line resistant to gefitinib
    Akira Takemura
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, Tokyo, Japan
    Int J Oncol 31:1325-32. 2007
  9. ncbi request reprint E-cadherin expression and epidermal growth factor receptor mutation status predict outcome in non-small cell lung cancer patients treated with gefitinib
    Akihiko Miyanaga
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Oncol Rep 19:377-83. 2008
  10. ncbi request reprint Proteomic signatures for histological types of lung cancer
    Masahiro Seike
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 5:2939-48. 2005

Detail Information

Publications68

  1. ncbi request reprint Drug-induced interstitial lung diseases associated with molecular-targeted anticancer agents
    Akihiko Gemma
    Division of Pulmonary Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 76:4-8. 2009
    ..These studies may shed light on the underlying mechanisms of drug-induced ILD and appropriate evidence-based strategies that can be used to prevent or manage these events...
  2. ncbi request reprint Phase I/II study of paclitaxel + carboplatin for refractory or recurrent non-small cell lung cancer
    Akihiko Gemma
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Tokyo, Japan
    Anticancer Res 26:3083-7. 2006
    ..The median survival time was 12 months. This combination showed a promising clinical activity with mild toxicity and should be selected for the investigational arm of phase III trials to be compared with either docetaxel or pemetrexed...
  3. pmc Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database
    Akihiko Gemma
    The Fourth Department of Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    BMC Cancer 6:174. 2006
    ..It is consequently desirable to find more appropriate therapeutic opportunities based on informed insights. A molecular pharmacological analysis was undertaken to design an improved chemotherapeutic strategy for advanced lung cancer...
  4. doi request reprint Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression
    Rintaro Noro
    Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Cancer Sci 101:1424-30. 2010
    ..We conclude that combination therapy with SAHA and S-1 in lung cancer may be promising due to its potential to overcome S-1 resistance via modulation of 5-FU/S-1 sensitivity-associated biomarker (TS) by HDAC inhibitor...
  5. doi request reprint Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model
    Akihiko Miyanaga
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Mol Cancer Ther 7:1923-30. 2008
    ....
  6. ncbi request reprint Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer
    Tetsuya Okano
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Oncol Rep 15:545-9. 2006
    ..These results suggest that the ING1 and ING2 genes have different roles in lung carcinogenesis and progression, and the ING2 gene may be an independent tumor suppressor candidate on p53...
  7. pmc Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation
    Rintaro Noro
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    BMC Cancer 6:277. 2006
    ..However, gefitinib-sensitive and prolonged stable-disease-defined tumors without EGFR gene mutation have also been reported...
  8. ncbi request reprint Gemcitabine resistance in a highly metastatic subpopulation of a pulmonary adenocarcinoma cell line resistant to gefitinib
    Akira Takemura
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, Tokyo, Japan
    Int J Oncol 31:1325-32. 2007
    ..The combination of anti-cancer drugs and inhibition of the molecules related with apoptosis and/or Akt pathway might be beneficial in the treatment of metastatic NSCLC...
  9. ncbi request reprint E-cadherin expression and epidermal growth factor receptor mutation status predict outcome in non-small cell lung cancer patients treated with gefitinib
    Akihiko Miyanaga
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Oncol Rep 19:377-83. 2008
    ..In patients with surgically resected NSCLC tumors, the EGFR mutation status and E-cadherin staining can select patients who will benefit from gefitinib therapy...
  10. ncbi request reprint Proteomic signatures for histological types of lung cancer
    Masahiro Seike
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 5:2939-48. 2005
    ..In conclusion, our results demonstrate the utility of quantitative proteomic analysis for molecular diagnosis and classification of lung cancer cells...
  11. doi request reprint A case of pneumocystis pneumonia associated with everolimus therapy for renal cell carcinoma
    Yoshinobu Saito
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan, Japan
    Jpn J Clin Oncol 43:559-62. 2013
    ....
  12. ncbi request reprint PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors
    Rintaro Noro
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Int J Oncol 31:1157-63. 2007
    ....
  13. ncbi request reprint Alternating chemotherapy with amrubicin plus cisplatin and weekly administration of irinotecan plus cisplatin for extensive-stage small cell lung cancer
    Rintaro Noro
    Department of Clinical Oncology, Tokyo Medical University Hospital, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Anticancer Res 33:1117-23. 2013
    ..A phase II study was conducted in order to determine the tumor efficacy and tolerance of alternating chemotherapy for extensive-stage small cell lung cancer (ED-SCLC)...
  14. doi request reprint Association between genetic variations in surfactant protein d and emphysema, interstitial pneumonia, and lung cancer in a Japanese population
    Takeo Ishii
    Department of Pulmonary Medicine, Infection and Oncology, The Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan
    COPD 9:409-16. 2012
    ..Our results suggested that SFTPD plays a role in the development of lung cancer and that the role for lung cancer may differ from that for interstitial pneumonia...
  15. pmc MiR-23a regulates TGF-β-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells
    Mengru Cao
    Department of Internal Medicine, Division of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Tokyo 113 8603, Japan
    Int J Oncol 41:869-75. 2012
    ..These findings suggest that miR-23a regulates TGF-β-induced EMT by targeting E-cadherin in lung cancer cells and may be useful as a new therapeutic target in NSCLC...
  16. doi request reprint The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias
    Yuji Minegishi
    Division of Pulmonary Medicine, Infectious Disease, and Oncology, Department of Internal Medicine, Nippon Mediccl School, Tokyo, Japan
    J Thorac Oncol 6:801-7. 2011
    ..Nevertheless, there has been no consensus and no evidence presented, regarding optimal treatment for advanced lung cancer with IIP...
  17. doi request reprint The safety and efficacy of weekly paclitaxel in combination with carboplatin for advanced non-small cell lung cancer with idiopathic interstitial pneumonias
    Yuji Minegishi
    Division of Pulmonary Medicine, Infectious Disease, and Oncology, Department of Internal Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Lung Cancer 71:70-4. 2011
    ..However, there has been no consensus and no evidence presented, regarding optimal treatment for advanced lung cancer with IIP...
  18. ncbi request reprint Increased expression of the LGALS3 (galectin 3) gene in human non-small-cell lung cancer
    Akinobu Yoshimura
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Genes Chromosomes Cancer 37:159-64. 2003
    ..Accordingly, LGALS3 may be a phenotypic marker that excludes small-cell lung cancer and may represent a novel target molecule in non-small-cell lung cancer therapy...
  19. ncbi request reprint Reduced transcription of the RB2/p130 gene in human lung cancer
    Hu Xue Jun
    Fourth Department of Medicine, Nippon Medical School, Tokyo, Japan
    Mol Carcinog 38:124-9. 2003
    ..The observed reduction in RB2/p130 gene expression may be due to histone deacetylation, altered mRNA stability, and/or other forms of transcriptional regulation...
  20. ncbi request reprint In vitro simulation study of individualized chemotherapy in lung cancer
    Cai Li
    Department of Pulmonary Medicine Infection and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nihon Med Sch 74:217-22. 2007
    ..With elucidation of additional drug sensitivity factors, selection of appropriate anticancer drugs by gene expression profiling may make it possible to increase the response rate in lung cancer chemotherapy...
  21. pmc A comparison of three multidimensional indices of COPD severity as predictors of future exacerbations
    Takashi Motegi
    Division of Pulmonary Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Int J Chron Obstruct Pulmon Dis 8:259-71. 2013
    ..Prediction of future exacerbations of chronic obstructive pulmonary disease (COPD) is a major concern for long-term management of this disease...
  22. doi request reprint Efficient integrated education for older patients with chronic obstructive pulmonary disease using the Lung Information Needs Questionnaire
    Ritsuko Wakabayashi
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan
    Geriatr Gerontol Int 11:422-30. 2011
    ..We tested the hypothesis that integrated care focusing on patient information needs for self-management can improve patient information needs and health outcomes...
  23. ncbi request reprint Exacerbation of idiopathic interstitial pneumonias associated with lung cancer therapy
    Yuji Minegishi
    Department of Internal Medicine, Nippon Medical School, Tokyo
    Intern Med 48:665-72. 2009
    ..We aimed to identify an appropriate strategy for treatment of this condition. We analyzed clinical features of 120 LC with IIP, retrospectively...
  24. pmc Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4-ALK-rearranged non-small-cell lung cancer harbored coexisting EGFR mutation
    Akihiko Miyanaga
    Department of Pulmonary Medicine and Oncology, Nippon Medical School, Tokyo, Japan
    BMC Cancer 13:262. 2013
    ..The EML4-ALK fusion gene occurs generally in NSCLC without mutations in epidermal growth factor receptor (EGFR) and KRAS...
  25. doi request reprint Reduction in serum high mobility group box-1 level by polymyxin B-immobilized fiber column in patients with idiopathic pulmonary fibrosis with acute exacerbation
    Shinji Abe
    Department of Pulmonary Medicine Infection and Oncology, Internal Medicine, Nippon Medical School, Tokyo, Japan sabe nms ac jp
    Blood Purif 32:310-6. 2011
    ..This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE...
  26. pmc Evaluation of fractional analysis of bronchoalveolar lavage combined with cellular morphological features
    Namiko Taniuchi
    Department of Molecular Pathology, Institute of Development and Aging Sciences, Nippon Medical School, Graduate School of Medicine, Kawasaki, Japan
    Int J Med Sci 6:1-8. 2009
    ..The purpose of this study was to develop and evaluate a sequential analysis of cell content in fractional BAL (FBAL) from the airways and alveolar sacs with incorporation of the cellular morphologic features...
  27. ncbi request reprint Mutational analysis of the macrophage scavenger receptor 1 (MSR1) gene in primary lung cancer
    Akinobu Yoshimura
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 71:99-104. 2004
    ....
  28. pmc Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease
    Ryuko Furutate
    Respiratory Care Clinic, Nippon Medical School, Kudan minami, Chiyoda ku, Tokyo, Japan
    Int J Chron Obstruct Pulmon Dis 6:423-30. 2011
    ..The aim of this study was to investigate the abdominal visceral fat accumulation and the association between visceral fat and the severity and changes in emphysema in COPD patients...
  29. pmc Involvement of surfactant protein D in emphysema revealed by genetic association study
    Takeo Ishii
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, Tokyo, Japan
    Eur J Hum Genet 20:230-5. 2012
    ..Subjects with a C allele at rs721917 have a lower serum SFTPD concentration and are more susceptible to emphysema. This suggests a protective effect of SFTPD against COPD and emphysema...
  30. doi request reprint Decreased serum transforming growth factor-β1 concentration with aging is associated with the severity of emphysema in chronic obstructive pulmonary disease
    Koichiro Kamio
    Division of Pulmonary Medicine, Infectious Diseases and Oncology, Department of Internal Medicine, The Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan
    Geriatr Gerontol Int 13:1069-75. 2013
    ..As impaired TGF-β1 signaling could cause emphysema-like changes, we hypothesized that decreased TGF-β1 with aging is correlated with emphysema...
  31. doi request reprint Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer
    Yuichi Takiguchi
    Department of Respirology B2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Lung Cancer 68:409-14. 2010
    ..The most frequent toxicities experienced were neutropenia, febrile neutropenia and appetite loss; all toxicities were however well manageable. The present regimen showed a potent activity with mild toxicity in untreated NSCLC...
  32. ncbi request reprint Concerns with the health check-up system for chronic obstructive pulmonary disease on two Japanese islands
    Kazuyoshi Kimura
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Respiratory Care Clinic, Nippon Medical School, Japan
    Intern Med 50:2135-41. 2011
    ..This study investigated whether using spirometry during mass screening to detect COPD among community residents might be ineffective because of variability in the training and experience of examiners...
  33. doi request reprint Retrospective analysis of efficacy and safety of amrubicin in refractory and relapsed small-cell lung cancer
    Tsuneo Shimokawa
    Department of Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    Int J Clin Oncol 14:63-9. 2009
    ..Amrubicin, a totally synthetic 9-aminoanthracycline, was evaluated retrospectively for the treatment of refractory and relapsed small-cell lung cancer (SCLC)...
  34. ncbi request reprint Sequential analysis of myofibroblast differentiation and transforming growth factor-β1/Smad pathway activation in murine pulmonary fibrosis
    Jiro Usuki
    Division of Pulmonary Medicine, Infection Diseases and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 79:46-59. 2012
    ..These findings suggest that in pulmonary fibrosis the molecular mechanism of myofibroblast differentiation is complex and that the difference between ASMA expression and type I collagen expression is mediated by the TGF-β/Smad pathway...
  35. doi request reprint Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study
    Shinji Abe
    Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Tokyo, Japan
    Blood Purif 29:321-6. 2010
    ..This study was aimed to clarify the mechanism of PMX treatment for acute exacerbation of interstitial pneumonia (IP)...
  36. doi request reprint Reduced transcription of the Smad4 gene during pulmonary carcinogenesis in idiopathic pulmonary fibrosis
    Kiyoshi Takenaka
    Department of Internal Medicine, Divisions of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, Tokyo 113 8602, Japan
    Mol Med Report 2:73-80. 2009
    ..These findings are useful for the development of preventive measures or treatment for lung cancer patients with IPF...
  37. ncbi request reprint Granuloma-forming interstitial pneumonia occurring one year after the start of everolimus therapy
    Yoshinobu Saito
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
    Intern Med 52:263-7. 2013
    ..This is a slow-onset case of everolimus-induced ILD in a patient with renal cell carcinoma. Physicians should thus be aware of the potential for the development of ILD at any time during the administration of everolimus therapy...
  38. doi request reprint Bevacizumab plus chemotherapy for advanced non-squamous non-small-cell lung cancer with malignant pleural effusion
    Kazuhiro Kitamura
    Division of Pulmonary Medicine, Infection and Oncology, Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Cancer Chemother Pharmacol 71:457-61. 2013
    ....
  39. doi request reprint α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD)
    Koichiro Kamio
    Dept of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, and Respiratory Care Clinic, Nippon Medical School, Tokyo 102 0074, Japan
    Biochem Biophys Res Commun 424:112-7. 2012
    ..These data suggest that reduced Fut8 activity is associated with the progression of COPD and serum Fut8 activity is a non-invasive predictive biomarker candidate for progression and exacerbation of COPD...
  40. doi request reprint Fatal pneumonia associated with temozolomide therapy in patients with malignant glioma
    Hiroki Hayashi
    Division of Pulmonary Medicine, Infectious Diseases, and Oncology, Department of Internal Medicine, Nippon Medical School, and Department of Internal Medicine, Heisei Tateisi Hospital, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Jpn J Clin Oncol 42:632-6. 2012
    ..The patients should also be adequately informed about Pneumocystis pneumonia, and prophylaxis against Pneumocystis pneumonia should be considered proactively before treatment with temozolomide is initiated...
  41. doi request reprint Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema
    Miki Yamada
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 56:857-60. 2011
    ..5±14.7 vs 32.7±13.9, P=0.02). The FUT8 gene Thr267Lys polymorphism is associated with human PE, and the Lys allele is the risk. The core fucosylation might be involved in the molecular pathogenesis of human PE...
  42. ncbi request reprint [EGFR and gefitinib (Iressa)]
    Rintaro Noro
    Division of Pulmonary Medicine, Infectious Disease, and Oncology, Dept of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Gan To Kagaku Ryoho 35:1076-9. 2008
    ..3%, in the USA(FDA Approval Letter). Further studies about the prediction of drug-induced interstitial lung disease including SNPs analyses of the EGFR gene and other related molecules...
  43. doi request reprint Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms
    Takeo Ishii
    Department of Pulmonary Medicine, Infection and Oncology, The Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan
    J Hum Genet 56:41-6. 2011
    ..SLC6A4 variation also affects depressive symptoms. SLC6A4 could be modified to prevent COPD and treat the depressive symptoms of COPD...
  44. ncbi request reprint The promoter region of the human BUBR1 gene and its expression analysis in lung cancer
    Masahiro Seike
    Fourth Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Lung Cancer 38:229-34. 2002
    ..Knowledge of the genomic structure and the promoter region of the hBUBR1 gene will facilitate investigation of its role in mitotic checkpoint control and tumor progression in human cancers...
  45. ncbi request reprint An effective training program for chest tube drainage for medical interns in a clinical simulation laboratory
    Akinobu Yoshimura
    Academic Quality and Development Office, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 79:403-8. 2012
    ..Other systematic programs of skill training for medical interns are recommended to ensure definite acquisition of basic skills...
  46. ncbi request reprint Successful Treatment of Histiocytic Sarcoma and Concurrent HIV Infection Using a Combination of CHOP and Antiretroviral Therapy
    Kosuke Narita
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
    Intern Med 52:2805-9. 2013
    ..The patient has been in complete remission for 12 months following the discontinuation of chemotherapy under continuous ART. This case report may help to promote further investigation of both HS and HIV-related malignancy. ..
  47. ncbi request reprint Staphylococcal enterotoxin B toxic shock syndrome induced by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)
    Takeru Kashiwada
    Internal Medicine, Department of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Japan
    Intern Med 51:3085-8. 2012
    ..Moreover, this is the first report describing immunological confirmation of SEB contributing directly to TSS in a patient fulfilling the diagnostic criteria of TSS...
  48. doi request reprint Long-term management of chronic obstructive pulmonary disease: a survey of collaboration among physicians involved in pulmonary rehabilitation in Japan
    Takashi Motegi
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, Tokyo, Japan
    Respir Investig 50:98-103. 2012
    ..This study evaluated the implementation of pulmonary rehabilitation (PR), and the extent of the collaboration between primary care and chest physicians involved in the management of chronic obstructive pulmonary disease (COPD) in Japan...
  49. doi request reprint Presence of in-home caregiver and health outcomes of older adults with chronic obstructive pulmonary disease
    Ritsuko Wakabayashi
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan
    J Am Geriatr Soc 59:44-9. 2011
    ..To determine whether the presence of in-home caregivers is associated with changes in the health outcomes of older adults with chronic obstructive pulmonary disease (COPD)...
  50. ncbi request reprint [Iressa (gefitinib)]
    Shoji Kudoh
    Fourth Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Gan To Kagaku Ryoho 30:1079-84. 2003
    ..Phase III study of second/third line or maintenance therapy using gefitinib is required for such an evaluation. The development of individualized therapy with gefitinib might be also be required...
  51. ncbi request reprint [Drug-induced interstitial lung disease]
    Akihiko Gemma
    Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Gan To Kagaku Ryoho 35:1668-70. 2008
    ..These studies may help to shed light on the underlying mechanisms of DILD and appropriate strategies for such events...
  52. ncbi request reprint Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population
    Yuji Minegishi
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Cancer 110:353-62. 2007
    ....
  53. doi request reprint Differences in the clinical characteristics of Pneumocystis jirovecii pneumonia in immunocompromized patients with and without HIV infection
    Tatsuji Enomoto
    Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital, Tokyo 150 0013, Japan
    Respirology 15:126-31. 2010
    ..Knowing the different characteristics and outcomes of PCP according to HIV status would help physicians manage and treat patients with PCP...
  54. ncbi request reprint [Therapeutic biomarkers of EGFR-TKI]
    Masahiro Seike
    Dept of Internal Medicine, Division of Pulmonary Medicine Infection and Oncology, Nippon Medical School, Tokyo 113 8603, Japan
    Gan To Kagaku Ryoho 39:1613-7. 2012
    ..Further studies should be performed to clarify other mechanisms associated with the acquired resistance to EGFR-TKI. In this review, we summarize recent advances in the therapeutic biomarkers to EGFR-TKI...
  55. ncbi request reprint Proteomic signature of human cancer cells
    Masahiro Seike
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 4:2776-88. 2004
    ....
  56. ncbi request reprint [Pleuritis carcinomatosa]
    Akihiko Miyanaga
    Dept of Internal Medicine, Nippon Medical School, Japan
    Gan To Kagaku Ryoho 38:524-7. 2011
    ..Intrapleural treatment using OK-432 in the management of MPE was selected because it had the highest 4-week pleural progression-free survival rate and toxicity was tolerable. At present, OK- 432 is the standard agent used in Japan...
  57. ncbi request reprint Basic and clinical studies on functional RNA molecules for advanced medical technologies
    Toshihiro Takizawa
    Division of Molecular Medicine and Anatomy, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:71-9. 2010
    ..This review article is based on a presentation given at a symposium entitled Basic and Clinical Studies on Functional RNA Molecules for Advanced Medical Technologies held at Nippon Medical School in Tokyo, Japan, on November 7, 2009...
  58. ncbi request reprint Sleep apnea syndrome: central sleep apnea and pulmonary hypertension worsened during treatment with auto-CPAP, but improved by adaptive servo-ventilation
    Hiroshi Ono
    Department of Internal Medicine, The Division of Respiratory Medicine, Infection Diseases, and Oncology, Nippon Medical School, Tokyo
    Intern Med 49:415-21. 2010
    ..After replacing auto-CPAP with adaptive servo-ventilation (ASV), the apnea-hypopnea index was 5.3/hour and PAP became 36 mmHg after 3 months. It was thought that the increase of PAP was due to long-term inadequate use of auto-CPAP...
  59. ncbi request reprint [Pemetrexed]
    Junko Sudoh
    Dept of Respiratory Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Gan To Kagaku Ryoho 35:1033-8. 2008
    ..Pemetrexed is the expected agent for use in high risk patients, especially elderly or poor performance status patients...
  60. doi request reprint Clarification of clinical features of interstitial lung disease induced by irinotecan based on postmarketing surveillance data and spontaneous reports
    Noritoshi Yoshii
    Pharmacovigilance Department, Daiichi Sankyo Company Limited, Tokyo, Japan
    Anticancer Drugs 22:563-8. 2011
    ..In addition, when patients are receiving this type of therapy, they also need to undergo chest imaging studies...
  61. ncbi request reprint Evaluation of the usefulness of spectral analysis of inspiratory lung sounds recorded with phonopneumography in patients with interstitial pneumonia
    Hiroshi Ono
    Division of Pulmonary Medicine, Infection Diseases and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 76:67-75. 2009
    ..We investigated whether spectral analysis with fast Fourier transform (FFT) of inspiratory lung sounds is useful in the diagnosis and evaluation of the severity of interstitial pneumonia (IP)...
  62. ncbi request reprint [Lung cancer]
    Hideaki Mizutani
    Dept of Respiratory Medicine, Nippon Medical School, Tokyo, Japan
    Gan To Kagaku Ryoho 36:171-5. 2009
    ..From now on, not the NSCLC classification, but further detailed classification is needed to choose a treatment. Treatment selection in terms of the individual will be possible with ongoing study...
  63. doi request reprint Evaluation of right ventricular function in patients with COPD
    Yosuke Tanaka
    Department of Respiratory Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan
    Respir Care 58:816-23. 2013
    ..The aim of the present study was to test the hypothesis that it would be useful to include noninvasive markers of RV function in the routine assessment and prognostic models of early stage COPD with or without pulmonary hypertension...
  64. doi request reprint Current status of DILD in molecular targeted therapies
    Yoshinobu Saito
    Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Int J Clin Oncol 17:534-41. 2012
    ..The features of DILD can differ for each drug, and clinicians should thus keep this information about DILD in mind while treating patients...
  65. ncbi request reprint [Interstitial lung disease associated with chemotherapy and molecularly-targeted drug: diagnosis and management]
    Yoshinobu Saito
    Division of Pulmonary Medicine, Infectious Diseases, and Oncology, Dept of Internal Medicine, Nippon Medical School
    Gan To Kagaku Ryoho 38:2531-7. 2011
    ..However, an exceptional treatment is required for DILD caused by mTOR inhibitor, for which we must take account of the adequate management...
  66. ncbi request reprint Bronchoalveolar lavage fluid analysis provides diagnostic information on pulmonary Langerhans cell histiocytosis
    Yuko Takizawa
    Department of Molecular Pathology, Graduate School of Medicine, Nippon Medical School, Kawasaki, Kanagawa, Japan
    J Nippon Med Sch 76:84-92. 2009
    ....
  67. doi request reprint Emphysema on imaging is associated with quality of life in elderly patients with chronic obstructive pulmonary disease
    Norihisa Motohashi
    Department of Pulmonary Medicine, Infection and Oncology, The Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan
    Geriatr Gerontol Int 10:17-24. 2010
    ..The aim of this study was to examine the association between HRQOL, physical parameters and structural alterations in lung of COPD patients...
  68. ncbi request reprint [Genomic alterations in preneoplastic lesions]
    Akihiko Gemma
    4th Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Gan To Kagaku Ryoho 29:2451-7. 2002
    ..Advances in research on genomic alterations in preneoplastic lesions will contribute to prevention and early detection of cancer...